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The map label for this gene is fadH [H]

Identifier: 37679337

GI number: 37679337

Start: 1165302

End: 1167314

Strand: Direct

Name: fadH [H]

Synonym: VV1153

Alternate gene names: 37679337

Gene position: 1165302-1167314 (Clockwise)

Preceding gene: 37679334

Following gene: 37679338

Centisome position: 34.74

GC content: 51.71

Gene sequence:

>2013_bases
ATGTCTGCCATGTACCCACATTTGTTACAGCCTTTGGATCTCGGATTCACTCAACTGCGAAATCGAGTGCTCATGGGTTC
GATGCATACAGGCCTTGAGGAGCATAAGGAAGGCTTACAAAAACTCGCTGCGTTTTACGAAGAGCGTGCCAAAGGTGGCG
TCGGTCTGATTGTGACGGGCGGTTTTTCACCGAATTTACGCGGTCGTCTGCACCCGCTGAGTGCGGAATTTAGTAAACCC
AAACACGCTCAAGCGCATAAAGTGGTGACGGAAGCCGTGCACAAACATGGCGGGAAAATCGCGCTGCAGATCCTGCATGC
TGGCCGCTATGCGATGCATCCTTTTGCGCAAAGTGCCTCTGGCATCAAAGCGCCTATCGCGAAGTTTGCACCCAGCGAAA
TGAGCCCAAGACAGATTCGCAAAACCATCGAAGCGTTCGCCAACAGCGCAGGTCTCGCGCAACTGGCAGGATACGATGGG
GTAGAGATCATGGGTTCCGAAGGTTACCTGATCAACCAATTCCTGTGTAAGCGTACCAATATGCGTTATGACGAGTGGGG
CGGTACCTACAAAAAACGCATGCGCTTTGCTGTGGAAATCGTCAAAGCGGTGCGCAAAGCGGTAGGCAGTGACTTCATCA
TTATTTTCCGCCTTTCTATGTTGGACTTGGTGGAGCAAGGCAGCACGTTTGAAGATGTGATTATGCTCGCCAAAGCGCTT
GAAGACGCAGGGGTGACGATCATTAACACTGGCATCGGCTGGCATGAAGCGCGAGTACCGACAATCGCAACGCAAGTGCC
TCGTGGCGCCTTCACTTGGGTTACTGAGAAAGTGAAGCCGCATGTCTCTGTGCCGATTGTGACCTGCAACCGAATCAACA
CCCCAGAAGAAGCAGAGCGCATTCTCGCTTCTGGGCAAGCGGACATGGTGTCGATGGCGCGACCTTTCCTCGCCGATCCG
CATTTCATTGCCAAAGCTGAGCAAGCGAAATCTCACCTTATCAATACCTGTATAGGCTGTAATCAGGCGTGTTTGGACAA
CGTATTCAAGGGCAAACGAGCCAGCTGTTTGGTTAACCCACTGGCGTGTCATGAAACCGAGTTGGTAGTGACGCCTGCGA
GTGAGAAAAAACGCATTGCGGTGGTGGGCGCAGGTCCTGCTGGGTTAGCGTGTTCAACCACCTTGGCGCAACGTGGCCAT
AGTGTTGATTTGATTGAACGAAATGATCGCATTGGTGGTCAGTTCCGCCTCGCGATGCAGATCCCTGGCAAAGAAGAATT
TCGTGAAACCATTCGCTACTTCGCCAATATGATTGACGAAACAGGGGTGAACTTACGCCTCGATACCGACGCCACGTTAG
AGCTGCTCAAAGAGTACGATGAAGTGGTGCTCGCCACTGGGGTTGAACCGCGCAAAGTGAAAATTGACGGCTTAACCGAA
AGCAGTAAAGTGATCGATTATCAAACATTGATCCGTGAGAAAACCCCAGTCGGTAACAAGATAGCGATTGTCGGTGCAGG
GGGAATTGGTGTCGATGTCGCGAGCATGGTCACAGAACCCGCTCAGCACAACCTAGACGACTGGCTACAAGAGTGGGGCA
TCGATAAAGAAATGACGCAACCGGGTGGCTTGTACCCATTCCCGGATGCGATGAGTGACAAAACAGTGTGGTTGCTGCAA
CGTCGTAAAGGTGCGGTAGGCAAAGGTCCGGGAAAAACCACAGGTTGGATTCACAAGCGCACATTGGAAAAACGTGGCGT
GAATTTGCTCGGGGGCGTGAGCTACGACAGTATCAAGCCTGAAGGATTGGAAATTACCGTCAATGGTAAGAAACAGTTAC
TTGATGCCGACACCATCATCATTTGTGCAGGCCAAGAATCGGTTCGCCCATTTGAAGACAAATGGCATGAGCTTGGCGAT
AAACTGCATGTGATCGGTGGGGCCGATTACGCAGGAGAACTGGATGCGGTTCGCGCGATTAAGCAAGGGGTCACGCTTGC
GACAAAACTTTAA

