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The map label for this gene is uvrB [H]

Identifier: 37679377

GI number: 37679377

Start: 1209387

End: 1211429

Strand: Direct

Name: uvrB [H]

Synonym: VV1193

Alternate gene names: 37679377

Gene position: 1209387-1211429 (Clockwise)

Preceding gene: 37679367

Following gene: 37679379

Centisome position: 36.05

GC content: 47.48

Gene sequence:

>2043_bases
GTGAGAGGGAAAATGAGCAAACTTTACGATCTGGTTTCTGACTATGCGCCATCGGGAGATCAACCAACGGCGATCAAACA
ACTGACAGAAGGGTTGGATGCTGGCTTGGCTCACCAAACCTTACTTGGGGTGACGGGATCCGGTAAAACATTTACTTTGG
CGAATGTGATTGCTCAAGCACAACGTCCTGCAATTCTGCTCGCGCCAAACAAAACTCTTGCCGCCCAACTTTACGGCGAG
ATGAAAGCGTTTTTCCCCAATAACGCGGTCGAATATTTTGTCTCTTACTACGATTATTACCAACCTGAAGCCTATGTGCC
AACCACCGACACCTTTATAGAGAAGGACTCATCGGTCAACGCTCATATTGAACAAATGCGTTTATCGGCCACCAAAGCGT
TATTGGAGCGAAAAGACGCTATTATCGTCGCCTCTGTTTCGGCTATTTATGGTTTGGGTGATCCCGAGGCCTACCTGCAA
ATGATGTTGCATATACGCCGTGGTGATGTGATGGATCAACGCGACATACTGCGCCGTTTGGCTGAGCTGCAATATAGCCG
TAACGATATTGCTTTTGAACGAGGCCAATTTCGCGTGCGCGGAGAGGTGATCGACGTTTTTCCGGCTGAATCGGACCAAG
ATGCGGTGCGCATCGAGATGTTTGATGATGAGATCGACTGCATCAGTGTGTTTGATCCACTGACCGGAGTGGTCAAACAA
CGCGATTTACCCCGCTTTACTATTTACCCTAAGACTCACTACGTCACACCTCGAGAGCGTATTCTGCAGGCGATTGAAAA
CATCAAACAAGAGCTGCGTGAGCGACAAACTTACTTGCGTGACAACAATAAATTGTTGGAAGAGCAACGTATTAGTCAGC
GTACCCAATTCGATATTGAAATGATGAATGAGCTGGGATTCTGCTCTGGCATCGAAAACTACTCGCGTTACCTCAGCGGT
CGAGCGGAAGGTGAGCCGCCTCCAACGTTATTTGACTACTTACCACACGACGGTTTGTTGATCATTGATGAATCTCACGT
GACAGTGCCACAAATTGGCGCAATGTATAAAGGTGACCGCTCACGGAAAGAGACCTTGGTTGAATATGGTTTCCGTTTGC
CTTCAGCATTGGACAATCGACCATTGAAATTTGAAGAGTTCGAAGCGCTTGCGCCACAAACTATTTTCGTTTCAGCCACT
CCGGGTAATTACGAACTAGAGAAAAGTGCGGGCGAAATTGCTGACCAAGTGGTACGTCCGACCGGATTGCTCGATCCTGT
ACTGGAAGTGCGACCAGTGGCGACTCAAGTGGATGATCTGCTTTCTGAGATCCGCATTCGCGCAGTGAAAGATGAACGCG
TGTTAGTGACAACACTGACCAAACGTATGGCGGAAGATCTAACTGAATACTTGCATGAGCACGATGTGAAAGTGCGTTAC
CTACACTCTGATATCGACACGGTTGAACGAGTGGAGATCATTCGTGACTTGAGGCTAGGGGAGTTCGATGTGTTGGTGGG
GATTAACTTGTTACGCGAGGGCCTCGACATGCCCGAAGTGTCTTTGGTTGCGATTCTCGATGCTGATAAAGAAGGCTTTT
TACGTTCAGAGCGCTCATTGATTCAGACCATTGGCCGTGCAGCCCGTAACCTCCATGGTAAAGCGATCTTGTATGCAGAC
TCCATCACCAAATCGATGAAGAAAGCGATGGATGAAACGGAACGACGCCGTGAGAAACAGCAAGCGTACAATGAAAAGAT
GGGCATTCAGCCTCAAGCCTTGAAGCGTAATATCAAAGATATTATGGAGCTGGGCGATATTACGAAATCCCGCAAGCAGA
AAGTGAGCAAAACGGTGCCATTGTCGAAAGTGGCTGAACCATCACTGTCCTATAATGTGTTGACGCCACAACAACTGGAA
AAAGAAATCACAAAACTGGAAGCGCAAATGTACAAACACGCTCAGGATTTGGAATTTGAGTTAGCCGCGCAGAAACGTGA
TGAAATTGAAAAGTTGCGTCAGCAGTTTATTGCTAACAGCTAA

Upstream 100 bases:

>100_bases
ATTCGCTTGGCTGACTAAAAGGTGTGGTGTATGCCTAAATTGCAACTGTTCTTATGAAGGTTGGGAGTGTATATTTATAC
AGTTTTTACGTTGTGCTGTA

Downstream 100 bases:

>100_bases
CCAGAGTGTGGTGAATTAGCGCTTGAAATGAACAAAAAAAAGCCAACAGTCATTTCACTATTGGCTATCAATTGTGAACA
CTAGGTTCACTAACAACGTC

Product: excinuclease ABC subunit B

Products: NA

Alternate protein names: Protein uvrB; Excinuclease ABC subunit B [H]

Number of amino acids: Translated: 680; Mature: 680

Protein sequence:

>680_residues
MRGKMSKLYDLVSDYAPSGDQPTAIKQLTEGLDAGLAHQTLLGVTGSGKTFTLANVIAQAQRPAILLAPNKTLAAQLYGE
MKAFFPNNAVEYFVSYYDYYQPEAYVPTTDTFIEKDSSVNAHIEQMRLSATKALLERKDAIIVASVSAIYGLGDPEAYLQ
MMLHIRRGDVMDQRDILRRLAELQYSRNDIAFERGQFRVRGEVIDVFPAESDQDAVRIEMFDDEIDCISVFDPLTGVVKQ
RDLPRFTIYPKTHYVTPRERILQAIENIKQELRERQTYLRDNNKLLEEQRISQRTQFDIEMMNELGFCSGIENYSRYLSG
RAEGEPPPTLFDYLPHDGLLIIDESHVTVPQIGAMYKGDRSRKETLVEYGFRLPSALDNRPLKFEEFEALAPQTIFVSAT
PGNYELEKSAGEIADQVVRPTGLLDPVLEVRPVATQVDDLLSEIRIRAVKDERVLVTTLTKRMAEDLTEYLHEHDVKVRY
LHSDIDTVERVEIIRDLRLGEFDVLVGINLLREGLDMPEVSLVAILDADKEGFLRSERSLIQTIGRAARNLHGKAILYAD
SITKSMKKAMDETERRREKQQAYNEKMGIQPQALKRNIKDIMELGDITKSRKQKVSKTVPLSKVAEPSLSYNVLTPQQLE
KEITKLEAQMYKHAQDLEFELAAQKRDEIEKLRQQFIANS

Sequences:

>Translated_680_residues
MRGKMSKLYDLVSDYAPSGDQPTAIKQLTEGLDAGLAHQTLLGVTGSGKTFTLANVIAQAQRPAILLAPNKTLAAQLYGE
MKAFFPNNAVEYFVSYYDYYQPEAYVPTTDTFIEKDSSVNAHIEQMRLSATKALLERKDAIIVASVSAIYGLGDPEAYLQ
MMLHIRRGDVMDQRDILRRLAELQYSRNDIAFERGQFRVRGEVIDVFPAESDQDAVRIEMFDDEIDCISVFDPLTGVVKQ
RDLPRFTIYPKTHYVTPRERILQAIENIKQELRERQTYLRDNNKLLEEQRISQRTQFDIEMMNELGFCSGIENYSRYLSG
RAEGEPPPTLFDYLPHDGLLIIDESHVTVPQIGAMYKGDRSRKETLVEYGFRLPSALDNRPLKFEEFEALAPQTIFVSAT
PGNYELEKSAGEIADQVVRPTGLLDPVLEVRPVATQVDDLLSEIRIRAVKDERVLVTTLTKRMAEDLTEYLHEHDVKVRY
LHSDIDTVERVEIIRDLRLGEFDVLVGINLLREGLDMPEVSLVAILDADKEGFLRSERSLIQTIGRAARNLHGKAILYAD
SITKSMKKAMDETERRREKQQAYNEKMGIQPQALKRNIKDIMELGDITKSRKQKVSKTVPLSKVAEPSLSYNVLTPQQLE
KEITKLEAQMYKHAQDLEFELAAQKRDEIEKLRQQFIANS
>Mature_680_residues
MRGKMSKLYDLVSDYAPSGDQPTAIKQLTEGLDAGLAHQTLLGVTGSGKTFTLANVIAQAQRPAILLAPNKTLAAQLYGE
MKAFFPNNAVEYFVSYYDYYQPEAYVPTTDTFIEKDSSVNAHIEQMRLSATKALLERKDAIIVASVSAIYGLGDPEAYLQ
MMLHIRRGDVMDQRDILRRLAELQYSRNDIAFERGQFRVRGEVIDVFPAESDQDAVRIEMFDDEIDCISVFDPLTGVVKQ
RDLPRFTIYPKTHYVTPRERILQAIENIKQELRERQTYLRDNNKLLEEQRISQRTQFDIEMMNELGFCSGIENYSRYLSG
RAEGEPPPTLFDYLPHDGLLIIDESHVTVPQIGAMYKGDRSRKETLVEYGFRLPSALDNRPLKFEEFEALAPQTIFVSAT
PGNYELEKSAGEIADQVVRPTGLLDPVLEVRPVATQVDDLLSEIRIRAVKDERVLVTTLTKRMAEDLTEYLHEHDVKVRY
LHSDIDTVERVEIIRDLRLGEFDVLVGINLLREGLDMPEVSLVAILDADKEGFLRSERSLIQTIGRAARNLHGKAILYAD
SITKSMKKAMDETERRREKQQAYNEKMGIQPQALKRNIKDIMELGDITKSRKQKVSKTVPLSKVAEPSLSYNVLTPQQLE
KEITKLEAQMYKHAQDLEFELAAQKRDEIEKLRQQFIANS

Specific function: The UvrABC repair system catalyzes the recognition and processing of DNA lesions. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. Upon binding of the uvrA(2)B(2) complex to a putative damaged site, the DNA

COG id: COG0556

COG function: function code L; Helicase subunit of the DNA excision repair complex

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 UVR domain [H]

Homologues:

Organism=Escherichia coli, GI1786996, Length=677, Percent_Identity=74.8892171344165, Blast_Score=1028, Evalue=0.0,
Organism=Escherichia coli, GI1787357, Length=312, Percent_Identity=25.6410256410256, Blast_Score=72, Evalue=1e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR014001
- InterPro:   IPR001650
- InterPro:   IPR014021
- InterPro:   IPR006935
- InterPro:   IPR001943
- InterPro:   IPR004807
- InterPro:   IPR009055 [H]

Pfam domain/function: PF00271 Helicase_C; PF04851 ResIII; PF02151 UVR [H]

EC number: NA

Molecular weight: Translated: 77566; Mature: 77566

Theoretical pI: Translated: 5.15; Mature: 5.15

Prosite motif: PS50151 UVR

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
2.6 %Met     (Translated Protein)
2.9 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
2.6 %Met     (Mature Protein)
2.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRGKMSKLYDLVSDYAPSGDQPTAIKQLTEGLDAGLAHQTLLGVTGSGKTFTLANVIAQA
CCCHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHCCHHHHHHEEECCCCCEEHHHHHHHHC
QRPAILLAPNKTLAAQLYGEMKAFFPNNAVEYFVSYYDYYQPEAYVPTTDTFIEKDSSVN
CCCEEEECCCHHHHHHHHHHHHHHCCCHHHHHHHHHHHHCCCCCCCCCCHHHHCCCCCCH
AHIEQMRLSATKALLERKDAIIVASVSAIYGLGDPEAYLQMMLHIRRGDVMDQRDILRRL
HHHHHHHHHHHHHHHHCCCCEEEEEHHHHHCCCCHHHHHHHHHHHHCCCCCCHHHHHHHH
AELQYSRNDIAFERGQFRVRGEVIDVFPAESDQDAVRIEMFDDEIDCISVFDPLTGVVKQ
HHHHHCCCCCEEECCCEEEECEEEEEECCCCCCCCEEEEEECCCCCHHHHHHHHHHHHHH
RDLPRFTIYPKTHYVTPRERILQAIENIKQELRERQTYLRDNNKLLEEQRISQRTQFDIE
CCCCCEEECCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHH
MMNELGFCSGIENYSRYLSGRAEGEPPPTLFDYLPHDGLLIIDESHVTVPQIGAMYKGDR
HHHHHHHHCCHHHHHHHHCCCCCCCCCCHHHHCCCCCCEEEEECCCCCHHHHHHHHCCCC
SRKETLVEYGFRLPSALDNRPLKFEEFEALAPQTIFVSATPGNYELEKSAGEIADQVVRP
HHHHHHHHHHCCCCHHHCCCCCCHHHHHHCCCCEEEEEECCCCCEEHHHHHHHHHHHHCC
TGLLDPVLEVRPVATQVDDLLSEIRIRAVKDERVLVTTLTKRMAEDLTEYLHEHDVKVRY
CCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHCCCEEEE
LHSDIDTVERVEIIRDLRLGEFDVLVGINLLREGLDMPEVSLVAILDADKEGFLRSERSL
ECCCHHHHHHHHHHHHCCCCCHHHHHHHHHHHCCCCCCCEEEEEEEECCCHHHHHHHHHH
IQTIGRAARNLHGKAILYADSITKSMKKAMDETERRREKQQAYNEKMGIQPQALKRNIKD
HHHHHHHHHCCCCCEEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHH
IMELGDITKSRKQKVSKTVPLSKVAEPSLSYNVLTPQQLEKEITKLEAQMYKHAQDLEFE
HHHHHHHHHHHHHHHHHCCCHHHHCCCCCCEECCCHHHHHHHHHHHHHHHHHHHHCCHHH
LAAQKRDEIEKLRQQFIANS
HHHHHHHHHHHHHHHHCCCC
>Mature Secondary Structure
MRGKMSKLYDLVSDYAPSGDQPTAIKQLTEGLDAGLAHQTLLGVTGSGKTFTLANVIAQA
CCCHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHCCHHHHHHEEECCCCCEEHHHHHHHHC
QRPAILLAPNKTLAAQLYGEMKAFFPNNAVEYFVSYYDYYQPEAYVPTTDTFIEKDSSVN
CCCEEEECCCHHHHHHHHHHHHHHCCCHHHHHHHHHHHHCCCCCCCCCCHHHHCCCCCCH
AHIEQMRLSATKALLERKDAIIVASVSAIYGLGDPEAYLQMMLHIRRGDVMDQRDILRRL
HHHHHHHHHHHHHHHHCCCCEEEEEHHHHHCCCCHHHHHHHHHHHHCCCCCCHHHHHHHH
AELQYSRNDIAFERGQFRVRGEVIDVFPAESDQDAVRIEMFDDEIDCISVFDPLTGVVKQ
HHHHHCCCCCEEECCCEEEECEEEEEECCCCCCCCEEEEEECCCCCHHHHHHHHHHHHHH
RDLPRFTIYPKTHYVTPRERILQAIENIKQELRERQTYLRDNNKLLEEQRISQRTQFDIE
CCCCCEEECCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHH
MMNELGFCSGIENYSRYLSGRAEGEPPPTLFDYLPHDGLLIIDESHVTVPQIGAMYKGDR
HHHHHHHHCCHHHHHHHHCCCCCCCCCCHHHHCCCCCCEEEEECCCCCHHHHHHHHCCCC
SRKETLVEYGFRLPSALDNRPLKFEEFEALAPQTIFVSATPGNYELEKSAGEIADQVVRP
HHHHHHHHHHCCCCHHHCCCCCCHHHHHHCCCCEEEEEECCCCCEEHHHHHHHHHHHHCC
TGLLDPVLEVRPVATQVDDLLSEIRIRAVKDERVLVTTLTKRMAEDLTEYLHEHDVKVRY
CCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHCCCEEEE
LHSDIDTVERVEIIRDLRLGEFDVLVGINLLREGLDMPEVSLVAILDADKEGFLRSERSL
ECCCHHHHHHHHHHHHCCCCCHHHHHHHHHHHCCCCCCCEEEEEEEECCCHHHHHHHHHH
IQTIGRAARNLHGKAILYADSITKSMKKAMDETERRREKQQAYNEKMGIQPQALKRNIKD
HHHHHHHHHCCCCCEEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHH
IMELGDITKSRKQKVSKTVPLSKVAEPSLSYNVLTPQQLEKEITKLEAQMYKHAQDLEFE
HHHHHHHHHHHHHHHHHCCCHHHHCCCCCCEECCCHHHHHHHHHHHHHHHHHHHHCCHHH
LAAQKRDEIEKLRQQFIANS
HHHHHHHHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: DNA [C]

Specific reaction: Protein + DNA = Protein-DNA [C]

General reaction: Hydrolase; Acting on ester bonds [C]

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 12620739 [H]