Click here to switch to the map view.

The map label for this gene is sdhA

Identifier: 37679214

GI number: 37679214

Start: 1027739

End: 1029505

Strand: Direct

Name: sdhA

Synonym: VV1030

Alternate gene names: 37679214

Gene position: 1027739-1029505 (Clockwise)

Preceding gene: 37679213

Following gene: 37679215

Centisome position: 30.64

GC content: 49.24

Gene sequence:

>1767_bases
GTGTCTATTCCAGTTCGCGAATTTGATGCCGTAGTAATCGGCGCTGGTGGTGCAGGTATGCGTGCTGCACTACAAATTTC
TGAGCAAGGCCTTTCTTGTGCATTGCTATCTAAAGTATTTCCAACACGCTCACACACTGTATCGGCTCAAGGTGGTATTA
CCGTTGCTCTAGGTAACTCGCACAAAGACGATTGGCAGTGGCATATGTATGACACCGTAAAAGGTTCTGACTACATTGGT
GACCAAAATGCCATTGAGTACATGTGTAAGAATGGTCCTGAGTCAGTGATCGAGCTTGAGAAAATGGGTCTGCCTTTCTC
TCGTTTTGATAACGGCAGTATCTACCAGCGTCCATTTGGTGGTCAGTCAAAAGAGTTTGGTGGCGAGCAAGCGGCGCGTA
CCGCTGCAGCGGCTGACCGTACTGGTCACGCATTGCTCCACACTCTGTATCAGCAAAACGTAAAACACAAAACCATGATC
TTCTCTGAGTGGTATGCACTTGACCTGGTGAAAAACCAAGATGGTGCGGTTGTGGGTTGTACAGCGGTATGCATGGAAAC
GGGTGAAATTTGCTACTTCAAGTCGAAAGCGACCATTTTAGCAACTGGTGGTGCTGGCCGTATTTACGCCTCAACAACGA
ACGCACACATCAATACTGGTGATGGTGTTGGTATGGCACTGCGCGCTGGCGTCCCAATGCAAGACATGGAAATGTGGCAG
TTCCACCCAACGGGTATCGCTGGTGCAGGTGTTCTTGTGACGGAAGGTTGTCGTGGTGAAGGCGGTTACCTTCTCAACAA
AGATGGTGAGCGTTTCATGGAGCGTTATGCTCCTAATGCGAAAGATTTGGCTGGTCGCGACGTTGTTGCACGTTCAATGA
TGATCGAAATCCGTGAAGGTCGTGGTTGTGATGGCCCTTGGGGTCCACACATTAAACTCAAGTTGGATCATCTAGGCAAA
GATGTGCTTGAATCGCGTCTACCAGGTATCTGTGAGTTATCGCGTACCTTCGCTCACGTTGACCCAGTGAAAGAGCCAAT
CCCAGTTATCCCAACTTGTCACTACATGATGGGTGGTGTACCAACGCAAGTTTCTGGTCAAGCGATCAAACAAACTGCCG
ATGGCAAAGACGTCGAAGTTCAAGGTCTATTCGCGTGTGGTGAAATTGCTTCTGTATCAGTACATGGCGCAAACCGTCTA
GGTGGTAACTCACTGCTTGACCTCGTGGTATTCGGTCGTGCAACGGGTCTTCACCTTGGTGAAACACTCGCTGCGCAGGC
AGAAGCGCGTGATGCATCAGCATCGGACATTGAAGCCTCACTTTCTCGCTACATGCGCTGGGAAAACAGCAAAGGTGGTG
AGGATCCTGTTCAGATTCGTAAAGATCTACAACGTTGTATGCAGAACAGCTTCTCGGTATTCCGTGAAGGTGACGCTATG
GCGACAGGTCTGGAAGAGCTGAAAGTGATTCGTGAGCGCCTGAAAGATGCACATCTTTCTGACAAATCAACTGAGTTCAA
TACTCAGCGTATCGAGTGTCTAGAGCTAGACAACTTGATGGAAACGGCATTCTCAACAGCGGTTGCGGCCAACTATCGCA
CAGAAAGTCGCGGTGCTCACGCCCGCTTTGACTTCCCAGATCGTGACGATGAAAACTGGCTATGCCACTCTATCTACAAC
CCGGAAACGGAGCAAATGAGCAAGCGTGATGTCAATATGACGCCTGTTCATCGTGATGCGTTCCCACCAAAAGTACGTAC
ATACTAA

Upstream 100 bases:

>100_bases
CATCAAGTGCGCCAAATTGCGTGGTGGTTTACAACTTGGTGTGATCGCACTGCTTTTCGGGTATTTCTTCTCTGGTCTGT
TTGTATTGTGGGGTGCATAA

Downstream 100 bases:

>100_bases
GGGAGGACTGAACATGAAACTGAACTTCTCTGTATATCGTTACAATCCGGATGTAGATACCAAACCATACATGAAAGACT
ATGTGCTGGAAGTGGAAGAC

Product: succinate dehydrogenase flavoprotein subunit

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 588; Mature: 587

Protein sequence:

>588_residues
MSIPVREFDAVVIGAGGAGMRAALQISEQGLSCALLSKVFPTRSHTVSAQGGITVALGNSHKDDWQWHMYDTVKGSDYIG
DQNAIEYMCKNGPESVIELEKMGLPFSRFDNGSIYQRPFGGQSKEFGGEQAARTAAAADRTGHALLHTLYQQNVKHKTMI
FSEWYALDLVKNQDGAVVGCTAVCMETGEICYFKSKATILATGGAGRIYASTTNAHINTGDGVGMALRAGVPMQDMEMWQ
FHPTGIAGAGVLVTEGCRGEGGYLLNKDGERFMERYAPNAKDLAGRDVVARSMMIEIREGRGCDGPWGPHIKLKLDHLGK
DVLESRLPGICELSRTFAHVDPVKEPIPVIPTCHYMMGGVPTQVSGQAIKQTADGKDVEVQGLFACGEIASVSVHGANRL
GGNSLLDLVVFGRATGLHLGETLAAQAEARDASASDIEASLSRYMRWENSKGGEDPVQIRKDLQRCMQNSFSVFREGDAM
ATGLEELKVIRERLKDAHLSDKSTEFNTQRIECLELDNLMETAFSTAVAANYRTESRGAHARFDFPDRDDENWLCHSIYN
PETEQMSKRDVNMTPVHRDAFPPKVRTY

Sequences:

>Translated_588_residues
MSIPVREFDAVVIGAGGAGMRAALQISEQGLSCALLSKVFPTRSHTVSAQGGITVALGNSHKDDWQWHMYDTVKGSDYIG
DQNAIEYMCKNGPESVIELEKMGLPFSRFDNGSIYQRPFGGQSKEFGGEQAARTAAAADRTGHALLHTLYQQNVKHKTMI
FSEWYALDLVKNQDGAVVGCTAVCMETGEICYFKSKATILATGGAGRIYASTTNAHINTGDGVGMALRAGVPMQDMEMWQ
FHPTGIAGAGVLVTEGCRGEGGYLLNKDGERFMERYAPNAKDLAGRDVVARSMMIEIREGRGCDGPWGPHIKLKLDHLGK
DVLESRLPGICELSRTFAHVDPVKEPIPVIPTCHYMMGGVPTQVSGQAIKQTADGKDVEVQGLFACGEIASVSVHGANRL
GGNSLLDLVVFGRATGLHLGETLAAQAEARDASASDIEASLSRYMRWENSKGGEDPVQIRKDLQRCMQNSFSVFREGDAM
ATGLEELKVIRERLKDAHLSDKSTEFNTQRIECLELDNLMETAFSTAVAANYRTESRGAHARFDFPDRDDENWLCHSIYN
PETEQMSKRDVNMTPVHRDAFPPKVRTY
>Mature_587_residues
SIPVREFDAVVIGAGGAGMRAALQISEQGLSCALLSKVFPTRSHTVSAQGGITVALGNSHKDDWQWHMYDTVKGSDYIGD
QNAIEYMCKNGPESVIELEKMGLPFSRFDNGSIYQRPFGGQSKEFGGEQAARTAAAADRTGHALLHTLYQQNVKHKTMIF
SEWYALDLVKNQDGAVVGCTAVCMETGEICYFKSKATILATGGAGRIYASTTNAHINTGDGVGMALRAGVPMQDMEMWQF
HPTGIAGAGVLVTEGCRGEGGYLLNKDGERFMERYAPNAKDLAGRDVVARSMMIEIREGRGCDGPWGPHIKLKLDHLGKD
VLESRLPGICELSRTFAHVDPVKEPIPVIPTCHYMMGGVPTQVSGQAIKQTADGKDVEVQGLFACGEIASVSVHGANRLG
GNSLLDLVVFGRATGLHLGETLAAQAEARDASASDIEASLSRYMRWENSKGGEDPVQIRKDLQRCMQNSFSVFREGDAMA
TGLEELKVIRERLKDAHLSDKSTEFNTQRIECLELDNLMETAFSTAVAANYRTESRGAHARFDFPDRDDENWLCHSIYNP
ETEQMSKRDVNMTPVHRDAFPPKVRTY

