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The map label for this gene is menB [H]

Identifier: 161486639

GI number: 161486639

Start: 1126379

End: 1127245

Strand: Direct

Name: menB [H]

Synonym: VV1118

Alternate gene names: 161486639

Gene position: 1126379-1127245 (Clockwise)

Preceding gene: 37679301

Following gene: 37679303

Centisome position: 33.58

GC content: 49.48

Gene sequence:

>867_bases
ATGGCTAAAACAGTAGGCATCACTGAAGCAGAACTTTACGCACCAGTTAATTGGAATGACTGTAGTGCGCCCTATGAAGA
TATTCAGTACCACAAGTCGGAAGACGGCATTGCAAAAATCACTATTGCACGCCCTCAAGTGCGTAATGCATTTCGCCCGC
AAACCGTCAAAGAAATGATCCAAGCACTGGCGGACGCTCGCTATGACTCTAACGTTGGCGTGATCATTTTGACCGGTCTC
GGCGAAGACGCGTTCTGCTCTGGCGGTGACCAAAAGATCCGCGGCGATTACGGCGGCTATAAAGATGACTCTGGTGTTCA
CCACCTGAATGTTCTTGATTTCCAACGTGATATTCGTACTTGTCCAAAACCTGTTATTGCGTCTGTCGCTGGTTGGGCTG
TTGGCGGCGGCCACGTTCTTCATATGATGTGTGACTTAACCATCGCGGCCGAAAACGCGCAATTTGGTCAAACTGGACCA
AAAGTGGGCTCGTTTGATGGCGGTTGGGGTGCTTCGTACATGGCACGTATTGTCGGACAGAAAAAAGCACGTGAGATTTG
GTTCCTATGTCGTTTTTATGACGCTCAAGAAGCGTTGGATATGGGGCTAGTGAACACCGTTGTGCCAATTGATGATCTAG
AAAAGGAAACCGTACGTTGGTGTCGTGAAGTACTTCAGCACAGCCCGATGGCACTGCGTTGCTTGAAAGCGGCATTGAAC
GCCGATTGCGATGGTCAAGCGGGTCTTCAAGAGTTGGCGGGCAACGCCACAATGATGTTCTATATGACGGATGAAGGGCA
AGAAGGGCGCAATGCGTTCAACGAAAAACGTCGTCCAGACTTCAATAAGTTTCCACGCAACCCTTAA

Upstream 100 bases:

>100_bases
AATGTCCATCAAGAGCAGCCTAACGCTTTTGCTGACATCGTCCGTGCGTTTATTCATTCGGTTTATCAACGATAAACACA
TTAGAACAATGGGAACCACC

Downstream 100 bases:

>100_bases
TTTTCTTCCCAAGGTGAGAACGATGCAGAGGCACAGAATCTGCATCGTTTAGGGACTTTTCTTTGCGATTGACGGTCTCA
TTCATAAAGAGTCTGACTTT

Product: naphthoate synthase

Products: NA

Alternate protein names: DHNA-CoA synthase [H]

Number of amino acids: Translated: 288; Mature: 287

Protein sequence:

>288_residues
MAKTVGITEAELYAPVNWNDCSAPYEDIQYHKSEDGIAKITIARPQVRNAFRPQTVKEMIQALADARYDSNVGVIILTGL
GEDAFCSGGDQKIRGDYGGYKDDSGVHHLNVLDFQRDIRTCPKPVIASVAGWAVGGGHVLHMMCDLTIAAENAQFGQTGP
KVGSFDGGWGASYMARIVGQKKAREIWFLCRFYDAQEALDMGLVNTVVPIDDLEKETVRWCREVLQHSPMALRCLKAALN
ADCDGQAGLQELAGNATMMFYMTDEGQEGRNAFNEKRRPDFNKFPRNP

Sequences:

>Translated_288_residues
MAKTVGITEAELYAPVNWNDCSAPYEDIQYHKSEDGIAKITIARPQVRNAFRPQTVKEMIQALADARYDSNVGVIILTGL
GEDAFCSGGDQKIRGDYGGYKDDSGVHHLNVLDFQRDIRTCPKPVIASVAGWAVGGGHVLHMMCDLTIAAENAQFGQTGP
KVGSFDGGWGASYMARIVGQKKAREIWFLCRFYDAQEALDMGLVNTVVPIDDLEKETVRWCREVLQHSPMALRCLKAALN
ADCDGQAGLQELAGNATMMFYMTDEGQEGRNAFNEKRRPDFNKFPRNP
>Mature_287_residues
AKTVGITEAELYAPVNWNDCSAPYEDIQYHKSEDGIAKITIARPQVRNAFRPQTVKEMIQALADARYDSNVGVIILTGLG
EDAFCSGGDQKIRGDYGGYKDDSGVHHLNVLDFQRDIRTCPKPVIASVAGWAVGGGHVLHMMCDLTIAAENAQFGQTGPK
VGSFDGGWGASYMARIVGQKKAREIWFLCRFYDAQEALDMGLVNTVVPIDDLEKETVRWCREVLQHSPMALRCLKAALNA
DCDGQAGLQELAGNATMMFYMTDEGQEGRNAFNEKRRPDFNKFPRNP

Specific function: Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA) [H]

COG id: COG0447

COG function: function code H; Dihydroxynaphthoic acid synthase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the enoyl-CoA hydratase/isomerase family [H]

Homologues:

Organism=Homo sapiens, GI194097323, Length=246, Percent_Identity=33.3333333333333, Blast_Score=119, Evalue=4e-27,
Organism=Homo sapiens, GI31542718, Length=252, Percent_Identity=30.952380952381, Blast_Score=96, Evalue=4e-20,
Organism=Homo sapiens, GI4502327, Length=254, Percent_Identity=30.3149606299213, Blast_Score=86, Evalue=3e-17,
Organism=Homo sapiens, GI45643119, Length=209, Percent_Identity=30.622009569378, Blast_Score=82, Evalue=6e-16,
Organism=Homo sapiens, GI260275230, Length=209, Percent_Identity=30.622009569378, Blast_Score=82, Evalue=6e-16,
Organism=Homo sapiens, GI260274832, Length=209, Percent_Identity=30.622009569378, Blast_Score=82, Evalue=8e-16,
Organism=Homo sapiens, GI25453481, Length=250, Percent_Identity=24.8, Blast_Score=75, Evalue=8e-14,
Organism=Homo sapiens, GI51538573, Length=250, Percent_Identity=24.8, Blast_Score=75, Evalue=8e-14,
Organism=Homo sapiens, GI4757966, Length=250, Percent_Identity=24.8, Blast_Score=75, Evalue=9e-14,
Organism=Homo sapiens, GI51538581, Length=250, Percent_Identity=24.8, Blast_Score=75, Evalue=9e-14,
Organism=Homo sapiens, GI4757968, Length=250, Percent_Identity=25.2, Blast_Score=74, Evalue=2e-13,
Organism=Homo sapiens, GI49355787, Length=250, Percent_Identity=25.2, Blast_Score=74, Evalue=2e-13,
Organism=Homo sapiens, GI213417737, Length=226, Percent_Identity=23.8938053097345, Blast_Score=73, Evalue=3e-13,
Organism=Homo sapiens, GI157694516, Length=226, Percent_Identity=23.8938053097345, Blast_Score=73, Evalue=4e-13,
Organism=Homo sapiens, GI68989263, Length=196, Percent_Identity=29.5918367346939, Blast_Score=71, Evalue=9e-13,
Organism=Homo sapiens, GI116235487, Length=235, Percent_Identity=25.531914893617, Blast_Score=69, Evalue=6e-12,
Organism=Homo sapiens, GI70995211, Length=229, Percent_Identity=27.0742358078603, Blast_Score=69, Evalue=7e-12,
Organism=Escherichia coli, GI1788597, Length=280, Percent_Identity=86.4285714285714, Blast_Score=516, Evalue=1e-148,
Organism=Escherichia coli, GI1787659, Length=244, Percent_Identity=30.327868852459, Blast_Score=107, Evalue=1e-24,
Organism=Escherichia coli, GI87082183, Length=237, Percent_Identity=28.2700421940928, Blast_Score=88, Evalue=8e-19,
Organism=Escherichia coli, GI221142681, Length=209, Percent_Identity=31.1004784688995, Blast_Score=86, Evalue=2e-18,
Organism=Escherichia coli, GI1787660, Length=259, Percent_Identity=28.1853281853282, Blast_Score=73, Evalue=2e-14,
Organism=Caenorhabditis elegans, GI17554946, Length=284, Percent_Identity=32.3943661971831, Blast_Score=120, Evalue=6e-28,
Organism=Caenorhabditis elegans, GI25145438, Length=258, Percent_Identity=32.5581395348837, Blast_Score=113, Evalue=1e-25,
Organism=Caenorhabditis elegans, GI17540714, Length=231, Percent_Identity=27.7056277056277, Blast_Score=112, Evalue=3e-25,
Organism=Caenorhabditis elegans, GI17535521, Length=213, Percent_Identity=27.2300469483568, Blast_Score=75, Evalue=5e-14,
Organism=Caenorhabditis elegans, GI17560910, Length=203, Percent_Identity=28.0788177339901, Blast_Score=67, Evalue=8e-12,
Organism=Drosophila melanogaster, GI20129971, Length=270, Percent_Identity=32.962962962963, Blast_Score=122, Evalue=2e-28,
Organism=Drosophila melanogaster, GI24653477, Length=270, Percent_Identity=32.962962962963, Blast_Score=122, Evalue=2e-28,
Organism=Drosophila melanogaster, GI24653139, Length=276, Percent_Identity=28.2608695652174, Blast_Score=110, Evalue=1e-24,
Organism=Drosophila melanogaster, GI21357171, Length=213, Percent_Identity=30.5164319248826, Blast_Score=80, Evalue=2e-15,
Organism=Drosophila melanogaster, GI24654903, Length=205, Percent_Identity=29.2682926829268, Blast_Score=71, Evalue=7e-13,
Organism=Drosophila melanogaster, GI19922422, Length=190, Percent_Identity=25.7894736842105, Blast_Score=67, Evalue=2e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR014748
- InterPro:   IPR001753
- InterPro:   IPR018376
- InterPro:   IPR010198 [H]

