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The map label for this gene is ribB [H]

Identifier: 37679047

GI number: 37679047

Start: 868030

End: 869184

Strand: Direct

Name: ribB [H]

Synonym: VV0863

Alternate gene names: 37679047

Gene position: 868030-869184 (Clockwise)

Preceding gene: 161486647

Following gene: 161486646

Centisome position: 25.88

GC content: 49.44

Gene sequence:

>1155_bases
GTGTCTATCAGCGTTTTAGCGCTTAAATTGACAGGAAATATCGCTATGCCAATCAGTACACCCCAAGAGATCATTGAAGA
CATTCGTTTGGGCAAAATGGTCATCTTAATGGACGATGAAGACCGCGAAAACGAAGGTGATTTGATTATGGCGGCGGAGC
ACATTACGCCAGAAGCCATCAATTTTATGGCCAAATATGGTCGCGGTTTGATCTGTTTGACCATGACCAAAGAGCGTTGC
CAGCGTCTTGGATTACCACCAATGGTGCAAGATAACAACGCGCAATACACCACCAACTTCACTGTTTCCATCGAAGCGGC
GGAAGGCGTGACAACAGGTATTTCAGCAGCGGATCGTGCTCGTACCGTGCAAGCGGCAGTCGCAAAAGAAGCTAAAGCGG
CAGACTTGGTGCAACCGGGGCACATTTTCCCATTAGCCGCGCAAGATGGTGGCGTATTGACTCGCGCGGGTCATACCGAG
GCAGGCTGCGACCTTGCTCGTTTGGCGGGTTTCGAACCAGCCTCTGTTATCGTTGAAATTCTGAATGACGATGGCACCAT
GGCACGTCGCCCTGATTTGGAAGTGTTTGCTGAGCAGCATGGTCTCAAACTCGGCACCATTGCCGATTTGATTGAGTATC
GAAACAACACGGAAACCACGATTGAGCGCGTTGCTGAGTGCAAGCTACCCACCGAGTTTGGTGAGTTTGATCTGGTGACT
TACCGCGACACCATTGATAATCAAATTCACTTTGCTTTGCGTAAAGGCACTGTGGGTGATCAAACACCACTGGTTCGTGT
TCATTTACAAGACACCTTTACCGATTTACTGCGCAGCGATCGCAATGCTGAGCGCAGTTGGACGCTTGATAAAGCGATGA
AGCGTATTGGCCAAGAAGGGGGCGTTCTGGTGATTCTGGGGAATGAAGAGTCGCCTGAGCTGCTGATCCATCGCGTCAAA
ATGTTTGAAGCTCAAGACAAAGAAGAGGCACCCAAATTGGCGAAGAAGCAGGGCACTTCACGTCGTGTTGGTGTCGGCTC
GCAAATTCTTGCAGACTTAGGTGTGCACGATATGCGTCTACTTTCTTCCAGCAACAAGAAATACCATGCCCTTGGCGGTT
TTGGTCTGAACGTTATTGAGTATGTGTGTGAATAA

Upstream 100 bases:

>100_bases
GAGTCCCGCATCACCATGGAATTCTTGCAACAGAATGGTTTTGCTTAGTTCACAGAATGTTAGCCCACAGGTTGACACTC
GGTAACGATGAATCAGACTA

Downstream 100 bases:

>100_bases
CACCGCTTCTAATAAACGCAGCGAAAATAACGCTGCGTTTATTTTTCTCCCCTAATTCGACTCATCTCTTCGCTGTAAGG
CAGTATTTCGTGGCGAAATA

Product: 3,4-dihydroxy-2-butanone 4-phosphate synthase/GTP cyclohydrolase II

Products: NA

Alternate protein names: DHBP synthase [H]

Number of amino acids: Translated: 384; Mature: 383

Protein sequence:

>384_residues
MSISVLALKLTGNIAMPISTPQEIIEDIRLGKMVILMDDEDRENEGDLIMAAEHITPEAINFMAKYGRGLICLTMTKERC
QRLGLPPMVQDNNAQYTTNFTVSIEAAEGVTTGISAADRARTVQAAVAKEAKAADLVQPGHIFPLAAQDGGVLTRAGHTE
AGCDLARLAGFEPASVIVEILNDDGTMARRPDLEVFAEQHGLKLGTIADLIEYRNNTETTIERVAECKLPTEFGEFDLVT
YRDTIDNQIHFALRKGTVGDQTPLVRVHLQDTFTDLLRSDRNAERSWTLDKAMKRIGQEGGVLVILGNEESPELLIHRVK
MFEAQDKEEAPKLAKKQGTSRRVGVGSQILADLGVHDMRLLSSSNKKYHALGGFGLNVIEYVCE

Sequences:

>Translated_384_residues
MSISVLALKLTGNIAMPISTPQEIIEDIRLGKMVILMDDEDRENEGDLIMAAEHITPEAINFMAKYGRGLICLTMTKERC
QRLGLPPMVQDNNAQYTTNFTVSIEAAEGVTTGISAADRARTVQAAVAKEAKAADLVQPGHIFPLAAQDGGVLTRAGHTE
AGCDLARLAGFEPASVIVEILNDDGTMARRPDLEVFAEQHGLKLGTIADLIEYRNNTETTIERVAECKLPTEFGEFDLVT
YRDTIDNQIHFALRKGTVGDQTPLVRVHLQDTFTDLLRSDRNAERSWTLDKAMKRIGQEGGVLVILGNEESPELLIHRVK
MFEAQDKEEAPKLAKKQGTSRRVGVGSQILADLGVHDMRLLSSSNKKYHALGGFGLNVIEYVCE
>Mature_383_residues
SISVLALKLTGNIAMPISTPQEIIEDIRLGKMVILMDDEDRENEGDLIMAAEHITPEAINFMAKYGRGLICLTMTKERCQ
RLGLPPMVQDNNAQYTTNFTVSIEAAEGVTTGISAADRARTVQAAVAKEAKAADLVQPGHIFPLAAQDGGVLTRAGHTEA
GCDLARLAGFEPASVIVEILNDDGTMARRPDLEVFAEQHGLKLGTIADLIEYRNNTETTIERVAECKLPTEFGEFDLVTY
RDTIDNQIHFALRKGTVGDQTPLVRVHLQDTFTDLLRSDRNAERSWTLDKAMKRIGQEGGVLVILGNEESPELLIHRVKM
FEAQDKEEAPKLAKKQGTSRRVGVGSQILADLGVHDMRLLSSSNKKYHALGGFGLNVIEYVCE

Specific function: Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate [H]

COG id: COG0108

COG function: function code H; 3,4-dihydroxy-2-butanone 4-phosphate synthase

Gene ontology:

Cell location: Membrane-Associated [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: In the C-terminal section; belongs to the GTP cyclohydrolase II family [H]

Homologues:

Organism=Escherichia coli, GI1789420, Length=205, Percent_Identity=54.6341463414634, Blast_Score=223, Evalue=2e-59,
Organism=Escherichia coli, GI1787533, Length=168, Percent_Identity=29.7619047619048, Blast_Score=69, Evalue=6e-13,
Organism=Saccharomyces cerevisiae, GI6320695, Length=203, Percent_Identity=42.3645320197044, Blast_Score=167, Evalue=3e-42,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR017945
- InterPro:   IPR000422
- InterPro:   IPR000926
- InterPro:   IPR016299 [H]

Pfam domain/function: PF00926 DHBP_synthase; PF00925 GTP_cyclohydro2 [H]

EC number: =4.1.99.12 [H]

Molecular weight: Translated: 42155; Mature: 42024

Theoretical pI: Translated: 4.94; Mature: 4.94

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
3.1 %Met     (Translated Protein)
4.4 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
2.9 %Met     (Mature Protein)
4.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSISVLALKLTGNIAMPISTPQEIIEDIRLGKMVILMDDEDRENEGDLIMAAEHITPEAI
CCEEEEEEEEECCEEECCCCHHHHHHHHCCCEEEEEECCCCCCCCCCEEEEECCCCHHHH
NFMAKYGRGLICLTMTKERCQRLGLPPMVQDNNAQYTTNFTVSIEAAEGVTTGISAADRA
HHHHHHCCCEEEEEECHHHHHHCCCCCEEECCCCEEEEEEEEEEECCCCCCCCCCHHHHH
RTVQAAVAKEAKAADLVQPGHIFPLAAQDGGVLTRAGHTEAGCDLARLAGFEPASVIVEI
HHHHHHHHHHHHHHHCCCCCCEEEEECCCCCEEEECCCCCCCCCHHHHCCCCHHHHHHHH
LNDDGTMARRPDLEVFAEQHGLKLGTIADLIEYRNNTETTIERVAECKLPTEFGEFDLVT
HCCCCCCCCCCCHHHHHHHCCCCHHHHHHHHHHCCCCHHHHHHHHHCCCCCCCCCEEEEE
YRDTIDNQIHFALRKGTVGDQTPLVRVHLQDTFTDLLRSDRNAERSWTLDKAMKRIGQEG
ECCCCCCEEEEEEECCCCCCCCCEEEEEEHHHHHHHHHCCCCCCCCCCHHHHHHHHCCCC
GVLVILGNEESPELLIHRVKMFEAQDKEEAPKLAKKQGTSRRVGVGSQILADLGVHDMRL
CEEEEECCCCCHHHHHHHHHHHHCCCHHHHHHHHHHCCCCCCCCCCHHHHHHCCHHHHHH
LSSSNKKYHALGGFGLNVIEYVCE
HHCCCCCEEEECCCHHHHHHHHCC
>Mature Secondary Structure 
SISVLALKLTGNIAMPISTPQEIIEDIRLGKMVILMDDEDRENEGDLIMAAEHITPEAI
CEEEEEEEEECCEEECCCCHHHHHHHHCCCEEEEEECCCCCCCCCCEEEEECCCCHHHH
NFMAKYGRGLICLTMTKERCQRLGLPPMVQDNNAQYTTNFTVSIEAAEGVTTGISAADRA
HHHHHHCCCEEEEEECHHHHHHCCCCCEEECCCCEEEEEEEEEEECCCCCCCCCCHHHHH
RTVQAAVAKEAKAADLVQPGHIFPLAAQDGGVLTRAGHTEAGCDLARLAGFEPASVIVEI
HHHHHHHHHHHHHHHCCCCCCEEEEECCCCCEEEECCCCCCCCCHHHHCCCCHHHHHHHH
LNDDGTMARRPDLEVFAEQHGLKLGTIADLIEYRNNTETTIERVAECKLPTEFGEFDLVT
HCCCCCCCCCCCHHHHHHHCCCCHHHHHHHHHHCCCCHHHHHHHHHCCCCCCCCCEEEEE
YRDTIDNQIHFALRKGTVGDQTPLVRVHLQDTFTDLLRSDRNAERSWTLDKAMKRIGQEG
ECCCCCCEEEEEEECCCCCCCCCEEEEEEHHHHHHHHHCCCCCCCCCCHHHHHHHHCCCC
GVLVILGNEESPELLIHRVKMFEAQDKEEAPKLAKKQGTSRRVGVGSQILADLGVHDMRL
CEEEEECCCCCHHHHHHHHHHHHCCCHHHHHHHHHHCCCCCCCCCCHHHHHHCCHHHHHH
LSSSNKKYHALGGFGLNVIEYVCE
HHCCCCCEEEECCCHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 8144477 [H]