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The map label for this gene is hsaA [H]

Identifier: 37679775

GI number: 37679775

Start: 1633505

End: 1634677

Strand: Direct

Name: hsaA [H]

Synonym: VV1591

Alternate gene names: 37679775

Gene position: 1633505-1634677 (Clockwise)

Preceding gene: 37679773

Following gene: 37679777

Centisome position: 48.7

GC content: 50.21

Gene sequence:

>1173_bases
ATGATGAAACAGCACAATCCTCTACTTGAAAAGTTAAACGCTATCTTGCCAACCATTGCAAAGAACGCACAACAGGCTGA
ACAAGACCGCACTCCACCTGAAGAAAACATCCGTCTACTACGCGAAATCGGCTTTTTCCGCGCGTTCCAACCAAAAGCTT
ACGGCGGTTTGGAAATCTCTCTACCTGAATTTACTGATTGCGTGGCAGCGCTGGCTGGTGCGTGTGGCGGTACAGCATGG
GGCGCGAGTTTGTTAGCGACTCACAGCCACCAAATGGCGATGTTCTCTAAGCAAGCTCAAGAAGAGTTCTGGGGCAGCAA
CCCAGAAGCAACAGCGAGTTCAAGCATTGCGCCATTTGGTAAAATCGAAGAAGCCGAAGGCGGTGTAATCATCAACGGTG
ACATGCGTTGGAGTAGTGGCTGTGACCATGCAGACTGGGCGATTTTAGGCTTCAACCGTTTTGACGACGCAGGTAACAAG
ATCTACTGTTTCGGTGTCGTTCCTCGTCACGAATACAAGATCGTTGATGACTGGTATGCCGCGGGCATGAAATCAAGCGG
TACGAAAACGCTCGTATTGGACAACGTGTTTATCCCTGAACACCGCATCGAAACGGCAAAAGGCATGATGGAAGGTCACT
CAGCGGGCTTCGATTTGTATCCTGACAGCGACATTTTCTACACACCTTACCGTCCTTACTTTGCTTGTGGCTTCGCAGCG
ATCAGCTTAGGCATCGCTGAGCGTATGTTGGTGGTCTTTGCCGAGAAGCAGAAAAACCGCGTTCGTGCTTACACGGGTGC
TAATGTCGGTGTCGCAACACCTGCACTAATGCGTCTGGCTGAATCGACTCACCAAGTTGCGGCAGCACGCGCATTGCTTG
AGAAAACATGGAACGATCACAAAGAACACGGCGAACGTAAAGAATACCCAGATGCGGAAACTTTGACTTACTGGCGTACG
AACCAAGCTTACGCTGTGAAAATGTGTATTGCTGCTGTCGACCGCTTATTTGAAGCGATGGGCGGCATGGCTTGGTTTAG
CGATAACGAAGGCCAACGTTTGTTCCGCGATTCACACATGACGGGCGCCCACGCTTACACGGATTACGATGTTTGTGCAC
AGATTCTCGGGAGACAATTGATGGGGTTAGAGCCGGATCCAACAATGGTTTAA

Upstream 100 bases:

>100_bases
GTAAACATAGGTAACATCCATTTAACATCACATCGAGTGTGGCAATAATGAACCTACATCCCAATGAGAACAACAACAGG
GTTTACGTCAAAAGGAATCG

Downstream 100 bases:

>100_bases
GCGAGTTTTCCAGCGCAGCTAAAGGGCTGCGCTGGAGAGTTGTTAGCCGTTTATGTAACGTCCAGACAAATGTTGTTTGA
AAAACTTCGCATTGAGTGTT

Product: acyl-CoA dehydrogenase

Products: NA

Alternate protein names: 3-hydroxy-9,10-seconandrost-1,3,5(10)-triene-9,17-dione 4-hydroxylase [H]

Number of amino acids: Translated: 390; Mature: 390

Protein sequence:

>390_residues
MMKQHNPLLEKLNAILPTIAKNAQQAEQDRTPPEENIRLLREIGFFRAFQPKAYGGLEISLPEFTDCVAALAGACGGTAW
GASLLATHSHQMAMFSKQAQEEFWGSNPEATASSSIAPFGKIEEAEGGVIINGDMRWSSGCDHADWAILGFNRFDDAGNK
IYCFGVVPRHEYKIVDDWYAAGMKSSGTKTLVLDNVFIPEHRIETAKGMMEGHSAGFDLYPDSDIFYTPYRPYFACGFAA
ISLGIAERMLVVFAEKQKNRVRAYTGANVGVATPALMRLAESTHQVAAARALLEKTWNDHKEHGERKEYPDAETLTYWRT
NQAYAVKMCIAAVDRLFEAMGGMAWFSDNEGQRLFRDSHMTGAHAYTDYDVCAQILGRQLMGLEPDPTMV

Sequences:

>Translated_390_residues
MMKQHNPLLEKLNAILPTIAKNAQQAEQDRTPPEENIRLLREIGFFRAFQPKAYGGLEISLPEFTDCVAALAGACGGTAW
GASLLATHSHQMAMFSKQAQEEFWGSNPEATASSSIAPFGKIEEAEGGVIINGDMRWSSGCDHADWAILGFNRFDDAGNK
IYCFGVVPRHEYKIVDDWYAAGMKSSGTKTLVLDNVFIPEHRIETAKGMMEGHSAGFDLYPDSDIFYTPYRPYFACGFAA
ISLGIAERMLVVFAEKQKNRVRAYTGANVGVATPALMRLAESTHQVAAARALLEKTWNDHKEHGERKEYPDAETLTYWRT
NQAYAVKMCIAAVDRLFEAMGGMAWFSDNEGQRLFRDSHMTGAHAYTDYDVCAQILGRQLMGLEPDPTMV
>Mature_390_residues
MMKQHNPLLEKLNAILPTIAKNAQQAEQDRTPPEENIRLLREIGFFRAFQPKAYGGLEISLPEFTDCVAALAGACGGTAW
GASLLATHSHQMAMFSKQAQEEFWGSNPEATASSSIAPFGKIEEAEGGVIINGDMRWSSGCDHADWAILGFNRFDDAGNK
IYCFGVVPRHEYKIVDDWYAAGMKSSGTKTLVLDNVFIPEHRIETAKGMMEGHSAGFDLYPDSDIFYTPYRPYFACGFAA
ISLGIAERMLVVFAEKQKNRVRAYTGANVGVATPALMRLAESTHQVAAARALLEKTWNDHKEHGERKEYPDAETLTYWRT
NQAYAVKMCIAAVDRLFEAMGGMAWFSDNEGQRLFRDSHMTGAHAYTDYDVCAQILGRQLMGLEPDPTMV

Specific function: Catalyzes the o-hydroxylation of 3-hydroxy-9,10- seconandrost-1,3,5(10)-triene-9,17-dione (3-HSA) to 3,4-dihydroxy- 9,10-seconandrost-1,3,5(10)-triene-9,17-dione (3,4-DHSA) in the catabolism of cholesterol. Also catalyzes the o-hydroxylation of a range of

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the FADH(2)-utilizing monooxygenase family [H]

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013107
- InterPro:   IPR006092
- InterPro:   IPR006091
- InterPro:   IPR009075
- InterPro:   IPR013786
- InterPro:   IPR009100 [H]

Pfam domain/function: PF08028 Acyl-CoA_dh_2; PF02771 Acyl-CoA_dh_N [H]

EC number: NA

Molecular weight: Translated: 43292; Mature: 43292

Theoretical pI: Translated: 5.59; Mature: 5.59

Prosite motif: PS00099 THIOLASE_3

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.8 %Cys     (Translated Protein)
4.1 %Met     (Translated Protein)
5.9 %Cys+Met (Translated Protein)
1.8 %Cys     (Mature Protein)
4.1 %Met     (Mature Protein)
5.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MMKQHNPLLEKLNAILPTIAKNAQQAEQDRTPPEENIRLLREIGFFRAFQPKAYGGLEIS
CCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHCCCCCCCCCEEEE
LPEFTDCVAALAGACGGTAWGASLLATHSHQMAMFSKQAQEEFWGSNPEATASSSIAPFG
CCHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCC
KIEEAEGGVIINGDMRWSSGCDHADWAILGFNRFDDAGNKIYCFGVVPRHEYKIVDDWYA
CCCCCCCCEEEECCCCCCCCCCCCCEEEEECHHHCCCCCEEEEEEECCCCCEEEHHHHHH
AGMKSSGTKTLVLDNVFIPEHRIETAKGMMEGHSAGFDLYPDSDIFYTPYRPYFACGFAA
CCCCCCCCEEEEEECEECCHHHHHHHHHHHHCCCCCCCCCCCCCEEECCCCHHHHHHHHH
ISLGIAERMLVVFAEKQKNRVRAYTGANVGVATPALMRLAESTHQVAAARALLEKTWNDH
HHHHHHHHHHHHHHHHHCCCEEEECCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
KEHGERKEYPDAETLTYWRTNQAYAVKMCIAAVDRLFEAMGGMAWFSDNEGQRLFRDSHM
HHCCCCCCCCCCCCEEEEECCCHHHHHHHHHHHHHHHHHHCCEEEECCCCCHHHHHHCCC
TGAHAYTDYDVCAQILGRQLMGLEPDPTMV
CCCCCCCCHHHHHHHHHHHHCCCCCCCCCC
>Mature Secondary Structure
MMKQHNPLLEKLNAILPTIAKNAQQAEQDRTPPEENIRLLREIGFFRAFQPKAYGGLEIS
CCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHCCCCCCCCCEEEE
LPEFTDCVAALAGACGGTAWGASLLATHSHQMAMFSKQAQEEFWGSNPEATASSSIAPFG
CCHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCC
KIEEAEGGVIINGDMRWSSGCDHADWAILGFNRFDDAGNKIYCFGVVPRHEYKIVDDWYA
CCCCCCCCEEEECCCCCCCCCCCCCEEEEECHHHCCCCCEEEEEEECCCCCEEEHHHHHH
AGMKSSGTKTLVLDNVFIPEHRIETAKGMMEGHSAGFDLYPDSDIFYTPYRPYFACGFAA
CCCCCCCCEEEEEECEECCHHHHHHHHHHHHCCCCCCCCCCCCCEEECCCCHHHHHHHHH
ISLGIAERMLVVFAEKQKNRVRAYTGANVGVATPALMRLAESTHQVAAARALLEKTWNDH
HHHHHHHHHHHHHHHHHCCCEEEECCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
KEHGERKEYPDAETLTYWRTNQAYAVKMCIAAVDRLFEAMGGMAWFSDNEGQRLFRDSHM
HHCCCCCCCCCCCCEEEEECCCHHHHHHHHHHHHHHHHHHCCEEEECCCCCHHHHHHCCC
TGAHAYTDYDVCAQILGRQLMGLEPDPTMV
CCCCCCCCHHHHHHHHHHHHCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9634230; 12218036 [H]