Upstream 100 bases:

>100_bases
TAAGATTGATCGGTGTTACAAAAATGTAAACGCATGTTTGATTTTTTAGATAAGAGCTCATACTCTGGTCTGACCACGAT
AATAAAAATGGAAGTTTGTC

Downstream 100 bases:

>100_bases
TCGGTGAAGGTTGAAGGTTTGAACATAAAAAATGCCGCGAAGTGATTCGCGGTATTTTTGTTTGAGCAGTTCTTGCGTAA
ATCGTGAATTTCCACAATAA

Product: 2,4-dienoyl-CoA reductase

Products: NA

Alternate protein names: 2,4-dienoyl coenzyme A reductase [H]

Number of amino acids: Translated: 670; Mature: 669

Protein sequence:

>670_residues
MSAMYPHLLQPLDLGFTQLRNRVLMGSMHTGLEEHKEGLQKLAAFYEERAKGGVGLIVTGGFSPNLRGRLHPLSAEFSKP
KHAQAHKVVTEAVHKHGGKIALQILHAGRYAMHPFAQSASGIKAPIAKFAPSEMSPRQIRKTIEAFANSAGLAQLAGYDG
VEIMGSEGYLINQFLCKRTNMRYDEWGGTYKKRMRFAVEIVKAVRKAVGSDFIIIFRLSMLDLVEQGSTFEDVIMLAKAL
EDAGVTIINTGIGWHEARVPTIATQVPRGAFTWVTEKVKPHVSVPIVTCNRINTPEEAERILASGQADMVSMARPFLADP
HFIAKAEQAKSHLINTCIGCNQACLDNVFKGKRASCLVNPLACHETELVVTPASEKKRIAVVGAGPAGLACSTTLAQRGH
SVDLIERNDRIGGQFRLAMQIPGKEEFRETIRYFANMIDETGVNLRLDTDATLELLKEYDEVVLATGVEPRKVKIDGLTE
SSKVIDYQTLIREKTPVGNKIAIVGAGGIGVDVASMVTEPAQHNLDDWLQEWGIDKEMTQPGGLYPFPDAMSDKTVWLLQ
RRKGAVGKGPGKTTGWIHKRTLEKRGVNLLGGVSYDSIKPEGLEITVNGKKQLLDADTIIICAGQESVRPFEDKWHELGD
KLHVIGGADYAGELDAVRAIKQGVTLATKL

Sequences:

>Translated_670_residues
MSAMYPHLLQPLDLGFTQLRNRVLMGSMHTGLEEHKEGLQKLAAFYEERAKGGVGLIVTGGFSPNLRGRLHPLSAEFSKP
KHAQAHKVVTEAVHKHGGKIALQILHAGRYAMHPFAQSASGIKAPIAKFAPSEMSPRQIRKTIEAFANSAGLAQLAGYDG
VEIMGSEGYLINQFLCKRTNMRYDEWGGTYKKRMRFAVEIVKAVRKAVGSDFIIIFRLSMLDLVEQGSTFEDVIMLAKAL
EDAGVTIINTGIGWHEARVPTIATQVPRGAFTWVTEKVKPHVSVPIVTCNRINTPEEAERILASGQADMVSMARPFLADP
HFIAKAEQAKSHLINTCIGCNQACLDNVFKGKRASCLVNPLACHETELVVTPASEKKRIAVVGAGPAGLACSTTLAQRGH
SVDLIERNDRIGGQFRLAMQIPGKEEFRETIRYFANMIDETGVNLRLDTDATLELLKEYDEVVLATGVEPRKVKIDGLTE
SSKVIDYQTLIREKTPVGNKIAIVGAGGIGVDVASMVTEPAQHNLDDWLQEWGIDKEMTQPGGLYPFPDAMSDKTVWLLQ
RRKGAVGKGPGKTTGWIHKRTLEKRGVNLLGGVSYDSIKPEGLEITVNGKKQLLDADTIIICAGQESVRPFEDKWHELGD
KLHVIGGADYAGELDAVRAIKQGVTLATKL
>Mature_669_residues
SAMYPHLLQPLDLGFTQLRNRVLMGSMHTGLEEHKEGLQKLAAFYEERAKGGVGLIVTGGFSPNLRGRLHPLSAEFSKPK
HAQAHKVVTEAVHKHGGKIALQILHAGRYAMHPFAQSASGIKAPIAKFAPSEMSPRQIRKTIEAFANSAGLAQLAGYDGV
EIMGSEGYLINQFLCKRTNMRYDEWGGTYKKRMRFAVEIVKAVRKAVGSDFIIIFRLSMLDLVEQGSTFEDVIMLAKALE
DAGVTIINTGIGWHEARVPTIATQVPRGAFTWVTEKVKPHVSVPIVTCNRINTPEEAERILASGQADMVSMARPFLADPH
FIAKAEQAKSHLINTCIGCNQACLDNVFKGKRASCLVNPLACHETELVVTPASEKKRIAVVGAGPAGLACSTTLAQRGHS
VDLIERNDRIGGQFRLAMQIPGKEEFRETIRYFANMIDETGVNLRLDTDATLELLKEYDEVVLATGVEPRKVKIDGLTES
SKVIDYQTLIREKTPVGNKIAIVGAGGIGVDVASMVTEPAQHNLDDWLQEWGIDKEMTQPGGLYPFPDAMSDKTVWLLQR
RKGAVGKGPGKTTGWIHKRTLEKRGVNLLGGVSYDSIKPEGLEITVNGKKQLLDADTIIICAGQESVRPFEDKWHELGDK
LHVIGGADYAGELDAVRAIKQGVTLATKL

Specific function: Catalyzes the NADP-dependent reduction of 2,4-dienoyl- CoA to yield trans-2- enoyl-CoA [H]

COG id: COG1902

COG function: function code C; NADH:flavin oxidoreductases, Old Yellow Enzyme family

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: NA

Homologues:

Organism=Escherichia coli, GI1789463, Length=671, Percent_Identity=55.7377049180328, Blast_Score=768, Evalue=0.0,
Organism=Escherichia coli, GI1787939, Length=352, Percent_Identity=26.4204545454545, Blast_Score=94, Evalue=3e-20,
Organism=Caenorhabditis elegans, GI17565138, Length=312, Percent_Identity=26.2820512820513, Blast_Score=98, Evalue=1e-20,
Organism=Caenorhabditis elegans, GI17566914, Length=306, Percent_Identity=28.1045751633987, Blast_Score=92, Evalue=6e-19,
Organism=Caenorhabditis elegans, GI17559802, Length=250, Percent_Identity=27.2, Blast_Score=90, Evalue=4e-18,
Organism=Caenorhabditis elegans, GI17559804, Length=253, Percent_Identity=26.0869565217391, Blast_Score=88, Evalue=1e-17,
Organism=Caenorhabditis elegans, GI17564188, Length=242, Percent_Identity=26.0330578512397, Blast_Score=86, Evalue=7e-17,
Organism=Caenorhabditis elegans, GI72001454, Length=322, Percent_Identity=23.9130434782609, Blast_Score=80, Evalue=3e-15,
Organism=Caenorhabditis elegans, GI17540738, Length=273, Percent_Identity=24.5421245421245, Blast_Score=78, Evalue=1e-14,
Organism=Saccharomyces cerevisiae, GI6325086, Length=237, Percent_Identity=28.2700421940928, Blast_Score=74, Evalue=7e-14,
Organism=Saccharomyces cerevisiae, GI6321973, Length=225, Percent_Identity=24.4444444444444, Blast_Score=73, Evalue=1e-13,
Organism=Drosophila melanogaster, GI28574881, Length=146, Percent_Identity=32.1917808219178, Blast_Score=70, Evalue=6e-12,
Organism=Drosophila melanogaster, GI24665539, Length=146, Percent_Identity=32.1917808219178, Blast_Score=70, Evalue=6e-12,
Organism=Drosophila melanogaster, GI24665547, Length=146, Percent_Identity=32.1917808219178, Blast_Score=69, Evalue=8e-12,
Organism=Drosophila melanogaster, GI24665543, Length=146, Percent_Identity=32.1917808219178, Blast_Score=69, Evalue=8e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013785
- InterPro:   IPR013027
- InterPro:   IPR001155 [H]

Pfam domain/function: PF00724 Oxidored_FMN; PF07992 Pyr_redox_2 [H]

EC number: =1.3.1.34 [H]

