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The map label for this gene is glyA

Identifier: 37679082

GI number: 37679082

Start: 901221

End: 902471

Strand: Direct

Name: glyA

Synonym: VV0898

Alternate gene names: 37679082

Gene position: 901221-902471 (Clockwise)

Preceding gene: 37679080

Following gene: 37679096

Centisome position: 26.87

GC content: 49.48

Gene sequence:

>1251_bases
ATGCTTAAGCGTGATATGAATATCGCTGATTACGATGCGGAGCTATTCGCAGCTATCCAGGAAGAAACTCTTCGCCAGGA
AGAACACATCGAGCTGATCGCTTCAGAAAACTACACAAGCCCACGTGTAATGGAAGCTCAAGGCTCTCAGCTAACCAATA
AGTACGCTGAAGGCTACCCAGGCAAGCGTTACTACGGTGGCTGTGAATATGTTGATAAAGCGGAAGCTCTCGCAATTGAT
CGCGCATGCCAGTTGTTCGGTTGTGAATATGCAAACGTACAGCCTCACTCAGGTTCTCAAGCAAACAGTGCAGTGTATAT
GGCGCTGCTTAACCCAGGCGACACTGTATTAGGTATGAGCCTTGCGCACGGTGGCCACTTGACGCACGGCTCACCAGTTA
ACTTCTCTGGTAAGCACTACAACGTTATCCCTTACGGTATCGATGAAGCGGGTCAAATTAACTACGACGAGATGGAAACG
CTAGCGCTTGAGCACAAACCTAAGATGATCATCGGTGGTTTCTCAGCGTACTCTCAAATCGTTGATTGGAAGCGCATGCG
TGAAATCGCGGACAAAGTTGACGCTTACCTATTCGTCGATATGGCGCACGTTGCGGGTCTTATCGCAGCAGGTGAATACC
CAACACCTGTGCCACACGCACACGTAGTAACGACAACGACGCACAAAACGCTAGCAGGTCCACGTGGTGGTCTTATCCTG
TCTAACGCTGGCGAAGACATGTACAAGAAACTGAACTCTGCGGTTTTCCCTGGTGGCCAAGGCGGTCCTCTAATGCACGT
TATCGCGGGTAAAGCAGTAGCGTTTAAAGAAGCGATGGAACCTGAGTTTAAAGCTTACCAAGCGCGCGTAGTGAAAAACG
CAAAAGCGATGGTGGCTCAGTTCCAAGAGCGCGGTTACAAGATCGTGTCAAACGGTACAGAAAACCACCTGTTCCTTGTT
GACCTTATCGACAAAGACATTACGGGTAAAGATGCGGATGCGGCACTAGGCGCAGCAAACATCACGGTAAACAAGAACTC
AGTGCCAAACGACCCTCGTAGCCCATTTGTCACTTCGGGTATTCGTGTTGGTACGCCAGCGATCACTCGCCGTGGCTTTA
CTGAAGCGGACGCGAAAGAGCTAGCAAACTGGATGTGTGACGTACTAGACAACATCGGCAATGAAGCGGTTATCGAAGCG
ACGAAACAGAAAGTCCTAGAAATTTGTAAGCGTCTACCTGTTTACGCATAA

Upstream 100 bases:

>100_bases
TTATGTAGAATGCGCGCCATTATGGTGACGAAAACGTTTGCGTTGGGTCATTAACCAGTTTTTTTGCAACTTTCAGTCAA
ATCTGAGTCAGGAGATACAG

Downstream 100 bases:

>100_bases
GATTTTGGCTACTTGAACATCAAAAAGGCTTCCGGATGGAAGCCTTTTTTCTTCTAACATTTCTTCGTCGAAACAGTAAA
AGGAACAAGAAAAGTCACCA

Product: serine hydroxymethyltransferase

Products: NA

Alternate protein names: SHMT 1; Serine methylase 1 [H]

Number of amino acids: Translated: 416; Mature: 416

Protein sequence:

>416_residues
MLKRDMNIADYDAELFAAIQEETLRQEEHIELIASENYTSPRVMEAQGSQLTNKYAEGYPGKRYYGGCEYVDKAEALAID
RACQLFGCEYANVQPHSGSQANSAVYMALLNPGDTVLGMSLAHGGHLTHGSPVNFSGKHYNVIPYGIDEAGQINYDEMET
LALEHKPKMIIGGFSAYSQIVDWKRMREIADKVDAYLFVDMAHVAGLIAAGEYPTPVPHAHVVTTTTHKTLAGPRGGLIL
SNAGEDMYKKLNSAVFPGGQGGPLMHVIAGKAVAFKEAMEPEFKAYQARVVKNAKAMVAQFQERGYKIVSNGTENHLFLV
DLIDKDITGKDADAALGAANITVNKNSVPNDPRSPFVTSGIRVGTPAITRRGFTEADAKELANWMCDVLDNIGNEAVIEA
TKQKVLEICKRLPVYA