Pfam domain/function: PF00378 ECH [H]

EC number: =4.1.3.36 [H]

Molecular weight: Translated: 31831; Mature: 31700

Theoretical pI: Translated: 5.40; Mature: 5.40

Prosite motif: PS00166 ENOYL_COA_HYDRATASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.8 %Cys     (Translated Protein)
3.5 %Met     (Translated Protein)
6.2 %Cys+Met (Translated Protein)
2.8 %Cys     (Mature Protein)
3.1 %Met     (Mature Protein)
5.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAKTVGITEAELYAPVNWNDCSAPYEDIQYHKSEDGIAKITIARPQVRNAFRPQTVKEMI
CCCCCCCCHHHEEECCCCCCCCCCHHHHHHCCCCCCEEEEEEECHHHHHCCCCHHHHHHH
QALADARYDSNVGVIILTGLGEDAFCSGGDQKIRGDYGGYKDDSGVHHLNVLDFQRDIRT
HHHHHCCCCCCCCEEEEECCCCCHHCCCCCCEECCCCCCCCCCCCCEEEEHHHHHHHHHH
CPKPVIASVAGWAVGGGHVLHMMCDLTIAAENAQFGQTGPKVGSFDGGWGASYMARIVGQ
CCHHHHHHHHHHCCCCHHHHHHHHHHEEEECCCCCCCCCCCCCCCCCCCHHHHHHHHHHH
KKAREIWFLCRFYDAQEALDMGLVNTVVPIDDLEKETVRWCREVLQHSPMALRCLKAALN
HHHHHHHHHHHHHCHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHCCCHHHHHHHHHHC
ADCDGQAGLQELAGNATMMFYMTDEGQEGRNAFNEKRRPDFNKFPRNP
CCCCCCHHHHHHCCCCEEEEEECCCCCCHHHHHHHHCCCCCCCCCCCC
>Mature Secondary Structure 
AKTVGITEAELYAPVNWNDCSAPYEDIQYHKSEDGIAKITIARPQVRNAFRPQTVKEMI
CCCCCCCHHHEEECCCCCCCCCCHHHHHHCCCCCCEEEEEEECHHHHHCCCCHHHHHHH
QALADARYDSNVGVIILTGLGEDAFCSGGDQKIRGDYGGYKDDSGVHHLNVLDFQRDIRT
HHHHHCCCCCCCCEEEEECCCCCHHCCCCCCEECCCCCCCCCCCCCEEEEHHHHHHHHHH
CPKPVIASVAGWAVGGGHVLHMMCDLTIAAENAQFGQTGPKVGSFDGGWGASYMARIVGQ
CCHHHHHHHHHHCCCCHHHHHHHHHHEEEECCCCCCCCCCCCCCCCCCCHHHHHHHHHHH
KKAREIWFLCRFYDAQEALDMGLVNTVVPIDDLEKETVRWCREVLQHSPMALRCLKAALN
HHHHHHHHHHHHHCHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHCCCHHHHHHHHHHC
ADCDGQAGLQELAGNATMMFYMTDEGQEGRNAFNEKRRPDFNKFPRNP
CCCCCCHHHHHHCCCCEEEEEECCCCCCHHHHHHHHCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 12471157 [H]