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The map label for this gene is rfbC [H]

Identifier: 37678487

GI number: 37678487

Start: 312253

End: 312810

Strand: Direct

Name: rfbC [H]

Synonym: VV0303

Alternate gene names: 37678487

Gene position: 312253-312810 (Clockwise)

Preceding gene: 37678486

Following gene: 161486669

Centisome position: 9.31

GC content: 44.98

Gene sequence:

>558_bases
ATGAAAGTGATAGAGACCAGTATTCCCGAGATCAAAATTATTGAGCCAATGGTCTTTGGTGATGAGCGCGGTTTTTTTAT
GGAAACCTGGCATCAGGCGCGATTTGAAGAACTTGTTACAGGCAAACCAACTCGATTTGTCCAAGATAATCATTCCAAAT
CAAAGCAAGGCATCCTACGAGGCTTGCATTATCAGATGCAACATACTCAAGGCAAGCTAGTACGTGTTGTTTCCGGTGAG
GTGTTTGATGTTGCAGTGGATATTCGGCAGGGCTCGCCGACCTTTGGTCAGTGGGTTGGGGTCTATCTATCGGCTGAAAA
CAAACGTCAAATGTGGGTGCCTGAGGGCTTTGCCCACGGCTTTTACGTGACCAGCGAAGAGGCTGAGTTCGTCTACAAAT
GCACCGATTACTACCATCCACAATCGGAACAATGCATTGCTTGGAACGATACTGTGATTGGCATTGACTGGCCAATACCT
ATAGGTAAAGGGCCAATGCTATCAAAGAAAGATGCATCAGCTCCAAATCTATCTGAATGTAAATATCTTTTAGGATAG

Upstream 100 bases:

>100_bases
CAAGGTTAGATTCAACAAAACTTAAGAGCCAACTGCAGCTTGAAGCGAGTGATTGGAAAGCGGCACTTAACCAACTCGAT
CGCTATGTGGAGCAAAAATA

Downstream 100 bases:

>100_bases
TTAGCTTGAGTTACTTTTGTAAAGCCAAACAGATGTATTTTCTACTAAAAAATCGTTTTTAATATAGAGATTTATCGCAG
CTACATTAGATGTTTGTGTC

Product: dTDP-6-deoxy-D-xylo-4-hexulose-3,5-epimerase

Products: NA

Alternate protein names: Thymidine diphospho-4-keto-rhamnose 3,5-epimerase; dTDP-4-keto-6-deoxyglucose 3,5-epimerase; dTDP-6-deoxy-D-xylo-4-hexulose 3,5-epimerase; dTDP-L-rhamnose synthase [H]

Number of amino acids: Translated: 185; Mature: 185

Protein sequence:

>185_residues
MKVIETSIPEIKIIEPMVFGDERGFFMETWHQARFEELVTGKPTRFVQDNHSKSKQGILRGLHYQMQHTQGKLVRVVSGE
VFDVAVDIRQGSPTFGQWVGVYLSAENKRQMWVPEGFAHGFYVTSEEAEFVYKCTDYYHPQSEQCIAWNDTVIGIDWPIP
IGKGPMLSKKDASAPNLSECKYLLG

Sequences:

>Translated_185_residues
MKVIETSIPEIKIIEPMVFGDERGFFMETWHQARFEELVTGKPTRFVQDNHSKSKQGILRGLHYQMQHTQGKLVRVVSGE
VFDVAVDIRQGSPTFGQWVGVYLSAENKRQMWVPEGFAHGFYVTSEEAEFVYKCTDYYHPQSEQCIAWNDTVIGIDWPIP
IGKGPMLSKKDASAPNLSECKYLLG
>Mature_185_residues
MKVIETSIPEIKIIEPMVFGDERGFFMETWHQARFEELVTGKPTRFVQDNHSKSKQGILRGLHYQMQHTQGKLVRVVSGE
VFDVAVDIRQGSPTFGQWVGVYLSAENKRQMWVPEGFAHGFYVTSEEAEFVYKCTDYYHPQSEQCIAWNDTVIGIDWPIP
IGKGPMLSKKDASAPNLSECKYLLG

Specific function: Catalyzes the epimerization of the C3' and C5'positions of dTDP-6-deoxy-D-xylo-4-hexulose, forming dTDP-6-deoxy-L-lyxo-4- hexulose [H]

COG id: COG1898

COG function: function code M; dTDP-4-dehydrorhamnose 3,5-epimerase and related enzymes

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the dTDP-4-dehydrorhamnose 3,5-epimerase family [H]

Homologues:

Organism=Escherichia coli, GI1788350, Length=180, Percent_Identity=56.1111111111111, Blast_Score=205, Evalue=2e-54,
Organism=Caenorhabditis elegans, GI17550412, Length=172, Percent_Identity=48.8372093023256, Blast_Score=154, Evalue=3e-38,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011051
- InterPro:   IPR000888
- InterPro:   IPR014710
- ProDom:   PD001462 [H]

Pfam domain/function: PF00908 dTDP_sugar_isom [H]

EC number: =5.1.3.13 [H]

Molecular weight: Translated: 21120; Mature: 21120

Theoretical pI: Translated: 6.24; Mature: 6.24

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.6 %Cys     (Translated Protein)
3.2 %Met     (Translated Protein)
4.9 %Cys+Met (Translated Protein)
1.6 %Cys     (Mature Protein)
3.2 %Met     (Mature Protein)
4.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKVIETSIPEIKIIEPMVFGDERGFFMETWHQARFEELVTGKPTRFVQDNHSKSKQGILR
CCCCCCCCCCEEEECEEEECCCCCCHHHHHHHHHHHHHHCCCCCEEECCCCCCHHHHHHH
GLHYQMQHTQGKLVRVVSGEVFDVAVDIRQGSPTFGQWVGVYLSAENKRQMWVPEGFAHG
HHHHHHHCCCCEEEEEECCCEEEEEEEEECCCCCCCCEEEEEEECCCCCEEECCCCCCCC
FYVTSEEAEFVYKCTDYYHPQSEQCIAWNDTVIGIDWPIPIGKGPMLSKKDASAPNLSEC
EEEECCCCEEEEEECCCCCCCCCCEEEECCEEEEEECCCCCCCCCCCCCCCCCCCCHHHH
KYLLG
HHHCC
>Mature Secondary Structure
MKVIETSIPEIKIIEPMVFGDERGFFMETWHQARFEELVTGKPTRFVQDNHSKSKQGILR
CCCCCCCCCCEEEECEEEECCCCCCHHHHHHHHHHHHHHCCCCCEEECCCCCCHHHHHHH
GLHYQMQHTQGKLVRVVSGEVFDVAVDIRQGSPTFGQWVGVYLSAENKRQMWVPEGFAHG
HHHHHHHCCCCEEEEEECCCEEEEEEEEECCCCCCCCEEEEEEECCCCCEEECCCCCCCC
FYVTSEEAEFVYKCTDYYHPQSEQCIAWNDTVIGIDWPIPIGKGPMLSKKDASAPNLSEC
EEEECCCCEEEEEECCCCCCCCCCEEEECCEEEEEECCCCCCCCCCCCCCCCCCCCHHHH
KYLLG
HHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 1710759; 11677609; 10802738 [H]