Sequences:

>Translated_416_residues
MLKRDMNIADYDAELFAAIQEETLRQEEHIELIASENYTSPRVMEAQGSQLTNKYAEGYPGKRYYGGCEYVDKAEALAID
RACQLFGCEYANVQPHSGSQANSAVYMALLNPGDTVLGMSLAHGGHLTHGSPVNFSGKHYNVIPYGIDEAGQINYDEMET
LALEHKPKMIIGGFSAYSQIVDWKRMREIADKVDAYLFVDMAHVAGLIAAGEYPTPVPHAHVVTTTTHKTLAGPRGGLIL
SNAGEDMYKKLNSAVFPGGQGGPLMHVIAGKAVAFKEAMEPEFKAYQARVVKNAKAMVAQFQERGYKIVSNGTENHLFLV
DLIDKDITGKDADAALGAANITVNKNSVPNDPRSPFVTSGIRVGTPAITRRGFTEADAKELANWMCDVLDNIGNEAVIEA
TKQKVLEICKRLPVYA
>Mature_416_residues
MLKRDMNIADYDAELFAAIQEETLRQEEHIELIASENYTSPRVMEAQGSQLTNKYAEGYPGKRYYGGCEYVDKAEALAID
RACQLFGCEYANVQPHSGSQANSAVYMALLNPGDTVLGMSLAHGGHLTHGSPVNFSGKHYNVIPYGIDEAGQINYDEMET
LALEHKPKMIIGGFSAYSQIVDWKRMREIADKVDAYLFVDMAHVAGLIAAGEYPTPVPHAHVVTTTTHKTLAGPRGGLIL
SNAGEDMYKKLNSAVFPGGQGGPLMHVIAGKAVAFKEAMEPEFKAYQARVVKNAKAMVAQFQERGYKIVSNGTENHLFLV
DLIDKDITGKDADAALGAANITVNKNSVPNDPRSPFVTSGIRVGTPAITRRGFTEADAKELANWMCDVLDNIGNEAVIEA
TKQKVLEICKRLPVYA

Specific function: Interconversion of serine and glycine [H]

COG id: COG0112

COG function: function code E; Glycine/serine hydroxymethyltransferase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the SHMT family [H]

Homologues:

Organism=Homo sapiens, GI19923315, Length=419, Percent_Identity=45.346062052506, Blast_Score=343, Evalue=1e-94,
Organism=Homo sapiens, GI261862352, Length=419, Percent_Identity=45.346062052506, Blast_Score=343, Evalue=1e-94,
Organism=Homo sapiens, GI261862350, Length=419, Percent_Identity=45.346062052506, Blast_Score=343, Evalue=1e-94,
Organism=Homo sapiens, GI261862348, Length=419, Percent_Identity=45.346062052506, Blast_Score=343, Evalue=1e-94,
Organism=Homo sapiens, GI261862346, Length=418, Percent_Identity=44.7368421052632, Blast_Score=333, Evalue=2e-91,
Organism=Homo sapiens, GI22547186, Length=401, Percent_Identity=47.6309226932668, Blast_Score=330, Evalue=1e-90,
Organism=Homo sapiens, GI22547189, Length=388, Percent_Identity=45.360824742268, Blast_Score=299, Evalue=3e-81,
Organism=Escherichia coli, GI1788902, Length=417, Percent_Identity=81.294964028777, Blast_Score=688, Evalue=0.0,
Organism=Caenorhabditis elegans, GI25144732, Length=401, Percent_Identity=44.6384039900249, Blast_Score=338, Evalue=3e-93,
Organism=Caenorhabditis elegans, GI25144729, Length=401, Percent_Identity=44.6384039900249, Blast_Score=338, Evalue=4e-93,
Organism=Saccharomyces cerevisiae, GI6319739, Length=419, Percent_Identity=43.436754176611, Blast_Score=362, Evalue=1e-101,
Organism=Saccharomyces cerevisiae, GI6323087, Length=402, Percent_Identity=44.5273631840796, Blast_Score=345, Evalue=5e-96,
Organism=Drosophila melanogaster, GI24640005, Length=427, Percent_Identity=44.9648711943794, Blast_Score=351, Evalue=4e-97,
Organism=Drosophila melanogaster, GI221329721, Length=427, Percent_Identity=44.9648711943794, Blast_Score=350, Evalue=1e-96,

Paralogues:

None

Copy number: 3180 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 300 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 240 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 12,000 Molecules/Cell In: Glucose minimal

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR015424
- InterPro:   IPR015421
- InterPro:   IPR015422
- InterPro:   IPR001085
- InterPro:   IPR019798 [H]

Pfam domain/function: PF00464 SHMT [H]

EC number: =2.1.2.1 [H]

Molecular weight: Translated: 45333; Mature: 45333

Theoretical pI: Translated: 5.91; Mature: 5.91

Prosite motif: PS00096 SHMT

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
3.4 %Met     (Translated Protein)
4.6 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
3.4 %Met     (Mature Protein)
4.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLKRDMNIADYDAELFAAIQEETLRQEEHIELIASENYTSPRVMEAQGSQLTNKYAEGYP
CCCCCCCCCCCCHHHHHHHHHHHHCHHHHEEEEECCCCCCCEEECCCCHHHHHHHHCCCC
GKRYYGGCEYVDKAEALAIDRACQLFGCEYANVQPHSGSQANSAVYMALLNPGDTVLGMS
CCCCCCCCCHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCEEEEEEECCCCCEEEEE
LAHGGHLTHGSPVNFSGKHYNVIPYGIDEAGQINYDEMETLALEHKPKMIIGGFSAYSQI
ECCCCCCCCCCCCCCCCCEEEEEEECCCCCCCCCHHHHHHHHHCCCCCEEEECHHHHHHH
VDWKRMREIADKVDAYLFVDMAHVAGLIAAGEYPTPVPHAHVVTTTTHKTLAGPRGGLIL
HHHHHHHHHHHHHHHHHEEEHHHHHHHHHCCCCCCCCCCCEEEEECCCHHHCCCCCCEEE
SNAGEDMYKKLNSAVFPGGQGGPLMHVIAGKAVAFKEAMEPEFKAYQARVVKNAKAMVAQ
ECCCHHHHHHHHHCCCCCCCCCCEEEEHHCCHHHHHHHCCHHHHHHHHHHHHHHHHHHHH
FQERGYKIVSNGTENHLFLVDLIDKDITGKDADAALGAANITVNKNSVPNDPRSPFVTSG
HHHCCEEEEECCCCCEEEEEEEECCCCCCCCCCHHCCEEEEEECCCCCCCCCCCCCEECC
IRVGTPAITRRGFTEADAKELANWMCDVLDNIGNEAVIEATKQKVLEICKRLPVYA
EEECCHHHHHCCCCHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHCCCCC
>Mature Secondary Structure
MLKRDMNIADYDAELFAAIQEETLRQEEHIELIASENYTSPRVMEAQGSQLTNKYAEGYP
CCCCCCCCCCCCHHHHHHHHHHHHCHHHHEEEEECCCCCCCEEECCCCHHHHHHHHCCCC
GKRYYGGCEYVDKAEALAIDRACQLFGCEYANVQPHSGSQANSAVYMALLNPGDTVLGMS
CCCCCCCCCHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCEEEEEEECCCCCEEEEE
LAHGGHLTHGSPVNFSGKHYNVIPYGIDEAGQINYDEMETLALEHKPKMIIGGFSAYSQI
ECCCCCCCCCCCCCCCCCEEEEEEECCCCCCCCCHHHHHHHHHCCCCCEEEECHHHHHHH
VDWKRMREIADKVDAYLFVDMAHVAGLIAAGEYPTPVPHAHVVTTTTHKTLAGPRGGLIL
HHHHHHHHHHHHHHHHHEEEHHHHHHHHHCCCCCCCCCCCEEEEECCCHHHCCCCCCEEE
SNAGEDMYKKLNSAVFPGGQGGPLMHVIAGKAVAFKEAMEPEFKAYQARVVKNAKAMVAQ
ECCCHHHHHHHHHCCCCCCCCCCEEEEHHCCHHHHHHHCCHHHHHHHHHHHHHHHHHHHH
FQERGYKIVSNGTENHLFLVDLIDKDITGKDADAALGAANITVNKNSVPNDPRSPFVTSG
HHHCCEEEEECCCCCEEEEEEEECCCCCCCCCCHHCCEEEEEECCCCCCCCCCCCCEECC
IRVGTPAITRRGFTEADAKELANWMCDVLDNIGNEAVIEATKQKVLEICKRLPVYA
EEECCHHHHHCCCCHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 10952301 [H]