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The map label for this gene is ald [H]

Identifier: 37523538

GI number: 37523538

Start: 4169098

End: 4170192

Strand: Direct

Name: ald [H]

Synonym: glr3969

Alternate gene names: 37523538

Gene position: 4169098-4170192 (Clockwise)

Preceding gene: 37523537

Following gene: 37523539

Centisome position: 89.48

GC content: 65.48

Gene sequence:

>1095_bases
ATGCACATCGGCGTTCCCAAAGAAATCAAAGATCAGGAATTCAGGGTCGGTTTGACTCCGGCGGCGGTGCGCGCTTTGAG
CGATCAGGGCCACAGCGTGGCTATCGAAGCGCGGGCGGGGGAGGGATCCGGCTTTACTGACCGGGACTATCTGGAGGCCG
GTGCCCGCATCGTGGAGACCGCCGCGGAGGTCTACGCCCAGCCGATGATCGTCAAAGTCAAAGAGCCCCTGCCCCTGGAG
TACGCCCTGCTGGGCAAGGGCCAGATTCTTTTTACTTATTTGCATCTGGCGGCGAGCCGCGAGTTGACCGAGGCGTTGCT
CAACTCAGGAGCCACCTGCATCGCCTACGAGACCGTGGCCCTGGCCGACGGGCGCCTGCCGCTGCTCACGCCGATGAGTG
CAATCGCGGGCCGTCTGGCGGTGCAGTTCGGGTCGCGCTTTCTGGAGAAGCAACAGGGTGGCCGCGGCGTACTCCTGGGT
GGGGTGCCCGGGGTGGCCGCGGGCCATGTGGCGATCTTGGGCGGCGGTATCGTCGGCACCGAGGCGGCCCGCATCGCCGT
CGGCATGGGGGCACGGGTGACGATTCTCGATGTCAACCTCGACCGGCTCGCCTACCTCGAAGATCTGTTCGGTTCGCGCG
TCGAACTGCTCTTCAGCACCCGCCGGACCATCGAACAGATGGTGCCGGGGGCGGATTTGCTGATTGGAGCGGTGCTGGTG
ACCGGGCGGCGTGCCCCCAAGCTGGTCAGCCGCGAGGTGGTGGGCCGCATGAATCCCGGCTCGGTGATCGTCGATGTGGC
CGTCGATCAGGGCGGCTGTGTGGAGACGCTCAGACCCACCTCCCACTCCGAACCGGTCTACCTCGAAGCAGGCGTCGTCC
ACTACGGCGTGCCCAATATGCCCGGGGCGGTGCCCTGGACGGCCACCCAGGCGCTCAACAACGCCACACTCCCCTACGTG
ATGAAACTGGCGGAACTGGGATATCCGCAGGCCACCGAGCGCGATCCGGCCCTTGCCTTAGGCATCAACATCGCCCACAG
CCGTCTGATCCACCCGGCGGTGCAGCAGGTCTTTCCCGATCTCATCCATGCTTGA

Upstream 100 bases:

>100_bases
GGCGTCTCCAGCGCGAGATCGACATTCTGCAGACCACCCTCAAGCATCTGGCTGCCAGGACGGTTCTCAAAGACACCTTG
AGCTAGCGACGGCGTCCACT

Downstream 100 bases:

>100_bases
GCGGGTGCTCGAACCGGAAGTCATGGATTCGCAGGCGGAGGCGGAGGCCTACGACGCCATGGACCACGGCGAGGTCAATG
CCCGTTTTGTGGCCGATGTG

Product: alanine dehydrogenase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 364; Mature: 364

Protein sequence:

>364_residues
MHIGVPKEIKDQEFRVGLTPAAVRALSDQGHSVAIEARAGEGSGFTDRDYLEAGARIVETAAEVYAQPMIVKVKEPLPLE
YALLGKGQILFTYLHLAASRELTEALLNSGATCIAYETVALADGRLPLLTPMSAIAGRLAVQFGSRFLEKQQGGRGVLLG
GVPGVAAGHVAILGGGIVGTEAARIAVGMGARVTILDVNLDRLAYLEDLFGSRVELLFSTRRTIEQMVPGADLLIGAVLV
TGRRAPKLVSREVVGRMNPGSVIVDVAVDQGGCVETLRPTSHSEPVYLEAGVVHYGVPNMPGAVPWTATQALNNATLPYV
MKLAELGYPQATERDPALALGINIAHSRLIHPAVQQVFPDLIHA

Sequences:

>Translated_364_residues
MHIGVPKEIKDQEFRVGLTPAAVRALSDQGHSVAIEARAGEGSGFTDRDYLEAGARIVETAAEVYAQPMIVKVKEPLPLE
YALLGKGQILFTYLHLAASRELTEALLNSGATCIAYETVALADGRLPLLTPMSAIAGRLAVQFGSRFLEKQQGGRGVLLG
GVPGVAAGHVAILGGGIVGTEAARIAVGMGARVTILDVNLDRLAYLEDLFGSRVELLFSTRRTIEQMVPGADLLIGAVLV
TGRRAPKLVSREVVGRMNPGSVIVDVAVDQGGCVETLRPTSHSEPVYLEAGVVHYGVPNMPGAVPWTATQALNNATLPYV
MKLAELGYPQATERDPALALGINIAHSRLIHPAVQQVFPDLIHA
>Mature_364_residues
MHIGVPKEIKDQEFRVGLTPAAVRALSDQGHSVAIEARAGEGSGFTDRDYLEAGARIVETAAEVYAQPMIVKVKEPLPLE
YALLGKGQILFTYLHLAASRELTEALLNSGATCIAYETVALADGRLPLLTPMSAIAGRLAVQFGSRFLEKQQGGRGVLLG
GVPGVAAGHVAILGGGIVGTEAARIAVGMGARVTILDVNLDRLAYLEDLFGSRVELLFSTRRTIEQMVPGADLLIGAVLV
TGRRAPKLVSREVVGRMNPGSVIVDVAVDQGGCVETLRPTSHSEPVYLEAGVVHYGVPNMPGAVPWTATQALNNATLPYV
MKLAELGYPQATERDPALALGINIAHSRLIHPAVQQVFPDLIHA

Specific function: May play a role in cell wall synthesis as L-alanine is an important constituent of the peptidoglycan layer [H]

COG id: COG0686

COG function: function code E; Alanine dehydrogenase

Gene ontology:

Cell location: Integral Membrane Protein. Inner Membrane [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the AlaDH/PNT family [H]

Homologues:

Organism=Homo sapiens, GI122939155, Length=343, Percent_Identity=31.4868804664723, Blast_Score=132, Evalue=6e-31,
Organism=Homo sapiens, GI122939153, Length=343, Percent_Identity=31.4868804664723, Blast_Score=132, Evalue=6e-31,
Organism=Escherichia coli, GI1787887, Length=350, Percent_Identity=31.1428571428571, Blast_Score=125, Evalue=5e-30,
Organism=Caenorhabditis elegans, GI17550456, Length=348, Percent_Identity=27.8735632183908, Blast_Score=128, Evalue=5e-30,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR007698
- InterPro:   IPR008142
- InterPro:   IPR008143
- InterPro:   IPR007886
- InterPro:   IPR008141 [H]

Pfam domain/function: PF01262 AlaDh_PNT_C; PF05222 AlaDh_PNT_N [H]

EC number: =1.4.1.1 [H]

Molecular weight: Translated: 38509; Mature: 38509

Theoretical pI: Translated: 6.43; Mature: 6.43

Prosite motif: PS00837 ALADH_PNT_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
2.2 %Met     (Translated Protein)
2.7 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
2.2 %Met     (Mature Protein)
2.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MHIGVPKEIKDQEFRVGLTPAAVRALSDQGHSVAIEARAGEGSGFTDRDYLEAGARIVET
CCCCCCCCCCCCCEEECCCHHHHHHHHCCCCEEEEEEECCCCCCCCCHHHHHHHHHHHHH
AAEVYAQPMIVKVKEPLPLEYALLGKGQILFTYLHLAASRELTEALLNSGATCIAYETVA
HHHHHHCCEEEEECCCCCEEEEEECCCHHHHHHHHHHHHHHHHHHHHHCCCEEEEEEEEE
LADGRLPLLTPMSAIAGRLAVQFGSRFLEKQQGGRGVLLGGVPGVAAGHVAILGGGIVGT
EECCCCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCEEEEECCCCCCCCCEEEEECCEECC
EAARIAVGMGARVTILDVNLDRLAYLEDLFGSRVELLFSTRRTIEQMVPGADLLIGAVLV
CHHEEEECCCCEEEEEECCHHHHHHHHHHHCCHHHHHHHHHHHHHHHCCCHHHHHHHHHH
TGRRAPKLVSREVVGRMNPGSVIVDVAVDQGGCVETLRPTSHSEPVYLEAGVVHYGVPNM
CCCCCHHHHHHHHHCCCCCCCEEEEEEECCCCCCCCCCCCCCCCCEEEECCEEEECCCCC
PGAVPWTATQALNNATLPYVMKLAELGYPQATERDPALALGINIAHSRLIHPAVQQVFPD
CCCCCCHHHHHHCCCCHHHHHHHHHCCCCCCCCCCCCEEEEEEHHHHHHHHHHHHHHHHH
LIHA
HHCC
>Mature Secondary Structure
MHIGVPKEIKDQEFRVGLTPAAVRALSDQGHSVAIEARAGEGSGFTDRDYLEAGARIVET
CCCCCCCCCCCCCEEECCCHHHHHHHHCCCCEEEEEEECCCCCCCCCHHHHHHHHHHHHH
AAEVYAQPMIVKVKEPLPLEYALLGKGQILFTYLHLAASRELTEALLNSGATCIAYETVA
HHHHHHCCEEEEECCCCCEEEEEECCCHHHHHHHHHHHHHHHHHHHHHCCCEEEEEEEEE
LADGRLPLLTPMSAIAGRLAVQFGSRFLEKQQGGRGVLLGGVPGVAAGHVAILGGGIVGT
EECCCCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCEEEEECCCCCCCCCEEEEECCEECC
EAARIAVGMGARVTILDVNLDRLAYLEDLFGSRVELLFSTRRTIEQMVPGADLLIGAVLV
CHHEEEECCCCEEEEEECCHHHHHHHHHHHCCHHHHHHHHHHHHHHHCCCHHHHHHHHHH
TGRRAPKLVSREVVGRMNPGSVIVDVAVDQGGCVETLRPTSHSEPVYLEAGVVHYGVPNM
CCCCCHHHHHHHHHCCCCCCCEEEEEEECCCCCCCCCCCCCCCCCEEEECCEEEECCCCC
PGAVPWTATQALNNATLPYVMKLAELGYPQATERDPALALGINIAHSRLIHPAVQQVFPD
CCCCCCHHHHHHCCCCHHHHHHHHHCCCCCCCCCCCCEEEEEEHHHHHHHHHHHHHHHHH
LIHA
HHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: NA