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The map label for this gene is frmB [H]

Identifier: 37523995

GI number: 37523995

Start: 4652890

End: 4653738

Strand: Direct

Name: frmB [H]

Synonym: glr4426

Alternate gene names: 37523995

Gene position: 4652890-4653738 (Clockwise)

Preceding gene: 37523994

Following gene: 37523997

Centisome position: 99.87

GC content: 64.08

Gene sequence:

>849_bases
ATGCGCGACGCACCCGAACTGTTATCCTCCCACCGCTGCTTCGGCGGGACGGTGGGCTTCTATCGGCACCACTCCGAGAC
CTGCGACAGCCCGATGCGCTTTTCGGTGTTCACCCCACCCCAGGCGGCGGCCGGTCCGGTGCCGGTGCTCTATTTTTTGG
CGGGTCTCACCTGTACCGAGGAAAATTTTATGGTCAAAGCCGGGGCACAGCGCGCCGCCGCCCGGTACGGCCTGATGCTG
GTTGCCCCCGACACCAGCCCCCGCAAAACAGGGATCCCGGGTGAGGACGACGAATGGGACTTCGGCGCCGGGGCCGGTTT
TTACGTCGATGCCACCGAGGAGCCGTGGAGCCTCCACTACCGCACGTACAGCTACGTGGTCGGCGAATTGCCATTGATCG
TCGCTGCCCACTTTCCGGCGGATCCCGAGCGCACCGGCATCAGCGGCCACTCGATGGGGGGCCACGGCGCGCTGGTGTGC
GCCTTCAAAAACCCGACGCGCTACCGCTCGGTCTCCGCCTTCGCGCCGATTGCCGCCCCGACGCGCTCGCCTTGGGGCCA
GAAAGCTTTCTCGCGCTATTTGGGAGCAGACGAAAAGACCTGGAAGAGCTACGACGCGAGCGCCCTGGTGGCACTGGGTA
CCATCGAGCCGACCATTCTCATCGACCAGGGAATGGCGGATCCGTACTTGGAGGAGCAGTTGCGCATCGACGAATTTGAG
CAGGCCTGCGCCGCAATCGGCCAATCGCTGCTGCTGCGCCGTCAGGAAGGCTATGACCACAGCTACTATTTCATCGCCAG
CTTCATCGACGATCACCTGCACCACCACGTCGAGGCGCTCGGGAGATAA

Upstream 100 bases:

>100_bases
GACGATCTGATCACCCATGTCCTGCCGCTGGGCGAGATCAACCAGGCGTTCGACCTGATGCACGAAGGCAAATCCATCCG
CACCGTGGTGACTTTTTAAG

Downstream 100 bases:

>100_bases
CCAATTCCGGGGGATGGGGTGATTCCTGGAGGGGCAAGCTCGTTATGGTGCTCTCAGTGGAGTGAGTCGGACAGCCCATG
GAGATCTACCAATTATTGGA

Product: S-formylglutathione hydrolase

Products: NA

Alternate protein names: FGH [H]

Number of amino acids: Translated: 282; Mature: 282

Protein sequence:

>282_residues
MRDAPELLSSHRCFGGTVGFYRHHSETCDSPMRFSVFTPPQAAAGPVPVLYFLAGLTCTEENFMVKAGAQRAAARYGLML
VAPDTSPRKTGIPGEDDEWDFGAGAGFYVDATEEPWSLHYRTYSYVVGELPLIVAAHFPADPERTGISGHSMGGHGALVC
AFKNPTRYRSVSAFAPIAAPTRSPWGQKAFSRYLGADEKTWKSYDASALVALGTIEPTILIDQGMADPYLEEQLRIDEFE
QACAAIGQSLLLRRQEGYDHSYYFIASFIDDHLHHHVEALGR

Sequences:

>Translated_282_residues
MRDAPELLSSHRCFGGTVGFYRHHSETCDSPMRFSVFTPPQAAAGPVPVLYFLAGLTCTEENFMVKAGAQRAAARYGLML
VAPDTSPRKTGIPGEDDEWDFGAGAGFYVDATEEPWSLHYRTYSYVVGELPLIVAAHFPADPERTGISGHSMGGHGALVC
AFKNPTRYRSVSAFAPIAAPTRSPWGQKAFSRYLGADEKTWKSYDASALVALGTIEPTILIDQGMADPYLEEQLRIDEFE
QACAAIGQSLLLRRQEGYDHSYYFIASFIDDHLHHHVEALGR
>Mature_282_residues
MRDAPELLSSHRCFGGTVGFYRHHSETCDSPMRFSVFTPPQAAAGPVPVLYFLAGLTCTEENFMVKAGAQRAAARYGLML
VAPDTSPRKTGIPGEDDEWDFGAGAGFYVDATEEPWSLHYRTYSYVVGELPLIVAAHFPADPERTGISGHSMGGHGALVC
AFKNPTRYRSVSAFAPIAAPTRSPWGQKAFSRYLGADEKTWKSYDASALVALGTIEPTILIDQGMADPYLEEQLRIDEFE
QACAAIGQSLLLRRQEGYDHSYYFIASFIDDHLHHHVEALGR

Specific function: Serine hydrolase involved in the detoxification of formaldehyde. Hydrolyzes S-formylglutathione to glutathione and formate [H]

COG id: COG0627

COG function: function code R; Predicted esterase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the esterase D family [H]

Homologues:

Organism=Homo sapiens, GI33413400, Length=280, Percent_Identity=54.6428571428571, Blast_Score=327, Evalue=1e-89,
Organism=Escherichia coli, GI1786551, Length=276, Percent_Identity=47.463768115942, Blast_Score=288, Evalue=2e-79,
Organism=Escherichia coli, GI1788477, Length=277, Percent_Identity=52.3465703971119, Blast_Score=277, Evalue=4e-76,
Organism=Caenorhabditis elegans, GI17510185, Length=282, Percent_Identity=46.0992907801418, Blast_Score=253, Evalue=1e-67,
Organism=Saccharomyces cerevisiae, GI6322393, Length=287, Percent_Identity=37.6306620209059, Blast_Score=200, Evalue=3e-52,
Organism=Drosophila melanogaster, GI45551932, Length=279, Percent_Identity=52.3297491039427, Blast_Score=291, Evalue=4e-79,
Organism=Drosophila melanogaster, GI24648347, Length=279, Percent_Identity=52.3297491039427, Blast_Score=290, Evalue=6e-79,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000801
- InterPro:   IPR014186 [H]

Pfam domain/function: PF00756 Esterase [H]

EC number: =3.1.2.12 [H]

Molecular weight: Translated: 31028; Mature: 31028

Theoretical pI: Translated: 5.71; Mature: 5.71

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.8 %Cys     (Translated Protein)
2.1 %Met     (Translated Protein)
3.9 %Cys+Met (Translated Protein)
1.8 %Cys     (Mature Protein)
2.1 %Met     (Mature Protein)
3.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRDAPELLSSHRCFGGTVGFYRHHSETCDSPMRFSVFTPPQAAAGPVPVLYFLAGLTCTE
CCCCHHHHHCCCCCCCCHHHHHCCCCCCCCCCEEEEECCCCCCCCCHHHHHHHHCCEECC
ENFMVKAGAQRAAARYGLMLVAPDTSPRKTGIPGEDDEWDFGAGAGFYVDATEEPWSLHY
CCEEEECCHHHHHHHHCEEEEECCCCCCCCCCCCCCCCCCCCCCCCEEEECCCCCCEEEE
RTYSYVVGELPLIVAAHFPADPERTGISGHSMGGHGALVCAFKNPTRYRSVSAFAPIAAP
EEEHHHHHCCCEEEEECCCCCCCCCCCCCCCCCCCCEEEEEECCCCHHCCHHHCCCCCCC
TRSPWGQKAFSRYLGADEKTWKSYDASALVALGTIEPTILIDQGMADPYLEEQLRIDEFE
CCCCCHHHHHHHHHCCCCHHHHCCCCCEEEEEECCCCEEEEECCCCCHHHHHHHCHHHHH
QACAAIGQSLLLRRQEGYDHSYYFIASFIDDHLHHHVEALGR
HHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHCC
>Mature Secondary Structure
MRDAPELLSSHRCFGGTVGFYRHHSETCDSPMRFSVFTPPQAAAGPVPVLYFLAGLTCTE
CCCCHHHHHCCCCCCCCHHHHHCCCCCCCCCCEEEEECCCCCCCCCHHHHHHHHCCEECC
ENFMVKAGAQRAAARYGLMLVAPDTSPRKTGIPGEDDEWDFGAGAGFYVDATEEPWSLHY
CCEEEECCHHHHHHHHCEEEEECCCCCCCCCCCCCCCCCCCCCCCCEEEECCCCCCEEEE
RTYSYVVGELPLIVAAHFPADPERTGISGHSMGGHGALVCAFKNPTRYRSVSAFAPIAAP
EEEHHHHHCCCEEEEECCCCCCCCCCCCCCCCCCCCEEEEEECCCCHHCCHHHCCCCCCC
TRSPWGQKAFSRYLGADEKTWKSYDASALVALGTIEPTILIDQGMADPYLEEQLRIDEFE
CCCCCHHHHHHHHHCCCCHHHHCCCCCEEEEEECCCCEEEEECCCCCHHHHHHHCHHHHH
QACAAIGQSLLLRRQEGYDHSYYFIASFIDDHLHHHVEALGR
HHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA