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The map label for this gene is ptmB [H]

Identifier: 37678500

GI number: 37678500

Start: 325292

End: 325993

Strand: Direct

Name: ptmB [H]

Synonym: VV0316

Alternate gene names: 37678500

Gene position: 325292-325993 (Clockwise)

Preceding gene: 37678499

Following gene: 37678501

Centisome position: 9.7

GC content: 45.16

Gene sequence:

>702_bases
GTGAATAATCGAATGAAAAACTGTGCTTTTATTTTTGCCCGAGGTGGGTCTAAGGGGCTACCAAGAAAAAATATTAAATT
ACTAGCGGGCAAACCATTACTGCAGTATTCCATTGATACTGCTTTGGCCACCCCTTCAATTGAGCATGTTTTTGTTTCAA
CTGATGATACTGAAATTGCAGACGTCGCGCGTGCATCGGGCGCGATAGTGATTGAGCGTCCAGCGGAGCTCGCCAGTGAT
ACAAGTCCTGAATGGCTGTCTTGGCGTCATGCTATTGAATGGGTGCAAGCACGCTATGGAGAGTTTGATGGGTTTATTAG
TTTACCTGCCACCAGTCCGTTGAGAAGTATTGATGATGTGGAAGGTGCTATCAACAAACTCTTTACCACCGAAGCAGATA
TCTGTATCTCAGTGACACCAGCGAGTCGCAGTCCTTTTTTTAATATGGTGAAGCAGACCGAAACTGGGATGGTTGAGCTC
GTCAATAAACCACAAGGTGAAGTGGCTCGCCGTCAAGATGCACCTGCGGTGTTTGATATCACCACGGTTGTGTATGCGAC
GACGCCTCACTTTGTGCTCAATCACTATGGTATTTTTTCTGGCAAAGTCACCAGTATCGAAGTACCAAAAGAGCGAGCGG
TGGATATCGATGATATTTATGACTTTAAATTAGCCCAAGCAATCCTTGAGGAAACCAACTAA

Upstream 100 bases:

>100_bases
AATCAATGTGTCTCTCTTGCTGAAGCAGCTCAAAGTGTTGAACTTATAGAAGAAATCAAACGGCGCTTTCCAATCACATC
GGTGTCAGGTGAGTTAAAAG

Downstream 100 bases:

>100_bases
TGGAACAATTGCTTAATAATAAAACTATTCTTGTTGCCGGGGCGGGTGGTCTTTTGGGGACCCGCTTAGTTCCCGCTTTA
CTCAAGCAAGGTGCTAAGGT

Product: CMP-N-acetylneuraminic acid synthetase

Products: diphosphate; CMP-N-acylneuraminate

Alternate protein names: NA

Number of amino acids: Translated: 233; Mature: 233

Protein sequence:

>233_residues
MNNRMKNCAFIFARGGSKGLPRKNIKLLAGKPLLQYSIDTALATPSIEHVFVSTDDTEIADVARASGAIVIERPAELASD
TSPEWLSWRHAIEWVQARYGEFDGFISLPATSPLRSIDDVEGAINKLFTTEADICISVTPASRSPFFNMVKQTETGMVEL
VNKPQGEVARRQDAPAVFDITTVVYATTPHFVLNHYGIFSGKVTSIEVPKERAVDIDDIYDFKLAQAILEETN

Sequences:

>Translated_233_residues
MNNRMKNCAFIFARGGSKGLPRKNIKLLAGKPLLQYSIDTALATPSIEHVFVSTDDTEIADVARASGAIVIERPAELASD
TSPEWLSWRHAIEWVQARYGEFDGFISLPATSPLRSIDDVEGAINKLFTTEADICISVTPASRSPFFNMVKQTETGMVEL
VNKPQGEVARRQDAPAVFDITTVVYATTPHFVLNHYGIFSGKVTSIEVPKERAVDIDDIYDFKLAQAILEETN
>Mature_233_residues
MNNRMKNCAFIFARGGSKGLPRKNIKLLAGKPLLQYSIDTALATPSIEHVFVSTDDTEIADVARASGAIVIERPAELASD
TSPEWLSWRHAIEWVQARYGEFDGFISLPATSPLRSIDDVEGAINKLFTTEADICISVTPASRSPFFNMVKQTETGMVEL
VNKPQGEVARRQDAPAVFDITTVVYATTPHFVLNHYGIFSGKVTSIEVPKERAVDIDDIYDFKLAQAILEETN

Specific function: Required for biosynthesis of LAH modification in the post-translational modification of Campylobacter coli flagellin [H]

COG id: COG1083

COG function: function code M; CMP-N-acetylneuraminic acid synthetase

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the CMP-NeuNAc synthase family [H]

Homologues:

Organism=Homo sapiens, GI8923900, Length=219, Percent_Identity=32.4200913242009, Blast_Score=87, Evalue=1e-17,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003329 [H]

Pfam domain/function: PF02348 CTP_transf_3 [H]

EC number: 2.7.7.43

Molecular weight: Translated: 25707; Mature: 25707

Theoretical pI: Translated: 4.84; Mature: 4.84

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
1.7 %Met     (Translated Protein)
2.6 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
1.7 %Met     (Mature Protein)
2.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNNRMKNCAFIFARGGSKGLPRKNIKLLAGKPLLQYSIDTALATPSIEHVFVSTDDTEIA
CCCCCCCEEEEEEECCCCCCCCCCEEEEECCCCEEEEHHHHHCCCCCEEEEEECCCCHHH
DVARASGAIVIERPAELASDTSPEWLSWRHAIEWVQARYGEFDGFISLPATSPLRSIDDV
HHHHCCCCEEEECCHHHHCCCCCHHHHHHHHHHHHHHHCCCCCCEEECCCCCCHHHHHHH
EGAINKLFTTEADICISVTPASRSPFFNMVKQTETGMVELVNKPQGEVARRQDAPAVFDI
HHHHHHHHCCCCCEEEEECCCCCCHHHHHHHHCCCCHHEECCCCCCHHHHHCCCCEEEEE
TTVVYATTPHFVLNHYGIFSGKVTSIEVPKERAVDIDDIYDFKLAQAILEETN
EEEEEECCCHHHHHCCCCCCCCEEEEECCHHHCCCHHHHHHHHHHHHHHHCCC
>Mature Secondary Structure
MNNRMKNCAFIFARGGSKGLPRKNIKLLAGKPLLQYSIDTALATPSIEHVFVSTDDTEIA
CCCCCCCEEEEEEECCCCCCCCCCEEEEECCCCEEEEHHHHHCCCCCEEEEEECCCCHHH
DVARASGAIVIERPAELASDTSPEWLSWRHAIEWVQARYGEFDGFISLPATSPLRSIDDV
HHHHCCCCEEEECCHHHHCCCCCHHHHHHHHHHHHHHHCCCCCCEEECCCCCCHHHHHHH
EGAINKLFTTEADICISVTPASRSPFFNMVKQTETGMVELVNKPQGEVARRQDAPAVFDI
HHHHHHHHCCCCCEEEEECCCCCCHHHHHHHHCCCCHHEECCCCCCHHHHHCCCCEEEEE
TTVVYATTPHFVLNHYGIFSGKVTSIEVPKERAVDIDDIYDFKLAQAILEETN
EEEEEECCCHHHHHCCCCCCCCEEEEECCHHHCCCHHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: CTP; N-acylneuraminate

Specific reaction: CTP + N-acylneuraminate = diphosphate + CMP-N-acylneuraminate

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8825781 [H]