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The map label for this gene is yeaP [H]

Identifier: 37678956

GI number: 37678956

Start: 777659

End: 778681

Strand: Direct

Name: yeaP [H]

Synonym: VV0772

Alternate gene names: 37678956

Gene position: 777659-778681 (Clockwise)

Preceding gene: 37678955

Following gene: 37678957

Centisome position: 23.18

GC content: 45.16

Gene sequence:

>1023_bases
ATGGATAGCATGAGACTTTTGGACGCCCATAGGTCGATCAATCAATTGTTGGGGAAGTTAGCCTTAGGATTGGAGAAAGA
TCAGTTAAATCGAGAAATTGTATCCTTGTCAGAGCATCTGTTTGGATCTCGTAAGGCCTCGATTTTGAAGCTGGATCCGC
AGCACAATACGCTGCATCTTGAATACGCCCCGAATCTTCCTGATTTTTACAATCAAGCAATTGAAGGTGTCGAGATTGGT
GAAAGGGTAGGATCGTGCGGAGCTGCAGCTTATAGCGGAAAGTCCGTGGTCGTGAGTGATATTGAGAGTCACCCGAATTG
GCAGCCCTATGCCGAGTTAGCGAAAGCGGCGAATGTGGCGGCATGTTGGTCTGTCCCGATTGTTTCCCGACAAGATAAAG
TGCTGGGCACCTTTGCCATTTACAGCGATATGCCTTCTAAACCAGCAAAAGAAGAACTGGAAATCTTGGATCTTCTCGCT
GCGCTTTATTCGATAGCACTAGAAAAGTATCACTTAGAAGAACAACTTCACTATCACGTAAATCGCGATCCTCTGACGCA
GTGTTACAACCGACGAATCTTCTACTTGGAATCCGAACCTTTGCTAGAAACAGCTCGGCACAGTGAGTATGGGATTGGCT
GTTTCTTTATTGATGTTGATGAGTTTAAGTACATCAATGATCGGTTTGGCCATGATGTTGGTGATGCCGTGTTAATCAAT
TTGGCCAATTGGTTAATGGCACAGTTTCCTCAACACGCTGTCATTTCTCGTTACGGAGGTGATGAGTTTGTCGCGATTTG
CCCATTTGTGCACAAACAGGCGTTCCAAGCGTTTTATCAGCAATTACAAAGCAAGATCAAAATGTTCTTCTTGATAGAGG
ATTATTCTGTTTCAGTCAGTATTGGCGCGGACTATGCGGAAGGTGAGTCTTTGGCCAACGTGGATGCACTTATTCGCCAA
GCTGACATCTGCATGTATCAAGTGAAACGTGCTCACCAAACCGTGAGCGCAAGATTGAATTGA

Upstream 100 bases:

>100_bases
TAAACTCCAGCTAACCATACCCTAGAGTTGCTGAGTGAATCAACAACACTAGGGTAAATCATAATAATATTGAGTAAAGT
TAGTACACTAGAGCGCTGTT

Downstream 100 bases:

>100_bases
TCTCATAGTGACAACGAGAAAAGAAAATGAACGAGAATCATTGCCCGATTTGCCAGCAGGAGCTGGAGTGGAACGGACAG
TATCACTGCCAACAGTGTGA

Product: GGDEF family protein

Products: NA

Alternate protein names: DGC [H]

Number of amino acids: Translated: 340; Mature: 340

Protein sequence:

>340_residues
MDSMRLLDAHRSINQLLGKLALGLEKDQLNREIVSLSEHLFGSRKASILKLDPQHNTLHLEYAPNLPDFYNQAIEGVEIG
ERVGSCGAAAYSGKSVVVSDIESHPNWQPYAELAKAANVAACWSVPIVSRQDKVLGTFAIYSDMPSKPAKEELEILDLLA
ALYSIALEKYHLEEQLHYHVNRDPLTQCYNRRIFYLESEPLLETARHSEYGIGCFFIDVDEFKYINDRFGHDVGDAVLIN
LANWLMAQFPQHAVISRYGGDEFVAICPFVHKQAFQAFYQQLQSKIKMFFLIEDYSVSVSIGADYAEGESLANVDALIRQ
ADICMYQVKRAHQTVSARLN

Sequences:

>Translated_340_residues
MDSMRLLDAHRSINQLLGKLALGLEKDQLNREIVSLSEHLFGSRKASILKLDPQHNTLHLEYAPNLPDFYNQAIEGVEIG
ERVGSCGAAAYSGKSVVVSDIESHPNWQPYAELAKAANVAACWSVPIVSRQDKVLGTFAIYSDMPSKPAKEELEILDLLA
ALYSIALEKYHLEEQLHYHVNRDPLTQCYNRRIFYLESEPLLETARHSEYGIGCFFIDVDEFKYINDRFGHDVGDAVLIN
LANWLMAQFPQHAVISRYGGDEFVAICPFVHKQAFQAFYQQLQSKIKMFFLIEDYSVSVSIGADYAEGESLANVDALIRQ
ADICMYQVKRAHQTVSARLN
>Mature_340_residues
MDSMRLLDAHRSINQLLGKLALGLEKDQLNREIVSLSEHLFGSRKASILKLDPQHNTLHLEYAPNLPDFYNQAIEGVEIG
ERVGSCGAAAYSGKSVVVSDIESHPNWQPYAELAKAANVAACWSVPIVSRQDKVLGTFAIYSDMPSKPAKEELEILDLLA
ALYSIALEKYHLEEQLHYHVNRDPLTQCYNRRIFYLESEPLLETARHSEYGIGCFFIDVDEFKYINDRFGHDVGDAVLIN
LANWLMAQFPQHAVISRYGGDEFVAICPFVHKQAFQAFYQQLQSKIKMFFLIEDYSVSVSIGADYAEGESLANVDALIRQ
ADICMYQVKRAHQTVSARLN

Specific function: Catalyzes the condensation of two GTP molecules to the cyclic dinucleotide di-GMP (c-di-GMP), which acts as a secondary messenger (Probable). Cyclic-di-GMP is a second messenger which controls cell surface-associated traits in bacteria [H]

COG id: COG2203

COG function: function code T; FOG: GAF domain

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 GGDEF domain [H]

Homologues:

Organism=Escherichia coli, GI87081977, Length=346, Percent_Identity=26.3005780346821, Blast_Score=97, Evalue=1e-21,
Organism=Escherichia coli, GI87081881, Length=164, Percent_Identity=31.7073170731707, Blast_Score=81, Evalue=1e-16,
Organism=Escherichia coli, GI87082007, Length=192, Percent_Identity=27.6041666666667, Blast_Score=74, Evalue=2e-14,
Organism=Escherichia coli, GI1786584, Length=170, Percent_Identity=26.4705882352941, Blast_Score=73, Evalue=3e-14,
Organism=Escherichia coli, GI1787541, Length=168, Percent_Identity=29.7619047619048, Blast_Score=72, Evalue=4e-14,
Organism=Escherichia coli, GI145693134, Length=170, Percent_Identity=29.4117647058824, Blast_Score=71, Evalue=9e-14,
Organism=Escherichia coli, GI1788381, Length=165, Percent_Identity=29.0909090909091, Blast_Score=71, Evalue=1e-13,
Organism=Escherichia coli, GI1787802, Length=171, Percent_Identity=28.0701754385965, Blast_Score=66, Evalue=4e-12,
Organism=Escherichia coli, GI1787262, Length=157, Percent_Identity=28.0254777070064, Blast_Score=65, Evalue=6e-12,
Organism=Escherichia coli, GI1787816, Length=159, Percent_Identity=25.1572327044025, Blast_Score=62, Evalue=4e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001054
- InterPro:   IPR000160
- InterPro:   IPR003018 [H]

Pfam domain/function: PF01590 GAF; PF00990 GGDEF [H]

EC number: =2.7.7.65 [H]

Molecular weight: Translated: 38409; Mature: 38409

Theoretical pI: Translated: 5.37; Mature: 5.37

Prosite motif: PS50887 GGDEF

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.8 %Cys     (Translated Protein)
1.8 %Met     (Translated Protein)
3.5 %Cys+Met (Translated Protein)
1.8 %Cys     (Mature Protein)
1.8 %Met     (Mature Protein)
3.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MDSMRLLDAHRSINQLLGKLALGLEKDQLNREIVSLSEHLFGSRKASILKLDPQHNTLHL
CCCCHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHCCCCCCEEEEECCCCCEEEE
EYAPNLPDFYNQAIEGVEIGERVGSCGAAAYSGKSVVVSDIESHPNWQPYAELAKAANVA
EECCCCCHHHHHHHHHHHHHHHHCCCCCHHCCCCEEEEEEHHCCCCCCHHHHHHHHCCHH
ACWSVPIVSRQDKVLGTFAIYSDMPSKPAKEELEILDLLAALYSIALEKYHLEEQLHYHV
HEECCCCCCCCCHHEEEEEECCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCC
NRDPLTQCYNRRIFYLESEPLLETARHSEYGIGCFFIDVDEFKYINDRFGHDVGDAVLIN
CCCHHHHHHCCEEEEECCCCHHHHHCCCCCCEEEEEEEHHHHHHHHHHHCCCHHHHHHHH
LANWLMAQFPQHAVISRYGGDEFVAICPFVHKQAFQAFYQQLQSKIKMFFLIEDYSVSVS
HHHHHHHHCCCHHHHHHCCCCCEEEECHHHHHHHHHHHHHHHHHHCEEEEEEECCEEEEE
IGADYAEGESLANVDALIRQADICMYQVKRAHQTVSARLN
ECCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCC
>Mature Secondary Structure
MDSMRLLDAHRSINQLLGKLALGLEKDQLNREIVSLSEHLFGSRKASILKLDPQHNTLHL
CCCCHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHCCCCCCEEEEECCCCCEEEE
EYAPNLPDFYNQAIEGVEIGERVGSCGAAAYSGKSVVVSDIESHPNWQPYAELAKAANVA
EECCCCCHHHHHHHHHHHHHHHHCCCCCHHCCCCEEEEEEHHCCCCCCHHHHHHHHCCHH
ACWSVPIVSRQDKVLGTFAIYSDMPSKPAKEELEILDLLAALYSIALEKYHLEEQLHYHV
HEECCCCCCCCCHHEEEEEECCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCC
NRDPLTQCYNRRIFYLESEPLLETARHSEYGIGCFFIDVDEFKYINDRFGHDVGDAVLIN
CCCHHHHHHCCEEEEECCCCHHHHHCCCCCCEEEEEEEHHHHHHHHHHHCCCHHHHHHHH
LANWLMAQFPQHAVISRYGGDEFVAICPFVHKQAFQAFYQQLQSKIKMFFLIEDYSVSVS
HHHHHHHHCCCHHHHHHCCCCCEEEECHHHHHHHHHHHHHHHHHHCEEEEEEECCEEEEE
IGADYAEGESLANVDALIRQADICMYQVKRAHQTVSARLN
ECCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9097040; 9278503 [H]