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The map label for this gene is aceB [H]

Identifier: 37678925

GI number: 37678925

Start: 746365

End: 748017

Strand: Direct

Name: aceB [H]

Synonym: VV0741

Alternate gene names: 37678925

Gene position: 746365-748017 (Clockwise)

Preceding gene: 37678924

Following gene: 37678926

Centisome position: 22.25

GC content: 46.94

Gene sequence:

>1653_bases
ATGAAAGGAAGAAGAATGATGCTTGCTCAAACGCCCGAAAAAGAAAACACACAGGCTGAACAACAGACCCAAGGCATGCT
TGAAGTAACAGGAACCCTGTCTCCTGAACATCAAGCTATTTTCCCTGTTGAAGCCCAAACCTTTTTATCTCAGCTGTGTG
AGCGATTCTCATTGCGCGTCGATCAATTGTTAACTGCCCGAGAAGAGAGGCAGAACAAGATCGATCAAGGAGAGTTACCT
GATTTTCTTACAGAGACTCAGGATATTCGAGAAGGGAGCTGGAAAATTTTGGGGATTCCCAACGATCTGCAAGATCGTCG
AGTCGAAATTACCGGGCCAACCGATCGTAAAATGGTGATCAACGCCCTAAACGCCAATGTAAAAGTCTTTATGGCGGATT
TCGAAGACTCGATGTCTCCAGCTTGGGATAAGGTGTTGGATGGCCAGATCAACTTGCGTGATGCGGTCAATGGCACCATC
TCCTATTCCAACCCCGATAATGGCAAGCATTATCAGCTGGGCAACAATCCAGCGGTGTTGATCTGCCGTGTCCGCGGTCT
TCATTTAAAAGAAAAGCATGTGACGTGGCGCGGTCAGATCATTCCAGGTTCCTTATTTGATTTTGCTCTTTATTTCTTTA
ATAACCACAAAGCGTTGCTGAAAAAAGGCAGTGGTCCTTATTTCTATCTTCCTAAGTTACAGTCTCATCATGAGGCGAAA
TGGTGGAGTGAAGTGTTCCATTTCACCGAAGAGTATTTCGGTTTGGATACTGGCACTATCAAAGCCACGGTATTGATCGA
GACGCTGCCTGCCGTCTTTGAAATGGATGAGATTCTCTTCTCGTTAAAAGAGCATATTGTTGGCCTCAACTGTGGCCGTT
GGGATTACATTTTTAGCTATATCAAAACACTGAAAAAGCACCCAGACCGTGTGCTGCCTGATCGTCAGGTGGTCACCATG
GACAAGCCGTTCCTCAATGCTTACTCGCGTTTACTTGTCCGCACCTGTCATAAACGTGGCGCGTTTGCGATGGGAGGGAT
GGCCGCCTTTATCCCAGCCAAAGATCCACAAGAGAATCAAAAGGTATTGGATAAGATCCAGAACGATAAATCACTCGAAG
CCAGTAATGGCCATGATGGCACTTGGGTTGCGCATCCTGGTTTAGCCGACACCGCCATGGACGTGTTTAATCGTGCTCTA
GGTGAGCGTAAAAACCAGCTTGATGTCACTCGCCAAGACGATGCGCCGATTACAGCTAAACAGTTACTGGAGCCTTGTGA
TGGAGCAAGAACAGAACAAGGTATGAGACACAATATTCGTGTTGCATTGCAGTACATCGAGGCGTGGATCTCGGGGAATG
GCTGTGTACCGATTTATGGCTTGATGGAAGATGCAGCGACCGCAGAGATCTCACGCGCTTCTATCTGGCAGTGGATTCAA
CATAGTAAGTCGTTAGATAACGGTGAAGTGGTGACCAAAGCGTTGTTTAAGCGTTATCTCGACGAAGAGATTCAAGTCGT
AAAACAAGAAGTGGGGGAGACTCGTTTTGATTCAGGCCGTTTCCATGAAGCCGCCGAGTTGATGGCTAGCCTGACCACCA
GTGATGAGCTAACCAACTTCTTAACCGTACCGGGTTATGACTACCTAGATTAA

Upstream 100 bases:

>100_bases
CGTAAAGACGAAATGCTAGATGGATTTTTGAACAAAGTGATGGCTTGGTTTTTGTGGTTTAAAACTTACAAATGTTGTTC
TGGAATCGTCGTAAAGCAAA

Downstream 100 bases:

>100_bases
TGAGTAAACCAATCAACAACCAATAACGTGAACCTTCATTGGCGGAGCAGGATGTACCGCTAACGAAATGGAATATATAG
CGCACTCAATTTTAATAATC

Product: malate synthase

Products: NA

Alternate protein names: MSA [H]

Number of amino acids: Translated: 550; Mature: 550

Protein sequence:

>550_residues
MKGRRMMLAQTPEKENTQAEQQTQGMLEVTGTLSPEHQAIFPVEAQTFLSQLCERFSLRVDQLLTAREERQNKIDQGELP
DFLTETQDIREGSWKILGIPNDLQDRRVEITGPTDRKMVINALNANVKVFMADFEDSMSPAWDKVLDGQINLRDAVNGTI
SYSNPDNGKHYQLGNNPAVLICRVRGLHLKEKHVTWRGQIIPGSLFDFALYFFNNHKALLKKGSGPYFYLPKLQSHHEAK
WWSEVFHFTEEYFGLDTGTIKATVLIETLPAVFEMDEILFSLKEHIVGLNCGRWDYIFSYIKTLKKHPDRVLPDRQVVTM
DKPFLNAYSRLLVRTCHKRGAFAMGGMAAFIPAKDPQENQKVLDKIQNDKSLEASNGHDGTWVAHPGLADTAMDVFNRAL
GERKNQLDVTRQDDAPITAKQLLEPCDGARTEQGMRHNIRVALQYIEAWISGNGCVPIYGLMEDAATAEISRASIWQWIQ
HSKSLDNGEVVTKALFKRYLDEEIQVVKQEVGETRFDSGRFHEAAELMASLTTSDELTNFLTVPGYDYLD

Sequences:

>Translated_550_residues
MKGRRMMLAQTPEKENTQAEQQTQGMLEVTGTLSPEHQAIFPVEAQTFLSQLCERFSLRVDQLLTAREERQNKIDQGELP
DFLTETQDIREGSWKILGIPNDLQDRRVEITGPTDRKMVINALNANVKVFMADFEDSMSPAWDKVLDGQINLRDAVNGTI
SYSNPDNGKHYQLGNNPAVLICRVRGLHLKEKHVTWRGQIIPGSLFDFALYFFNNHKALLKKGSGPYFYLPKLQSHHEAK
WWSEVFHFTEEYFGLDTGTIKATVLIETLPAVFEMDEILFSLKEHIVGLNCGRWDYIFSYIKTLKKHPDRVLPDRQVVTM
DKPFLNAYSRLLVRTCHKRGAFAMGGMAAFIPAKDPQENQKVLDKIQNDKSLEASNGHDGTWVAHPGLADTAMDVFNRAL
GERKNQLDVTRQDDAPITAKQLLEPCDGARTEQGMRHNIRVALQYIEAWISGNGCVPIYGLMEDAATAEISRASIWQWIQ
HSKSLDNGEVVTKALFKRYLDEEIQVVKQEVGETRFDSGRFHEAAELMASLTTSDELTNFLTVPGYDYLD
>Mature_550_residues
MKGRRMMLAQTPEKENTQAEQQTQGMLEVTGTLSPEHQAIFPVEAQTFLSQLCERFSLRVDQLLTAREERQNKIDQGELP
DFLTETQDIREGSWKILGIPNDLQDRRVEITGPTDRKMVINALNANVKVFMADFEDSMSPAWDKVLDGQINLRDAVNGTI
SYSNPDNGKHYQLGNNPAVLICRVRGLHLKEKHVTWRGQIIPGSLFDFALYFFNNHKALLKKGSGPYFYLPKLQSHHEAK
WWSEVFHFTEEYFGLDTGTIKATVLIETLPAVFEMDEILFSLKEHIVGLNCGRWDYIFSYIKTLKKHPDRVLPDRQVVTM
DKPFLNAYSRLLVRTCHKRGAFAMGGMAAFIPAKDPQENQKVLDKIQNDKSLEASNGHDGTWVAHPGLADTAMDVFNRAL
GERKNQLDVTRQDDAPITAKQLLEPCDGARTEQGMRHNIRVALQYIEAWISGNGCVPIYGLMEDAATAEISRASIWQWIQ
HSKSLDNGEVVTKALFKRYLDEEIQVVKQEVGETRFDSGRFHEAAELMASLTTSDELTNFLTVPGYDYLD

Specific function: Glyoxylate bypass; second step. [C]

COG id: COG2225

COG function: function code C; Malate synthase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the malate synthase family [H]

Homologues:

Organism=Escherichia coli, GI1790444, Length=527, Percent_Identity=71.7267552182163, Blast_Score=800, Evalue=0.0,
Organism=Caenorhabditis elegans, GI17561814, Length=538, Percent_Identity=49.0706319702602, Blast_Score=494, Evalue=1e-140,
Organism=Caenorhabditis elegans, GI71982926, Length=432, Percent_Identity=51.1574074074074, Blast_Score=404, Evalue=1e-113,
Organism=Saccharomyces cerevisiae, GI6324212, Length=517, Percent_Identity=45.8413926499033, Blast_Score=442, Evalue=1e-125,
Organism=Saccharomyces cerevisiae, GI6322222, Length=517, Percent_Identity=45.2611218568665, Blast_Score=436, Evalue=1e-123,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011076
- InterPro:   IPR006252
- InterPro:   IPR001465
- InterPro:   IPR019830 [H]

Pfam domain/function: PF01274 Malate_synthase [H]

EC number: =2.3.3.9 [H]

Molecular weight: Translated: 62499; Mature: 62499

Theoretical pI: Translated: 5.87; Mature: 5.87

Prosite motif: PS00510 MALATE_SYNTHASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
2.7 %Met     (Translated Protein)
3.8 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
2.7 %Met     (Mature Protein)
3.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKGRRMMLAQTPEKENTQAEQQTQGMLEVTGTLSPEHQAIFPVEAQTFLSQLCERFSLRV
CCCCEEEEECCCCCCCCHHHHHHCCCEEEECCCCCCCCEEECCHHHHHHHHHHHHHHHHH
DQLLTAREERQNKIDQGELPDFLTETQDIREGSWKILGIPNDLQDRRVEITGPTDRKMVI
HHHHHHHHHHHCCCCCCCCCHHHHHHHHHCCCCEEEEECCCCCCCCEEEEECCCCCHHHH
NALNANVKVFMADFEDSMSPAWDKVLDGQINLRDAVNGTISYSNPDNGKHYQLGNNPAVL
HEECCCEEEEEECCCCCCCHHHHHHHCCCEEEHHCCCCEEEECCCCCCCEEEECCCCEEE
ICRVRGLHLKEKHVTWRGQIIPGSLFDFALYFFNNHKALLKKGSGPYFYLPKLQSHHEAK
EEEECCCEEECCCCEEECEECCCHHHHHHHHHHCCCHHHHCCCCCCEEECCCCCCCCHHH
WWSEVFHFTEEYFGLDTGTIKATVLIETLPAVFEMDEILFSLKEHIVGLNCGRWDYIFSY
HHHHHHHHHHHHHCCCCCCEEEEEHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHH
IKTLKKHPDRVLPDRQVVTMDKPFLNAYSRLLVRTCHKRGAFAMGGMAAFIPAKDPQENQ
HHHHHHCCCCCCCCCEEEEECCHHHHHHHHHHHHHHHHCCCEEECCEEEECCCCCCCHHH
KVLDKIQNDKSLEASNGHDGTWVAHPGLADTAMDVFNRALGERKNQLDVTRQDDAPITAK
HHHHHHCCCCCCCCCCCCCCCEEECCCCHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCHH
QLLEPCDGARTEQGMRHNIRVALQYIEAWISGNGCVPIYGLMEDAATAEISRASIWQWIQ
HHHCCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCCEEEHHHHHHHHHHHHHHHHHHHHHH
HSKSLDNGEVVTKALFKRYLDEEIQVVKQEVGETRFDSGRFHEAAELMASLTTSDELTNF
HHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHCCHHHHHHE
LTVPGYDYLD
EECCCCCCCC
>Mature Secondary Structure
MKGRRMMLAQTPEKENTQAEQQTQGMLEVTGTLSPEHQAIFPVEAQTFLSQLCERFSLRV
CCCCEEEEECCCCCCCCHHHHHHCCCEEEECCCCCCCCEEECCHHHHHHHHHHHHHHHHH
DQLLTAREERQNKIDQGELPDFLTETQDIREGSWKILGIPNDLQDRRVEITGPTDRKMVI
HHHHHHHHHHHCCCCCCCCCHHHHHHHHHCCCCEEEEECCCCCCCCEEEEECCCCCHHHH
NALNANVKVFMADFEDSMSPAWDKVLDGQINLRDAVNGTISYSNPDNGKHYQLGNNPAVL
HEECCCEEEEEECCCCCCCHHHHHHHCCCEEEHHCCCCEEEECCCCCCCEEEECCCCEEE
ICRVRGLHLKEKHVTWRGQIIPGSLFDFALYFFNNHKALLKKGSGPYFYLPKLQSHHEAK
EEEECCCEEECCCCEEECEECCCHHHHHHHHHHCCCHHHHCCCCCCEEECCCCCCCCHHH
WWSEVFHFTEEYFGLDTGTIKATVLIETLPAVFEMDEILFSLKEHIVGLNCGRWDYIFSY
HHHHHHHHHHHHHCCCCCCEEEEEHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHH
IKTLKKHPDRVLPDRQVVTMDKPFLNAYSRLLVRTCHKRGAFAMGGMAAFIPAKDPQENQ
HHHHHHCCCCCCCCCEEEEECCHHHHHHHHHHHHHHHHCCCEEECCEEEECCCCCCCHHH
KVLDKIQNDKSLEASNGHDGTWVAHPGLADTAMDVFNRALGERKNQLDVTRQDDAPITAK
HHHHHHCCCCCCCCCCCCCCCEEECCCCHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCHH
QLLEPCDGARTEQGMRHNIRVALQYIEAWISGNGCVPIYGLMEDAATAEISRASIWQWIQ
HHHCCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCCEEEHHHHHHHHHHHHHHHHHHHHHH
HSKSLDNGEVVTKALFKRYLDEEIQVVKQEVGETRFDSGRFHEAAELMASLTTSDELTNF
HHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHCCHHHHHHE
LTVPGYDYLD
EECCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 3050899; 3060852; 8265357; 9278503 [H]