Molecular weight: Translated: 73261; Mature: 73130

Theoretical pI: Translated: 8.46; Mature: 8.46

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
2.7 %Met     (Translated Protein)
4.0 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
2.5 %Met     (Mature Protein)
3.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSAMYPHLLQPLDLGFTQLRNRVLMGSMHTGLEEHKEGLQKLAAFYEERAKGGVGLIVTG
CCCCCHHHHCHHHCCHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHCCCEEEEEEC
GFSPNLRGRLHPLSAEFSKPKHAQAHKVVTEAVHKHGGKIALQILHAGRYAMHPFAQSAS
CCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHCCCEEEEEEECCCCHHHCHHHHCCC
GIKAPIAKFAPSEMSPRQIRKTIEAFANSAGLAQLAGYDGVEIMGSEGYLINQFLCKRTN
CCHHHHHHCCCCCCCHHHHHHHHHHHHCCCCHHHHCCCCCEEEECCCCCCHHHHHHHHCC
MRYDEWGGTYKKRMRFAVEIVKAVRKAVGSDFIIIFRLSMLDLVEQGSTFEDVIMLAKAL
CCCHHCCCHHHHHHHHHHHHHHHHHHHHCCCEEEEHHHHHHHHHHCCCCHHHHHHHHHHH
EDAGVTIINTGIGWHEARVPTIATQVPRGAFTWVTEKVKPHVSVPIVTCNRINTPEEAER
HHCCEEEEECCCCCCCCCCCHHHHHCCCCHHHHHHHHCCCCCEEEEEEECCCCCHHHHHH
ILASGQADMVSMARPFLADPHFIAKAEQAKSHLINTCIGCNQACLDNVFKGKRASCLVNP
HHHCCCHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHCCCHHHHHHHHCCCCCCEEECC
LACHETELVVTPASEKKRIAVVGAGPAGLACSTTLAQRGHSVDLIERNDRIGGQFRLAMQ
HHCCCCEEEEECCCCCCEEEEEECCCCCCHHHHHHHHCCCCEEEEECCCCCCCEEEEEEE
IPGKEEFRETIRYFANMIDETGVNLRLDTDATLELLKEYDEVVLATGVEPRKVKIDGLTE
CCCHHHHHHHHHHHHHHHHHCCCEEEECCHHHHHHHHHHHHEEEECCCCCCEEEECCCCC
SSKVIDYQTLIREKTPVGNKIAIVGAGGIGVDVASMVTEPAQHNLDDWLQEWGIDKEMTQ
CCHHHHHHHHHHCCCCCCCEEEEEECCCCCHHHHHHHCCHHHCCHHHHHHHHCCCCCCCC
PGGLYPFPDAMSDKTVWLLQRRKGAVGKGPGKTTGWIHKRTLEKRGVNLLGGVSYDSIKP
CCCCCCCCCCCCCCEEEEEEHHCCCCCCCCCCCCCHHHHHHHHHCCCCEECCCCCCCCCC
EGLEITVNGKKQLLDADTIIICAGQESVRPFEDKWHELGDKLHVIGGADYAGELDAVRAI
CCEEEEECCCHHEECCCEEEEECCCCCCCCHHHHHHHCCCEEEEEECCCCCCHHHHHHHH
KQGVTLATKL
HHCCCEECCC
>Mature Secondary Structure 
SAMYPHLLQPLDLGFTQLRNRVLMGSMHTGLEEHKEGLQKLAAFYEERAKGGVGLIVTG
CCCCHHHHCHHHCCHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHCCCEEEEEEC
GFSPNLRGRLHPLSAEFSKPKHAQAHKVVTEAVHKHGGKIALQILHAGRYAMHPFAQSAS
CCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHCCCEEEEEEECCCCHHHCHHHHCCC
GIKAPIAKFAPSEMSPRQIRKTIEAFANSAGLAQLAGYDGVEIMGSEGYLINQFLCKRTN
CCHHHHHHCCCCCCCHHHHHHHHHHHHCCCCHHHHCCCCCEEEECCCCCCHHHHHHHHCC
MRYDEWGGTYKKRMRFAVEIVKAVRKAVGSDFIIIFRLSMLDLVEQGSTFEDVIMLAKAL
CCCHHCCCHHHHHHHHHHHHHHHHHHHHCCCEEEEHHHHHHHHHHCCCCHHHHHHHHHHH
EDAGVTIINTGIGWHEARVPTIATQVPRGAFTWVTEKVKPHVSVPIVTCNRINTPEEAER
HHCCEEEEECCCCCCCCCCCHHHHHCCCCHHHHHHHHCCCCCEEEEEEECCCCCHHHHHH
ILASGQADMVSMARPFLADPHFIAKAEQAKSHLINTCIGCNQACLDNVFKGKRASCLVNP
HHHCCCHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHCCCHHHHHHHHCCCCCCEEECC
LACHETELVVTPASEKKRIAVVGAGPAGLACSTTLAQRGHSVDLIERNDRIGGQFRLAMQ
HHCCCCEEEEECCCCCCEEEEEECCCCCCHHHHHHHHCCCCEEEEECCCCCCCEEEEEEE
IPGKEEFRETIRYFANMIDETGVNLRLDTDATLELLKEYDEVVLATGVEPRKVKIDGLTE
CCCHHHHHHHHHHHHHHHHHCCCEEEECCHHHHHHHHHHHHEEEECCCCCCEEEECCCCC
SSKVIDYQTLIREKTPVGNKIAIVGAGGIGVDVASMVTEPAQHNLDDWLQEWGIDKEMTQ
CCHHHHHHHHHHCCCCCCCEEEEEECCCCCHHHHHHHCCHHHCCHHHHHHHHCCCCCCCC
PGGLYPFPDAMSDKTVWLLQRRKGAVGKGPGKTTGWIHKRTLEKRGVNLLGGVSYDSIKP
CCCCCCCCCCCCCCEEEEEEHHCCCCCCCCCCCCCHHHHHHHHHCCCCEECCCCCCCCCC
EGLEITVNGKKQLLDADTIIICAGQESVRPFEDKWHELGDKLHVIGGADYAGELDAVRAI
CCEEEEECCCHHEECCCEEEEECCCCCCCCHHHHHHHCCCEEEEEECCCCCCHHHHHHHH
KQGVTLATKL
HHCCCEECCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9346310; 9278503 [H]