Specific function: Two distinct, membrane-bound, FAD-containing enzymes are responsible for the catalysis of fumarate and succinate interconversion; the fumarate reductase is used in anaerobic growth, and the succinate dehydrogenase is used in aerobic growth [H]

COG id: COG1053

COG function: function code C; Succinate dehydrogenase/fumarate reductase, flavoprotein subunit

Gene ontology:

Cell location: Cell inner membrane; Peripheral membrane protein; Cytoplasmic side [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the FAD-dependent oxidoreductase 2 family. FRD/SDH subfamily [H]

Homologues:

Organism=Homo sapiens, GI156416003, Length=546, Percent_Identity=53.8461538461538, Blast_Score=547, Evalue=1e-155,
Organism=Escherichia coli, GI1786942, Length=588, Percent_Identity=82.9931972789116, Blast_Score=986, Evalue=0.0,
Organism=Escherichia coli, GI1790597, Length=573, Percent_Identity=39.7905759162304, Blast_Score=393, Evalue=1e-110,
Organism=Escherichia coli, GI1788928, Length=567, Percent_Identity=30.1587301587302, Blast_Score=214, Evalue=1e-56,
Organism=Caenorhabditis elegans, GI17550100, Length=591, Percent_Identity=51.7766497461929, Blast_Score=561, Evalue=1e-160,
Organism=Caenorhabditis elegans, GI17505833, Length=590, Percent_Identity=49.4915254237288, Blast_Score=546, Evalue=1e-156,
Organism=Saccharomyces cerevisiae, GI6322701, Length=592, Percent_Identity=52.3648648648649, Blast_Score=588, Evalue=1e-169,
Organism=Saccharomyces cerevisiae, GI6322416, Length=591, Percent_Identity=52.6226734348562, Blast_Score=581, Evalue=1e-166,
Organism=Drosophila melanogaster, GI17137288, Length=545, Percent_Identity=54.6788990825688, Blast_Score=564, Evalue=1e-161,
Organism=Drosophila melanogaster, GI24655642, Length=545, Percent_Identity=54.6788990825688, Blast_Score=564, Evalue=1e-161,
Organism=Drosophila melanogaster, GI24655647, Length=545, Percent_Identity=54.6788990825688, Blast_Score=564, Evalue=1e-161,
Organism=Drosophila melanogaster, GI24663005, Length=548, Percent_Identity=50.1824817518248, Blast_Score=531, Evalue=1e-151,

Paralogues:

None

Copy number: 1900 Molecules/Cell In: Growth-Phase, Minimal-Media (Based on E. coli). 1360 Molecules/Cell In: Stationary Phase, Rich Media (Based on E. coli). 1100 Molecules/Cell In: Glucose minimal media [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003953
- InterPro:   IPR013027
- InterPro:   IPR003952
- InterPro:   IPR015939
- InterPro:   IPR004112
- InterPro:   IPR011281
- InterPro:   IPR014006 [H]

Pfam domain/function: PF00890 FAD_binding_2; PF02910 Succ_DH_flav_C [H]

EC number: =1.3.99.1 [H]

