Click here to switch to the map view.

The map label for this gene is fucA [C]

Identifier: 37523855

GI number: 37523855

Start: 4509474

End: 4510340

Strand: Reverse

Name: fucA [C]

Synonym: gll4286

Alternate gene names: 37523855

Gene position: 4510340-4509474 (Counterclockwise)

Preceding gene: 37523864

Following gene: 37523854

Centisome position: 96.81

GC content: 67.36

Gene sequence:

>867_bases
GTGCAACCATTTTTCGCGGGGGACCGCCGCGCTCCGTGCCACAATTTTAGGTGTCGGCGCGTCGCCGACGCTCAGCACCC
CAAGGCCATGGAAACGATCACCCGCCCGCAACCGGCCATTCCCGAACCGCCGGTCTTTACCCATCCGGCCGAGGAGCGTC
GCCACCTCAAGGAACGTCTGGCGGCCGCATTCCGGCTGTTTGCCCGCTACGGCTTCGACGACGGCATCGCCGGGCACATC
ACCGCCCGCGACCCCGGGCGGCCGGACCACTTCTGGGTCAATCCTTTCGGGATGTACTTCGGCCACATCCGCGTGCGCGA
CCTGCTGCTGGTCGACGCTGGAGGTGCGGTGGTCGAGGGGGACCGCCCGCTCAACACCGCCGCCTTCGCCATCCACTCGC
AAATCCACGCCCATCGCCCCGACGTGGTGGCCTCGGCCCATTCCCATTCGATGTACGGCAAAGCCTGGTCCACCCTCGGC
CGCAAACTCGACCCGCTCACCCAGGACGCCTGTGCGTTCTACGAGGACCACGGTCTGTTTGAAGACTACACCGGGCTCGT
CCTCGACCCTGCCGAAGGGCGGCGCATCGCGGCGGCCCTCGGTCCCCACAAGGCGGTCATCCTGCGCAACCATGGCCTTT
TGACCGTCGGCCGCAGCGTCGATGAGGCAGCCTGGTGGTTCATCGCCATGGACCGCTCCTGCCAGGTGCAGCTGTTGGCC
GAAGCGGCGGGCGAGCCGGCGCTGATCGATCCGCACCAGGCCCGCCTCGCCTGCGGCCAGGTGGGCAGCCACCACCAGGG
TTGGTTCAGCTTCCAGCCGCTCTTTGATCGCATCGTCCGCGAACAGCCGGATCTGCTCGAAAGTTGA

Upstream 100 bases:

>100_bases
CAGGCCGCCCTCGGCGGTGCAGACGAGCAGTTCCCAGCGCACCTGTCCATCGGCTCCCACCAGCGGACAGCGATAAAAAT
CCAGCTCCCACAGCTCCACG

Downstream 100 bases:

>100_bases
GCGGCGCCGCCGGGCTGGGCCTGCACACTTCCACTGACACCCTGGGCCTTGCCCTCTGGGATGGGGCGAACTTGCGAACG
CAATTGTTCGCGGAGGGACG

Product: hypothetical protein

Products: Dihydroxyacetone phosphate; L-Lactaldehyde [C]

Alternate protein names: NA

Number of amino acids: Translated: 288; Mature: 288

Protein sequence:

>288_residues
MQPFFAGDRRAPCHNFRCRRVADAQHPKAMETITRPQPAIPEPPVFTHPAEERRHLKERLAAAFRLFARYGFDDGIAGHI
TARDPGRPDHFWVNPFGMYFGHIRVRDLLLVDAGGAVVEGDRPLNTAAFAIHSQIHAHRPDVVASAHSHSMYGKAWSTLG
RKLDPLTQDACAFYEDHGLFEDYTGLVLDPAEGRRIAAALGPHKAVILRNHGLLTVGRSVDEAAWWFIAMDRSCQVQLLA
EAAGEPALIDPHQARLACGQVGSHHQGWFSFQPLFDRIVREQPDLLES

Sequences:

>Translated_288_residues
MQPFFAGDRRAPCHNFRCRRVADAQHPKAMETITRPQPAIPEPPVFTHPAEERRHLKERLAAAFRLFARYGFDDGIAGHI
TARDPGRPDHFWVNPFGMYFGHIRVRDLLLVDAGGAVVEGDRPLNTAAFAIHSQIHAHRPDVVASAHSHSMYGKAWSTLG
RKLDPLTQDACAFYEDHGLFEDYTGLVLDPAEGRRIAAALGPHKAVILRNHGLLTVGRSVDEAAWWFIAMDRSCQVQLLA
EAAGEPALIDPHQARLACGQVGSHHQGWFSFQPLFDRIVREQPDLLES
>Mature_288_residues
MQPFFAGDRRAPCHNFRCRRVADAQHPKAMETITRPQPAIPEPPVFTHPAEERRHLKERLAAAFRLFARYGFDDGIAGHI
TARDPGRPDHFWVNPFGMYFGHIRVRDLLLVDAGGAVVEGDRPLNTAAFAIHSQIHAHRPDVVASAHSHSMYGKAWSTLG
RKLDPLTQDACAFYEDHGLFEDYTGLVLDPAEGRRIAAALGPHKAVILRNHGLLTVGRSVDEAAWWFIAMDRSCQVQLLA
EAAGEPALIDPHQARLACGQVGSHHQGWFSFQPLFDRIVREQPDLLES

Specific function: Fucose metabolism; third step. [C]

COG id: COG0235

COG function: function code G; Ribulose-5-phosphate 4-epimerase and related epimerases and aldolases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the aldolase class II family [H]

Homologues:

Organism=Homo sapiens, GI29826325, Length=218, Percent_Identity=33.4862385321101, Blast_Score=118, Evalue=5e-27,
Organism=Homo sapiens, GI29826323, Length=218, Percent_Identity=33.4862385321101, Blast_Score=118, Evalue=6e-27,
Organism=Homo sapiens, GI29826321, Length=219, Percent_Identity=33.3333333333333, Blast_Score=118, Evalue=7e-27,
Organism=Homo sapiens, GI29826319, Length=219, Percent_Identity=33.3333333333333, Blast_Score=117, Evalue=1e-26,
Organism=Homo sapiens, GI89276787, Length=231, Percent_Identity=29.004329004329, Blast_Score=99, Evalue=3e-21,
Organism=Homo sapiens, GI297307160, Length=231, Percent_Identity=29.004329004329, Blast_Score=99, Evalue=4e-21,
Organism=Homo sapiens, GI9257190, Length=231, Percent_Identity=29.004329004329, Blast_Score=99, Evalue=4e-21,
Organism=Homo sapiens, GI297307158, Length=231, Percent_Identity=29.004329004329, Blast_Score=98, Evalue=7e-21,
Organism=Homo sapiens, GI9257192, Length=231, Percent_Identity=29.004329004329, Blast_Score=98, Evalue=7e-21,
Organism=Homo sapiens, GI9943848, Length=197, Percent_Identity=28.4263959390863, Blast_Score=86, Evalue=3e-17,
Organism=Homo sapiens, GI9951927, Length=197, Percent_Identity=28.4263959390863, Blast_Score=86, Evalue=3e-17,
Organism=Homo sapiens, GI62912453, Length=197, Percent_Identity=28.4263959390863, Blast_Score=86, Evalue=3e-17,
Organism=Caenorhabditis elegans, GI115533216, Length=192, Percent_Identity=30.2083333333333, Blast_Score=99, Evalue=3e-21,
Organism=Caenorhabditis elegans, GI115533218, Length=185, Percent_Identity=30.8108108108108, Blast_Score=97, Evalue=1e-20,
Organism=Caenorhabditis elegans, GI71989560, Length=207, Percent_Identity=27.0531400966184, Blast_Score=81, Evalue=6e-16,
Organism=Caenorhabditis elegans, GI71989550, Length=207, Percent_Identity=27.0531400966184, Blast_Score=81, Evalue=8e-16,
Organism=Caenorhabditis elegans, GI71989541, Length=207, Percent_Identity=27.0531400966184, Blast_Score=81, Evalue=8e-16,
Organism=Caenorhabditis elegans, GI71989544, Length=207, Percent_Identity=27.0531400966184, Blast_Score=81, Evalue=8e-16,
Organism=Caenorhabditis elegans, GI71989555, Length=207, Percent_Identity=27.0531400966184, Blast_Score=80, Evalue=9e-16,
Organism=Drosophila melanogaster, GI281363755, Length=215, Percent_Identity=34.8837209302326, Blast_Score=109, Evalue=3e-24,
Organism=Drosophila melanogaster, GI281363751, Length=215, Percent_Identity=34.8837209302326, Blast_Score=109, Evalue=3e-24,
Organism=Drosophila melanogaster, GI24655690, Length=215, Percent_Identity=34.8837209302326, Blast_Score=109, Evalue=3e-24,
Organism=Drosophila melanogaster, GI24655685, Length=213, Percent_Identity=34.7417840375587, Blast_Score=108, Evalue=3e-24,
Organism=Drosophila melanogaster, GI281363761, Length=213, Percent_Identity=34.7417840375587, Blast_Score=108, Evalue=4e-24,
Organism=Drosophila melanogaster, GI281363759, Length=213, Percent_Identity=34.7417840375587, Blast_Score=108, Evalue=4e-24,
Organism=Drosophila melanogaster, GI281363753, Length=213, Percent_Identity=34.7417840375587, Blast_Score=108, Evalue=4e-24,
Organism=Drosophila melanogaster, GI281363763, Length=215, Percent_Identity=35.3488372093023, Blast_Score=102, Evalue=3e-22,
Organism=Drosophila melanogaster, GI281363757, Length=215, Percent_Identity=35.3488372093023, Blast_Score=102, Evalue=3e-22,
Organism=Drosophila melanogaster, GI17136738, Length=215, Percent_Identity=35.3488372093023, Blast_Score=102, Evalue=3e-22,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001303 [H]

Pfam domain/function: PF00596 Aldolase_II [H]

EC number: 4.1.2.17 [C]

Molecular weight: Translated: 32149; Mature: 32149

Theoretical pI: Translated: 7.16; Mature: 7.16

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.7 %Cys     (Translated Protein)
1.7 %Met     (Translated Protein)
3.5 %Cys+Met (Translated Protein)
1.7 %Cys     (Mature Protein)
1.7 %Met     (Mature Protein)
3.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MQPFFAGDRRAPCHNFRCRRVADAQHPKAMETITRPQPAIPEPPVFTHPAEERRHLKERL
CCCCCCCCCCCCCCCCCHHHHCCCCCCHHHHHHCCCCCCCCCCCCCCCCHHHHHHHHHHH
AAAFRLFARYGFDDGIAGHITARDPGRPDHFWVNPFGMYFGHIRVRDLLLVDAGGAVVEG
HHHHHHHHHCCCCCCCEEEEEECCCCCCCCEEECHHHHHHHHEEEEEEEEEECCCEEEEC
DRPLNTAAFAIHSQIHAHRPDVVASAHSHSMYGKAWSTLGRKLDPLTQDACAFYEDHGLF
CCCCCHHHHHHHHHHHCCCCCCEECCCCCHHHHHHHHHHCCCCCCCHHHHHHHHHHCCCC
EDYTGLVLDPAEGRRIAAALGPHKAVILRNHGLLTVGRSVDEAAWWFIAMDRSCQVQLLA
CCCCCEEEECCCCCEEEEECCCCEEEEEECCCEEEECCCCCCCEEEEEEECCCCEEEEEE
EAAGEPALIDPHQARLACGQVGSHHQGWFSFQPLFDRIVREQPDLLES
HHCCCCCEECCHHHHHHHHCCCCCCCCCEEHHHHHHHHHHCCCHHHCC
>Mature Secondary Structure
MQPFFAGDRRAPCHNFRCRRVADAQHPKAMETITRPQPAIPEPPVFTHPAEERRHLKERL
CCCCCCCCCCCCCCCCCHHHHCCCCCCHHHHHHCCCCCCCCCCCCCCCCHHHHHHHHHHH
AAAFRLFARYGFDDGIAGHITARDPGRPDHFWVNPFGMYFGHIRVRDLLLVDAGGAVVEG
HHHHHHHHHCCCCCCCEEEEEECCCCCCCCEEECHHHHHHHHEEEEEEEEEECCCEEEEC
DRPLNTAAFAIHSQIHAHRPDVVASAHSHSMYGKAWSTLGRKLDPLTQDACAFYEDHGLF
CCCCCHHHHHHHHHHHCCCCCCEECCCCCHHHHHHHHHHCCCCCCCHHHHHHHHHHCCCC
EDYTGLVLDPAEGRRIAAALGPHKAVILRNHGLLTVGRSVDEAAWWFIAMDRSCQVQLLA
CCCCCEEEECCCCCEEEEECCCCEEEEEECCCEEEECCCCCCCEEEEEEECCCCEEEEEE
EAAGEPALIDPHQARLACGQVGSHHQGWFSFQPLFDRIVREQPDLLES
HHCCCCCEECCHHHHHHHHCCCCCCCCCEEHHHHHHHHHHCCCHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: Ca2+; Co2+; Mg2+; Mn2+; Zn2+ [C]

Kcat value (1/min): 19.3 [C]

Specific activity: 21.0

Km value (mM): 0.7 {L-fuculose} [C]

Substrates: L-Fuculose 1-phosphate [C]

Specific reaction: L-Fuculose 1-phosphate <==> Dihydroxyacetone phosphate + L-Lactaldehyde [C]

General reaction: Elimination of an aldehyde C-C bond; Cleavage [C]

Inhibitor: EDTA; Phosphoglycolohydroxamate [C]

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11259647 [H]