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The map label for this gene is (rmlA1 [H]

Identifier: 37678485

GI number: 37678485

Start: 310488

End: 311375

Strand: Direct

Name: (rmlA1 [H]

Synonym: VV0301

Alternate gene names: 37678485

Gene position: 310488-311375 (Clockwise)

Preceding gene: 37678484

Following gene: 37678486

Centisome position: 9.26

GC content: 46.85

Gene sequence:

>888_bases
ATGAAAGGTATAATTCTCGCCGGTGGCTCAGGCACTCGTCTCTATCCGATTACGCGTGGCGTGTCTAAGCAGTTATTGCC
AGTGTACGATAAGCCGATGATTTACTACCCGTTATCGGTACTTATGCTGGCGGGTATTCAAGAGATTTTGGTGATCACCA
CACCAGAAGATCAAGCGAGCTTTCAACGCCTGCTCGGCGATGGTACTGACTTTGGGCTTTCACTGCATTACGCTGTCCAG
CCGAGCCCCGATGGTTTAGCGCAAGCATTCATTATTGGTGAAGAGTTCATTGGTGATGATTGCGTGTGCTTGGTTTTGGG
TGACAATATCTTTTATGGTCAGGATTTTACCACAAAGTTAAAAAGCGCGGTTGAAAACGCAGAAAACGGCCATGGTGCTA
CGGTGTTTGGTTATCAAGTCAAAGATCCAGAGCGCTTTGGTGTCGTGGAGTTTGACGACAAGATGCAGGCACTATCGATA
GAAGAAAAACCGCATGTGCCCAAATCAGATTACGCCGTGACAGGGCTTTATTTTTACGACAACCAAGTGGTTGTGATGGC
TAAGATGGTGAAACCTTCGGCTCGCGGCGAGCTAGAAATCACCGCCTTGAATCAGATGTACCTTGAGCAAGGAAATCTAA
ACGTAGAGTTACTTGGGCGAGGTTTTGCTTGGTTGGATACTGGTACGCACGCGAGCCTACATGAGGCGTCTTCGTTTGTT
GAAACGATTGAAAACGTGCAAGGTTTAAAGGTTGCATGCTTGGAAGAGATTGCTTGGCGTAGTGGCTGGCTGAGTCACAA
GCAACTTACCTCTCTCGCAACGGCTATGCTTAAAAATGATTATGGCCAATATCTAATGAAGTTGGTCACGGAGAAAGTAA
AACCATGA

Upstream 100 bases:

>100_bases
CGTCTGGGCGTGAACTAACTTATCGCATTATTCAAATTTTTGGTCCTGTGCTCTCGTATTTTTCTTGAACCTAGGACCTA
GAAAATGAGGACCTATTTTA

Downstream 100 bases:

>100_bases
GAGTGTTGATTGTTGGATCAAGTGGACAACTGGGCCACTGTTTGGTGAGATCTCTGCAGACTGAGCATGACATTTTGGCG
CTGGATCGCCAGCAGCTGGA

Product: D-glucose-1-phosphate thymidylyltransferase

Products: NA

Alternate protein names: dTDP-glucose pyrophosphorylase; dTDP-glucose synthase [H]

Number of amino acids: Translated: 295; Mature: 295

Protein sequence:

>295_residues
MKGIILAGGSGTRLYPITRGVSKQLLPVYDKPMIYYPLSVLMLAGIQEILVITTPEDQASFQRLLGDGTDFGLSLHYAVQ
PSPDGLAQAFIIGEEFIGDDCVCLVLGDNIFYGQDFTTKLKSAVENAENGHGATVFGYQVKDPERFGVVEFDDKMQALSI
EEKPHVPKSDYAVTGLYFYDNQVVVMAKMVKPSARGELEITALNQMYLEQGNLNVELLGRGFAWLDTGTHASLHEASSFV
ETIENVQGLKVACLEEIAWRSGWLSHKQLTSLATAMLKNDYGQYLMKLVTEKVKP

Sequences:

>Translated_295_residues
MKGIILAGGSGTRLYPITRGVSKQLLPVYDKPMIYYPLSVLMLAGIQEILVITTPEDQASFQRLLGDGTDFGLSLHYAVQ
PSPDGLAQAFIIGEEFIGDDCVCLVLGDNIFYGQDFTTKLKSAVENAENGHGATVFGYQVKDPERFGVVEFDDKMQALSI
EEKPHVPKSDYAVTGLYFYDNQVVVMAKMVKPSARGELEITALNQMYLEQGNLNVELLGRGFAWLDTGTHASLHEASSFV
ETIENVQGLKVACLEEIAWRSGWLSHKQLTSLATAMLKNDYGQYLMKLVTEKVKP
>Mature_295_residues
MKGIILAGGSGTRLYPITRGVSKQLLPVYDKPMIYYPLSVLMLAGIQEILVITTPEDQASFQRLLGDGTDFGLSLHYAVQ
PSPDGLAQAFIIGEEFIGDDCVCLVLGDNIFYGQDFTTKLKSAVENAENGHGATVFGYQVKDPERFGVVEFDDKMQALSI
EEKPHVPKSDYAVTGLYFYDNQVVVMAKMVKPSARGELEITALNQMYLEQGNLNVELLGRGFAWLDTGTHASLHEASSFV
ETIENVQGLKVACLEEIAWRSGWLSHKQLTSLATAMLKNDYGQYLMKLVTEKVKP

Specific function: Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis [H]

COG id: COG1209

COG function: function code M; dTDP-glucose pyrophosphorylase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the glucose-1-phosphate thymidylyltransferase family [H]

Homologues:

Organism=Escherichia coli, GI1790224, Length=294, Percent_Identity=70.7482993197279, Blast_Score=437, Evalue=1e-124,
Organism=Escherichia coli, GI1788351, Length=290, Percent_Identity=67.9310344827586, Blast_Score=405, Evalue=1e-114,
Organism=Escherichia coli, GI1787488, Length=243, Percent_Identity=25.9259259259259, Blast_Score=68, Evalue=9e-13,
Organism=Caenorhabditis elegans, GI133931050, Length=230, Percent_Identity=27.8260869565217, Blast_Score=72, Evalue=3e-13,
Organism=Saccharomyces cerevisiae, GI6320148, Length=231, Percent_Identity=26.8398268398268, Blast_Score=73, Evalue=5e-14,
Organism=Drosophila melanogaster, GI21355443, Length=229, Percent_Identity=24.4541484716157, Blast_Score=65, Evalue=5e-11,
Organism=Drosophila melanogaster, GI24644084, Length=229, Percent_Identity=24.4541484716157, Blast_Score=65, Evalue=5e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005907
- InterPro:   IPR005835 [H]

Pfam domain/function: PF00483 NTP_transferase [H]

EC number: =2.7.7.24 [H]

Molecular weight: Translated: 32556; Mature: 32556

Theoretical pI: Translated: 4.72; Mature: 4.72

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
3.1 %Met     (Translated Protein)
4.1 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
3.1 %Met     (Mature Protein)
4.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKGIILAGGSGTRLYPITRGVSKQLLPVYDKPMIYYPLSVLMLAGIQEILVITTPEDQAS
CCCEEEECCCCCEEEEECCCCCCCCCCCCCCCEEEHHHHHHHHHCCCEEEEEECCCHHHH
FQRLLGDGTDFGLSLHYAVQPSPDGLAQAFIIGEEFIGDDCVCLVLGDNIFYGQDFTTKL
HHHHHCCCCCCCEEEEEEECCCCCHHHEEEEECHHHCCCCEEEEEEECCEEECCCHHHHH
KSAVENAENGHGATVFGYQVKDPERFGVVEFDDKMQALSIEEKPHVPKSDYAVTGLYFYD
HHHHHCCCCCCCEEEEEEEECCCCCCCEEEECCCCEEEECCCCCCCCCCCCEEEEEEEEC
NQVVVMAKMVKPSARGELEITALNQMYLEQGNLNVELLGRGFAWLDTGTHASLHEASSFV
CEEEEEEEECCCCCCCCEEEEEEHHHHHHCCCCEEEEEECCEEEEECCCCCHHHHHHHHH
ETIENVQGLKVACLEEIAWRSGWLSHKQLTSLATAMLKNDYGQYLMKLVTEKVKP
HHHHHCCCCHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCC
>Mature Secondary Structure
MKGIILAGGSGTRLYPITRGVSKQLLPVYDKPMIYYPLSVLMLAGIQEILVITTPEDQAS
CCCEEEECCCCCEEEEECCCCCCCCCCCCCCCEEEHHHHHHHHHCCCEEEEEECCCHHHH
FQRLLGDGTDFGLSLHYAVQPSPDGLAQAFIIGEEFIGDDCVCLVLGDNIFYGQDFTTKL
HHHHHCCCCCCCEEEEEEECCCCCHHHEEEEECHHHCCCCEEEEEEECCEEECCCHHHHH
KSAVENAENGHGATVFGYQVKDPERFGVVEFDDKMQALSIEEKPHVPKSDYAVTGLYFYD
HHHHHCCCCCCCEEEEEEEECCCCCCCEEEECCCCEEEECCCCCCCCCCCCEEEEEEEEC
NQVVVMAKMVKPSARGELEITALNQMYLEQGNLNVELLGRGFAWLDTGTHASLHEASSFV
CEEEEEEEECCCCCCCCEEEEEEHHHHHHCCCCEEEEEECCEEEEECCCCCHHHHHHHHH
ETIENVQGLKVACLEEIAWRSGWLSHKQLTSLATAMLKNDYGQYLMKLVTEKVKP
HHHHHCCCCHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 10761919 [H]