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The map label for this gene is thrA [H]

Identifier: 37523864

GI number: 37523864

Start: 4516770

End: 4518053

Strand: Reverse

Name: thrA [H]

Synonym: gvip559

Alternate gene names: 37523864

Gene position: 4518053-4516770 (Counterclockwise)

Preceding gene: 37523867

Following gene: 37523855

Centisome position: 96.97

GC content: 67.45

Gene sequence:

>1284_bases
ATGGCAACCCCCTTGCGTCTGGCACTCATCGGGCTGGGTACGGTCGGCAGCGGCGTCCTGCGTATTTTGCACGACACGGC
CGGGCGCGACGCGCGGCTGGGCACGGTACAGGTAGTGGGTGTGGCCGTGCGCGATCTCGAAAGACCCAGAGACCTGCCGG
TGTTGCCCCCGCTCACCGACGACCCGTTCTCACTGGTGCGCGATCCGGAGGTGGATGTGGTAGCCGAGGTGATGGGGGGA
GTGGATCTGCCTTACCGGCTGTTGACCGCGGCGCTCAAGGCGGGCAAGCACGTGATCACCGCGAACAAAGCCTTGCTTGC
CCGCCACGGCCAGGAGTTGTTCGCCCTGGCGCGCGCCCAAAATCGCCAGTTGCGCTACGAGGCGGCGGTGGGCGGCGGCA
TCCCGCTCATTCAACCGCTGGAGCAGTGCCTGGGGGCCAACCGCATCCACTCGGTGACGGCCATCATCAACGGCACGACC
AATTACATCCTCACCCAGATGGCCACCCGCCAGATGGCCTACACCCAGGCCCTCGCCGAAGCCCAGGCCCTGGGTTACGC
CGAGGCCGACCCGGCGGCGGACGTCGAGGGGGCCGACGCCCAGGAGAAGCTCACGATCCTGGCCAGCATCGCCTTTCGCA
TCCCGCTGCCGCCTCTGGAGGCGATTTACCGCGAGGGGATCACCGCAATCGATCTGCCCGATGTGATCAACGCCCAGCAG
TTGGGTTTTGGGATCAAACTGCTGGCCCTGGCGGAGCGCTGCCCGGACGGACGGCTCGATCTGCGGGTGCACCCGACGCT
GGTGCCGGTCGATCATCCCCTCAGCCGGGTGGACGGTGCCTACAACGCGGTGCTCATCGAGGCGGAACCGGTGGGGTCGA
TCATGTTCTTTGGTCCCGGGGCCGGGGGCGGTCCCACCGCAAGCGCGGTGATTTCCGATCTGATCAATATCCTCGCCGAC
CGGCCCGCCGGACCCACCCCCGCCGACTTTGCCCAACCGCCGCCTGGTTATCTATCCATCGACGAAGTCCAGACCCGCTT
TTATATCCGCCTGCGCGCCCTCGACCGGCCGGGGGTGGTCGGCCATATCGGCCAGATCTTCGGTCGCCACTCGGTGAGCC
TTGCCTCGATCGTCCAGAAGAACCCGCGCGGGGCCGCCGCCGAACTGGTGATCATCACCCACGACGTGGCGGAAGCGCGC
CTGCGGGCGGCCCTGGCCGAGTTGCGCGCCAGCAGCGAGGTGCAGGATTTTTGCACCGCCATCCGGGTTCTGCCCGAGGG
CTGA

Upstream 100 bases:

>100_bases
GGCTTCCAATTTCTGACCCCGCATGTACCCGGGCTGGGGAGCCGCGCCGGGTGCCGGGGCCGGTGGGATTGTGATAGCCT
GCTACGGTTGGCGGAGGACC

Downstream 100 bases:

>100_bases
GCGATATCCCCCCGCCTGCAACGTCTATAAAGAACTGACTTGCCCCGAGGAGGTCTACGAGAAGATCTCCAGCTACCACG
AACAGAAGGCCCGTTCGTAG

Product: homoserine dehydrogenase

Products: NA

Alternate protein names: HDH [H]

Number of amino acids: Translated: 427; Mature: 426

Protein sequence:

>427_residues
MATPLRLALIGLGTVGSGVLRILHDTAGRDARLGTVQVVGVAVRDLERPRDLPVLPPLTDDPFSLVRDPEVDVVAEVMGG
VDLPYRLLTAALKAGKHVITANKALLARHGQELFALARAQNRQLRYEAAVGGGIPLIQPLEQCLGANRIHSVTAIINGTT
NYILTQMATRQMAYTQALAEAQALGYAEADPAADVEGADAQEKLTILASIAFRIPLPPLEAIYREGITAIDLPDVINAQQ
LGFGIKLLALAERCPDGRLDLRVHPTLVPVDHPLSRVDGAYNAVLIEAEPVGSIMFFGPGAGGGPTASAVISDLINILAD
RPAGPTPADFAQPPPGYLSIDEVQTRFYIRLRALDRPGVVGHIGQIFGRHSVSLASIVQKNPRGAAAELVIITHDVAEAR
LRAALAELRASSEVQDFCTAIRVLPEG

Sequences:

>Translated_427_residues
MATPLRLALIGLGTVGSGVLRILHDTAGRDARLGTVQVVGVAVRDLERPRDLPVLPPLTDDPFSLVRDPEVDVVAEVMGG
VDLPYRLLTAALKAGKHVITANKALLARHGQELFALARAQNRQLRYEAAVGGGIPLIQPLEQCLGANRIHSVTAIINGTT
NYILTQMATRQMAYTQALAEAQALGYAEADPAADVEGADAQEKLTILASIAFRIPLPPLEAIYREGITAIDLPDVINAQQ
LGFGIKLLALAERCPDGRLDLRVHPTLVPVDHPLSRVDGAYNAVLIEAEPVGSIMFFGPGAGGGPTASAVISDLINILAD
RPAGPTPADFAQPPPGYLSIDEVQTRFYIRLRALDRPGVVGHIGQIFGRHSVSLASIVQKNPRGAAAELVIITHDVAEAR
LRAALAELRASSEVQDFCTAIRVLPEG
>Mature_426_residues
ATPLRLALIGLGTVGSGVLRILHDTAGRDARLGTVQVVGVAVRDLERPRDLPVLPPLTDDPFSLVRDPEVDVVAEVMGGV
DLPYRLLTAALKAGKHVITANKALLARHGQELFALARAQNRQLRYEAAVGGGIPLIQPLEQCLGANRIHSVTAIINGTTN
YILTQMATRQMAYTQALAEAQALGYAEADPAADVEGADAQEKLTILASIAFRIPLPPLEAIYREGITAIDLPDVINAQQL
GFGIKLLALAERCPDGRLDLRVHPTLVPVDHPLSRVDGAYNAVLIEAEPVGSIMFFGPGAGGGPTASAVISDLINILADR
PAGPTPADFAQPPPGYLSIDEVQTRFYIRLRALDRPGVVGHIGQIFGRHSVSLASIVQKNPRGAAAELVIITHDVAEARL
RAALAELRASSEVQDFCTAIRVLPEG

Specific function: Catalyzes 2 nonconsecutive reactions in the common biosynthetic pathway leading from Asp to diaminopimelate and Lys, to Met, and to Thr and Ile. [C]

COG id: COG0460

COG function: function code E; Homoserine dehydrogenase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 ACT domain [H]

Homologues:

Organism=Escherichia coli, GI1786183, Length=260, Percent_Identity=26.5384615384615, Blast_Score=67, Evalue=2e-12,
Organism=Escherichia coli, GI1790376, Length=247, Percent_Identity=28.3400809716599, Blast_Score=62, Evalue=7e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002912
- InterPro:   IPR005106
- InterPro:   IPR016204
- InterPro:   IPR001342
- InterPro:   IPR019811
- InterPro:   IPR016040 [H]

Pfam domain/function: PF01842 ACT; PF00742 Homoserine_dh; PF03447 NAD_binding_3 [H]

EC number: =1.1.1.3 [H]

Molecular weight: Translated: 45325; Mature: 45194

Theoretical pI: Translated: 5.85; Mature: 5.85

Prosite motif: PS01042 HOMOSER_DHGENASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
1.2 %Met     (Translated Protein)
1.9 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
0.9 %Met     (Mature Protein)
1.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MATPLRLALIGLGTVGSGVLRILHDTAGRDARLGTVQVVGVAVRDLERPRDLPVLPPLTD
CCCCCEEEEEECCCHHHHHHHHHHHCCCCCCCCCEEEEHHHHHHHHCCCCCCCCCCCCCC
DPFSLVRDPEVDVVAEVMGGVDLPYRLLTAALKAGKHVITANKALLARHGQELFALARAQ
CCHHHHCCCCHHHHHHHHCCCCCHHHHHHHHHHCCCEEEECCHHHHHHCCHHHHHHHHHC
NRQLRYEAAVGGGIPLIQPLEQCLGANRIHSVTAIINGTTNYILTQMATRQMAYTQALAE
CCCEEEEEECCCCCHHHHHHHHHHCCCHHEEEEEEECCCHHHHHHHHHHHHHHHHHHHHH
AQALGYAEADPAADVEGADAQEKLTILASIAFRIPLPPLEAIYREGITAIDLPDVINAQQ
HHHCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHCCCCHHHHHHHCCCCEECCCCCCCHHH
LGFGIKLLALAERCPDGRLDLRVHPTLVPVDHPLSRVDGAYNAVLIEAEPVGSIMFFGPG
HCCCHHHHHHHHHCCCCCEEEEECCEEECCCCCHHHCCCCCEEEEEEECCCCEEEEECCC
AGGGPTASAVISDLINILADRPAGPTPADFAQPPPGYLSIDEVQTRFYIRLRALDRPGVV
CCCCCHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCEEHHHHCEEEEEEEEECCCCCHH
GHIGQIFGRHSVSLASIVQKNPRGAAAELVIITHDVAEARLRAALAELRASSEVQDFCTA
HHHHHHHCCCCHHHHHHHHCCCCCCCEEEEEEECHHHHHHHHHHHHHHHCCCHHHHHHHH
IRVLPEG
HHHCCCC
>Mature Secondary Structure 
ATPLRLALIGLGTVGSGVLRILHDTAGRDARLGTVQVVGVAVRDLERPRDLPVLPPLTD
CCCCEEEEEECCCHHHHHHHHHHHCCCCCCCCCEEEEHHHHHHHHCCCCCCCCCCCCCC
DPFSLVRDPEVDVVAEVMGGVDLPYRLLTAALKAGKHVITANKALLARHGQELFALARAQ
CCHHHHCCCCHHHHHHHHCCCCCHHHHHHHHHHCCCEEEECCHHHHHHCCHHHHHHHHHC
NRQLRYEAAVGGGIPLIQPLEQCLGANRIHSVTAIINGTTNYILTQMATRQMAYTQALAE
CCCEEEEEECCCCCHHHHHHHHHHCCCHHEEEEEEECCCHHHHHHHHHHHHHHHHHHHHH
AQALGYAEADPAADVEGADAQEKLTILASIAFRIPLPPLEAIYREGITAIDLPDVINAQQ
HHHCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHCCCCHHHHHHHCCCCEECCCCCCCHHH
LGFGIKLLALAERCPDGRLDLRVHPTLVPVDHPLSRVDGAYNAVLIEAEPVGSIMFFGPG
HCCCHHHHHHHHHCCCCCEEEEECCEEECCCCCHHHCCCCCEEEEEEECCCCEEEEECCC
AGGGPTASAVISDLINILADRPAGPTPADFAQPPPGYLSIDEVQTRFYIRLRALDRPGVV
CCCCCHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCEEHHHHCEEEEEEEEECCCCCHH
GHIGQIFGRHSVSLASIVQKNPRGAAAELVIITHDVAEARLRAALAELRASSEVQDFCTA
HHHHHHHCCCCHHHHHHHHCCCCCCCEEEEEEECHHHHHHHHHHHHHHHCCCHHHHHHHH
IRVLPEG
HHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8590279; 8905231 [H]