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The map label for this gene is speA

Identifier: 37523639

GI number: 37523639

Start: 4262997

End: 4264931

Strand: Reverse

Name: speA

Synonym: gll4070

Alternate gene names: 37523639

Gene position: 4264931-4262997 (Counterclockwise)

Preceding gene: 37523640

Following gene: 37523638

Centisome position: 91.54

GC content: 61.24

Gene sequence:

>1935_bases
ATGCAAGATTGGACAATCGAAGACAGCGCCGAGCTGTACCAGATTCACGGTTGGGGGGAGCCCTACTTCAAGATCAACGA
CAAAGGGCACGTCGCTGTGATGCCGCGCGGCGAGGGCAACGGTGAGATCGACCTGTTCCACCTGGTGCAAGACATCCAGA
AGCGCGGCCTGAACATGCCGATGCTGATTCGCTTCTCCGATATCCTGGCCGACCGCATCGCCCGCCTCAACGCCTGCTTT
GTCGAGGCCATCCGCGAATACGACTACCCGGGGATCTACAAAGGCGTCTACCCGGTCAAGGTCAACCAGCAGCGCCACGT
CGTCGAGGAAGTGGTCGAATTTGGCCGGCCCTTTCAATATGGTCTGGAAGCAGGTTCCAAGCCCGAACTGCTCATCGCCC
TGGCCACCCTCAAGACGCCGGGGGCCTTGATTATCTGCAACGGCTACAAAGACAGCGAATATATCGAGACGGCGCTGTTG
GCCCAACGGCTCGGCCACACCCCTTTCGTGGTGATCGAACGCTTTCACGAGTTGACGCTGCTCATCGAAGCGGCCCAAAA
GCTCGGCATCCGTCCGCTCATCGGTGTGCGGGCCAAGCTTACCGCCCGGGGCATCGGGCGCTGGGGCGATTCCACCGGCG
ATCGAGCCAAATTCGGCCTGAGCGCCGGGGAGATCATGGAGGTGGTGGCCCAACTCAAAGCCGCCGACTTGCTTTCCTCG
CTGCAACTGCTGCACTTTCACATCGGCTCGCAAATCTCGGCCATCAACGTGATCAAGACGGCCCTGCGCGAGGCGTCCTG
CGTCTACGTCGAACTTGCGCAGATGGGAGCCCCCATGCAGTACTGCGACGTGGGCGGGGGGCTGGCCATCGACTATGACG
GCTCGAAGACCAACTTTCGCGCCTCCAAAAACTACAACATGCAGGAGTACGCCTACGACGTGGTGGCCGCCTTCCAGGAC
GCCTGCCGCACCAAGAACGTGCCGGTGCCGACCCTGGTGAGCGAGTCGGGTCGGGCGATCACCAGCCACCAGTCGGTGCT
CGTCTTCGATGTGATGGGGGTGAGCCACCTGCAATTCGGCGAACCGGAGCCTCCCGCCCGCAACGAGCACTCGATCATCC
GCAACCTCTACGAGACCTATACCCAGATCACCCCCGACAACGTGCAAGAAGCCTTCAACGACGCTTCGCAATTTAAAGAA
GAAGCCCTCAGCCTTTTTGCTCTGGGCTACTTGGGCCTGGGGGAACGCGCCCGGGCCGAGCGGCTCTACTGGGGCTGCTG
CGAGAAGATCCTCAACCTGGTGCGCGAACTCGACTACATCCCGGACGAGCTGGCGGACCTCGAGAAGAATATGGCTTCGA
CCTACTACTGCAACTTCTCGGTCTTCCAGTCCGCCCCCGATAGTTGGGCCATCGACCAGCTCTTTCCGATCATGCCCATC
CACAGGCTGGACGAGGAGCCCAAGGCCCGCGGCACCCTCGCGGATCTCACCTGCGACAGCGACGGCAAAATCGACCAGTT
TATCGACCTGCGCGACGTCAAGGGCGTGCTCGAACTGCACCCGGTGCGGCCGGAGGAACCCTATTACCTGGGGATGTTCC
TCAACGGTGCCTACCAAGAAATTCTGGGGGACATGCACAACCTGTTCGGCGACACCAACACCGTTCACATTCATCTCGCC
TCCGACGAGCCGGGCGAGCAGAGTTACCGGCTTGAACACGTCGTCAAGGGCGACACGATGACCGAGGTGCTCAAGTACGT
CCAGTACGACCACGAAGCGATGCTGGAGAGTATTCGCCGCGAGACCGAGCAGGCGCTCAGGGAGCGGCGCATCACCCTGA
GCGAATCGCGGTTGTTGCTGCAGCACTACGAGCGCTCCTTGAGCGGCTACACCTACCTCACCAACGAACTCCAGGTCGAA
CTGGCCGCGCGCTAG

