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The map label for this gene is btuD [H]

Identifier: 37679665

GI number: 37679665

Start: 1518492

End: 1519256

Strand: Direct

Name: btuD [H]

Synonym: VV1481

Alternate gene names: 37679665

Gene position: 1518492-1519256 (Clockwise)

Preceding gene: 37679664

Following gene: 37679669

Centisome position: 45.27

GC content: 51.11

Gene sequence:

>765_bases
ATGCACATTAATCATATTAGTGTCGGCAATCGGCTTTTACCTCTGTCTTTTCAATGCGCTGCAGGTGAAAAAGTGTATGT
GGCGGGCCCAAACGGTTCTGGAAAAAGTACCTTATTGTCAGCCATTGCGGGCACACTGAGCTCGCGTGAAGGAGTCAAGG
GGGAAGTGTTGATCAACGAGACCTCTTTACTCACGCTGCCTTTAGCGGAACAAGCAATTTATCGGGCTTACCTGTGTCAG
CAATCGAGACCGGCGTTTAATGTCGACGTGTTTCAGATGTTGGCGCTCTCGTTACCGGCTGGAAGGCATGTGGTTGAGCC
AGAGGTTCAAGCGGCTGTGCGTAGAGTGGTGGAGTTGGTGCAACTGCAAGACAAGTTGCATCGCAGCGTGCAGGCCCTCT
CGGGTGGTGAATGGCAACGCGTGCGTCTAGCTGCGGTGTGCTTGCAAGTGTGGCGCTCGCTAAATCCTTACTCGCAATTG
CTGATCTTGGATGAGCCTGCCGCGCCGCTGGATGTTGCCCAAGCGAAGTGGTTGTATCAACTTATCGATGAGATGGCTGC
GCAAGGCTTGGTGGTGATTGTCGCCAATCATGATCTCAATCGTGTTTATCAACATGCGGACAAGGTGTTGTTGCTCAACC
AAGGCGTGTTAACCGCTTATGGCTCCGCAGACGAAGTGATGAGTGTGGAAAATCTACAACAGGTATTTGAAACGCCAGTA
AAAAAAGTGGCCGTTGACGGGCAGCCGTATTTGATTTTCACTTAG

Upstream 100 bases:

>100_bases
TGGGCAAGAACTTTATTGGATTCGGCAGAGCTGCCGCTGGGGGTGATGACCACCACCATTGGCGCGCCTATCTTTATCTG
GATGCTGATAAGGAGCCACG

Downstream 100 bases:

>100_bases
TATTGCAACAAAAAGCACCATTATAAAGAAGCCCGCACTTAGGCGGGCTAGCTTCATCAAACGGTTGGTTTGCTAAAACC
GGATGGCCAACTGAGAACAG

Product: vitamin B12-transporter ATPase

Products: NA

Alternate protein names: Vitamin B12-transporting ATPase [H]

Number of amino acids: Translated: 254; Mature: 254

Protein sequence:

>254_residues
MHINHISVGNRLLPLSFQCAAGEKVYVAGPNGSGKSTLLSAIAGTLSSREGVKGEVLINETSLLTLPLAEQAIYRAYLCQ
QSRPAFNVDVFQMLALSLPAGRHVVEPEVQAAVRRVVELVQLQDKLHRSVQALSGGEWQRVRLAAVCLQVWRSLNPYSQL
LILDEPAAPLDVAQAKWLYQLIDEMAAQGLVVIVANHDLNRVYQHADKVLLLNQGVLTAYGSADEVMSVENLQQVFETPV
KKVAVDGQPYLIFT

Sequences:

>Translated_254_residues
MHINHISVGNRLLPLSFQCAAGEKVYVAGPNGSGKSTLLSAIAGTLSSREGVKGEVLINETSLLTLPLAEQAIYRAYLCQ
QSRPAFNVDVFQMLALSLPAGRHVVEPEVQAAVRRVVELVQLQDKLHRSVQALSGGEWQRVRLAAVCLQVWRSLNPYSQL
LILDEPAAPLDVAQAKWLYQLIDEMAAQGLVVIVANHDLNRVYQHADKVLLLNQGVLTAYGSADEVMSVENLQQVFETPV
KKVAVDGQPYLIFT
>Mature_254_residues
MHINHISVGNRLLPLSFQCAAGEKVYVAGPNGSGKSTLLSAIAGTLSSREGVKGEVLINETSLLTLPLAEQAIYRAYLCQ
QSRPAFNVDVFQMLALSLPAGRHVVEPEVQAAVRRVVELVQLQDKLHRSVQALSGGEWQRVRLAAVCLQVWRSLNPYSQL
LILDEPAAPLDVAQAKWLYQLIDEMAAQGLVVIVANHDLNRVYQHADKVLLLNQGVLTAYGSADEVMSVENLQQVFETPV
KKVAVDGQPYLIFT

Specific function: Part of the ABC transporter complex BtuCDF involved in vitamin B12 import. Responsible for energy coupling to the transport system [H]

COG id: COG4138

COG function: function code H; ABC-type cobalamin transport system, ATPase component

Gene ontology:

Cell location: Cell inner membrane; Peripheral membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 ABC transporter domain [H]

Homologues:

Organism=Escherichia coli, GI1788002, Length=254, Percent_Identity=38.9763779527559, Blast_Score=170, Evalue=7e-44,
Organism=Escherichia coli, GI1786345, Length=237, Percent_Identity=34.1772151898734, Blast_Score=97, Evalue=1e-21,
Organism=Escherichia coli, GI1788165, Length=228, Percent_Identity=32.4561403508772, Blast_Score=78, Evalue=6e-16,
Organism=Escherichia coli, GI1788761, Length=219, Percent_Identity=29.6803652968037, Blast_Score=77, Evalue=1e-15,
Organism=Escherichia coli, GI1790739, Length=247, Percent_Identity=27.9352226720648, Blast_Score=77, Evalue=1e-15,
Organism=Escherichia coli, GI1790467, Length=215, Percent_Identity=29.7674418604651, Blast_Score=74, Evalue=6e-15,
Organism=Escherichia coli, GI1786803, Length=230, Percent_Identity=25.2173913043478, Blast_Score=73, Evalue=2e-14,
Organism=Escherichia coli, GI1790162, Length=232, Percent_Identity=28.0172413793103, Blast_Score=73, Evalue=2e-14,
Organism=Escherichia coli, GI1788053, Length=195, Percent_Identity=33.8461538461538, Blast_Score=72, Evalue=5e-14,
Organism=Escherichia coli, GI87081791, Length=213, Percent_Identity=26.7605633802817, Blast_Score=71, Evalue=7e-14,
Organism=Escherichia coli, GI1789593, Length=223, Percent_Identity=25.1121076233184, Blast_Score=71, Evalue=8e-14,
Organism=Escherichia coli, GI1790190, Length=215, Percent_Identity=25.5813953488372, Blast_Score=69, Evalue=3e-13,
Organism=Escherichia coli, GI87081834, Length=211, Percent_Identity=28.9099526066351, Blast_Score=69, Evalue=4e-13,
Organism=Escherichia coli, GI48994883, Length=222, Percent_Identity=28.3783783783784, Blast_Score=67, Evalue=1e-12,
Organism=Escherichia coli, GI1787792, Length=235, Percent_Identity=25.1063829787234, Blast_Score=67, Evalue=1e-12,
Organism=Escherichia coli, GI1787370, Length=228, Percent_Identity=26.3157894736842, Blast_Score=66, Evalue=2e-12,
Organism=Escherichia coli, GI1789672, Length=209, Percent_Identity=23.9234449760766, Blast_Score=66, Evalue=3e-12,
Organism=Escherichia coli, GI1786398, Length=218, Percent_Identity=28.8990825688073, Blast_Score=65, Evalue=3e-12,
Organism=Escherichia coli, GI1789873, Length=222, Percent_Identity=27.4774774774775, Blast_Score=65, Evalue=3e-12,
Organism=Escherichia coli, GI48994997, Length=232, Percent_Identity=26.7241379310345, Blast_Score=65, Evalue=4e-12,
Organism=Escherichia coli, GI1786253, Length=219, Percent_Identity=26.9406392694064, Blast_Score=65, Evalue=6e-12,
Organism=Escherichia coli, GI1786698, Length=202, Percent_Identity=29.7029702970297, Blast_Score=64, Evalue=6e-12,
Organism=Escherichia coli, GI1787029, Length=210, Percent_Identity=22.8571428571429, Blast_Score=64, Evalue=8e-12,
Organism=Escherichia coli, GI87081709, Length=206, Percent_Identity=25.7281553398058, Blast_Score=64, Evalue=8e-12,
Organism=Escherichia coli, GI87082267, Length=217, Percent_Identity=26.7281105990783, Blast_Score=63, Evalue=2e-11,
Organism=Escherichia coli, GI87081782, Length=210, Percent_Identity=28.5714285714286, Blast_Score=63, Evalue=2e-11,
Organism=Escherichia coli, GI1788225, Length=226, Percent_Identity=25.2212389380531, Blast_Score=62, Evalue=4e-11,
Organism=Escherichia coli, GI145693107, Length=242, Percent_Identity=27.2727272727273, Blast_Score=61, Evalue=9e-11,
Organism=Drosophila melanogaster, GI28574533, Length=214, Percent_Identity=28.0373831775701, Blast_Score=70, Evalue=1e-12,
Organism=Drosophila melanogaster, GI19920532, Length=221, Percent_Identity=27.1493212669683, Blast_Score=70, Evalue=1e-12,
Organism=Drosophila melanogaster, GI24580930, Length=221, Percent_Identity=27.1493212669683, Blast_Score=70, Evalue=1e-12,
Organism=Drosophila melanogaster, GI24666092, Length=212, Percent_Identity=30.188679245283, Blast_Score=68, Evalue=4e-12,
Organism=Drosophila melanogaster, GI85724858, Length=195, Percent_Identity=27.6923076923077, Blast_Score=66, Evalue=3e-11,
Organism=Drosophila melanogaster, GI85724856, Length=195, Percent_Identity=27.6923076923077, Blast_Score=66, Evalue=3e-11,
Organism=Drosophila melanogaster, GI24580547, Length=195, Percent_Identity=27.6923076923077, Blast_Score=66, Evalue=3e-11,
Organism=Drosophila melanogaster, GI24580551, Length=195, Percent_Identity=27.6923076923077, Blast_Score=66, Evalue=3e-11,
Organism=Drosophila melanogaster, GI24580549, Length=195, Percent_Identity=27.6923076923077, Blast_Score=66, Evalue=3e-11,
Organism=Drosophila melanogaster, GI24580545, Length=195, Percent_Identity=27.6923076923077, Blast_Score=66, Evalue=3e-11,
Organism=Drosophila melanogaster, GI161076682, Length=202, Percent_Identity=26.7326732673267, Blast_Score=65, Evalue=4e-11,
Organism=Drosophila melanogaster, GI161076684, Length=202, Percent_Identity=26.7326732673267, Blast_Score=65, Evalue=4e-11,
Organism=Drosophila melanogaster, GI24581617, Length=202, Percent_Identity=26.7326732673267, Blast_Score=65, Evalue=4e-11,
Organism=Drosophila melanogaster, GI24581615, Length=202, Percent_Identity=26.7326732673267, Blast_Score=65, Evalue=4e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003439
- InterPro:   IPR003593 [H]

Pfam domain/function: PF00005 ABC_tran [H]

EC number: =3.6.3.33 [H]

Molecular weight: Translated: 27832; Mature: 27832

Theoretical pI: Translated: 6.51; Mature: 6.51

Prosite motif: PS50893 ABC_TRANSPORTER_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
1.6 %Met     (Translated Protein)
2.8 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
1.6 %Met     (Mature Protein)
2.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MHINHISVGNRLLPLSFQCAAGEKVYVAGPNGSGKSTLLSAIAGTLSSREGVKGEVLINE
CCCCEECCCCEEECEEEEECCCCEEEEECCCCCCHHHHHHHHHHHHHCCCCCCCEEEEEC
TSLLTLPLAEQAIYRAYLCQQSRPAFNVDVFQMLALSLPAGRHVVEPEVQAAVRRVVELV
CCEEEECHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHH
QLQDKLHRSVQALSGGEWQRVRLAAVCLQVWRSLNPYSQLLILDEPAAPLDVAQAKWLYQ
HHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHCCCCCCEEEEEECCCCCHHHHHHHHHHH
LIDEMAAQGLVVIVANHDLNRVYQHADKVLLLNQGVLTAYGSADEVMSVENLQQVFETPV
HHHHHHHCCEEEEEECCCHHHHHHHHCCEEEEECCEEEECCCHHHHHHHHHHHHHHHHHH
KKVAVDGQPYLIFT
HHEEECCCCEEEEC
>Mature Secondary Structure
MHINHISVGNRLLPLSFQCAAGEKVYVAGPNGSGKSTLLSAIAGTLSSREGVKGEVLINE
CCCCEECCCCEEECEEEEECCCCEEEEECCCCCCHHHHHHHHHHHHHCCCCCCCEEEEEC
TSLLTLPLAEQAIYRAYLCQQSRPAFNVDVFQMLALSLPAGRHVVEPEVQAAVRRVVELV
CCEEEECHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHH
QLQDKLHRSVQALSGGEWQRVRLAAVCLQVWRSLNPYSQLLILDEPAAPLDVAQAKWLYQ
HHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHCCCCCCEEEEEECCCCCHHHHHHHHHHH
LIDEMAAQGLVVIVANHDLNRVYQHADKVLLLNQGVLTAYGSADEVMSVENLQQVFETPV
HHHHHHHCCEEEEEECCCHHHHHHHHCCEEEEECCEEEECCCHHHHHHHHHHHHHHHHHH
KKVAVDGQPYLIFT
HHEEECCCCEEEEC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: NA