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The map label for this gene is fadE [H]

Identifier: 37679620

GI number: 37679620

Start: 1466488

End: 1468773

Strand: Direct

Name: fadE [H]

Synonym: VV1436

Alternate gene names: 37679620

Gene position: 1466488-1468773 (Clockwise)

Preceding gene: 37679619

Following gene: 37679621

Centisome position: 43.72

GC content: 48.51

Gene sequence:

>2286_bases
ATGTGCTCTCTAAGAAAAAAATGGGTCAGCGACCCAGCATTTAAAATGTTCAAAAAAGTACTTCCTCCTTTGTCTGAAAC
AGAGAAGGAAGCAATGGAAGCGGGAAGTGTTTGGTGGGACGCGGAGCTGTTTTCTGGGAAGCCAGATTTCTCCAAACTGC
ATCACTATCCAAAACCGACCTTGTCGGTTGAAGAGCAAGCTTTCATTGATAACGAGCTAGAAACACTGCTTGCAATGCTC
GATGATCATAAGATTGTGAAAGAAGATCGTGATTTACCGAAAGAGGTGTGGGAATACCTGCGTAAAGAGCGTTTTTTCTC
ACTGATCATTTCGAAGAAATATGGTGGCCGTCAGTTTTCTGCACTGGCGAACTCAACCATAGTAACCAAAATTGCGACAC
GTAGTATCAGTACCGCCGTGACGGTTATGGTACCGAACTCATTAGGCCCTGGTGAGCTCCTTTCTCACTACGGTACACAG
GCACAAAAAGATTACTGGCTACCTCGTCTTGCCGATGGTACAGACATTCCTTGTTTTGCATTGACGGGTCCAGAAGCTGG
CTCGGATGCTGGCGGTATTCCCGATCAAGGCGTGGTCTGCTATGGCATGCATGAAGGCAAAGAAGTTCTTGGTATTCGTT
TGAGTTGGAACAAGCGTTACATCACTCTCGCCCCTGTCGCAACCGTGCTTGGTCTCGCATTTAAACTTCAAGACCCTGAT
CATCTGTTAGGTGATAAAACCGATGTTGGCATCACTTGTGCTTTGATTCCCGCCGATCATGAAGGTGTGGTGATTGGTGA
GCGTCACGATCCTCTAGGTCTGGCGTTTATGAACGGCCCAACTCGTGGCCATGATGTGTTCATCCCGATGGACTGGCTGA
TTGGTGGTGCGGATTATGCTGGTAAAGGCTGGCGCATGCTGGTGGAGTGTTTATCGGCTGGGCGTGGTATTTCACTGCCT
GCGCTTGGCACGGCCATAGGTCATTTGACCACGCGCACAACGGGGGCATACGCCTATGTGCGCAAACAATTTGGCATGTC
GATCGGTAAGTTTGAAGGTGTTGCAGAAGCGATGGGACGAATTGGCGGTTTGACCTACTTATTGGAAGCCACTCGTACTT
TGACCACAACATCGCTCGATCTGAAGGAAAAACCTGGCATTGTAACCGCTATTGCTAAGTATCACATGACGGAGATGGCA
AGAACGATTCTTGATGACTCGATGGATATTCACTCTGGTCGTGCGATTCAAGATGGTCCGATGAACTACCTAGCGACCCA
TTATCTTGGTATCCCTGTAGCGATTACGGTTGAAGGTGCCAATATTCTCACTCGTAACCTAATGATTTTTGGCCAAGGTG
CAACGCGATGCCATCCTTACGTTTTGAAAGAAATGGAAGCCGCAGCGAACCCAGATGCCAAAGAAGGTGCGAAACAATTC
GACGATTTGCTGTTTAAGCATATTAAACATGCCACGTTCAATACTCTCGGTGCCTTAGGTGCCGCGCTAACTGGCTCACG
CTTTGTAAAAGCACACATGAGCGGCCCAACGCAACGTTACTACAAAGACATGACACGTCTGAGTCGAGCCTTGGCGGTCA
GTGCCGATTTCGCCATGTTAACACTAGGCGGTGAACTGAAACGTAAAGAGATGATTTCTGCACGTTTGGGTGATGGCCTT
AGCTATCTTTACATGGCCTCAGCAGCATTGAAAAAATATGAAGACGAAGGTCGCCAACAAGCGGATCTCAACTTCGTCCA
TTACGCAGTGCAGCACTGTTTGCATCACGCAGCGAAGTCGTTGAACGAAGCCTATGCTAACTTCCCAGTGAAATATGTCG
GTGGCGTGCTCAAAGGGCTACTATTCCCACTTGGCAATCACTTTGCTAAACCAAGTGATGAACTCTGTGTGGATATTGCG
GAAGCGATGATGACCCCAGGCGTGCAGCGCGACCGATTGACTAACTTGTGTTACATCGGCAAAGAGAAAGACGACAGTGT
TGGTTTGATGGAGCAAGCATTCCTTGCGATGTACGACATCAAACCGCTGGAGCGTAAGCTGATGAAAGCGGCAAAAGATG
GCAAAGTGGCTCGTAAAGGCTTGCTGGCTGAGCGTCTGCAACAAGCGCTAGACGCCGATGTGCTAACGCAAAGTGAAGTG
GATAAAATCTTGGCCGCCGATAAGCTGCGTTACCAAGCGATCCAAGTGGATCACTTCAGCTTTGACTTCTCAAAGACGCT
TACCAATGCGCCTGAGAAAAAAAAGAAGTTAACTAGCGCGGCGTAG

Upstream 100 bases:

>100_bases
TGATTCCCTATCTCTCAGCCGGCATGTCCGCTGAGTAGCTATTATTAAAATACAAACAAGGACCAATAGGTTCCACCAAG
TGAACAAAAGGATCTGAACT

Downstream 100 bases:

>100_bases
CACCATCGCAGTGAAGAGACGAACCAAGCACCTCAAATGAGGTGCTTTTTCGTATGGTTAGCAATAGAAATCGGTGCATA
GAGCTCCAACCACTTGCATT

Product: acyl-CoA dehydrogenase

Products: NA

Alternate protein names: ACDH [H]

Number of amino acids: Translated: 761; Mature: 761

Protein sequence:

>761_residues
MCSLRKKWVSDPAFKMFKKVLPPLSETEKEAMEAGSVWWDAELFSGKPDFSKLHHYPKPTLSVEEQAFIDNELETLLAML
DDHKIVKEDRDLPKEVWEYLRKERFFSLIISKKYGGRQFSALANSTIVTKIATRSISTAVTVMVPNSLGPGELLSHYGTQ
AQKDYWLPRLADGTDIPCFALTGPEAGSDAGGIPDQGVVCYGMHEGKEVLGIRLSWNKRYITLAPVATVLGLAFKLQDPD
HLLGDKTDVGITCALIPADHEGVVIGERHDPLGLAFMNGPTRGHDVFIPMDWLIGGADYAGKGWRMLVECLSAGRGISLP
ALGTAIGHLTTRTTGAYAYVRKQFGMSIGKFEGVAEAMGRIGGLTYLLEATRTLTTTSLDLKEKPGIVTAIAKYHMTEMA
RTILDDSMDIHSGRAIQDGPMNYLATHYLGIPVAITVEGANILTRNLMIFGQGATRCHPYVLKEMEAAANPDAKEGAKQF
DDLLFKHIKHATFNTLGALGAALTGSRFVKAHMSGPTQRYYKDMTRLSRALAVSADFAMLTLGGELKRKEMISARLGDGL
SYLYMASAALKKYEDEGRQQADLNFVHYAVQHCLHHAAKSLNEAYANFPVKYVGGVLKGLLFPLGNHFAKPSDELCVDIA
EAMMTPGVQRDRLTNLCYIGKEKDDSVGLMEQAFLAMYDIKPLERKLMKAAKDGKVARKGLLAERLQQALDADVLTQSEV
DKILAADKLRYQAIQVDHFSFDFSKTLTNAPEKKKKLTSAA

Sequences:

>Translated_761_residues
MCSLRKKWVSDPAFKMFKKVLPPLSETEKEAMEAGSVWWDAELFSGKPDFSKLHHYPKPTLSVEEQAFIDNELETLLAML
DDHKIVKEDRDLPKEVWEYLRKERFFSLIISKKYGGRQFSALANSTIVTKIATRSISTAVTVMVPNSLGPGELLSHYGTQ
AQKDYWLPRLADGTDIPCFALTGPEAGSDAGGIPDQGVVCYGMHEGKEVLGIRLSWNKRYITLAPVATVLGLAFKLQDPD
HLLGDKTDVGITCALIPADHEGVVIGERHDPLGLAFMNGPTRGHDVFIPMDWLIGGADYAGKGWRMLVECLSAGRGISLP
ALGTAIGHLTTRTTGAYAYVRKQFGMSIGKFEGVAEAMGRIGGLTYLLEATRTLTTTSLDLKEKPGIVTAIAKYHMTEMA
RTILDDSMDIHSGRAIQDGPMNYLATHYLGIPVAITVEGANILTRNLMIFGQGATRCHPYVLKEMEAAANPDAKEGAKQF
DDLLFKHIKHATFNTLGALGAALTGSRFVKAHMSGPTQRYYKDMTRLSRALAVSADFAMLTLGGELKRKEMISARLGDGL
SYLYMASAALKKYEDEGRQQADLNFVHYAVQHCLHHAAKSLNEAYANFPVKYVGGVLKGLLFPLGNHFAKPSDELCVDIA
EAMMTPGVQRDRLTNLCYIGKEKDDSVGLMEQAFLAMYDIKPLERKLMKAAKDGKVARKGLLAERLQQALDADVLTQSEV
DKILAADKLRYQAIQVDHFSFDFSKTLTNAPEKKKKLTSAA
>Mature_761_residues
MCSLRKKWVSDPAFKMFKKVLPPLSETEKEAMEAGSVWWDAELFSGKPDFSKLHHYPKPTLSVEEQAFIDNELETLLAML
DDHKIVKEDRDLPKEVWEYLRKERFFSLIISKKYGGRQFSALANSTIVTKIATRSISTAVTVMVPNSLGPGELLSHYGTQ
AQKDYWLPRLADGTDIPCFALTGPEAGSDAGGIPDQGVVCYGMHEGKEVLGIRLSWNKRYITLAPVATVLGLAFKLQDPD
HLLGDKTDVGITCALIPADHEGVVIGERHDPLGLAFMNGPTRGHDVFIPMDWLIGGADYAGKGWRMLVECLSAGRGISLP
ALGTAIGHLTTRTTGAYAYVRKQFGMSIGKFEGVAEAMGRIGGLTYLLEATRTLTTTSLDLKEKPGIVTAIAKYHMTEMA
RTILDDSMDIHSGRAIQDGPMNYLATHYLGIPVAITVEGANILTRNLMIFGQGATRCHPYVLKEMEAAANPDAKEGAKQF
DDLLFKHIKHATFNTLGALGAALTGSRFVKAHMSGPTQRYYKDMTRLSRALAVSADFAMLTLGGELKRKEMISARLGDGL
SYLYMASAALKKYEDEGRQQADLNFVHYAVQHCLHHAAKSLNEAYANFPVKYVGGVLKGLLFPLGNHFAKPSDELCVDIA
EAMMTPGVQRDRLTNLCYIGKEKDDSVGLMEQAFLAMYDIKPLERKLMKAAKDGKVARKGLLAERLQQALDADVLTQSEV
DKILAADKLRYQAIQVDHFSFDFSKTLTNAPEKKKKLTSAA

Specific function: Catalyzes the dehydrogenation of acyl-CoA [H]

COG id: COG1960

COG function: function code I; Acyl-CoA dehydrogenases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the acyl-CoA dehydrogenase family [H]

Homologues:

Organism=Homo sapiens, GI21361497, Length=387, Percent_Identity=27.906976744186, Blast_Score=103, Evalue=6e-22,
Organism=Homo sapiens, GI4557233, Length=317, Percent_Identity=29.3375394321767, Blast_Score=86, Evalue=2e-16,
Organism=Homo sapiens, GI4501859, Length=360, Percent_Identity=28.0555555555556, Blast_Score=83, Evalue=9e-16,
Organism=Homo sapiens, GI4557235, Length=408, Percent_Identity=24.0196078431373, Blast_Score=83, Evalue=1e-15,
Organism=Homo sapiens, GI76496475, Length=387, Percent_Identity=24.031007751938, Blast_Score=80, Evalue=7e-15,
Organism=Escherichia coli, GI87081702, Length=758, Percent_Identity=50.131926121372, Blast_Score=768, Evalue=0.0,
Organism=Caenorhabditis elegans, GI17508101, Length=372, Percent_Identity=29.0322580645161, Blast_Score=85, Evalue=1e-16,
Organism=Caenorhabditis elegans, GI71985184, Length=387, Percent_Identity=25.8397932816537, Blast_Score=83, Evalue=7e-16,
Organism=Caenorhabditis elegans, GI17506239, Length=276, Percent_Identity=27.536231884058, Blast_Score=75, Evalue=1e-13,
Organism=Caenorhabditis elegans, GI32563615, Length=269, Percent_Identity=26.3940520446097, Blast_Score=72, Evalue=1e-12,
Organism=Caenorhabditis elegans, GI71985192, Length=352, Percent_Identity=25.2840909090909, Blast_Score=72, Evalue=1e-12,
Organism=Drosophila melanogaster, GI281363737, Length=538, Percent_Identity=23.4200743494424, Blast_Score=89, Evalue=1e-17,
Organism=Drosophila melanogaster, GI24666513, Length=337, Percent_Identity=26.7062314540059, Blast_Score=67, Evalue=4e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006092
- InterPro:   IPR006090
- InterPro:   IPR006091
- InterPro:   IPR009075
- InterPro:   IPR013786
- InterPro:   IPR009100
- InterPro:   IPR015396 [H]

Pfam domain/function: PF00441 Acyl-CoA_dh_1; PF02770 Acyl-CoA_dh_M; PF02771 Acyl-CoA_dh_N; PF09317 DUF1974 [H]

EC number: NA

Molecular weight: Translated: 83723; Mature: 83723

Theoretical pI: Translated: 7.85; Mature: 7.85

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
3.5 %Met     (Translated Protein)
4.7 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
3.5 %Met     (Mature Protein)
4.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MCSLRKKWVSDPAFKMFKKVLPPLSETEKEAMEAGSVWWDAELFSGKPDFSKLHHYPKPT
CCCCCHHHCCCHHHHHHHHHCCCCCHHHHHHHHCCCCEEEHHHCCCCCCHHHHCCCCCCC
LSVEEQAFIDNELETLLAMLDDHKIVKEDRDLPKEVWEYLRKERFFSLIISKKYGGRQFS
CCCCHHHHHHHHHHHHHHHHCCCHHHHHHCCCHHHHHHHHHHHHHHHHHHHCCCCCCHHH
ALANSTIVTKIATRSISTAVTVMVPNSLGPGELLSHYGTQAQKDYWLPRLADGTDIPCFA
HHHCCHHHHHHHHHHHCEEEEEEECCCCCHHHHHHHCCCCCCCCCCCCCCCCCCCCCEEE
LTGPEAGSDAGGIPDQGVVCYGMHEGKEVLGIRLSWNKRYITLAPVATVLGLAFKLQDPD
ECCCCCCCCCCCCCCCCEEEEECCCCCEEEEEEEECCCEEEEHHHHHHHHHHHHCCCCCH
HLLGDKTDVGITCALIPADHEGVVIGERHDPLGLAFMNGPTRGHDVFIPMDWLIGGADYA
HHCCCCCCCCEEEEEEECCCCCEEEECCCCCCEEEEECCCCCCCEEEEEHHHHCCCCCCC
GKGWRMLVECLSAGRGISLPALGTAIGHLTTRTTGAYAYVRKQFGMSIGKFEGVAEAMGR
CCHHHHHHHHHHCCCCCCCCHHHHHHHHHHHCCCHHHHHHHHHHCCCHHHHHHHHHHHHH
IGGLTYLLEATRTLTTTSLDLKEKPGIVTAIAKYHMTEMARTILDDSMDIHSGRAIQDGP
HHHHHHHHHHHHHHEEEECCCCCCCCHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCC
MNYLATHYLGIPVAITVEGANILTRNLMIFGQGATRCHPYVLKEMEAAANPDAKEGAKQF
HHHHHHHHCCCCEEEEECCCCEEEEEEEEEECCCCCCCHHHHHHHHHHCCCCHHHHHHHH
DDLLFKHIKHATFNTLGALGAALTGSRFVKAHMSGPTQRYYKDMTRLSRALAVSADFAML
HHHHHHHHHHHHHHHHHHHHHHHCCCHHHEECCCCCHHHHHHHHHHHHHHHHHCCCEEEE
TLGGELKRKEMISARLGDGLSYLYMASAALKKYEDEGRQQADLNFVHYAVQHCLHHAAKS
ECCCHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHH
LNEAYANFPVKYVGGVLKGLLFPLGNHFAKPSDELCVDIAEAMMTPGVQRDRLTNLCYIG
HHHHHHCCCHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHCCCCCHHHHCCEEEEC
KEKDDSVGLMEQAFLAMYDIKPLERKLMKAAKDGKVARKGLLAERLQQALDADVLTQSEV
CCCCCCCHHHHHHHHHHHCCCHHHHHHHHHHCCCHHHHHHHHHHHHHHHHCHHHHHHHHH
DKILAADKLRYQAIQVDHFSFDFSKTLTNAPEKKKKLTSAA
HHHHHHHHHHHEEEEEEECCCCHHHHHCCCCHHHHHHHCCC
>Mature Secondary Structure
MCSLRKKWVSDPAFKMFKKVLPPLSETEKEAMEAGSVWWDAELFSGKPDFSKLHHYPKPT
CCCCCHHHCCCHHHHHHHHHCCCCCHHHHHHHHCCCCEEEHHHCCCCCCHHHHCCCCCCC
LSVEEQAFIDNELETLLAMLDDHKIVKEDRDLPKEVWEYLRKERFFSLIISKKYGGRQFS
CCCCHHHHHHHHHHHHHHHHCCCHHHHHHCCCHHHHHHHHHHHHHHHHHHHCCCCCCHHH
ALANSTIVTKIATRSISTAVTVMVPNSLGPGELLSHYGTQAQKDYWLPRLADGTDIPCFA
HHHCCHHHHHHHHHHHCEEEEEEECCCCCHHHHHHHCCCCCCCCCCCCCCCCCCCCCEEE
LTGPEAGSDAGGIPDQGVVCYGMHEGKEVLGIRLSWNKRYITLAPVATVLGLAFKLQDPD
ECCCCCCCCCCCCCCCCEEEEECCCCCEEEEEEEECCCEEEEHHHHHHHHHHHHCCCCCH
HLLGDKTDVGITCALIPADHEGVVIGERHDPLGLAFMNGPTRGHDVFIPMDWLIGGADYA
HHCCCCCCCCEEEEEEECCCCCEEEECCCCCCEEEEECCCCCCCEEEEEHHHHCCCCCCC
GKGWRMLVECLSAGRGISLPALGTAIGHLTTRTTGAYAYVRKQFGMSIGKFEGVAEAMGR
CCHHHHHHHHHHCCCCCCCCHHHHHHHHHHHCCCHHHHHHHHHHCCCHHHHHHHHHHHHH
IGGLTYLLEATRTLTTTSLDLKEKPGIVTAIAKYHMTEMARTILDDSMDIHSGRAIQDGP
HHHHHHHHHHHHHHEEEECCCCCCCCHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCC
MNYLATHYLGIPVAITVEGANILTRNLMIFGQGATRCHPYVLKEMEAAANPDAKEGAKQF
HHHHHHHHCCCCEEEEECCCCEEEEEEEEEECCCCCCCHHHHHHHHHHCCCCHHHHHHHH
DDLLFKHIKHATFNTLGALGAALTGSRFVKAHMSGPTQRYYKDMTRLSRALAVSADFAML
HHHHHHHHHHHHHHHHHHHHHHHCCCHHHEECCCCCHHHHHHHHHHHHHHHHHCCCEEEE
TLGGELKRKEMISARLGDGLSYLYMASAALKKYEDEGRQQADLNFVHYAVQHCLHHAAKS
ECCCHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHH
LNEAYANFPVKYVGGVLKGLLFPLGNHFAKPSDELCVDIAEAMMTPGVQRDRLTNLCYIG
HHHHHHCCCHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHCCCCCHHHHCCEEEEC
KEKDDSVGLMEQAFLAMYDIKPLERKLMKAAKDGKVARKGLLAERLQQALDADVLTQSEV
CCCCCCCHHHHHHHHHHHCCCHHHHHHHHHHCCCHHHHHHHHHHHHHHHHCHHHHHHHHH
DKILAADKLRYQAIQVDHFSFDFSKTLTNAPEKKKKLTSAA
HHHHHHHHHHHEEEEEEECCCCHHHHHCCCCHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]