Upstream 100 bases:

>100_bases
TCTTCTTAGGCCCGACGGGAGTCTGCGACCACACGCTTAATCAACCGATAAACAATAATGGGTAAGCTTTGGGTTTGTTT
CCGGGCCGAGAGGGACAGGC

Downstream 100 bases:

>100_bases
GGTGGCGGGATCGCCCGCCCGAAACTGCTGGACGAGGCGCTCGTCCGGCTTGCCGGGGTGATTGGGGCTGAGTGCCAACT
GCGTCAGTACCGGATTGCGT

Product: arginine decarboxylase

Products: NA

Alternate protein names: ADC

Number of amino acids: Translated: 644; Mature: 644

Protein sequence:

>644_residues
MQDWTIEDSAELYQIHGWGEPYFKINDKGHVAVMPRGEGNGEIDLFHLVQDIQKRGLNMPMLIRFSDILADRIARLNACF
VEAIREYDYPGIYKGVYPVKVNQQRHVVEEVVEFGRPFQYGLEAGSKPELLIALATLKTPGALIICNGYKDSEYIETALL
AQRLGHTPFVVIERFHELTLLIEAAQKLGIRPLIGVRAKLTARGIGRWGDSTGDRAKFGLSAGEIMEVVAQLKAADLLSS
LQLLHFHIGSQISAINVIKTALREASCVYVELAQMGAPMQYCDVGGGLAIDYDGSKTNFRASKNYNMQEYAYDVVAAFQD
ACRTKNVPVPTLVSESGRAITSHQSVLVFDVMGVSHLQFGEPEPPARNEHSIIRNLYETYTQITPDNVQEAFNDASQFKE
EALSLFALGYLGLGERARAERLYWGCCEKILNLVRELDYIPDELADLEKNMASTYYCNFSVFQSAPDSWAIDQLFPIMPI
HRLDEEPKARGTLADLTCDSDGKIDQFIDLRDVKGVLELHPVRPEEPYYLGMFLNGAYQEILGDMHNLFGDTNTVHIHLA
SDEPGEQSYRLEHVVKGDTMTEVLKYVQYDHEAMLESIRRETEQALRERRITLSESRLLLQHYERSLSGYTYLTNELQVE
LAAR

Sequences:

>Translated_644_residues
MQDWTIEDSAELYQIHGWGEPYFKINDKGHVAVMPRGEGNGEIDLFHLVQDIQKRGLNMPMLIRFSDILADRIARLNACF
VEAIREYDYPGIYKGVYPVKVNQQRHVVEEVVEFGRPFQYGLEAGSKPELLIALATLKTPGALIICNGYKDSEYIETALL
AQRLGHTPFVVIERFHELTLLIEAAQKLGIRPLIGVRAKLTARGIGRWGDSTGDRAKFGLSAGEIMEVVAQLKAADLLSS
LQLLHFHIGSQISAINVIKTALREASCVYVELAQMGAPMQYCDVGGGLAIDYDGSKTNFRASKNYNMQEYAYDVVAAFQD
ACRTKNVPVPTLVSESGRAITSHQSVLVFDVMGVSHLQFGEPEPPARNEHSIIRNLYETYTQITPDNVQEAFNDASQFKE
EALSLFALGYLGLGERARAERLYWGCCEKILNLVRELDYIPDELADLEKNMASTYYCNFSVFQSAPDSWAIDQLFPIMPI
HRLDEEPKARGTLADLTCDSDGKIDQFIDLRDVKGVLELHPVRPEEPYYLGMFLNGAYQEILGDMHNLFGDTNTVHIHLA
SDEPGEQSYRLEHVVKGDTMTEVLKYVQYDHEAMLESIRRETEQALRERRITLSESRLLLQHYERSLSGYTYLTNELQVE
LAAR
>Mature_644_residues
MQDWTIEDSAELYQIHGWGEPYFKINDKGHVAVMPRGEGNGEIDLFHLVQDIQKRGLNMPMLIRFSDILADRIARLNACF
VEAIREYDYPGIYKGVYPVKVNQQRHVVEEVVEFGRPFQYGLEAGSKPELLIALATLKTPGALIICNGYKDSEYIETALL
AQRLGHTPFVVIERFHELTLLIEAAQKLGIRPLIGVRAKLTARGIGRWGDSTGDRAKFGLSAGEIMEVVAQLKAADLLSS
LQLLHFHIGSQISAINVIKTALREASCVYVELAQMGAPMQYCDVGGGLAIDYDGSKTNFRASKNYNMQEYAYDVVAAFQD
ACRTKNVPVPTLVSESGRAITSHQSVLVFDVMGVSHLQFGEPEPPARNEHSIIRNLYETYTQITPDNVQEAFNDASQFKE
EALSLFALGYLGLGERARAERLYWGCCEKILNLVRELDYIPDELADLEKNMASTYYCNFSVFQSAPDSWAIDQLFPIMPI
HRLDEEPKARGTLADLTCDSDGKIDQFIDLRDVKGVLELHPVRPEEPYYLGMFLNGAYQEILGDMHNLFGDTNTVHIHLA
SDEPGEQSYRLEHVVKGDTMTEVLKYVQYDHEAMLESIRRETEQALRERRITLSESRLLLQHYERSLSGYTYLTNELQVE
LAAR

Specific function: Catalyzes the biosynthesis of agmatine from arginine

COG id: COG1166

COG function: function code E; Arginine decarboxylase (spermidine biosynthesis)

Gene ontology:

Cell location: Periplasmic Protein [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the Orn/Lys/Arg decarboxylase class-II family. SpeA subfamily

Homologues:

Organism=Escherichia coli, GI1789307, Length=630, Percent_Identity=39.3650793650794, Blast_Score=486, Evalue=1e-138,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): SPEA_GLOVI (Q7NE10)

Other databases:

- EMBL:   BA000045
- RefSeq:   NP_927016.1
- ProteinModelPortal:   Q7NE10
- GeneID:   2602453
- GenomeReviews:   BA000045_GR
- KEGG:   gvi:gll4070
- NMPDR:   fig|251221.1.peg.4070
- HOGENOM:   HBG321436
- OMA:   TCDSDGE
- ProtClustDB:   PRK05354
- BioCyc:   GVIO251221:GLL4070-MONOMER
- BRENDA:   4.1.1.19
- HAMAP:   MF_01417
- InterPro:   IPR009006
- InterPro:   IPR002985
- InterPro:   IPR022643
- InterPro:   IPR022644
- InterPro:   IPR022653
- InterPro:   IPR000183
- Gene3D:   G3DSA:2.40.37.10
- PANTHER:   PTHR11482:SF3
- PIRSF:   PIRSF001336
- PRINTS:   PR01180
- PRINTS:   PR01179
- TIGRFAMs:   TIGR01273

