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The map label for this gene is lacF [H]

Identifier: 37523844

GI number: 37523844

Start: 4496260

End: 4497123

Strand: Reverse

Name: lacF [H]

Synonym: gll4275

Alternate gene names: 37523844

Gene position: 4497123-4496260 (Counterclockwise)

Preceding gene: 37523845

Following gene: 37523843

Centisome position: 96.53

GC content: 61.57

Gene sequence:

>864_bases
ATGCCCAAAGGCCGACCTTTCGACACATTGAGCGCCTGGCTGTACCTTTTGCCGGCCCTGCTGCTGTTGGGCTTGTTCGT
GCTCTGGCCTGTGACCTACCTGGTCGGCCTCAGCTTCACCGACGGCTCGCTGCGCGACCCCCTATTCGTGGGCACCGCCA
ACTTTGAGCGGCTGTTGGGCAGTGAGAGCTTCCTGCAGGTGCTCGTCAATACGCTCGTATTTACTGCCGGTTCGGCGATT
CCGAGTGTGGTGCTGGCGCTTCTGGTGGCGGTGGTGCTCTCGCGGTCGGTGCCTTTGCAGGGATTGCTGCGTTCCGCTTA
CTTTCTGCCCACGATTATCTCGCTGGTAGCGGCGGGGGTAGCATTCCGCTGGCTCTTCCACCCGCAAGGCTGGGTGAACG
CGCTCGTCGCTTGGCTGGGAGCTTCGCCGGTCAGTTGGCTTTCCAGTCCCACCTGGGCGATGCCGGTGCTCATCTTCGTC
GCCACCTGGAAGCAAATCGGCTTCAATGTCGTGATTTTTCTGGCGGGCCTGGGCGCGGTGCCCAAGAACCGCTACGAAGC
GGCCGAACTCGATGGGGCCAACGGCTGGCAGCAATTGTGGTTTATTACCGTGCCGGGCATCCGGCCAACCCTCGTGTTCG
CCACGATCACCACGGTCATTTTTACTTTTAGGAGCTTTGAGCCGGTCTACGTGATGACCGGCGGCGGTCCGCTCGGCACC
ACGAACATTCTGGTCTACTACGTTTGGGAGCAAGCCTTCGGTCTGTTCAACTTCGGCCTATCGGCCGCCGCCGCCACCTT
GCTGCTGGTGGGAGTGCTGCTGGTGACCGCTATCCAGCTCTGGGCGGCAAGCGGCGAAGATTGA

Upstream 100 bases:

>100_bases
GGCGCGGCTATCCATTCGAGGCGTTGTATTCGATCGAAGAATTTCGCAGCCGTTAGGCCGGTGTGCTACGTGTATTCTGC
AAAGCGGTGCACCGAGTGCC

Downstream 100 bases:

>100_bases
CGAAACGCTCTTCGCGGGCCGCCAGAATGCACAACATGTTTGAACGCCGCTGTGTCTCACCGGCGAGGCTCTTGCGCACT
AGTCCCGATTGACCGAGAAT

Product: sugar transport inner membrane protein

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 287; Mature: 286

Protein sequence:

>287_residues
MPKGRPFDTLSAWLYLLPALLLLGLFVLWPVTYLVGLSFTDGSLRDPLFVGTANFERLLGSESFLQVLVNTLVFTAGSAI
PSVVLALLVAVVLSRSVPLQGLLRSAYFLPTIISLVAAGVAFRWLFHPQGWVNALVAWLGASPVSWLSSPTWAMPVLIFV
ATWKQIGFNVVIFLAGLGAVPKNRYEAAELDGANGWQQLWFITVPGIRPTLVFATITTVIFTFRSFEPVYVMTGGGPLGT
TNILVYYVWEQAFGLFNFGLSAAAATLLLVGVLLVTAIQLWAASGED

Sequences:

>Translated_287_residues
MPKGRPFDTLSAWLYLLPALLLLGLFVLWPVTYLVGLSFTDGSLRDPLFVGTANFERLLGSESFLQVLVNTLVFTAGSAI
PSVVLALLVAVVLSRSVPLQGLLRSAYFLPTIISLVAAGVAFRWLFHPQGWVNALVAWLGASPVSWLSSPTWAMPVLIFV
ATWKQIGFNVVIFLAGLGAVPKNRYEAAELDGANGWQQLWFITVPGIRPTLVFATITTVIFTFRSFEPVYVMTGGGPLGT
TNILVYYVWEQAFGLFNFGLSAAAATLLLVGVLLVTAIQLWAASGED
>Mature_286_residues
PKGRPFDTLSAWLYLLPALLLLGLFVLWPVTYLVGLSFTDGSLRDPLFVGTANFERLLGSESFLQVLVNTLVFTAGSAIP
SVVLALLVAVVLSRSVPLQGLLRSAYFLPTIISLVAAGVAFRWLFHPQGWVNALVAWLGASPVSWLSSPTWAMPVLIFVA
TWKQIGFNVVIFLAGLGAVPKNRYEAAELDGANGWQQLWFITVPGIRPTLVFATITTVIFTFRSFEPVYVMTGGGPLGTT
NILVYYVWEQAFGLFNFGLSAAAATLLLVGVLLVTAIQLWAASGED

Specific function: Part of the binding-protein-dependent transport system for lactose. Probably responsible for the translocation of the substrate across the membrane [H]

COG id: COG1175

COG function: function code G; ABC-type sugar transport systems, permease components

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 ABC transmembrane type-1 domain [H]

Homologues:

Organism=Escherichia coli, GI1787570, Length=263, Percent_Identity=29.6577946768061, Blast_Score=98, Evalue=5e-22,
Organism=Escherichia coli, GI1789861, Length=292, Percent_Identity=27.3972602739726, Blast_Score=91, Evalue=8e-20,
Organism=Escherichia coli, GI1790465, Length=253, Percent_Identity=31.6205533596838, Blast_Score=89, Evalue=3e-19,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000515 [H]

Pfam domain/function: PF00528 BPD_transp_1 [H]

EC number: NA

Molecular weight: Translated: 31084; Mature: 30953

Theoretical pI: Translated: 7.51; Mature: 7.51

Prosite motif: PS50928 ABC_TM1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
1.0 %Met     (Translated Protein)
1.0 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
0.7 %Met     (Mature Protein)
0.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPKGRPFDTLSAWLYLLPALLLLGLFVLWPVTYLVGLSFTDGSLRDPLFVGTANFERLLG
CCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCEEEECCHHHHHHC
SESFLQVLVNTLVFTAGSAIPSVVLALLVAVVLSRSVPLQGLLRSAYFLPTIISLVAAGV
CHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHH
AFRWLFHPQGWVNALVAWLGASPVSWLSSPTWAMPVLIFVATWKQIGFNVVIFLAGLGAV
HHHHHCCCCHHHHHHHHHHCCCCHHHHCCCCHHHHHHHHHHHHHHHCHHHHHHHHHCCCC
PKNRYEAAELDGANGWQQLWFITVPGIRPTLVFATITTVIFTFRSFEPVYVMTGGGPLGT
CCCCCCHHHCCCCCCCEEEEEEECCCCCHHHHHHHHHHHHHHHHCCCCEEEEECCCCCCH
TNILVYYVWEQAFGLFNFGLSAAAATLLLVGVLLVTAIQLWAASGED
HHHHEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCC
>Mature Secondary Structure 
PKGRPFDTLSAWLYLLPALLLLGLFVLWPVTYLVGLSFTDGSLRDPLFVGTANFERLLG
CCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCEEEECCHHHHHHC
SESFLQVLVNTLVFTAGSAIPSVVLALLVAVVLSRSVPLQGLLRSAYFLPTIISLVAAGV
CHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHH
AFRWLFHPQGWVNALVAWLGASPVSWLSSPTWAMPVLIFVATWKQIGFNVVIFLAGLGAV
HHHHHCCCCHHHHHHHHHHCCCCHHHHCCCCHHHHHHHHHHHHHHHCHHHHHHHHHCCCC
PKNRYEAAELDGANGWQQLWFITVPGIRPTLVFATITTVIFTFRSFEPVYVMTGGGPLGT
CCCCCCHHHCCCCCCCEEEEEEECCCCCHHHHHHHHHHHHHHHHCCCCEEEEECCCCCCH
TNILVYYVWEQAFGLFNFGLSAAAATLLLVGVLLVTAIQLWAASGED
HHHHEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: 1630315 [H]