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The map label for this gene is sdhB

Identifier: 37679215

GI number: 37679215

Start: 1029471

End: 1030229

Strand: Direct

Name: sdhB

Synonym: VV1031

Alternate gene names: 37679215

Gene position: 1029471-1030229 (Clockwise)

Preceding gene: 37679214

Following gene: 37679216

Centisome position: 30.69

GC content: 45.06

Gene sequence:

>759_bases
GTGATGCGTTCCCACCAAAAGTACGTACATACTAAGGGAGGACTGAACATGAAACTGAACTTCTCTGTATATCGTTACAA
TCCGGATGTAGATACCAAACCATACATGAAAGACTATGTGCTGGAAGTGGAAGACGGCTCTGACATGATGGTGTTGGATG
CACTGATTCTACTCAAAGAGCAAGACGCTACGATCTCTTTCCGTCGTTCTTGTCGTGAAGGCGTGTGTGGATCGGATGGT
CTTAACATGAATGGTAAGAACGGTTTGGCGTGTATCACACCGCTGTCTGCGTTGAAAGCGGACAAAATTGTGATTCGTCC
ATTACCTGGGTTACCTGTGATTCGCGATCTTATCGTTGACATGACACAGTTCTACGATAACTATGCGAAAGTTAAGCCTT
TCTTGATTTCAGATGGTGCACTTCCGCCTTCTCGAGAAAACTTACAATCACCAGATGAGCGTGCACATTTGGATGGTTTG
TACGAATGTATCATGTGTGCATGTTGTACAACCTCGTGCCCATCATTCTGGTGGAACCCGGACAAGTTTATCGGACCAGC
GGGTCTTCTGGCAGCGTATCGTTGGCTGATTGACAGTCGTGATACTGCAACAGATGAACGTTTGTCTAATCTTGATGACG
CATTTAGCGTTTTTCGTTGCCACGGCATTATGAATTGTGTAAGTGTTTGTCCTAAGGGGCTAAATCCTACAAAAGCTATT
GGCCATATCAAGAGTATGCTGGTCAATCGTTCGGTGTAA

Upstream 100 bases:

>100_bases
TTCCCAGATCGTGACGATGAAAACTGGCTATGCCACTCTATCTACAACCCGGAAACGGAGCAAATGAGCAAGCGTGATGT
CAATATGACGCCTGTTCATC

Downstream 100 bases:

>100_bases
TAAACAACAAAATTGCCGACAGTGTTCTAACCAACCTGTCGGCTCTATAGTAGCTCGGCGAAGACCGCAGCAAACGTGAA
AACTACTGGTTAAGGGAAAA

Product: succinate dehydrogenase iron-sulfur subunit

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 252; Mature: 252

Protein sequence:

>252_residues
MMRSHQKYVHTKGGLNMKLNFSVYRYNPDVDTKPYMKDYVLEVEDGSDMMVLDALILLKEQDATISFRRSCREGVCGSDG
LNMNGKNGLACITPLSALKADKIVIRPLPGLPVIRDLIVDMTQFYDNYAKVKPFLISDGALPPSRENLQSPDERAHLDGL
YECIMCACCTTSCPSFWWNPDKFIGPAGLLAAYRWLIDSRDTATDERLSNLDDAFSVFRCHGIMNCVSVCPKGLNPTKAI
GHIKSMLVNRSV

Sequences:

>Translated_252_residues
MMRSHQKYVHTKGGLNMKLNFSVYRYNPDVDTKPYMKDYVLEVEDGSDMMVLDALILLKEQDATISFRRSCREGVCGSDG
LNMNGKNGLACITPLSALKADKIVIRPLPGLPVIRDLIVDMTQFYDNYAKVKPFLISDGALPPSRENLQSPDERAHLDGL
YECIMCACCTTSCPSFWWNPDKFIGPAGLLAAYRWLIDSRDTATDERLSNLDDAFSVFRCHGIMNCVSVCPKGLNPTKAI
GHIKSMLVNRSV
>Mature_252_residues
MMRSHQKYVHTKGGLNMKLNFSVYRYNPDVDTKPYMKDYVLEVEDGSDMMVLDALILLKEQDATISFRRSCREGVCGSDG
LNMNGKNGLACITPLSALKADKIVIRPLPGLPVIRDLIVDMTQFYDNYAKVKPFLISDGALPPSRENLQSPDERAHLDGL
YECIMCACCTTSCPSFWWNPDKFIGPAGLLAAYRWLIDSRDTATDERLSNLDDAFSVFRCHGIMNCVSVCPKGLNPTKAI
GHIKSMLVNRSV

Specific function: Two distinct, membrane-bound, FAD-containing enzymes are responsible for the catalysis of fumarate and succinate interconversion; the fumarate reductase is used in anaerobic growth, and the succinate dehydrogenase is used in aerobic growth [H]

COG id: COG0479

COG function: function code C; Succinate dehydrogenase/fumarate reductase, Fe-S protein subunit

Gene ontology:

Cell location: Cell inner membrane; Peripheral membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 4Fe-4S ferredoxin-type domain [H]

Homologues:

Organism=Homo sapiens, GI115387094, Length=233, Percent_Identity=51.931330472103, Blast_Score=253, Evalue=1e-67,
Organism=Escherichia coli, GI1786943, Length=238, Percent_Identity=76.0504201680672, Blast_Score=390, Evalue=1e-110,
Organism=Escherichia coli, GI1790596, Length=227, Percent_Identity=37.8854625550661, Blast_Score=150, Evalue=6e-38,
Organism=Caenorhabditis elegans, GI17533915, Length=241, Percent_Identity=49.792531120332, Blast_Score=248, Evalue=2e-66,
Organism=Saccharomyces cerevisiae, GI6322987, Length=231, Percent_Identity=50.2164502164502, Blast_Score=251, Evalue=6e-68,
Organism=Drosophila melanogaster, GI17137106, Length=232, Percent_Identity=51.7241379310345, Blast_Score=258, Evalue=4e-69,
Organism=Drosophila melanogaster, GI24643156, Length=232, Percent_Identity=50.4310344827586, Blast_Score=244, Evalue=6e-65,

Paralogues:

None

Copy number: 480 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR017896
- InterPro:   IPR017900
- InterPro:   IPR012675
- InterPro:   IPR001041
- InterPro:   IPR012285
- InterPro:   IPR009051
- InterPro:   IPR004489 [H]

Pfam domain/function: NA

EC number: =1.3.99.1 [H]

Molecular weight: Translated: 28168; Mature: 28168

Theoretical pI: Translated: 7.29; Mature: 7.29

Prosite motif: PS51085 2FE2S_FER_2 ; PS00198 4FE4S_FERREDOXIN

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

4.4 %Cys     (Translated Protein)
4.4 %Met     (Translated Protein)
8.7 %Cys+Met (Translated Protein)
4.4 %Cys     (Mature Protein)
4.4 %Met     (Mature Protein)
8.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MMRSHQKYVHTKGGLNMKLNFSVYRYNPDVDTKPYMKDYVLEVEDGSDMMVLDALILLKE
CCCCCCHHHCCCCCCEEEEEEEEEEECCCCCCCCCHHHEEEEECCCCCHHHHHHHHHHHC
QDATISFRRSCREGVCGSDGLNMNGKNGLACITPLSALKADKIVIRPLPGLPVIRDLIVD
CCCHHHHHHHHHCCCCCCCCCCCCCCCCEEEECCHHHHCCCCEEEECCCCCHHHHHHHHH
MTQFYDNYAKVKPFLISDGALPPSRENLQSPDERAHLDGLYECIMCACCTTSCPSFWWNP
HHHHHHHHHHCCCEEEECCCCCCCHHHCCCCHHHHHHHHHHHHHHHHHHHCCCCCCCCCC
DKFIGPAGLLAAYRWLIDSRDTATDERLSNLDDAFSVFRCHGIMNCVSVCPKGLNPTKAI
CHHCCHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHH
GHIKSMLVNRSV
HHHHHHHHHCCC
>Mature Secondary Structure
MMRSHQKYVHTKGGLNMKLNFSVYRYNPDVDTKPYMKDYVLEVEDGSDMMVLDALILLKE
CCCCCCHHHCCCCCCEEEEEEEEEEECCCCCCCCCHHHEEEEECCCCCHHHHHHHHHHHC
QDATISFRRSCREGVCGSDGLNMNGKNGLACITPLSALKADKIVIRPLPGLPVIRDLIVD
CCCHHHHHHHHHCCCCCCCCCCCCCCCCEEEECCHHHHCCCCEEEECCCCCHHHHHHHHH
MTQFYDNYAKVKPFLISDGALPPSRENLQSPDERAHLDGLYECIMCACCTTSCPSFWWNP
HHHHHHHHHHCCCEEEECCCCCCCHHHCCCCHHHHHHHHHHHHHHHHHHHCCCCCCCCCC
DKFIGPAGLLAAYRWLIDSRDTATDERLSNLDDAFSVFRCHGIMNCVSVCPKGLNPTKAI
CHHCCHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHH
GHIKSMLVNRSV
HHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: 6388571; 8905232; 9278503; 6376123; 9298646 [H]