Pfam domain/function: PF02784 Orn_Arg_deC_N; PF00278 Orn_DAP_Arg_deC

EC number: =4.1.1.19

Molecular weight: Translated: 72695; Mature: 72695

Theoretical pI: Translated: 4.88; Mature: 4.88

Prosite motif: PS00878 ODR_DC_2_1; PS00879 ODR_DC_2_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.4 %Cys     (Translated Protein)
2.3 %Met     (Translated Protein)
3.7 %Cys+Met (Translated Protein)
1.4 %Cys     (Mature Protein)
2.3 %Met     (Mature Protein)
3.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MQDWTIEDSAELYQIHGWGEPYFKINDKGHVAVMPRGEGNGEIDLFHLVQDIQKRGLNMP
CCCCCCCCCCCEEEEECCCCCCEEECCCCCEEEEECCCCCCCCHHHHHHHHHHHCCCCCC
MLIRFSDILADRIARLNACFVEAIREYDYPGIYKGVYPVKVNQQRHVVEEVVEFGRPFQY
EEEHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCEEEEEECCHHHHHHHHHHHCCCEEH
GLEAGSKPELLIALATLKTPGALIICNGYKDSEYIETALLAQRLGHTPFVVIERFHELTL
HCCCCCCCCEEEEEEECCCCCEEEEECCCCCHHHHHHHHHHHHHCCCHHHHHHHHHHHHH
LIEAAQKLGIRPLIGVRAKLTARGIGRWGDSTGDRAKFGLSAGEIMEVVAQLKAADLLSS
HHHHHHHCCCCCHHCCHHHHHHCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHH
LQLLHFHIGSQISAINVIKTALREASCVYVELAQMGAPMQYCDVGGGLAIDYDGSKTNFR
HHHHHHHHCCCHHHHHHHHHHHHHCHHHEEEHHHHCCCCHHHCCCCCEEEEECCCCCCEE
ASKNYNMQEYAYDVVAAFQDACRTKNVPVPTLVSESGRAITSHQSVLVFDVMGVSHLQFG
CCCCCCHHHHHHHHHHHHHHHHHCCCCCCCCEECCCCCEEECCCCEEEEEECCCHHCCCC
EPEPPARNEHSIIRNLYETYTQITPDNVQEAFNDASQFKEEALSLFALGYLGLGERARAE
CCCCCCCCHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHH
RLYWGCCEKILNLVRELDYIPDELADLEKNMASTYYCNFSVFQSAPDSWAIDQLFPIMPI
HHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHEEEEEEHHHHCCCCCCCHHHHHCCCCH
HRLDEEPKARGTLADLTCDSDGKIDQFIDLRDVKGVLELHPVRPEEPYYLGMFLNGAYQE
HHCCCCCCCCCCEEEEEECCCCCHHHHCCHHHHCCHHHCCCCCCCCCEEEEEEECHHHHH
ILGDMHNLFGDTNTVHIHLASDEPGEQSYRLEHVVKGDTMTEVLKYVQYDHEAMLESIRR
HHHHHHHHCCCCCEEEEEECCCCCCCHHHHHHHHHCCCCHHHHHHHHHCCHHHHHHHHHH
ETEQALRERRITLSESRLLLQHYERSLSGYTYLTNELQVELAAR
HHHHHHHHHCCCHHHHHHHHHHHHHHHCCCEEEECEEEEEEECC
>Mature Secondary Structure
MQDWTIEDSAELYQIHGWGEPYFKINDKGHVAVMPRGEGNGEIDLFHLVQDIQKRGLNMP
CCCCCCCCCCCEEEEECCCCCCEEECCCCCEEEEECCCCCCCCHHHHHHHHHHHCCCCCC
MLIRFSDILADRIARLNACFVEAIREYDYPGIYKGVYPVKVNQQRHVVEEVVEFGRPFQY
EEEHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCEEEEEECCHHHHHHHHHHHCCCEEH
GLEAGSKPELLIALATLKTPGALIICNGYKDSEYIETALLAQRLGHTPFVVIERFHELTL
HCCCCCCCCEEEEEEECCCCCEEEEECCCCCHHHHHHHHHHHHHCCCHHHHHHHHHHHHH
LIEAAQKLGIRPLIGVRAKLTARGIGRWGDSTGDRAKFGLSAGEIMEVVAQLKAADLLSS
HHHHHHHCCCCCHHCCHHHHHHCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHH
LQLLHFHIGSQISAINVIKTALREASCVYVELAQMGAPMQYCDVGGGLAIDYDGSKTNFR
HHHHHHHHCCCHHHHHHHHHHHHHCHHHEEEHHHHCCCCHHHCCCCCEEEEECCCCCCEE
ASKNYNMQEYAYDVVAAFQDACRTKNVPVPTLVSESGRAITSHQSVLVFDVMGVSHLQFG
CCCCCCHHHHHHHHHHHHHHHHHCCCCCCCCEECCCCCEEECCCCEEEEEECCCHHCCCC
EPEPPARNEHSIIRNLYETYTQITPDNVQEAFNDASQFKEEALSLFALGYLGLGERARAE
CCCCCCCCHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHH
RLYWGCCEKILNLVRELDYIPDELADLEKNMASTYYCNFSVFQSAPDSWAIDQLFPIMPI
HHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHEEEEEEHHHHCCCCCCCHHHHHCCCCH
HRLDEEPKARGTLADLTCDSDGKIDQFIDLRDVKGVLELHPVRPEEPYYLGMFLNGAYQE
HHCCCCCCCCCCEEEEEECCCCCHHHHCCHHHHCCHHHCCCCCCCCCEEEEEEECHHHHH
ILGDMHNLFGDTNTVHIHLASDEPGEQSYRLEHVVKGDTMTEVLKYVQYDHEAMLESIRR
HHHHHHHHCCCCCEEEEEECCCCCCCHHHHHHHHHCCCCHHHHHHHHHCCHHHHHHHHHH
ETEQALRERRITLSESRLLLQHYERSLSGYTYLTNELQVELAAR
HHHHHHHHHCCCHHHHHHHHHHHHHHHCCCEEEECEEEEEEECC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 14621292