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The map label for this gene is gloA [H]

Identifier: 37678339

GI number: 37678339

Start: 162336

End: 162731

Strand: Direct

Name: gloA [H]

Synonym: VV0155

Alternate gene names: 37678339

Gene position: 162336-162731 (Clockwise)

Preceding gene: 37678338

Following gene: 37678340

Centisome position: 4.84

GC content: 39.9

Gene sequence:

>396_bases
ATGGTGAAAATGATTCATACTATGATCCGCGTAAGCGATCTAGAGTGTTCTCTTAAGTTCTACCGCGATATACTTGAGCT
AGAAATCAAGGATCAATACATATTCGACGGCTTTTCTCTTATTTACCTCGGGAACTCAGAAACAGGGTTCGAGCTTGAAC
TGACCCACAATCATGACCAAAGTGAACCGTACACTCATGGATCAGGTTATGGTCACCTTGCGGTTAACGTTGAAGATATT
GAAGCTGTACATCGCCGCTTAACGTCACTTGATATTGAGGTCAGTGATATCAAGGTATTTAATTACCAGCAAAAACATTT
AGCAACCTTCTTTTTCGTCACTGATCCTGATGGTTACAAAATTGAATTCTTACAACGACAAGGTCGTTACCTTTAA

Upstream 100 bases:

>100_bases
TATCCTAATAAAAGAAGAAAACAATCTAAAAGTAAGAAAAAATAATTTAGTAAAATCATTATATATTAATTAATATTGAT
TGGAAATTTTAGGATTAATT

Downstream 100 bases:

>100_bases
TAGCGACAAAGGAGTAAACATAACTATGATTAATTTAACTGCAGCATTTCACGCGAAACCAGAACACACATCGACACTTA
AGCAAGCACTAGAGGCTATG

Product: lactoylglutathione lyase

Products: NA

Alternate protein names: Aldoketomutase; Glyoxalase I; Glx I; Ketone-aldehyde mutase; Methylglyoxalase; S-D-lactoylglutathione methylglyoxal lyase [H]

Number of amino acids: Translated: 131; Mature: 131

Protein sequence:

>131_residues
MVKMIHTMIRVSDLECSLKFYRDILELEIKDQYIFDGFSLIYLGNSETGFELELTHNHDQSEPYTHGSGYGHLAVNVEDI
EAVHRRLTSLDIEVSDIKVFNYQQKHLATFFFVTDPDGYKIEFLQRQGRYL

Sequences:

>Translated_131_residues
MVKMIHTMIRVSDLECSLKFYRDILELEIKDQYIFDGFSLIYLGNSETGFELELTHNHDQSEPYTHGSGYGHLAVNVEDI
EAVHRRLTSLDIEVSDIKVFNYQQKHLATFFFVTDPDGYKIEFLQRQGRYL
>Mature_131_residues
MVKMIHTMIRVSDLECSLKFYRDILELEIKDQYIFDGFSLIYLGNSETGFELELTHNHDQSEPYTHGSGYGHLAVNVEDI
EAVHRRLTSLDIEVSDIKVFNYQQKHLATFFFVTDPDGYKIEFLQRQGRYL

Specific function: Catalyzes the conversion of hemimercaptal, formed from methylglyoxal and glutathione, to S-lactoylglutathione [H]

COG id: COG0346

COG function: function code E; Lactoylglutathione lyase and related lyases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the glyoxalase I family [H]

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004360
- InterPro:   IPR004361
- InterPro:   IPR018146 [H]

Pfam domain/function: PF00903 Glyoxalase [H]

EC number: =4.4.1.5 [H]

Molecular weight: Translated: 15385; Mature: 15385

Theoretical pI: Translated: 4.96; Mature: 4.96

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
2.3 %Met     (Translated Protein)
3.1 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
2.3 %Met     (Mature Protein)
3.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MVKMIHTMIRVSDLECSLKFYRDILELEIKDQYIFDGFSLIYLGNSETGFELELTHNHDQ
CHHHHHHHHHHCCCEEHHHHHHHHHEEEECCEEEECCEEEEEECCCCCCEEEEEECCCCC
SEPYTHGSGYGHLAVNVEDIEAVHRRLTSLDIEVSDIKVFNYQQKHLATFFFVTDPDGYK
CCCCCCCCCCEEEEEEHHHHHHHHHHHHHCCEEEEEEEEEEECCCCEEEEEEEECCCCCE
IEFLQRQGRYL
EEEEECCCCCC
>Mature Secondary Structure
MVKMIHTMIRVSDLECSLKFYRDILELEIKDQYIFDGFSLIYLGNSETGFELELTHNHDQ
CHHHHHHHHHHCCCEEHHHHHHHHHEEEECCEEEECCEEEEEECCCCCCEEEEEECCCCC
SEPYTHGSGYGHLAVNVEDIEAVHRRLTSLDIEVSDIKVFNYQQKHLATFFFVTDPDGYK
CCCCCCCCCCEEEEEEHHHHHHHHHHHHHCCEEEEEEEEEEECCCCEEEEEEEECCCCCE
IEFLQRQGRYL
EEEEECCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 7542800; 9719565 [H]