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The map label for this gene is btuC [H]

Identifier: 37679664

GI number: 37679664

Start: 1517477

End: 1518502

Strand: Direct

Name: btuC [H]

Synonym: VV1480

Alternate gene names: 37679664

Gene position: 1517477-1518502 (Clockwise)

Preceding gene: 37679663

Following gene: 37679665

Centisome position: 45.24

GC content: 51.66

Gene sequence:

>1026_bases
TTGTTTAGCGAGCGAATTGAATCATTGCCCATGGAACTGCACCAACTGATAGCCCACAAAGAGAAGCGATGGCGAGCCAC
CTTATTGGTGATGTTGGCTGTGCTTTTGGTTCTCTCTGCTCTCTATTTGATGGTGGGTGAAGTCTTTCTTTCTCCGTTTT
CTTCCTTGAGCAGTTTTGAACACAAGCTGTTGGTTGATTTGCGTCTGCCGCGACTGATGGCGGCAATGGTGATCGGCGCG
GCATTAGCGGTCTCGGGGGCAACGTTACAAGTCTTGCTTGGCAATGTGCTTGCTGAACCTGGTGTGTTAGGAATCTCCGG
CGGGGCAAGTTTGGCCATGGTGATTGCGCTCTTTTTATTGCCAGTGATGCCGACGCCAACGGTGTTTATGCTGGCAGCGA
TCATTGGTGCCTTGGTTTTTACGTTGATTTTGGTGGGGATGGCAAGAGCGATGCACTTGTCGACCTCGAGAATGCTCCTC
GTGGGGGTGGCGCTCGGTATTTTATCGGGCGCGTTTGTCACTTGGGCCTTTTATTTCAGTGACGATCTCAGCTTGCGTCA
ATTGATGTATTGGTTAATGGGGAGCATTGGTGGGGCAAGTTGGCACCATCATATGGTGACACTTGTATTGCTTCCGGTCT
TGGTTTGGCTTTGTCTGCAAGGGCAAACTTTGGACAAACTGATGCTGGGTGAAACGCACGCCGTGCAACTGGGCGTTGAT
GTGCACAAGGTACGTTGGCGGCTGATTTTGGCGGTCTCCATCTTGATCGGCTGCGCGGTGGCTCTTGGCGGTATTATCAG
CTTTGTTGGTTTGGTCGTGCCTCATTTGCTGCGCATGGCATTTGGTTCCGAAAACCGATTCTTGTTGCCGCTGTCGGCGT
TTGCCGGGGCGACGTTATTGGTCTTTTCTGACATTTGGGCAAGAACTTTATTGGATTCGGCAGAGCTGCCGCTGGGGGTG
ATGACCACCACCATTGGCGCGCCTATCTTTATCTGGATGCTGATAAGGAGCCACGATGCACATTAA

Upstream 100 bases:

>100_bases
GTTTACGATTAAGCTCTTTTGCGCTCAGGCTGCTTAAGAGCACCAAGAGAGCGAGTTTAATGGTTTATTTCTGAAAGGCT
TAACGTTAGAGTTAAGCCTT

Downstream 100 bases:

>100_bases
TCATATTAGTGTCGGCAATCGGCTTTTACCTCTGTCTTTTCAATGCGCTGCAGGTGAAAAAGTGTATGTGGCGGGCCCAA
ACGGTTCTGGAAAAAGTACC

Product: vtamin B12-transporter permease

Products: ADP; phosphate; cob(I)alamin [Cytoplasm] [C]

Alternate protein names: NA

Number of amino acids: Translated: 341; Mature: 341

Protein sequence:

>341_residues
MFSERIESLPMELHQLIAHKEKRWRATLLVMLAVLLVLSALYLMVGEVFLSPFSSLSSFEHKLLVDLRLPRLMAAMVIGA
ALAVSGATLQVLLGNVLAEPGVLGISGGASLAMVIALFLLPVMPTPTVFMLAAIIGALVFTLILVGMARAMHLSTSRMLL
VGVALGILSGAFVTWAFYFSDDLSLRQLMYWLMGSIGGASWHHHMVTLVLLPVLVWLCLQGQTLDKLMLGETHAVQLGVD
VHKVRWRLILAVSILIGCAVALGGIISFVGLVVPHLLRMAFGSENRFLLPLSAFAGATLLVFSDIWARTLLDSAELPLGV
MTTTIGAPIFIWMLIRSHDAH

Sequences:

>Translated_341_residues
MFSERIESLPMELHQLIAHKEKRWRATLLVMLAVLLVLSALYLMVGEVFLSPFSSLSSFEHKLLVDLRLPRLMAAMVIGA
ALAVSGATLQVLLGNVLAEPGVLGISGGASLAMVIALFLLPVMPTPTVFMLAAIIGALVFTLILVGMARAMHLSTSRMLL
VGVALGILSGAFVTWAFYFSDDLSLRQLMYWLMGSIGGASWHHHMVTLVLLPVLVWLCLQGQTLDKLMLGETHAVQLGVD
VHKVRWRLILAVSILIGCAVALGGIISFVGLVVPHLLRMAFGSENRFLLPLSAFAGATLLVFSDIWARTLLDSAELPLGV
MTTTIGAPIFIWMLIRSHDAH
>Mature_341_residues
MFSERIESLPMELHQLIAHKEKRWRATLLVMLAVLLVLSALYLMVGEVFLSPFSSLSSFEHKLLVDLRLPRLMAAMVIGA
ALAVSGATLQVLLGNVLAEPGVLGISGGASLAMVIALFLLPVMPTPTVFMLAAIIGALVFTLILVGMARAMHLSTSRMLL
VGVALGILSGAFVTWAFYFSDDLSLRQLMYWLMGSIGGASWHHHMVTLVLLPVLVWLCLQGQTLDKLMLGETHAVQLGVD
VHKVRWRLILAVSILIGCAVALGGIISFVGLVVPHLLRMAFGSENRFLLPLSAFAGATLLVFSDIWARTLLDSAELPLGV
MTTTIGAPIFIWMLIRSHDAH

Specific function: Part of the ABC transporter complex BtuCDF involved in vitamin B12 import. Involved in the translocation of the substrate across the membrane [H]

COG id: COG4139

COG function: function code H; ABC-type cobalamin transport system, permease component

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily [H]

Homologues:

Organism=Escherichia coli, GI1788004, Length=292, Percent_Identity=47.6027397260274, Blast_Score=230, Evalue=1e-61,
Organism=Escherichia coli, GI1790740, Length=282, Percent_Identity=40.4255319148936, Blast_Score=145, Evalue=2e-36,
Organism=Escherichia coli, GI1790741, Length=286, Percent_Identity=32.8671328671329, Blast_Score=124, Evalue=9e-30,
Organism=Escherichia coli, GI1786805, Length=297, Percent_Identity=34.3434343434343, Blast_Score=113, Evalue=2e-26,
Organism=Escherichia coli, GI1786347, Length=288, Percent_Identity=36.8055555555556, Blast_Score=106, Evalue=3e-24,
Organism=Escherichia coli, GI1786804, Length=306, Percent_Identity=30.0653594771242, Blast_Score=87, Evalue=1e-18,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000522 [H]

Pfam domain/function: PF01032 FecCD [H]

EC number: NA

Molecular weight: Translated: 36949; Mature: 36949

Theoretical pI: Translated: 8.31; Mature: 8.31

Prosite motif: PS00041 HTH_ARAC_FAMILY_1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
5.6 %Met     (Translated Protein)
6.2 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
5.6 %Met     (Mature Protein)
6.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MFSERIESLPMELHQLIAHKEKRWRATLLVMLAVLLVLSALYLMVGEVFLSPFSSLSSFE
CCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
HKLLVDLRLPRLMAAMVIGAALAVSGATLQVLLGNVLAEPGVLGISGGASLAMVIALFLL
HHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHCCCCCEEECCCHHHHHHHHHHHH
PVMPTPTVFMLAAIIGALVFTLILVGMARAMHLSTSRMLLVGVALGILSGAFVTWAFYFS
HCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHC
DDLSLRQLMYWLMGSIGGASWHHHMVTLVLLPVLVWLCLQGQTLDKLMLGETHAVQLGVD
CCHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHCCCHHEEECCH
VHKVRWRLILAVSILIGCAVALGGIISFVGLVVPHLLRMAFGSENRFLLPLSAFAGATLL
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEHHHHHHHHHH
VFSDIWARTLLDSAELPLGVMTTTIGAPIFIWMLIRSHDAH
HHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHCCCC
>Mature Secondary Structure
MFSERIESLPMELHQLIAHKEKRWRATLLVMLAVLLVLSALYLMVGEVFLSPFSSLSSFE
CCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
HKLLVDLRLPRLMAAMVIGAALAVSGATLQVLLGNVLAEPGVLGISGGASLAMVIALFLL
HHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHCCCCCEEECCCHHHHHHHHHHHH
PVMPTPTVFMLAAIIGALVFTLILVGMARAMHLSTSRMLLVGVALGILSGAFVTWAFYFS
HCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHC
DDLSLRQLMYWLMGSIGGASWHHHMVTLVLLPVLVWLCLQGQTLDKLMLGETHAVQLGVD
CCHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHCCCHHEEECCH
VHKVRWRLILAVSILIGCAVALGGIISFVGLVVPHLLRMAFGSENRFLLPLSAFAGATLL
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEHHHHHHHHHH
VFSDIWARTLLDSAELPLGVMTTTIGAPIFIWMLIRSHDAH
HHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: ATP; cob(I)alamin [Periplasm]; H2O [C]

Specific reaction: ATP + cob(I)alamin [Periplasm] + H2O = ADP + phosphate + cob(I)alamin [Cytoplasm] [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: NA