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The map label for this gene is adhI [H]

Identifier: 37523994

GI number: 37523994

Start: 4651779

End: 4652888

Strand: Direct

Name: adhI [H]

Synonym: glr4425

Alternate gene names: 37523994

Gene position: 4651779-4652888 (Clockwise)

Preceding gene: 37523993

Following gene: 37523995

Centisome position: 99.84

GC content: 61.44

Gene sequence:

>1110_bases
ATGCAGGTAAAAGCGGCCGTGGCAATGGAAGCCGGCAAGCCTTTGCAGATAGAAAGCGTCGAACTGGAAGGCCCCAAAGC
CGGTGAAGTCCTCGTCGAAATCAAGGCGACCGGCATCTGCCACACCGACGCCTTCACACTCTCAGGCGCGGATCCGGAGG
GGCTCTTTCCGGCGATTTTGGGCCACGAGGGGGCCGGGGTGGTGGTGGAAGTCGGACCCGGGGTGACAAGCGTCAAACTG
GGCGATCACGTCATTCCGCTGTACACCCCCGAGTGCCGCCAGTGCGAGTACTGTTTGAGCCGGAAGACCAACCTCTGCCA
GGCCATCCGCACCACCCAGGGCCGGGGAGTGATGCCCGACGGCACCAGCCGCTTTTCGCTCGGTGGCGAGCCGCTCTACC
ACTACATGGGCACCTCGACATTCTCGAACTTCACGGTGCTGCCGGAAATTGCCGTGGCGAAGATTCGCGAGGACGCTCCC
TTCGACAAAGTTTGCTACATCGGCTGCGGGGTGACCACCGGCGTCGGTGCCGTCCTCTACACCGCCCAAGTCGAGCCGGG
GGCGAACGTGGTCGTCTTTGGCCTGGGCGGCATCGGCCTCAACGTCATCCAGGGCTGCCGGATGGTGGGAGCCGACAAGA
TCATCGGAGTCGATACCAATCCGGCCAAAAAAGAACTGGCCGAGAAATTCGGCATGACCCACTTTGTCAACCCGAAAGAA
GTCGAAGGCGACCTGGTGCCCTATCTGGTTGAATTGACCAAAGGCGGAGCCGACTACAGTTTTGAATGCATCGGCAATGT
CAACGTGATGCGCCAGGCGCTGGAGTGCTGCCACAAAGGCTGGGGGGTGAGCGTGATTATCGGCGTGGCGGGAGCGGGCC
AGGAGATCCGCACGCGACCGTTTCAACTGGTGACCGGCCGGATCTGGAAGGGCTCCGCCTTCGGTGGAGCGCGCGGGCGC
ACCGACGTGCCCAAGATCGTCGACTGGTACATGGAAGGCAAGATCAACATCGACGATCTGATCACCCATGTCCTGCCGCT
GGGCGAGATCAACCAGGCGTTCGACCTGATGCACGAAGGCAAATCCATCCGCACCGTGGTGACTTTTTAA

Upstream 100 bases:

>100_bases
GCGACCGGCCCGTGTACAGATTGATAAACGGCCCGATGAACCGTTGCGCCCGGTGCGTTAGCCTTGTCTGTGGCCAAAAC
GGACAGGCAAGGAGCAGCGC

Downstream 100 bases:

>100_bases
GATGCGCGACGCACCCGAACTGTTATCCTCCCACCGCTGCTTCGGCGGGACGGTGGGCTTCTATCGGCACCACTCCGAGA
CCTGCGACAGCCCGATGCGC

Product: glutathione dependent formaldehyde dehydrogenase

Products: NA

Alternate protein names: Alcohol dehydrogenase class-III; Glutathione-dependent formaldehyde dehydrogenase; FALDH; FDH; GSH-FDH; S-(hydroxymethyl)glutathione dehydrogenase [H]

Number of amino acids: Translated: 369; Mature: 369

Protein sequence:

>369_residues
MQVKAAVAMEAGKPLQIESVELEGPKAGEVLVEIKATGICHTDAFTLSGADPEGLFPAILGHEGAGVVVEVGPGVTSVKL
GDHVIPLYTPECRQCEYCLSRKTNLCQAIRTTQGRGVMPDGTSRFSLGGEPLYHYMGTSTFSNFTVLPEIAVAKIREDAP
FDKVCYIGCGVTTGVGAVLYTAQVEPGANVVVFGLGGIGLNVIQGCRMVGADKIIGVDTNPAKKELAEKFGMTHFVNPKE
VEGDLVPYLVELTKGGADYSFECIGNVNVMRQALECCHKGWGVSVIIGVAGAGQEIRTRPFQLVTGRIWKGSAFGGARGR
TDVPKIVDWYMEGKINIDDLITHVLPLGEINQAFDLMHEGKSIRTVVTF

Sequences:

>Translated_369_residues
MQVKAAVAMEAGKPLQIESVELEGPKAGEVLVEIKATGICHTDAFTLSGADPEGLFPAILGHEGAGVVVEVGPGVTSVKL
GDHVIPLYTPECRQCEYCLSRKTNLCQAIRTTQGRGVMPDGTSRFSLGGEPLYHYMGTSTFSNFTVLPEIAVAKIREDAP
FDKVCYIGCGVTTGVGAVLYTAQVEPGANVVVFGLGGIGLNVIQGCRMVGADKIIGVDTNPAKKELAEKFGMTHFVNPKE
VEGDLVPYLVELTKGGADYSFECIGNVNVMRQALECCHKGWGVSVIIGVAGAGQEIRTRPFQLVTGRIWKGSAFGGARGR
TDVPKIVDWYMEGKINIDDLITHVLPLGEINQAFDLMHEGKSIRTVVTF
>Mature_369_residues
MQVKAAVAMEAGKPLQIESVELEGPKAGEVLVEIKATGICHTDAFTLSGADPEGLFPAILGHEGAGVVVEVGPGVTSVKL
GDHVIPLYTPECRQCEYCLSRKTNLCQAIRTTQGRGVMPDGTSRFSLGGEPLYHYMGTSTFSNFTVLPEIAVAKIREDAP
FDKVCYIGCGVTTGVGAVLYTAQVEPGANVVVFGLGGIGLNVIQGCRMVGADKIIGVDTNPAKKELAEKFGMTHFVNPKE
VEGDLVPYLVELTKGGADYSFECIGNVNVMRQALECCHKGWGVSVIIGVAGAGQEIRTRPFQLVTGRIWKGSAFGGARGR
TDVPKIVDWYMEGKINIDDLITHVLPLGEINQAFDLMHEGKSIRTVVTF

Specific function: Oxidizes long-chain aliphatic alcohols, long-chain hydroxylated fatty acids and S-hydroxymethylglutathione (hmGSH) in increasing order of preference. Shows little or no activity with short-chain aliphatic alcohols [H]

COG id: COG1062

COG function: function code C; Zn-dependent alcohol dehydrogenases, class III

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the zinc-containing alcohol dehydrogenase family. Class-III subfamily [H]

Homologues:

Organism=Homo sapiens, GI71565154, Length=367, Percent_Identity=62.125340599455, Blast_Score=460, Evalue=1e-129,
Organism=Homo sapiens, GI71565152, Length=374, Percent_Identity=47.5935828877005, Blast_Score=364, Evalue=1e-101,
Organism=Homo sapiens, GI34577061, Length=369, Percent_Identity=48.5094850948509, Blast_Score=362, Evalue=1e-100,
Organism=Homo sapiens, GI4501933, Length=369, Percent_Identity=47.4254742547426, Blast_Score=352, Evalue=3e-97,
Organism=Homo sapiens, GI262073058, Length=370, Percent_Identity=47.2972972972973, Blast_Score=349, Evalue=2e-96,
Organism=Homo sapiens, GI71743840, Length=370, Percent_Identity=47.2972972972973, Blast_Score=349, Evalue=3e-96,
Organism=Homo sapiens, GI4501929, Length=369, Percent_Identity=47.1544715447154, Blast_Score=347, Evalue=1e-95,
Organism=Homo sapiens, GI156523966, Length=367, Percent_Identity=44.4141689373297, Blast_Score=331, Evalue=8e-91,
Organism=Homo sapiens, GI4501939, Length=361, Percent_Identity=44.5983379501385, Blast_Score=325, Evalue=3e-89,
Organism=Escherichia coli, GI1786552, Length=369, Percent_Identity=62.3306233062331, Blast_Score=461, Evalue=1e-131,
Organism=Escherichia coli, GI87082125, Length=380, Percent_Identity=25.7894736842105, Blast_Score=100, Evalue=2e-22,
Organism=Escherichia coli, GI1788073, Length=349, Percent_Identity=26.9340974212034, Blast_Score=97, Evalue=1e-21,
Organism=Escherichia coli, GI226510992, Length=361, Percent_Identity=25.207756232687, Blast_Score=89, Evalue=6e-19,
Organism=Escherichia coli, GI1787863, Length=376, Percent_Identity=24.7340425531915, Blast_Score=88, Evalue=1e-18,
Organism=Escherichia coli, GI1790045, Length=379, Percent_Identity=25.8575197889182, Blast_Score=86, Evalue=3e-18,
Organism=Escherichia coli, GI87081918, Length=353, Percent_Identity=29.1784702549575, Blast_Score=84, Evalue=2e-17,
Organism=Escherichia coli, GI1786825, Length=267, Percent_Identity=26.5917602996255, Blast_Score=77, Evalue=1e-15,
Organism=Escherichia coli, GI1788075, Length=361, Percent_Identity=26.5927977839335, Blast_Score=75, Evalue=5e-15,
Organism=Escherichia coli, GI1790718, Length=357, Percent_Identity=24.9299719887955, Blast_Score=72, Evalue=7e-14,
Organism=Escherichia coli, GI1788407, Length=231, Percent_Identity=27.2727272727273, Blast_Score=66, Evalue=4e-12,
Organism=Escherichia coli, GI1786518, Length=367, Percent_Identity=26.158038147139, Blast_Score=61, Evalue=1e-10,
Organism=Caenorhabditis elegans, GI25146526, Length=373, Percent_Identity=56.5683646112601, Blast_Score=440, Evalue=1e-124,
Organism=Caenorhabditis elegans, GI71997431, Length=375, Percent_Identity=56.2666666666667, Blast_Score=435, Evalue=1e-122,
Organism=Caenorhabditis elegans, GI17565904, Length=343, Percent_Identity=56.5597667638484, Blast_Score=406, Evalue=1e-114,
Organism=Caenorhabditis elegans, GI17562584, Length=370, Percent_Identity=28.6486486486486, Blast_Score=100, Evalue=1e-21,
Organism=Caenorhabditis elegans, GI71988145, Length=371, Percent_Identity=27.2237196765499, Blast_Score=93, Evalue=2e-19,
Organism=Caenorhabditis elegans, GI17562582, Length=367, Percent_Identity=26.9754768392371, Blast_Score=88, Evalue=7e-18,
Organism=Caenorhabditis elegans, GI17562878, Length=264, Percent_Identity=28.030303030303, Blast_Score=70, Evalue=2e-12,
Organism=Saccharomyces cerevisiae, GI6320033, Length=367, Percent_Identity=56.4032697547684, Blast_Score=440, Evalue=1e-124,
Organism=Saccharomyces cerevisiae, GI6319621, Length=372, Percent_Identity=30.1075268817204, Blast_Score=105, Evalue=8e-24,
Organism=Saccharomyces cerevisiae, GI6323729, Length=366, Percent_Identity=28.4153005464481, Blast_Score=102, Evalue=1e-22,
Organism=Saccharomyces cerevisiae, GI6323961, Length=365, Percent_Identity=26.8493150684932, Blast_Score=97, Evalue=4e-21,
Organism=Saccharomyces cerevisiae, GI6324486, Length=372, Percent_Identity=26.6129032258064, Blast_Score=93, Evalue=6e-20,
Organism=Saccharomyces cerevisiae, GI6323099, Length=385, Percent_Identity=27.012987012987, Blast_Score=90, Evalue=5e-19,
Organism=Saccharomyces cerevisiae, GI6319257, Length=339, Percent_Identity=25.0737463126844, Blast_Score=77, Evalue=3e-15,
Organism=Saccharomyces cerevisiae, GI6319258, Length=265, Percent_Identity=26.7924528301887, Blast_Score=67, Evalue=6e-12,
Organism=Drosophila melanogaster, GI17737895, Length=368, Percent_Identity=63.0434782608696, Blast_Score=490, Evalue=1e-139,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR014183
- InterPro:   IPR013149
- InterPro:   IPR013154
- InterPro:   IPR002085
- InterPro:   IPR002328
- InterPro:   IPR011032
- InterPro:   IPR016040 [H]

Pfam domain/function: PF08240 ADH_N; PF00107 ADH_zinc_N [H]

EC number: =1.1.1.1; =1.1.1.284 [H]

Molecular weight: Translated: 39374; Mature: 39374

Theoretical pI: Translated: 5.64; Mature: 5.64

Prosite motif: PS00059 ADH_ZINC

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

3.0 %Cys     (Translated Protein)
2.4 %Met     (Translated Protein)
5.4 %Cys+Met (Translated Protein)
3.0 %Cys     (Mature Protein)
2.4 %Met     (Mature Protein)
5.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MQVKAAVAMEAGKPLQIESVELEGPKAGEVLVEIKATGICHTDAFTLSGADPEGLFPAIL
CCCCEEEEECCCCCEEEEEEEECCCCCCCEEEEEEECCEEECCEEEECCCCCCCCCHHHH
GHEGAGVVVEVGPGVTSVKLGDHVIPLYTPECRQCEYCLSRKTNLCQAIRTTQGRGVMPD
CCCCCEEEEEECCCEEEEECCCEEEEEECCCHHHHHHHHHCCHHHHHHHHHCCCCCCCCC
GTSRFSLGGEPLYHYMGTSTFSNFTVLPEIAVAKIREDAPFDKVCYIGCGVTTGVGAVLY
CCCEECCCCCHHHHHHCCCCCCCEEECHHHHHHHHHCCCCCCCEEEEECCHHHCCCEEEE
TAQVEPGANVVVFGLGGIGLNVIQGCRMVGADKIIGVDTNPAKKELAEKFGMTHFVNPKE
EEEECCCCCEEEEECCCCCHHHHHHHHHCCCCEEEECCCCHHHHHHHHHHCCEECCCHHH
VEGDLVPYLVELTKGGADYSFECIGNVNVMRQALECCHKGWGVSVIIGVAGAGQEIRTRP
CCCCHHHHHHEECCCCCCEEEEEECCHHHHHHHHHHHHCCCCEEEEEEECCCCHHHHCCC
FQLVTGRIWKGSAFGGARGRTDVPKIVDWYMEGKINIDDLITHVLPLGEINQAFDLMHEG
EEEEECEEEECCCCCCCCCCCCCHHHHHHHHCCCCCHHHHHHHHCCCCHHHHHHHHHHCC
KSIRTVVTF
CCEEEEEEC
>Mature Secondary Structure
MQVKAAVAMEAGKPLQIESVELEGPKAGEVLVEIKATGICHTDAFTLSGADPEGLFPAIL
CCCCEEEEECCCCCEEEEEEEECCCCCCCEEEEEEECCEEECCEEEECCCCCCCCCHHHH
GHEGAGVVVEVGPGVTSVKLGDHVIPLYTPECRQCEYCLSRKTNLCQAIRTTQGRGVMPD
CCCCCEEEEEECCCEEEEECCCEEEEEECCCHHHHHHHHHCCHHHHHHHHHCCCCCCCCC
GTSRFSLGGEPLYHYMGTSTFSNFTVLPEIAVAKIREDAPFDKVCYIGCGVTTGVGAVLY
CCCEECCCCCHHHHHHCCCCCCCEEECHHHHHHHHHCCCCCCCEEEEECCHHHCCCEEEE
TAQVEPGANVVVFGLGGIGLNVIQGCRMVGADKIIGVDTNPAKKELAEKFGMTHFVNPKE
EEEECCCCCEEEEECCCCCHHHHHHHHHCCCCEEEECCCCHHHHHHHHHHCCEECCCHHH
VEGDLVPYLVELTKGGADYSFECIGNVNVMRQALECCHKGWGVSVIIGVAGAGQEIRTRP
CCCCHHHHHHEECCCCCCEEEEEECCHHHHHHHHHHHHCCCCEEEEEEECCCCHHHHCCC
FQLVTGRIWKGSAFGGARGRTDVPKIVDWYMEGKINIDDLITHVLPLGEINQAFDLMHEG
EEEEECEEEECCCCCCCCCCCCCHHHHHHHHCCCCCHHHHHHHHCCCCHHHHHHHHHHCC
KSIRTVVTF
CCEEEEEEC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8631716 [H]