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The map label for this gene is rfbD [C]

Identifier: 37678486

GI number: 37678486

Start: 311372

End: 312253

Strand: Direct

Name: rfbD [C]

Synonym: VV0302

Alternate gene names: 37678486

Gene position: 311372-312253 (Clockwise)

Preceding gene: 37678485

Following gene: 37678487

Centisome position: 9.28

GC content: 47.28

Gene sequence:

>882_bases
ATGAGAGTGTTGATTGTTGGATCAAGTGGACAACTGGGCCACTGTTTGGTGAGATCTCTGCAGACTGAGCATGACATTTT
GGCGCTGGATCGCCAGCAGCTGGATATTTGTGAAGAGCAAGCTGTGGAAAAGGTATTTGCAACCTTTCAGCCCCAGTTTG
TGATTAACGCGGCTGCTTATACGGCGGTTGATAAAGCGGAAAGTGAGCCAGAGATGGCTTATCGGGTTAATGAGGAAGGC
CCCAAATTATTGGCTCAAGAATGCCATCATCATGGCTGTCCTCTGGTACATATCTCTACAGACTATGTCTTTGATGGCGA
TAAAAATGGCCTTTACTGCGAAGATGATCGTCCTGCGCCAGGTAATATTTACGGGATGAGTAAACTCGCCGGAGAGCATG
CGGTACAACACGCTTGTTCACAGTACTATATTTTGCGTACCTCTTGGGTGTTTTCTGAGTTTGGCAATAACTTCGTCAAA
ACCATGTTAAGGCAAGGGGCTGAAAGAACACAATTGGGTATTGTTTCTGATCAAGTCGGTGGGCCAACCTACGCTGGAGA
TATCGCGCGTGTGATCGGAAGGTTACTTGAACGCTTTCAGTTTGGCGAGCCCGTTGAGTATGGTCTGTACCATTTTTCGG
GCATGCCACACGTGAGTTGGTTTGAGTTTGCTCAAGCGATTTTTGGGTTGGCGCACGAGCAAGGAGTGTTGAAAAGGAAG
GTTGAGTTAAAACCACTGAGCACACGAGAGTACCCGACCGCCGCAATAAGGCCGATGAACTCAAGGTTAGATTCAACAAA
ACTTAAGAGCCAACTGCAGCTTGAAGCGAGTGATTGGAAAGCGGCACTTAACCAACTCGATCGCTATGTGGAGCAAAAAT
AA

Upstream 100 bases:

>100_bases
GCTGGCTGAGTCACAAGCAACTTACCTCTCTCGCAACGGCTATGCTTAAAAATGATTATGGCCAATATCTAATGAAGTTG
GTCACGGAGAAAGTAAAACC

Downstream 100 bases:

>100_bases
TGAAAGTGATAGAGACCAGTATTCCCGAGATCAAAATTATTGAGCCAATGGTCTTTGGTGATGAGCGCGGTTTTTTTATG
GAAACCTGGCATCAGGCGCG

Product: dTDP-4-dehydrorhamnose reductase

Products: NA

Alternate protein names: dTDP-4-keto-L-rhamnose reductase; dTDP-6-deoxy-L-lyxo-4-hexulose reductase; dTDP-6-deoxy-L-mannose dehydrogenase; dTDP-L-rhamnose synthase [H]

Number of amino acids: Translated: 293; Mature: 293

Protein sequence:

>293_residues
MRVLIVGSSGQLGHCLVRSLQTEHDILALDRQQLDICEEQAVEKVFATFQPQFVINAAAYTAVDKAESEPEMAYRVNEEG
PKLLAQECHHHGCPLVHISTDYVFDGDKNGLYCEDDRPAPGNIYGMSKLAGEHAVQHACSQYYILRTSWVFSEFGNNFVK
TMLRQGAERTQLGIVSDQVGGPTYAGDIARVIGRLLERFQFGEPVEYGLYHFSGMPHVSWFEFAQAIFGLAHEQGVLKRK
VELKPLSTREYPTAAIRPMNSRLDSTKLKSQLQLEASDWKAALNQLDRYVEQK

Sequences:

>Translated_293_residues
MRVLIVGSSGQLGHCLVRSLQTEHDILALDRQQLDICEEQAVEKVFATFQPQFVINAAAYTAVDKAESEPEMAYRVNEEG
PKLLAQECHHHGCPLVHISTDYVFDGDKNGLYCEDDRPAPGNIYGMSKLAGEHAVQHACSQYYILRTSWVFSEFGNNFVK
TMLRQGAERTQLGIVSDQVGGPTYAGDIARVIGRLLERFQFGEPVEYGLYHFSGMPHVSWFEFAQAIFGLAHEQGVLKRK
VELKPLSTREYPTAAIRPMNSRLDSTKLKSQLQLEASDWKAALNQLDRYVEQK
>Mature_293_residues
MRVLIVGSSGQLGHCLVRSLQTEHDILALDRQQLDICEEQAVEKVFATFQPQFVINAAAYTAVDKAESEPEMAYRVNEEG
PKLLAQECHHHGCPLVHISTDYVFDGDKNGLYCEDDRPAPGNIYGMSKLAGEHAVQHACSQYYILRTSWVFSEFGNNFVK
TMLRQGAERTQLGIVSDQVGGPTYAGDIARVIGRLLERFQFGEPVEYGLYHFSGMPHVSWFEFAQAIFGLAHEQGVLKRK
VELKPLSTREYPTAAIRPMNSRLDSTKLKSQLQLEASDWKAALNQLDRYVEQK

Specific function: Catalyzes the reduction of dTDP-6-deoxy-L-lyxo-4- hexulose to yield dTDP-L-rhamnose. RmlD uses NADH and NADPH nearly equally well [H]

COG id: COG1091

COG function: function code M; dTDP-4-dehydrorhamnose reductase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the dTDP-4-dehydrorhamnose reductase family [H]

Homologues:

Organism=Homo sapiens, GI33519455, Length=285, Percent_Identity=29.8245614035088, Blast_Score=107, Evalue=1e-23,
Organism=Homo sapiens, GI11034825, Length=285, Percent_Identity=29.8245614035088, Blast_Score=107, Evalue=2e-23,
Organism=Escherichia coli, GI1788352, Length=290, Percent_Identity=37.5862068965517, Blast_Score=213, Evalue=1e-56,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005913
- InterPro:   IPR016040 [H]

Pfam domain/function: PF04321 RmlD_sub_bind [H]

EC number: =1.1.1.133 [H]

Molecular weight: Translated: 32983; Mature: 32983

Theoretical pI: Translated: 6.13; Mature: 6.13

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.0 %Cys     (Translated Protein)
2.0 %Met     (Translated Protein)
4.1 %Cys+Met (Translated Protein)
2.0 %Cys     (Mature Protein)
2.0 %Met     (Mature Protein)
4.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRVLIVGSSGQLGHCLVRSLQTEHDILALDRQQLDICEEQAVEKVFATFQPQFVINAAAY
CEEEEECCCCCHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEHHHHH
TAVDKAESEPEMAYRVNEEGPKLLAQECHHHGCPLVHISTDYVFDGDKNGLYCEDDRPAP
HHHHHCCCCCCCEEEECCCCHHHHHHHHHHCCCCEEEEECCEEEECCCCCEEECCCCCCC
GNIYGMSKLAGEHAVQHACSQYYILRTSWVFSEFGNNFVKTMLRQGAERTQLGIVSDQVG
CCEEEHHHHHHHHHHHHHHHHEEEHHHHHHHHHHCHHHHHHHHHCCCCHHEECEEECCCC
GPTYAGDIARVIGRLLERFQFGEPVEYGLYHFSGMPHVSWFEFAQAIFGLAHEQGVLKRK
CCCHHHHHHHHHHHHHHHHCCCCCHHHHHHHCCCCCCCHHHHHHHHHHHHHHHCCHHHHH
VELKPLSTREYPTAAIRPMNSRLDSTKLKSQLQLEASDWKAALNQLDRYVEQK
HCCCCCCCCCCCCHHHCCHHHHHHHHHHHHHHEECHHHHHHHHHHHHHHHHCC
>Mature Secondary Structure
MRVLIVGSSGQLGHCLVRSLQTEHDILALDRQQLDICEEQAVEKVFATFQPQFVINAAAY
CEEEEECCCCCHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEHHHHH
TAVDKAESEPEMAYRVNEEGPKLLAQECHHHGCPLVHISTDYVFDGDKNGLYCEDDRPAP
HHHHHCCCCCCCEEEECCCCHHHHHHHHHHCCCCEEEEECCEEEECCCCCEEECCCCCCC
GNIYGMSKLAGEHAVQHACSQYYILRTSWVFSEFGNNFVKTMLRQGAERTQLGIVSDQVG
CCEEEHHHHHHHHHHHHHHHHEEEHHHHHHHHHHCHHHHHHHHHCCCCHHEECEEECCCC
GPTYAGDIARVIGRLLERFQFGEPVEYGLYHFSGMPHVSWFEFAQAIFGLAHEQGVLKRK
CCCHHHHHHHHHHHHHHHHCCCCCHHHHHHHCCCCCCCHHHHHHHHHHHHHHHCCHHHHH
VELKPLSTREYPTAAIRPMNSRLDSTKLKSQLQLEASDWKAALNQLDRYVEQK
HCCCCCCCCCCCCHHHCCHHHHHHHHHHHHHHEECHHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9163424 [H]