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The map label for this gene is menC [H]

Identifier: 37679303

GI number: 37679303

Start: 1127385

End: 1128374

Strand: Direct

Name: menC [H]

Synonym: VV1119

Alternate gene names: 37679303

Gene position: 1127385-1128374 (Clockwise)

Preceding gene: 161486639

Following gene: 37679304

Centisome position: 33.61

GC content: 50.2

Gene sequence:

>990_bases
ATGAAATCAGCCAAACTGTACCGCTACACCTTGCCAATGGACAGCGGTGTTGTGCTAAGAGATGAGAAACTGACGGAGCG
TGTTGGCTACATTATTGAGCTGAACATGAACGGTCAAAAAGGGTATGGCGAAGTTGCACCATTACCAGGATTTAGCTTAG
AGACCATAGAAGAAGCGGGCATTGAAGCGCAAGCACAGCTTGAGTTGTGGATGAACACCGATCATCCCATCGATTACGAC
GCCTTGCTGCCTTCCGTTGCGTTTGGTCTTTCCACCGCGATGTATGAGTTGGAAGGGAAGTTGCCTCGCGATGGGCACTA
TTTGCCCGCGCCACTTTGTACTGGCGATCCCGATGAACTCATTCCGGTATTGAATGCGATGCAAGGTGAGAAAGTCGCCA
AAGTCAAAGTGGGTTTGTACGAACCAATTCGTGATGGCATGCTGGTCAACTTGTTCTTGGAAAGCATCCCAGATCTCACA
CTGAGACTGGATGCCAATCGTGCTTGGACGCCAGAAAAAGCGCAGCAATTTGCCAAGTACATCACCCCCTCTTTGCGTCA
GCGGATCGTGTTTATCGAAGAGCCCTGCCAAAAGCCCGGAGATAGCCTCTCTTTTGCTATCAACACCGGGATTGCGATTG
CATGGGATGAAACCTTACAACACGCGCTGCACCGACCTGACTTTGCGCTTGACGATCTCACGGGCGTGAAAGCGATCGTC
ATCAAACCAACGTTGATCGGTTCATTGCCTCGTTGTATTGCGCTGATCAAAAAAGCGCACTCTTTGGGCATCAAAGCGGT
CATCAGTTCAAGTATCGAATCAAGTTTAGGGCTTACCCAGTTAGCGCGTTTTGCCAAATGGCAGTTGCCTGACGTGACGC
CGGGCTTGGACACCATAAGTTTGTTCCAATCGCAGTTAATGGTGGGATGGCCGAAATGCTCGCTGCCGATCGCCTCGTTA
GAAGAACAGCAATTGGTGTGGCATTCATAA

Upstream 100 bases:

>100_bases
CTGCATCGTTTAGGGACTTTTCTTTGCGATTGACGGTCTCATTCATAAAGAGTCTGACTTTCAGTAAAGCAATTTGTCGA
TGAAGTATTAAGGGACAGCT

Downstream 100 bases:

>100_bases
TGGGTGAAAAGGCATTGGTCAGTGAACAACCATTGTGGAAATATTGGGCTCAGCAGAGCCCATTTTCTATGGCGCTGAAC
TCATCACGTTATCAATTCAA

Product: O-succinylbenzoate synthase

Products: NA

Alternate protein names: OSB synthase; OSBS; 4-(2'-carboxyphenyl)-4-oxybutyric acid synthase; o-succinylbenzoic acid synthase [H]

Number of amino acids: Translated: 329; Mature: 329

Protein sequence:

>329_residues
MKSAKLYRYTLPMDSGVVLRDEKLTERVGYIIELNMNGQKGYGEVAPLPGFSLETIEEAGIEAQAQLELWMNTDHPIDYD
ALLPSVAFGLSTAMYELEGKLPRDGHYLPAPLCTGDPDELIPVLNAMQGEKVAKVKVGLYEPIRDGMLVNLFLESIPDLT
LRLDANRAWTPEKAQQFAKYITPSLRQRIVFIEEPCQKPGDSLSFAINTGIAIAWDETLQHALHRPDFALDDLTGVKAIV
IKPTLIGSLPRCIALIKKAHSLGIKAVISSSIESSLGLTQLARFAKWQLPDVTPGLDTISLFQSQLMVGWPKCSLPIASL
EEQQLVWHS

Sequences:

>Translated_329_residues
MKSAKLYRYTLPMDSGVVLRDEKLTERVGYIIELNMNGQKGYGEVAPLPGFSLETIEEAGIEAQAQLELWMNTDHPIDYD
ALLPSVAFGLSTAMYELEGKLPRDGHYLPAPLCTGDPDELIPVLNAMQGEKVAKVKVGLYEPIRDGMLVNLFLESIPDLT
LRLDANRAWTPEKAQQFAKYITPSLRQRIVFIEEPCQKPGDSLSFAINTGIAIAWDETLQHALHRPDFALDDLTGVKAIV
IKPTLIGSLPRCIALIKKAHSLGIKAVISSSIESSLGLTQLARFAKWQLPDVTPGLDTISLFQSQLMVGWPKCSLPIASL
EEQQLVWHS
>Mature_329_residues
MKSAKLYRYTLPMDSGVVLRDEKLTERVGYIIELNMNGQKGYGEVAPLPGFSLETIEEAGIEAQAQLELWMNTDHPIDYD
ALLPSVAFGLSTAMYELEGKLPRDGHYLPAPLCTGDPDELIPVLNAMQGEKVAKVKVGLYEPIRDGMLVNLFLESIPDLT
LRLDANRAWTPEKAQQFAKYITPSLRQRIVFIEEPCQKPGDSLSFAINTGIAIAWDETLQHALHRPDFALDDLTGVKAIV
IKPTLIGSLPRCIALIKKAHSLGIKAVISSSIESSLGLTQLARFAKWQLPDVTPGLDTISLFQSQLMVGWPKCSLPIASL
EEQQLVWHS

Specific function: Converts SHCHC to OSB [H]

COG id: COG1441

COG function: function code H; O-succinylbenzoate synthase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the mandelate racemase/muconate lactonizing enzyme family. MenC type 1 subfamily [H]

Homologues:

Organism=Escherichia coli, GI1788596, Length=321, Percent_Identity=56.386292834891, Blast_Score=354, Evalue=4e-99,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013342
- InterPro:   IPR010196 [H]

Pfam domain/function: PF01188 MR_MLE [H]

EC number: =4.2.1.113 [H]

Molecular weight: Translated: 36376; Mature: 36376

Theoretical pI: Translated: 4.96; Mature: 4.96

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
2.4 %Met     (Translated Protein)
3.6 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
2.4 %Met     (Mature Protein)
3.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKSAKLYRYTLPMDSGVVLRDEKLTERVGYIIELNMNGQKGYGEVAPLPGFSLETIEEAG
CCCCCEEEEECCCCCCEEEECHHHHHHCCEEEEEECCCCCCCCCCCCCCCCCHHHHHHCC
IEAQAQLELWMNTDHPIDYDALLPSVAFGLSTAMYELEGKLPRDGHYLPAPLCTGDPDEL
CCEEEEEEEEECCCCCCCHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCHHHH
IPVLNAMQGEKVAKVKVGLYEPIRDGMLVNLFLESIPDLTLRLDANRAWTPEKAQQFAKY
HHHHHHHCCCCEEEEEECCHHHHHCCHHHHHHHHHCCCEEEEEECCCCCCHHHHHHHHHH
ITPSLRQRIVFIEEPCQKPGDSLSFAINTGIAIAWDETLQHALHRPDFALDDLTGVKAIV
HCHHHHHEEEEEECCCCCCCCCEEEEEECCEEEEEHHHHHHHHCCCCCCCCCCCCCEEEE
IKPTLIGSLPRCIALIKKAHSLGIKAVISSSIESSLGLTQLARFAKWQLPDVTPGLDTIS
ECCHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHCCHHHHHHHHHCCCCCCCCCCHHHH
LFQSQLMVGWPKCSLPIASLEEQQLVWHS
HHHHHHHCCCCCCCCCHHCCCCCHHCCCC
>Mature Secondary Structure
MKSAKLYRYTLPMDSGVVLRDEKLTERVGYIIELNMNGQKGYGEVAPLPGFSLETIEEAG
CCCCCEEEEECCCCCCEEEECHHHHHHCCEEEEEECCCCCCCCCCCCCCCCCHHHHHHCC
IEAQAQLELWMNTDHPIDYDALLPSVAFGLSTAMYELEGKLPRDGHYLPAPLCTGDPDEL
CCEEEEEEEEECCCCCCCHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCHHHH
IPVLNAMQGEKVAKVKVGLYEPIRDGMLVNLFLESIPDLTLRLDANRAWTPEKAQQFAKY
HHHHHHHCCCCEEEEEECCHHHHHCCHHHHHHHHHCCCEEEEEECCCCCCHHHHHHHHHH
ITPSLRQRIVFIEEPCQKPGDSLSFAINTGIAIAWDETLQHALHRPDFALDDLTGVKAIV
HCHHHHHEEEEEECCCCCCCCCEEEEEECCEEEEEHHHHHHHHCCCCCCCCCCCCCEEEE
IKPTLIGSLPRCIALIKKAHSLGIKAVISSSIESSLGLTQLARFAKWQLPDVTPGLDTIS
ECCHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHCCHHHHHHHHHCCCCCCCCCCHHHH
LFQSQLMVGWPKCSLPIASLEEQQLVWHS
HHHHHHHCCCCCCCCCHHCCCCCHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 10952301 [H]