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The map label for this gene is mutS [H]

Identifier: 37523572

GI number: 37523572

Start: 4207025

End: 4208884

Strand: Reverse

Name: mutS [H]

Synonym: gll4003

Alternate gene names: 37523572

Gene position: 4208884-4207025 (Counterclockwise)

Preceding gene: 37523573

Following gene: 37523571

Centisome position: 90.34

GC content: 66.13

Gene sequence:

>1860_bases
ATGGATCTTCAGGCTGAAAAACGTTCGATCGAAGCTATCTACCAGGAGCGTTTGGAGCGCTTCGGTGCGGCGCGGCGGCT
GTACGAGCGGCGCACCGGGCGGATTGCCAACGCCCGGGTGGCGGTGTTTTTGATCGCCCTGGCCTTTGTGATCGTGGGGC
TTGCCGACCGCAACGCTTTTCAACCGCTGATGCTCACCTTGGCGGCGGCGGGCGCCGTGGGCTTTGTCGGGCTGTTGGTT
TTGTTTGGGCGCAACGAGAGGGAGCTGCGACGCCTCGAAGCGCTGGAGGAAGAGAATCGCGAAGCCCTCGCCCGTCACCG
CCGCGACTGGCAGGCGGCACCGGTCCCCGAGACGCCCGAATTTGCCGAGCAAGCCACTTTCGCGCGCGATCTGGATCTGT
TCGGGCACGCCTCGCTGTTTCAATTGACCTGCACCGCCCACACACCGATGGGCCGGAGGCTTCTGGCGCGCTGGCTGCTC
GAACCGGCCGGGCCGGCGGCGATTGCCGGGCGGCAGCGGGCGATTGCCGATCTGGCCCCTTTGCTCGACTGGCGGCAGGA
TCTGGCGGCCGCCGGTCGGTTCCTCGCCCAGAAGCCCCCCGACCCGGCGTCCTTCGTGGCCTGGGCGGAGGCTCCATCCT
GGCTCGACCAACGTCCCTGGCTTGTCTGGGTGGCGCGGCTGTCGGCCGCTGCCACGGCGGCGCTCATCGCGCTGCAGGCG
GCGGAAGTTTTGTCGTTGCCGCTGTGGCTCGGACCTTTGACGCTCAATATTGTCCTAAGCGGCATCTACACCGCTTCGAT
ACATCAAACCTTCGCCGCGGTTTCCAACCGCTCCGGCAGCGTGCGCGCCTACGCGGGGCTCTTCGCGGCGCTGTCGCGCC
TTGAATGCCGCGACGAAACCCTCAAATCCCTCCAGGCCGAAAGCCTGAATGCCGAGGATCGCCTGCGCAAGCTCGATACG
CTCGTGGGCTGTTCGGATCTGCGCTTCTCGCAACTGATCTACCTGGCGGTGCAGTGGATTACCCTCTGGGACGTACACGT
GCTGGGCTTGCTTGAAAGCTGGCGGCGGCAATCGGGGGACCGGGTGCGCAGCTGGCTTGAAGCGCTCGCCCAAATCGAAG
CGCTCGCCTCCCTCGCCTCCCTCGCCCACGACCAGCCGGAGTGGGTGTTCGCCGAGGTGGACACGCGCTTGCAAGTCATT
GCTGCCGGGCAACTGGGCCATCCACTCATCGGCGAAGCGGTGCGGGTCGCCAACGATGTCACCCTCGGTCCTCCCGGCAC
GTTTTTGCTGGTGACCGGCTCGAACATGTCCGGCAAAAGCACTTTACTGCGATCCATCGGCCTCAACATCGTGCTCGCTC
TGGCCGGGGCACCCGTGTGCGCCCGCTCGCTGAGGCTGCCGCCGGTGACGCTCAAGACGAGCATGCGCGTGCAAGATTCG
CTCGCAAGCGGTCTGTCGTTCTACATGGCCGAGCTGCAGCGGCTCAAAGAAGTAGTCGACGCTGCCCGGCCTGCGGAGCG
TCCGCTGCTGTACCTGCTCGATGAAATTTTGCTCGGCACCAACTCTGCCGAGCGGCAGGTGGCCGTGCGCCGAGTGCTCA
GCTTCCTGCTGGGTCGCGGCGCCCTGGGGGCCATCTCCACCCACGATCTGGCCCTGGCCGATCTGCCGGAATTGGCTGCG
GCCGCCCGCACGGTGCACTTTCGCGAACATTTCGCGGCGGGGGCCGCAGGACCGGTGATGACCTTTGACTACCGCATGCG
CCCCGGCGTCGCCCCGACCACCAATGCCCTCAAACTGCTGGAGTTGGTCGGCCTGGGCGACCCCGAAGATAACCGACCCG
ACGACCGGACCAACGTATAG

Upstream 100 bases:

>100_bases
AACCAGGGCATCGCCGAAAATTACCTGATGGGCGAGAGCGAATACGAGCGCTTCTTGCGGCGGATCTACTTCGGCGCCGG
ACGGGTGGTCTAGACACCCG

Downstream 100 bases:

>100_bases
CCAATCTCCTCGACCGACCAACGCAATTGGTCGTCGGTGCAACCTCTACCATCCCTAAGGAGCATGGGCTGTCTACTTTG
TGTGTTTTCGATGGTATGGG

Product: hypothetical protein

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 619; Mature: 619

Protein sequence:

>619_residues
MDLQAEKRSIEAIYQERLERFGAARRLYERRTGRIANARVAVFLIALAFVIVGLADRNAFQPLMLTLAAAGAVGFVGLLV
LFGRNERELRRLEALEEENREALARHRRDWQAAPVPETPEFAEQATFARDLDLFGHASLFQLTCTAHTPMGRRLLARWLL
EPAGPAAIAGRQRAIADLAPLLDWRQDLAAAGRFLAQKPPDPASFVAWAEAPSWLDQRPWLVWVARLSAAATAALIALQA
AEVLSLPLWLGPLTLNIVLSGIYTASIHQTFAAVSNRSGSVRAYAGLFAALSRLECRDETLKSLQAESLNAEDRLRKLDT
LVGCSDLRFSQLIYLAVQWITLWDVHVLGLLESWRRQSGDRVRSWLEALAQIEALASLASLAHDQPEWVFAEVDTRLQVI
AAGQLGHPLIGEAVRVANDVTLGPPGTFLLVTGSNMSGKSTLLRSIGLNIVLALAGAPVCARSLRLPPVTLKTSMRVQDS
LASGLSFYMAELQRLKEVVDAARPAERPLLYLLDEILLGTNSAERQVAVRRVLSFLLGRGALGAISTHDLALADLPELAA
AARTVHFREHFAAGAAGPVMTFDYRMRPGVAPTTNALKLLELVGLGDPEDNRPDDRTNV

Sequences:

>Translated_619_residues
MDLQAEKRSIEAIYQERLERFGAARRLYERRTGRIANARVAVFLIALAFVIVGLADRNAFQPLMLTLAAAGAVGFVGLLV
LFGRNERELRRLEALEEENREALARHRRDWQAAPVPETPEFAEQATFARDLDLFGHASLFQLTCTAHTPMGRRLLARWLL
EPAGPAAIAGRQRAIADLAPLLDWRQDLAAAGRFLAQKPPDPASFVAWAEAPSWLDQRPWLVWVARLSAAATAALIALQA
AEVLSLPLWLGPLTLNIVLSGIYTASIHQTFAAVSNRSGSVRAYAGLFAALSRLECRDETLKSLQAESLNAEDRLRKLDT
LVGCSDLRFSQLIYLAVQWITLWDVHVLGLLESWRRQSGDRVRSWLEALAQIEALASLASLAHDQPEWVFAEVDTRLQVI
AAGQLGHPLIGEAVRVANDVTLGPPGTFLLVTGSNMSGKSTLLRSIGLNIVLALAGAPVCARSLRLPPVTLKTSMRVQDS
LASGLSFYMAELQRLKEVVDAARPAERPLLYLLDEILLGTNSAERQVAVRRVLSFLLGRGALGAISTHDLALADLPELAA
AARTVHFREHFAAGAAGPVMTFDYRMRPGVAPTTNALKLLELVGLGDPEDNRPDDRTNV
>Mature_619_residues
MDLQAEKRSIEAIYQERLERFGAARRLYERRTGRIANARVAVFLIALAFVIVGLADRNAFQPLMLTLAAAGAVGFVGLLV
LFGRNERELRRLEALEEENREALARHRRDWQAAPVPETPEFAEQATFARDLDLFGHASLFQLTCTAHTPMGRRLLARWLL
EPAGPAAIAGRQRAIADLAPLLDWRQDLAAAGRFLAQKPPDPASFVAWAEAPSWLDQRPWLVWVARLSAAATAALIALQA
AEVLSLPLWLGPLTLNIVLSGIYTASIHQTFAAVSNRSGSVRAYAGLFAALSRLECRDETLKSLQAESLNAEDRLRKLDT
LVGCSDLRFSQLIYLAVQWITLWDVHVLGLLESWRRQSGDRVRSWLEALAQIEALASLASLAHDQPEWVFAEVDTRLQVI
AAGQLGHPLIGEAVRVANDVTLGPPGTFLLVTGSNMSGKSTLLRSIGLNIVLALAGAPVCARSLRLPPVTLKTSMRVQDS
LASGLSFYMAELQRLKEVVDAARPAERPLLYLLDEILLGTNSAERQVAVRRVLSFLLGRGALGAISTHDLALADLPELAA
AARTVHFREHFAAGAAGPVMTFDYRMRPGVAPTTNALKLLELVGLGDPEDNRPDDRTNV

Specific function: This protein is involved in the repair of mismatches in DNA. It is possible that it carries out the mismatch recognition step. This protein has a weak ATPase activity [H]

COG id: COG0249

COG function: function code L; Mismatch repair ATPase (MutS family)

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the DNA mismatch repair mutS family [H]

Homologues:

Organism=Homo sapiens, GI36949366, Length=215, Percent_Identity=28.3720930232558, Blast_Score=72, Evalue=1e-12,
Organism=Escherichia coli, GI1789089, Length=245, Percent_Identity=28.5714285714286, Blast_Score=74, Evalue=4e-14,
Organism=Drosophila melanogaster, GI24664545, Length=258, Percent_Identity=27.1317829457364, Blast_Score=74, Evalue=3e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005748
- InterPro:   IPR007695
- InterPro:   IPR000432
- InterPro:   IPR007861
- InterPro:   IPR007860
- InterPro:   IPR007696
- InterPro:   IPR016151 [H]

Pfam domain/function: PF01624 MutS_I; PF05188 MutS_II; PF05192 MutS_III; PF05190 MutS_IV; PF00488 MutS_V [H]

EC number: NA

Molecular weight: Translated: 67700; Mature: 67700

Theoretical pI: Translated: 7.67; Mature: 7.67

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
1.3 %Met     (Translated Protein)
1.9 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
1.3 %Met     (Mature Protein)
1.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MDLQAEKRSIEAIYQERLERFGAARRLYERRTGRIANARVAVFLIALAFVIVGLADRNAF
CCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHCCCCH
QPLMLTLAAAGAVGFVGLLVLFGRNERELRRLEALEEENREALARHRRDWQAAPVPETPE
HHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCHH
FAEQATFARDLDLFGHASLFQLTCTAHTPMGRRLLARWLLEPAGPAAIAGRQRAIADLAP
HHHHHHHHHHHHHHCCCCEEEEEEECCCCHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHH
LLDWRQDLAAAGRFLAQKPPDPASFVAWAEAPSWLDQRPWLVWVARLSAAATAALIALQA
HHHHHHHHHHHHHHHHCCCCCCHHHEEHHCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHH
AEVLSLPLWLGPLTLNIVLSGIYTASIHQTFAAVSNRSGSVRAYAGLFAALSRLECRDET
HHHHHCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHH
LKSLQAESLNAEDRLRKLDTLVGCSDLRFSQLIYLAVQWITLWDVHVLGLLESWRRQSGD
HHHHHHHCCCHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCH
RVRSWLEALAQIEALASLASLAHDQPEWVFAEVDTRLQVIAAGQLGHPLIGEAVRVANDV
HHHHHHHHHHHHHHHHHHHHHCCCCCCEEEEECCCCEEEEECCCCCCCHHHHHHHHHCCC
TLGPPGTFLLVTGSNMSGKSTLLRSIGLNIVLALAGAPVCARSLRLPPVTLKTSMRVQDS
EECCCCCEEEEECCCCCHHHHHHHHHHHHHHHHHHCCHHHHHHCCCCCEEHHHHHHHHHH
LASGLSFYMAELQRLKEVVDAARPAERPLLYLLDEILLGTNSAERQVAVRRVLSFLLGRG
HHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHCCCCHHHHHHHHHHHHHHHCCC
ALGAISTHDLALADLPELAAAARTVHFREHFAAGAAGPVMTFDYRMRPGVAPTTNALKLL
CCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCEEEEEEECCCCCCCHHHHHHH
ELVGLGDPEDNRPDDRTNV
HHHCCCCCCCCCCCCCCCC
>Mature Secondary Structure
MDLQAEKRSIEAIYQERLERFGAARRLYERRTGRIANARVAVFLIALAFVIVGLADRNAF
CCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHCCCCH
QPLMLTLAAAGAVGFVGLLVLFGRNERELRRLEALEEENREALARHRRDWQAAPVPETPE
HHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCHH
FAEQATFARDLDLFGHASLFQLTCTAHTPMGRRLLARWLLEPAGPAAIAGRQRAIADLAP
HHHHHHHHHHHHHHCCCCEEEEEEECCCCHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHH
LLDWRQDLAAAGRFLAQKPPDPASFVAWAEAPSWLDQRPWLVWVARLSAAATAALIALQA
HHHHHHHHHHHHHHHHCCCCCCHHHEEHHCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHH
AEVLSLPLWLGPLTLNIVLSGIYTASIHQTFAAVSNRSGSVRAYAGLFAALSRLECRDET
HHHHHCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHH
LKSLQAESLNAEDRLRKLDTLVGCSDLRFSQLIYLAVQWITLWDVHVLGLLESWRRQSGD
HHHHHHHCCCHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCH
RVRSWLEALAQIEALASLASLAHDQPEWVFAEVDTRLQVIAAGQLGHPLIGEAVRVANDV
HHHHHHHHHHHHHHHHHHHHHCCCCCCEEEEECCCCEEEEECCCCCCCHHHHHHHHHCCC
TLGPPGTFLLVTGSNMSGKSTLLRSIGLNIVLALAGAPVCARSLRLPPVTLKTSMRVQDS
EECCCCCEEEEECCCCCHHHHHHHHHHHHHHHHHHCCHHHHHHCCCCCEEHHHHHHHHHH
LASGLSFYMAELQRLKEVVDAARPAERPLLYLLDEILLGTNSAERQVAVRRVLSFLLGRG
HHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHCCCCHHHHHHHHHHHHHHHCCC
ALGAISTHDLALADLPELAAAARTVHFREHFAAGAAGPVMTFDYRMRPGVAPTTNALKLL
CCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCEEEEEEECCCCCCCHHHHHHH
ELVGLGDPEDNRPDDRTNV
HHHCCCCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 12566566 [H]