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The map label for this gene is pgm [H]

Identifier: 37679204

GI number: 37679204

Start: 1017622

End: 1019280

Strand: Direct

Name: pgm [H]

Synonym: VV1020

Alternate gene names: 37679204

Gene position: 1017622-1019280 (Clockwise)

Preceding gene: 37679203

Following gene: 37679205

Centisome position: 30.34

GC content: 47.98

Gene sequence:

>1659_bases
ATGTCATTAATGGCTATGCACCCTCGTGCAGGGCAGAAAGCTCTGCAAGAAGATCTTCACAATATCCCAGCACTCGTTGC
TAATTATTTCCTCCTTCAACCCGATCCAACAAACCCAGCACACAAAGTCGAGTTTGGTACGTCAGGGCATCGTGGTTGTG
CGGATAAATCCACTTTTAACGAACATCATATTTTAGCGATTGCTCAAGCGGTGGCTGAAGTACGTGCAGAGCAAGGGACA
ACGGGTCCTCTTTTTGTGGGTAAAGATACGCATGCGTTGTCTGAGCCAGCGTTTTCTACCGTTGTTGAAGTGCTGATTGC
CAATGGCGTGACCGTGATTGTACAAGAACAAAATGGCTATACCCCAACTCCGGGTATTTCTCATGCGATCCTGACATACA
ACTTACAACACGAAGAAAAAGCAGACGGTATTGTGATCACTCCGTCTCATAACCCACCACAAGATGGCGGTATCAAATAC
AATCCGACTCATGGTGGCCCCGCTGAAGGCGAGCTAACACAGCGAATTGAGGATCGTGCAAACGTACTCATCGCAGAGGG
GTTGCAAGGTGTTAAGCGTATGCCTTTGGCGCAAGCAAAAGCGTCATCGCTGTTTGTAGAGCAAGATCTGGTCAAACCTT
ATGTCGATGACTTGGTGAATGTGATCGATATGGCTGCCATCCAAAAAGCAGGCCTGAAATTGGGTGTCGATCCTCTTGGC
GGCAGTGGCATTGATTATTGGCGTCAGATTGGTACAGCATACAATTTAGATCTTACTTTAGTGAGTGAAGCCATTGACCC
TTCTTTCCAGTTTATGTCATTGGATAAAGATGGTGTGGTGCGTATGGACTGCTCTTCTCCCTACGCAATGGCTGGATTGC
TGGCGCTAAAAGATCAGTATGATCTCGCGTTTGGTAATGACCCAGATTACGATCGCCATGGTATTGTCACGCCAACAAAA
GGCTTGATGAATCCGAACCACTTCTTAGCTGTTTGTATTGATTATCTATACCGTCATCGTCAAGGTTGGGCTGCGGATGT
GGCAGTGGGTAAAACCCTAGTTTCTAGCGCCATGATTGACCGAGTGGTGGCCGATCTTGGCCGTGAGCTATGTGAAGTAC
CGGTTGGCTTTAAATGGTTTGTGGATGGGTTGTACAACGGTAAGTTTGGCTTTGGTGGCGAAGAGAGTGCGGGAGCCTCA
TTCTTGCGCCAAGATGGTACACCATGGTCGACAGACAAAGATGGCATCATTCTTTGTTTACTGGCTGCGGAAATCACCGC
AGTGACTGGTAAAAACCCGCAGCAATATTATGACGAGCTGGCGGCTAAACACGGTGAGTCTCAGTACAGCCGAATCCAAG
CCGTTGCCAATGGTCCTCAGAAAGAGGTACTGAAGAAGCTCTCTGCTGAAATGGTGAAGGCGGAAACTTTAGCTGGTGAT
GAGATTACCGCGAGACTGACCCATGCACCTGGTAATGGCGCAGCGATTGGTGGTCTAAAAGTGACAACTGCGAACGGTTG
GTTTGCTGCGCGTCCATCGGGTACTGAAGATATCTATAAGATCTATTGTGAGAGCTTCAAAGGCGCAGAGCACCTCAAAC
AAATTGAGTTGGAAGCGCAAGAGATTGTCAATCAAGTCTTTGCCGAAGCAGGTCTATAA

Upstream 100 bases:

>100_bases
AGTAACAGGTTCAATTTAAGAAACCTGATAGAAGCCTCATAATGCGCAAGATTATGCCGATATTATGAGGCTTTTTTGTT
TGAGTATATTTTAAGAAAGG

Downstream 100 bases:

>100_bases
TTCTTTACGACTGATAATGGCTTTCCAATGATAATTAAAATCCCAAACACAGTGTTTGGGATTTTTTATTGTCGGAATAA
AATTAAATTCATATGTCGAA

Product: phosphoglucomutase

Products: NA

Alternate protein names: PGM; Glucose phosphomutase [H]

Number of amino acids: Translated: 552; Mature: 551

Protein sequence:

>552_residues
MSLMAMHPRAGQKALQEDLHNIPALVANYFLLQPDPTNPAHKVEFGTSGHRGCADKSTFNEHHILAIAQAVAEVRAEQGT
TGPLFVGKDTHALSEPAFSTVVEVLIANGVTVIVQEQNGYTPTPGISHAILTYNLQHEEKADGIVITPSHNPPQDGGIKY
NPTHGGPAEGELTQRIEDRANVLIAEGLQGVKRMPLAQAKASSLFVEQDLVKPYVDDLVNVIDMAAIQKAGLKLGVDPLG
GSGIDYWRQIGTAYNLDLTLVSEAIDPSFQFMSLDKDGVVRMDCSSPYAMAGLLALKDQYDLAFGNDPDYDRHGIVTPTK
GLMNPNHFLAVCIDYLYRHRQGWAADVAVGKTLVSSAMIDRVVADLGRELCEVPVGFKWFVDGLYNGKFGFGGEESAGAS
FLRQDGTPWSTDKDGIILCLLAAEITAVTGKNPQQYYDELAAKHGESQYSRIQAVANGPQKEVLKKLSAEMVKAETLAGD
EITARLTHAPGNGAAIGGLKVTTANGWFAARPSGTEDIYKIYCESFKGAEHLKQIELEAQEIVNQVFAEAGL

Sequences:

>Translated_552_residues
MSLMAMHPRAGQKALQEDLHNIPALVANYFLLQPDPTNPAHKVEFGTSGHRGCADKSTFNEHHILAIAQAVAEVRAEQGT
TGPLFVGKDTHALSEPAFSTVVEVLIANGVTVIVQEQNGYTPTPGISHAILTYNLQHEEKADGIVITPSHNPPQDGGIKY
NPTHGGPAEGELTQRIEDRANVLIAEGLQGVKRMPLAQAKASSLFVEQDLVKPYVDDLVNVIDMAAIQKAGLKLGVDPLG
GSGIDYWRQIGTAYNLDLTLVSEAIDPSFQFMSLDKDGVVRMDCSSPYAMAGLLALKDQYDLAFGNDPDYDRHGIVTPTK
GLMNPNHFLAVCIDYLYRHRQGWAADVAVGKTLVSSAMIDRVVADLGRELCEVPVGFKWFVDGLYNGKFGFGGEESAGAS
FLRQDGTPWSTDKDGIILCLLAAEITAVTGKNPQQYYDELAAKHGESQYSRIQAVANGPQKEVLKKLSAEMVKAETLAGD
EITARLTHAPGNGAAIGGLKVTTANGWFAARPSGTEDIYKIYCESFKGAEHLKQIELEAQEIVNQVFAEAGL
>Mature_551_residues
SLMAMHPRAGQKALQEDLHNIPALVANYFLLQPDPTNPAHKVEFGTSGHRGCADKSTFNEHHILAIAQAVAEVRAEQGTT
GPLFVGKDTHALSEPAFSTVVEVLIANGVTVIVQEQNGYTPTPGISHAILTYNLQHEEKADGIVITPSHNPPQDGGIKYN
PTHGGPAEGELTQRIEDRANVLIAEGLQGVKRMPLAQAKASSLFVEQDLVKPYVDDLVNVIDMAAIQKAGLKLGVDPLGG
SGIDYWRQIGTAYNLDLTLVSEAIDPSFQFMSLDKDGVVRMDCSSPYAMAGLLALKDQYDLAFGNDPDYDRHGIVTPTKG
LMNPNHFLAVCIDYLYRHRQGWAADVAVGKTLVSSAMIDRVVADLGRELCEVPVGFKWFVDGLYNGKFGFGGEESAGASF
LRQDGTPWSTDKDGIILCLLAAEITAVTGKNPQQYYDELAAKHGESQYSRIQAVANGPQKEVLKKLSAEMVKAETLAGDE
ITARLTHAPGNGAAIGGLKVTTANGWFAARPSGTEDIYKIYCESFKGAEHLKQIELEAQEIVNQVFAEAGL

Specific function: This enzyme participates in both the breakdown and synthesis of glucose [H]

COG id: COG0033

COG function: function code G; Phosphoglucomutase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the phosphohexose mutase family [H]

Homologues:

Organism=Homo sapiens, GI133922562, Length=440, Percent_Identity=25, Blast_Score=97, Evalue=3e-20,
Organism=Homo sapiens, GI290463102, Length=479, Percent_Identity=26.3048016701461, Blast_Score=97, Evalue=4e-20,
Organism=Homo sapiens, GI21361621, Length=470, Percent_Identity=25.531914893617, Blast_Score=87, Evalue=5e-17,
Organism=Escherichia coli, GI1786904, Length=547, Percent_Identity=70.2010968921389, Blast_Score=787, Evalue=0.0,
Organism=Caenorhabditis elegans, GI17535441, Length=448, Percent_Identity=27.2321428571429, Blast_Score=89, Evalue=8e-18,
Organism=Saccharomyces cerevisiae, GI6323752, Length=573, Percent_Identity=26.7015706806283, Blast_Score=114, Evalue=3e-26,
Organism=Saccharomyces cerevisiae, GI6322722, Length=494, Percent_Identity=28.1376518218623, Blast_Score=102, Evalue=1e-22,
Organism=Drosophila melanogaster, GI17864244, Length=469, Percent_Identity=26.0127931769723, Blast_Score=105, Evalue=8e-23,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005844
- InterPro:   IPR016055
- InterPro:   IPR005845
- InterPro:   IPR005846
- InterPro:   IPR005843
- InterPro:   IPR016066
- InterPro:   IPR005852 [H]

Pfam domain/function: PF02878 PGM_PMM_I; PF02879 PGM_PMM_II; PF02880 PGM_PMM_III; PF00408 PGM_PMM_IV [H]

EC number: =5.4.2.2 [H]

Molecular weight: Translated: 59538; Mature: 59407

Theoretical pI: Translated: 4.99; Mature: 4.99

Prosite motif: PS00710 PGM_PMM

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
2.0 %Met     (Translated Protein)
3.1 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
1.8 %Met     (Mature Protein)
2.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSLMAMHPRAGQKALQEDLHNIPALVANYFLLQPDPTNPAHKVEFGTSGHRGCADKSTFN
CCCEECCCCCHHHHHHHHHHHHHHHHHCEEEECCCCCCCCCEEECCCCCCCCCCCCCCCC
EHHILAIAQAVAEVRAEQGTTGPLFVGKDTHALSEPAFSTVVEVLIANGVTVIVQEQNGY
CHHHHHHHHHHHHHHHHCCCCCCEEECCCCCHHCCHHHHHHHHHHHHCCCEEEEECCCCC
TPTPGISHAILTYNLQHEEKADGIVITPSHNPPQDGGIKYNPTHGGPAEGELTQRIEDRA
CCCCCCCEEEEEEEECCCCCCCCEEECCCCCCCCCCCEEECCCCCCCCCCHHHHHHHHHH
NVLIAEGLQGVKRMPLAQAKASSLFVEQDLVKPYVDDLVNVIDMAAIQKAGLKLGVDPLG
CEEHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEECCCCCC
GSGIDYWRQIGTAYNLDLTLVSEAIDPSFQFMSLDKDGVVRMDCSSPYAMAGLLALKDQY
CCCHHHHHHHCCEECCCCEEHHHHCCCCEEEEEECCCCEEEEECCCCHHHHHHHHHCCCC
DLAFGNDPDYDRHGIVTPTKGLMNPNHFLAVCIDYLYRHRQGWAADVAVGKTLVSSAMID
CEECCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHH
RVVADLGRELCEVPVGFKWFVDGLYNGKFGFGGEESAGASFLRQDGTPWSTDKDGIILCL
HHHHHHHHHHHHCCCCHHHHHHHHCCCCCCCCCCCCHHHHHHHCCCCCCCCCCCCEEEEE
LAAEITAVTGKNPQQYYDELAAKHGESQYSRIQAVANGPQKEVLKKLSAEMVKAETLAGD
EEHHHHHHCCCCHHHHHHHHHHHCCCHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHCCCC
EITARLTHAPGNGAAIGGLKVTTANGWFAARPSGTEDIYKIYCESFKGAEHLKQIELEAQ
CEEEEEEECCCCCCEECCEEEEECCCEEEECCCCHHHHHHHHHHHCCCHHHHHHHHHHHH
EIVNQVFAEAGL
HHHHHHHHHCCC
>Mature Secondary Structure 
SLMAMHPRAGQKALQEDLHNIPALVANYFLLQPDPTNPAHKVEFGTSGHRGCADKSTFN
CCEECCCCCHHHHHHHHHHHHHHHHHCEEEECCCCCCCCCEEECCCCCCCCCCCCCCCC
EHHILAIAQAVAEVRAEQGTTGPLFVGKDTHALSEPAFSTVVEVLIANGVTVIVQEQNGY
CHHHHHHHHHHHHHHHHCCCCCCEEECCCCCHHCCHHHHHHHHHHHHCCCEEEEECCCCC
TPTPGISHAILTYNLQHEEKADGIVITPSHNPPQDGGIKYNPTHGGPAEGELTQRIEDRA
CCCCCCCEEEEEEEECCCCCCCCEEECCCCCCCCCCCEEECCCCCCCCCCHHHHHHHHHH
NVLIAEGLQGVKRMPLAQAKASSLFVEQDLVKPYVDDLVNVIDMAAIQKAGLKLGVDPLG
CEEHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEECCCCCC
GSGIDYWRQIGTAYNLDLTLVSEAIDPSFQFMSLDKDGVVRMDCSSPYAMAGLLALKDQY
CCCHHHHHHHCCEECCCCEEHHHHCCCCEEEEEECCCCEEEEECCCCHHHHHHHHHCCCC
DLAFGNDPDYDRHGIVTPTKGLMNPNHFLAVCIDYLYRHRQGWAADVAVGKTLVSSAMID
CEECCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHH
RVVADLGRELCEVPVGFKWFVDGLYNGKFGFGGEESAGASFLRQDGTPWSTDKDGIILCL
HHHHHHHHHHHHCCCCHHHHHHHHCCCCCCCCCCCCHHHHHHHCCCCCCCCCCCCEEEEE
LAAEITAVTGKNPQQYYDELAAKHGESQYSRIQAVANGPQKEVLKKLSAEMVKAETLAGD
EEHHHHHHCCCCHHHHHHHHHHHCCCHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHCCCC
EITARLTHAPGNGAAIGGLKVTTANGWFAARPSGTEDIYKIYCESFKGAEHLKQIELEAQ
CEEEEEEECCCCCCEECCEEEEECCCEEEECCCCHHHHHHHHHHHCCCHHHHHHHHHHHH
EIVNQVFAEAGL
HHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8083177; 8905232; 9278503; 8011018 [H]