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The map label for this gene is lon [H]

Identifier: 37523537

GI number: 37523537

Start: 4168445

End: 4169083

Strand: Direct

Name: lon [H]

Synonym: glr3968

Alternate gene names: 37523537

Gene position: 4168445-4169083 (Clockwise)

Preceding gene: 37523536

Following gene: 37523538

Centisome position: 89.47

GC content: 60.09

Gene sequence:

>639_bases
ATGAGTCTTTCCTTCTCACTCGCCGTACAGGAATTGCCGCTCTTTCCGCTGCCGGATGTGGTGCTGTTTCCAGGACGGCC
ATTGCCGCTGCACATCTTCGAGCCGCGCTACCGGATGATGATGAACACGGTGCTCGACACCGACTGCCGCTTCGGGGTGC
TGCTGTGGGATCAAGAGACCAAGCAGCCGGCACGGGTCGGCAGCTGCGCCGAAATCACCCAGGTCGACCGCCTGCCTGAC
GACCGGATGAACGTTTTGACCGTGGGGATCAAGCGCTTTCGGGTTCTGGAGTACACCCGCCAGAAACCCTACCGGGTGGG
TCTGGTGCAGTGGATCGACGACGAGCCGGTCGAAGGCGATCTCAGCGCCCTGACCCAGGAAGCCAAAAAACTGCTCGCCG
ATGTGGTGCGCCTCTCCAGTAAGCTGATGGAGAAACCGCTCCAGTTGCCGACACTTCCGGAGGAGCCCCTCGAACTTTCC
TACTGGATTGGGGGCAGCTTCTACGGTGCTTCCGAAGAACAGCAGGCGCTATTGGAACTGCAAGATACTGCCCGGCGTCT
CCAGCGCGAGATCGACATTCTGCAGACCACCCTCAAGCATCTGGCTGCCAGGACGGTTCTCAAAGACACCTTGAGCTAG

Upstream 100 bases:

>100_bases
CCCAGGCCCGTCTTCGCATTGAGGAATTGGCCCGCGCGAGCGAGGTTGACCTCATCACCGTCGAGCTCGTCCAAAAAGCC
CGTTTGGAGTTTGGTCAATA

Downstream 100 bases:

>100_bases
CGACGGCGTCCACTATGCACATCGGCGTTCCCAAAGAAATCAAAGATCAGGAATTCAGGGTCGGTTTGACTCCGGCGGCG
GTGCGCGCTTTGAGCGATCA

Product: ATP-dependent protease

Products: NA

Alternate protein names: ATP-dependent protease La [H]

Number of amino acids: Translated: 212; Mature: 211

Protein sequence:

>212_residues
MSLSFSLAVQELPLFPLPDVVLFPGRPLPLHIFEPRYRMMMNTVLDTDCRFGVLLWDQETKQPARVGSCAEITQVDRLPD
DRMNVLTVGIKRFRVLEYTRQKPYRVGLVQWIDDEPVEGDLSALTQEAKKLLADVVRLSSKLMEKPLQLPTLPEEPLELS
YWIGGSFYGASEEQQALLELQDTARRLQREIDILQTTLKHLAARTVLKDTLS

Sequences:

>Translated_212_residues
MSLSFSLAVQELPLFPLPDVVLFPGRPLPLHIFEPRYRMMMNTVLDTDCRFGVLLWDQETKQPARVGSCAEITQVDRLPD
DRMNVLTVGIKRFRVLEYTRQKPYRVGLVQWIDDEPVEGDLSALTQEAKKLLADVVRLSSKLMEKPLQLPTLPEEPLELS
YWIGGSFYGASEEQQALLELQDTARRLQREIDILQTTLKHLAARTVLKDTLS
>Mature_211_residues
SLSFSLAVQELPLFPLPDVVLFPGRPLPLHIFEPRYRMMMNTVLDTDCRFGVLLWDQETKQPARVGSCAEITQVDRLPDD
RMNVLTVGIKRFRVLEYTRQKPYRVGLVQWIDDEPVEGDLSALTQEAKKLLADVVRLSSKLMEKPLQLPTLPEEPLELSY
WIGGSFYGASEEQQALLELQDTARRLQREIDILQTTLKHLAARTVLKDTLS

Specific function: ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced

COG id: COG2802

COG function: function code R; Uncharacterized protein, similar to the N-terminal domain of Lon protease

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 Lon domain [H]

Homologues:

Organism=Homo sapiens, GI148528975, Length=112, Percent_Identity=36.6071428571429, Blast_Score=77, Evalue=1e-14,
Organism=Homo sapiens, GI73747840, Length=115, Percent_Identity=35.6521739130435, Blast_Score=74, Evalue=1e-13,
Organism=Homo sapiens, GI37622896, Length=115, Percent_Identity=35.6521739130435, Blast_Score=73, Evalue=2e-13,
Organism=Homo sapiens, GI87080813, Length=113, Percent_Identity=35.3982300884956, Blast_Score=69, Evalue=3e-12,

Paralogues:

None

Copy number: 2,000 Molecules/Cell In: Glucose minimal media [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003593
- InterPro:   IPR003959
- InterPro:   IPR008269
- InterPro:   IPR004815
- InterPro:   IPR003111
- InterPro:   IPR008268
- InterPro:   IPR001984
- InterPro:   IPR015947
- InterPro:   IPR020568 [H]

Pfam domain/function: PF00004 AAA; PF02190 LON; PF05362 Lon_C [H]

EC number: =3.4.21.53 [H]

Molecular weight: Translated: 24278; Mature: 24146

Theoretical pI: Translated: 4.97; Mature: 4.97

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
2.8 %Met     (Translated Protein)
3.8 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
2.4 %Met     (Mature Protein)
3.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSLSFSLAVQELPLFPLPDVVLFPGRPLPLHIFEPRYRMMMNTVLDTDCRFGVLLWDQET
CCCCHHHHHHHCCCCCCCCEEEECCCCCEEEEECHHHHHHHHHHHCCCCCEEEEEECCCC
KQPARVGSCAEITQVDRLPDDRMNVLTVGIKRFRVLEYTRQKPYRVGLVQWIDDEPVEGD
CCCHHCCCHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHCCCEEEHHEEECCCCCCCCH
LSALTQEAKKLLADVVRLSSKLMEKPLQLPTLPEEPLELSYWIGGSFYGASEEQQALLEL
HHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCEEEEEECCEECCCCHHHHHHHHH
QDTARRLQREIDILQTTLKHLAARTVLKDTLS
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCC
>Mature Secondary Structure 
SLSFSLAVQELPLFPLPDVVLFPGRPLPLHIFEPRYRMMMNTVLDTDCRFGVLLWDQET
CCCHHHHHHHCCCCCCCCEEEECCCCCEEEEECHHHHHHHHHHHCCCCCEEEEEECCCC
KQPARVGSCAEITQVDRLPDDRMNVLTVGIKRFRVLEYTRQKPYRVGLVQWIDDEPVEGD
CCCHHCCCHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHCCCEEEHHEEECCCCCCCCH
LSALTQEAKKLLADVVRLSSKLMEKPLQLPTLPEEPLELSYWIGGSFYGASEEQQALLEL
HHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCEEEEEECCEECCCCHHHHHHHHH
QDTARRLQREIDILQTTLKHLAARTVLKDTLS
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA