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The map label for this gene is estA [H]

Identifier: 37523330

GI number: 37523330

Start: 3969744

End: 3970388

Strand: Reverse

Name: estA [H]

Synonym: gll3761

Alternate gene names: 37523330

Gene position: 3970388-3969744 (Counterclockwise)

Preceding gene: 37523331

Following gene: 37523329

Centisome position: 85.22

GC content: 64.03

Gene sequence:

>645_bases
ATGCTCAAATGCGACACCCTCGAAGCCTCCTGCGGTGCTCCGCAGGCCACCGTGTTTATGCTGCACGGCCGGGGAGCCGA
TTGCACCGACCTGGTGCCCCTTGCTGAAGCTTTGGAACTACCGGGGGTGCGCTACTGCTTCCCGAACGCCCCGTTCGGCG
TCGAAGGCTATAGCCCTGGCAGCCAGTGGTACGCTTTCGGCCCGAAGCACGCCGAGGGGGTAGCCCAAAGCGCCGTGTTG
CTCAAAGCGCTGGTTGAACGGGAGCGCGAAGCTTGTCCACAGTTGCCCTACGCGTTTATGGGCTTTTCGCAGGGGGCGGT
GATGGCCCTAGGTGCCGGTCTCCTTTTCGAGCCGCCGCCCGCTGCGATCGTCGCCCTCAGTGGATATCTATTCGAGCCTG
AGGCGCTCTGGGCGAAGCGTCCCCGGGATCTCGCCCCGCCGGCTGTCCTGATCGCCCACGGCAGTCAGGATCCGATCATC
CCGGTGCGGGCCGGCCAGGCCGCCGCCGCCGCCCTGGCCGGTAAAGGTTTCCCGGTGCAGTACCACGAATTTGCCATGGG
ACATCAGATCAACCAGGCCGAAATCGAGCTTGTGCGGGACTTTTTGCAGCACACCCTCGGTCTGAGGGCGGGTAAAATTC
AGTAA

Upstream 100 bases:

>100_bases
GCCGGCGCGCCAAGGTGCGCGATTATCTGGAGCTGATGGAATAAGCCCTGCGCTCAGGGTGTTACATTGAGGGCCGTCCC
GTCGGGCGGCCCTGCTTTTT

Downstream 100 bases:

>100_bases
ACCATGCCTCAGGCGGCCTGCCGACGCGCTGATTGCGGCGCGATTGGCCGGATTTGCGCGCCTACGACCCGCTCGCCGCC
GCCCGCACTCTGAAAACTCC

Product: carboxylesterase

Products: NA

Alternate protein names: Esterase I [H]

Number of amino acids: Translated: 214; Mature: 214

Protein sequence:

>214_residues
MLKCDTLEASCGAPQATVFMLHGRGADCTDLVPLAEALELPGVRYCFPNAPFGVEGYSPGSQWYAFGPKHAEGVAQSAVL
LKALVEREREACPQLPYAFMGFSQGAVMALGAGLLFEPPPAAIVALSGYLFEPEALWAKRPRDLAPPAVLIAHGSQDPII
PVRAGQAAAAALAGKGFPVQYHEFAMGHQINQAEIELVRDFLQHTLGLRAGKIQ

Sequences:

>Translated_214_residues
MLKCDTLEASCGAPQATVFMLHGRGADCTDLVPLAEALELPGVRYCFPNAPFGVEGYSPGSQWYAFGPKHAEGVAQSAVL
LKALVEREREACPQLPYAFMGFSQGAVMALGAGLLFEPPPAAIVALSGYLFEPEALWAKRPRDLAPPAVLIAHGSQDPII
PVRAGQAAAAALAGKGFPVQYHEFAMGHQINQAEIELVRDFLQHTLGLRAGKIQ
>Mature_214_residues
MLKCDTLEASCGAPQATVFMLHGRGADCTDLVPLAEALELPGVRYCFPNAPFGVEGYSPGSQWYAFGPKHAEGVAQSAVL
LKALVEREREACPQLPYAFMGFSQGAVMALGAGLLFEPPPAAIVALSGYLFEPEALWAKRPRDLAPPAVLIAHGSQDPII
PVRAGQAAAAALAGKGFPVQYHEFAMGHQINQAEIELVRDFLQHTLGLRAGKIQ

Specific function: Hydrolyzes carboxylic ester bonds with relatively broad substrate specificity [H]

COG id: COG0400

COG function: function code R; Predicted esterase

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the AB hydrolase 2 family [H]

Homologues:

Organism=Homo sapiens, GI9966764, Length=211, Percent_Identity=29.8578199052133, Blast_Score=66, Evalue=2e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003140 [H]

Pfam domain/function: PF02230 Abhydrolase_2 [H]

EC number: =3.1.1.1 [H]

Molecular weight: Translated: 22764; Mature: 22764

Theoretical pI: Translated: 5.92; Mature: 5.92

Prosite motif: PS01323 PHOSPHOTRIESTERASE_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.3 %Cys     (Translated Protein)
2.3 %Met     (Translated Protein)
4.7 %Cys+Met (Translated Protein)
2.3 %Cys     (Mature Protein)
2.3 %Met     (Mature Protein)
4.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLKCDTLEASCGAPQATVFMLHGRGADCTDLVPLAEALELPGVRYCFPNAPFGVEGYSPG
CCCCCCCCCCCCCCCEEEEEEECCCCCHHHHHHHHHHHCCCCEEEECCCCCCCCCCCCCC
SQWYAFGPKHAEGVAQSAVLLKALVEREREACPQLPYAFMGFSQGAVMALGAGLLFEPPP
CCEEEECCHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHCCCCCHHHHHCCCCEECCCC
AAIVALSGYLFEPEALWAKRPRDLAPPAVLIAHGSQDPIIPVRAGQAAAAALAGKGFPVQ
CEEEEECCCEECCHHHHHCCCCCCCCCEEEEEECCCCCEEEEECCCHHHHHHHCCCCCCH
YHEFAMGHQINQAEIELVRDFLQHTLGLRAGKIQ
HHHHHHCCCCCHHHHHHHHHHHHHHHCCCCCCCC
>Mature Secondary Structure
MLKCDTLEASCGAPQATVFMLHGRGADCTDLVPLAEALELPGVRYCFPNAPFGVEGYSPG
CCCCCCCCCCCCCCCEEEEEEECCCCCHHHHHHHHHHHCCCCEEEECCCCCCCCCCCCCC
SQWYAFGPKHAEGVAQSAVLLKALVEREREACPQLPYAFMGFSQGAVMALGAGLLFEPPP
CCEEEECCHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHCCCCCHHHHHCCCCEECCCC
AAIVALSGYLFEPEALWAKRPRDLAPPAVLIAHGSQDPIIPVRAGQAAAAALAGKGFPVQ
CEEEEECCCEECCHHHHHCCCCCCCCCEEEEEECCCCCEEEEECCCHHHHHHHCCCCCCH
YHEFAMGHQINQAEIELVRDFLQHTLGLRAGKIQ
HHHHHHCCCCCHHHHHHHHHHHHHHHCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA