Click here to switch to the map view.

The map label for this gene is pyrE [H]

Identifier: 37523845

GI number: 37523845

Start: 4497168

End: 4497794

Strand: Reverse

Name: pyrE [H]

Synonym: gll4276

Alternate gene names: 37523845

Gene position: 4497794-4497168 (Counterclockwise)

Preceding gene: 37523850

Following gene: 37523844

Centisome position: 96.54

GC content: 62.84

Gene sequence:

>627_bases
GTGTCAACAGCTGTTACGCTGGATGCGCCTTGTTTCGTGATTTGCACGCCGATGTCCTCGCCCCTCGACTGGGATCTGGC
CAGACAGCGCAGCGAGCTGCTGGAGTTGATGCGCACGCTCTGCTACCGCGAGGGCGACTTCAAGCTCTCCTCCGGCCAGA
GCAGCAGTTACTACATCGACAGCAAAAAAGCGACGCTCCATCCGCTAGGTGCCCTGCTCGCGGGCTCGCTGCTCTACGAA
AGGCTGCCCGAAGGCACGGCGGCGATCGGCGGGCTGACCCTCGGGGCCGATCCGATCGTGACGGCGGTGGCCGTGGTCTC
GGCCCTGCGCCATCCCGCAGGCGGTGTGGGAGCCTTTATCGTGCGCAAGGAAGTCAAAAAACACGGCTCCCAGCAGTGGA
TTGAAGGGCCGAGCCTTGCTGTGGGCACACCGGTAGTGATTGTGGACGATGTAGTGACCACCGGCGCGAGCGGCTTGCAG
GCAGCCGAAAAAGCTGAGGAGGCAGGCTTGAAAGTCGTCAAGATCCTGGCCCTTGTCGACCGCCACCAGGGCGGCGGAGC
ACTCTACGCCGGGCGCGGCTATCCATTCGAGGCGTTGTATTCGATCGAAGAATTTCGCAGCCGTTAG

Upstream 100 bases:

>100_bases
GGTAGAGTAAGCACAAGGCGAAGGATGGCCGAGCAAACAGGGCATACGTTCCCTTCTATTAGGAAAGCTGGATATCTAAT
GTAAGTCGCGCAACGGCCAA

Downstream 100 bases:

>100_bases
GCCGGTGTGCTACGTGTATTCTGCAAAGCGGTGCACCGAGTGCCATGCCCAAAGGCCGACCTTTCGACACATTGAGCGCC
TGGCTGTACCTTTTGCCGGC

Product: phosphoribosyltransferase

Products: NA

Alternate protein names: OPRT; OPRTase [H]

Number of amino acids: Translated: 208; Mature: 207

Protein sequence:

>208_residues
MSTAVTLDAPCFVICTPMSSPLDWDLARQRSELLELMRTLCYREGDFKLSSGQSSSYYIDSKKATLHPLGALLAGSLLYE
RLPEGTAAIGGLTLGADPIVTAVAVVSALRHPAGGVGAFIVRKEVKKHGSQQWIEGPSLAVGTPVVIVDDVVTTGASGLQ
AAEKAEEAGLKVVKILALVDRHQGGGALYAGRGYPFEALYSIEEFRSR

Sequences:

>Translated_208_residues
MSTAVTLDAPCFVICTPMSSPLDWDLARQRSELLELMRTLCYREGDFKLSSGQSSSYYIDSKKATLHPLGALLAGSLLYE
RLPEGTAAIGGLTLGADPIVTAVAVVSALRHPAGGVGAFIVRKEVKKHGSQQWIEGPSLAVGTPVVIVDDVVTTGASGLQ
AAEKAEEAGLKVVKILALVDRHQGGGALYAGRGYPFEALYSIEEFRSR
>Mature_207_residues
STAVTLDAPCFVICTPMSSPLDWDLARQRSELLELMRTLCYREGDFKLSSGQSSSYYIDSKKATLHPLGALLAGSLLYER
LPEGTAAIGGLTLGADPIVTAVAVVSALRHPAGGVGAFIVRKEVKKHGSQQWIEGPSLAVGTPVVIVDDVVTTGASGLQA
AEKAEEAGLKVVKILALVDRHQGGGALYAGRGYPFEALYSIEEFRSR

Specific function: Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP) [H]

COG id: COG0461

COG function: function code F; Orotate phosphoribosyltransferase

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the purine/pyrimidine phosphoribosyltransferase family. PyrE subfamily [H]

Homologues:

Organism=Homo sapiens, GI4507835, Length=167, Percent_Identity=27.5449101796407, Blast_Score=68, Evalue=5e-12,
Organism=Caenorhabditis elegans, GI17508631, Length=181, Percent_Identity=30.3867403314917, Blast_Score=76, Evalue=2e-14,
Organism=Caenorhabditis elegans, GI17554964, Length=181, Percent_Identity=29.2817679558011, Blast_Score=66, Evalue=1e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004467
- InterPro:   IPR023031
- InterPro:   IPR000836 [H]

Pfam domain/function: PF00156 Pribosyltran [H]

EC number: =2.4.2.10 [H]

Molecular weight: Translated: 22032; Mature: 21900

Theoretical pI: Translated: 6.51; Mature: 6.51

Prosite motif: PS00103 PUR_PYR_PR_TRANSFER

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.4 %Cys     (Translated Protein)
1.4 %Met     (Translated Protein)
2.9 %Cys+Met (Translated Protein)
1.4 %Cys     (Mature Protein)
1.0 %Met     (Mature Protein)
2.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSTAVTLDAPCFVICTPMSSPLDWDLARQRSELLELMRTLCYREGDFKLSSGQSSSYYID
CCCEEEECCCEEEEECCCCCCCCHHHHHHHHHHHHHHHHHHHCCCCCEECCCCCCCEEEE
SKKATLHPLGALLAGSLLYERLPEGTAAIGGLTLGADPIVTAVAVVSALRHPAGGVGAFI
CCCCHHHHHHHHHHHHHHHHHCCCCHHHHCCEECCCHHHHHHHHHHHHHHCCCCCHHHHH
VRKEVKKHGSQQWIEGPSLAVGTPVVIVDDVVTTGASGLQAAEKAEEAGLKVVKILALVD
HHHHHHHCCCHHHCCCCCEECCCCEEEECCHHHCCCHHHHHHHHHHHHHHHHHHHHHHHH
RHQGGGALYAGRGYPFEALYSIEEFRSR
CCCCCCEEEECCCCCHHHHHHHHHHHCC
>Mature Secondary Structure 
STAVTLDAPCFVICTPMSSPLDWDLARQRSELLELMRTLCYREGDFKLSSGQSSSYYID
CCEEEECCCEEEEECCCCCCCCHHHHHHHHHHHHHHHHHHHCCCCCEECCCCCCCEEEE
SKKATLHPLGALLAGSLLYERLPEGTAAIGGLTLGADPIVTAVAVVSALRHPAGGVGAFI
CCCCHHHHHHHHHHHHHHHHHCCCCHHHHCCEECCCHHHHHHHHHHHHHHCCCCCHHHHH
VRKEVKKHGSQQWIEGPSLAVGTPVVIVDDVVTTGASGLQAAEKAEEAGLKVVKILALVD
HHHHHHHCCCHHHCCCCCEECCCCEEEECCHHHCCCHHHHHHHHHHHHHHHHHHHHHHHH
RHQGGGALYAGRGYPFEALYSIEEFRSR
CCCCCCEEEECCCCCHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11759840 [H]