Molecular weight: Translated: 64299; Mature: 64168

Theoretical pI: Translated: 6.04; Mature: 6.04

Prosite motif: PS00504 FRD_SDH_FAD_BINDING

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.2 %Cys     (Translated Protein)
3.7 %Met     (Translated Protein)
6.0 %Cys+Met (Translated Protein)
2.2 %Cys     (Mature Protein)
3.6 %Met     (Mature Protein)
5.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSIPVREFDAVVIGAGGAGMRAALQISEQGLSCALLSKVFPTRSHTVSAQGGITVALGNS
CCCCCCCCCEEEEECCCCCCEEEEEEHHCCCHHHHHHHHCCCCCCEEECCCCEEEEECCC
HKDDWQWHMYDTVKGSDYIGDQNAIEYMCKNGPESVIELEKMGLPFSRFDNGSIYQRPFG
CCCCCEEEEEEECCCCCCCCCHHHHHHHHCCCCHHHHHHHHHCCCHHHCCCCCEEECCCC
GQSKEFGGEQAARTAAAADRTGHALLHTLYQQNVKHKTMIFSEWYALDLVKNQDGAVVGC
CCCCCCCCHHHHHHHHHHCCCHHHHHHHHHHHCCCHHEEEEECEEEEEEEECCCCCEEEH
TAVCMETGEICYFKSKATILATGGAGRIYASTTNAHINTGDGVGMALRAGVPMQDMEMWQ
HHHHHCCCCEEEEECCEEEEEECCCCEEEEECCCCEEECCCCCCEEEECCCCHHHCHHHE
FHPTGIAGAGVLVTEGCRGEGGYLLNKDGERFMERYAPNAKDLAGRDVVARSMMIEIREG
ECCCCCCCCCEEEECCCCCCCCEEECCCHHHHHHHHCCCHHHHCCHHHHHHHHHEEEECC
RGCDGPWGPHIKLKLDHLGKDVLESRLPGICELSRTFAHVDPVKEPIPVIPTCHYMMGGV
CCCCCCCCCEEEEEHHHCCHHHHHHHCCCHHHHHHHHHHCCCCCCCCCCCCCHHHHHCCC
PTQVSGQAIKQTADGKDVEVQGLFACGEIASVSVHGANRLGGNSLLDLVVFGRATGLHLG
CCCCCCHHHHHCCCCCCEEEEEEEEECCEEEEEECCCCCCCCCHHHHHHHHCCCCCCCCC
ETLAAQAEARDASASDIEASLSRYMRWENSKGGEDPVQIRKDLQRCMQNSFSVFREGDAM
HHHHHHHHHCCCCHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHCCCCHH
ATGLEELKVIRERLKDAHLSDKSTEFNTQRIECLELDNLMETAFSTAVAANYRTESRGAH
HHHHHHHHHHHHHHHHCCCCCCCCCCCCCCEEEEHHHHHHHHHHHHHHHHCCCCCCCCCE
ARFDFPDRDDENWLCHSIYNPETEQMSKRDVNMTPVHRDAFPPKVRTY
EECCCCCCCCCCEEEEECCCCCHHHHHHCCCCCCCCCCCCCCCCCCCC
>Mature Secondary Structure 
SIPVREFDAVVIGAGGAGMRAALQISEQGLSCALLSKVFPTRSHTVSAQGGITVALGNS
CCCCCCCCEEEEECCCCCCEEEEEEHHCCCHHHHHHHHCCCCCCEEECCCCEEEEECCC
HKDDWQWHMYDTVKGSDYIGDQNAIEYMCKNGPESVIELEKMGLPFSRFDNGSIYQRPFG
CCCCCEEEEEEECCCCCCCCCHHHHHHHHCCCCHHHHHHHHHCCCHHHCCCCCEEECCCC
GQSKEFGGEQAARTAAAADRTGHALLHTLYQQNVKHKTMIFSEWYALDLVKNQDGAVVGC
CCCCCCCCHHHHHHHHHHCCCHHHHHHHHHHHCCCHHEEEEECEEEEEEEECCCCCEEEH
TAVCMETGEICYFKSKATILATGGAGRIYASTTNAHINTGDGVGMALRAGVPMQDMEMWQ
HHHHHCCCCEEEEECCEEEEEECCCCEEEEECCCCEEECCCCCCEEEECCCCHHHCHHHE
FHPTGIAGAGVLVTEGCRGEGGYLLNKDGERFMERYAPNAKDLAGRDVVARSMMIEIREG
ECCCCCCCCCEEEECCCCCCCCEEECCCHHHHHHHHCCCHHHHCCHHHHHHHHHEEEECC
RGCDGPWGPHIKLKLDHLGKDVLESRLPGICELSRTFAHVDPVKEPIPVIPTCHYMMGGV
CCCCCCCCCEEEEEHHHCCHHHHHHHCCCHHHHHHHHHHCCCCCCCCCCCCCHHHHHCCC
PTQVSGQAIKQTADGKDVEVQGLFACGEIASVSVHGANRLGGNSLLDLVVFGRATGLHLG
CCCCCCHHHHHCCCCCCEEEEEEEEECCEEEEEECCCCCCCCCHHHHHHHHCCCCCCCCC
ETLAAQAEARDASASDIEASLSRYMRWENSKGGEDPVQIRKDLQRCMQNSFSVFREGDAM
HHHHHHHHHCCCCHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHCCCCHH
ATGLEELKVIRERLKDAHLSDKSTEFNTQRIECLELDNLMETAFSTAVAANYRTESRGAH
HHHHHHHHHHHHHHHHCCCCCCCCCCCCCCEEEEHHHHHHHHHHHHHHHHCCCCCCCCCE
ARFDFPDRDDENWLCHSIYNPETEQMSKRDVNMTPVHRDAFPPKVRTY
EECCCCCCCCCCEEEEECCCCCHHHHHHCCCCCCCCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]