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The map label for this gene is sigC [H]

Identifier: 37523331

GI number: 37523331

Start: 3970445

End: 3971533

Strand: Reverse

Name: sigC [H]

Synonym: gll3762

Alternate gene names: 37523331

Gene position: 3971533-3970445 (Counterclockwise)

Preceding gene: 37523334

Following gene: 37523330

Centisome position: 85.24

GC content: 62.63

Gene sequence:

>1089_bases
ATGCACATTGTCGATATCGATAGAATGGCGACCCCGGACGAGCTGGAGGGGGGTCCGGACCCGGTGCTTGATCCCCAGAC
GCTCGAAGCCTTTGTGCAGGTGGACATCACTGACGAACGTCCGGCTCGCCCGGGTAGCTCCACGGATCTGGTGCGCGTTT
ACCTGCAGGAGATCGGCCGCGTGCCGCTGTTGGGTCGCGACGAAGAAGTCGAACTGGCCCAGCAGGTCCAGAAGCTCATG
AAGCTCACGGCCCTCAAAGAGTCGCTCCAGACTTCTTTGGGCAGCGAATACAGCGACGAGCAGTGGGCCGAGGCGGCCAA
GGTCGGCCTGTTCGAACTCAAACGACAGGTGCTGGCCGGCAGCCGGGCCAAAAAGAAGATGATCGAGGCCAACTTGCGTC
TGGTGGTCTCGGTGGCCAAAAAGTACCAGAACCGCGGTCTGGAGCTGCTGGATCTGGTGCAGGAGGGCACGCTTGGCTTG
GAGCGGGCGGTCGAGAAATTCGACCCGACCAAGGGCTACCGCTTCTCGACCTACGCCTACTGGTGGATTCGCCAGGGGAT
CACCCGCGCCATCGCCACCCAGTCGCGCACCATTCGCCTGCCGGTGCACATCACCGAAAAGCTCAACCGCATCAAGAAGA
CCCAGCGCAAGCTTTCGCAGAACCTGGGCCGCACGCCGACCATCTCCGAAATTGCCGAAGAACTGGAAATGGAGCCGGCC
CATGTGCGCGAGTTGATGAGCCGCGTGCCCCGCTCGGTCTCGCTGGAGACCCGCGTGGGTAAGGACAAGGATACCGAACT
GGGCGAGTTGCTCGAAGCGGAGGAGGTCTCCCCCGAAGAGAGCGCCGTCCAAGAATCGCTGCGCCGCGACGTCAAAGAGC
TGCTCGACGATCTGACCCTGCGCGAGCGCGATGTGATCACGATGCGCTACGGGCTATTGGACGGCCGCACCTACTCGCTC
TCTGAGATTGGCCGGGCTCTGGATCTCTCGCGCGAGCGCGTGCGCCAGATCGAATCGAAGGCGCTGCAGAAATTGCGCCA
GCCGCGCCGGCGCGCCAAGGTGCGCGATTATCTGGAGCTGATGGAATAA

Upstream 100 bases:

>100_bases
AGACAGATAGAGCGATGGCTCCCACGGGTGTGCACCAAACCGTTTCCAGTTTCCCCGGTTTGTTTTCAAGGCAATCACGT
TACCGAAGGTTGAACGAAAA

Downstream 100 bases:

>100_bases
GCCCTGCGCTCAGGGTGTTACATTGAGGGCCGTCCCGTCGGGCGGCCCTGCTTTTTATGCTCAAATGCGACACCCTCGAA
GCCTCCTGCGGTGCTCCGCA

Product: RNA polymerase sigma factor SigC

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 362; Mature: 362

Protein sequence:

>362_residues
MHIVDIDRMATPDELEGGPDPVLDPQTLEAFVQVDITDERPARPGSSTDLVRVYLQEIGRVPLLGRDEEVELAQQVQKLM
KLTALKESLQTSLGSEYSDEQWAEAAKVGLFELKRQVLAGSRAKKKMIEANLRLVVSVAKKYQNRGLELLDLVQEGTLGL
ERAVEKFDPTKGYRFSTYAYWWIRQGITRAIATQSRTIRLPVHITEKLNRIKKTQRKLSQNLGRTPTISEIAEELEMEPA
HVRELMSRVPRSVSLETRVGKDKDTELGELLEAEEVSPEESAVQESLRRDVKELLDDLTLRERDVITMRYGLLDGRTYSL
SEIGRALDLSRERVRQIESKALQKLRQPRRRAKVRDYLELME

Sequences:

>Translated_362_residues
MHIVDIDRMATPDELEGGPDPVLDPQTLEAFVQVDITDERPARPGSSTDLVRVYLQEIGRVPLLGRDEEVELAQQVQKLM
KLTALKESLQTSLGSEYSDEQWAEAAKVGLFELKRQVLAGSRAKKKMIEANLRLVVSVAKKYQNRGLELLDLVQEGTLGL
ERAVEKFDPTKGYRFSTYAYWWIRQGITRAIATQSRTIRLPVHITEKLNRIKKTQRKLSQNLGRTPTISEIAEELEMEPA
HVRELMSRVPRSVSLETRVGKDKDTELGELLEAEEVSPEESAVQESLRRDVKELLDDLTLRERDVITMRYGLLDGRTYSL
SEIGRALDLSRERVRQIESKALQKLRQPRRRAKVRDYLELME
>Mature_362_residues
MHIVDIDRMATPDELEGGPDPVLDPQTLEAFVQVDITDERPARPGSSTDLVRVYLQEIGRVPLLGRDEEVELAQQVQKLM
KLTALKESLQTSLGSEYSDEQWAEAAKVGLFELKRQVLAGSRAKKKMIEANLRLVVSVAKKYQNRGLELLDLVQEGTLGL
ERAVEKFDPTKGYRFSTYAYWWIRQGITRAIATQSRTIRLPVHITEKLNRIKKTQRKLSQNLGRTPTISEIAEELEMEPA
HVRELMSRVPRSVSLETRVGKDKDTELGELLEAEEVSPEESAVQESLRRDVKELLDDLTLRERDVITMRYGLLDGRTYSL
SEIGRALDLSRERVRQIESKALQKLRQPRRRAKVRDYLELME

Specific function: Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released [H]

COG id: COG0568

COG function: function code K; DNA-directed RNA polymerase, sigma subunit (sigma70/sigma32)

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the sigma-70 factor family [H]

Homologues:

Organism=Escherichia coli, GI1789448, Length=239, Percent_Identity=49.3723849372385, Blast_Score=248, Evalue=3e-67,
Organism=Escherichia coli, GI1789098, Length=301, Percent_Identity=40.1993355481728, Blast_Score=207, Evalue=9e-55,
Organism=Escherichia coli, GI1789871, Length=248, Percent_Identity=28.2258064516129, Blast_Score=84, Evalue=1e-17,
Organism=Escherichia coli, GI1788231, Length=202, Percent_Identity=28.7128712871287, Blast_Score=74, Evalue=2e-14,

Paralogues:

None

Copy number: 700 (log & stationary phase) [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR014284
- InterPro:   IPR000943
- InterPro:   IPR009042
- InterPro:   IPR007627
- InterPro:   IPR007624
- InterPro:   IPR007630
- InterPro:   IPR013325
- InterPro:   IPR013324
- InterPro:   IPR017848
- InterPro:   IPR011991 [H]

Pfam domain/function: PF00140 Sigma70_r1_2; PF04542 Sigma70_r2; PF04539 Sigma70_r3; PF04545 Sigma70_r4 [H]

EC number: NA

Molecular weight: Translated: 41488; Mature: 41488

Theoretical pI: Translated: 6.37; Mature: 6.37

Prosite motif: PS00715 SIGMA70_1 ; PS00716 SIGMA70_2 ; PS00867 CPSASE_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
2.2 %Met     (Translated Protein)
2.2 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
2.2 %Met     (Mature Protein)
2.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MHIVDIDRMATPDELEGGPDPVLDPQTLEAFVQVDITDERPARPGSSTDLVRVYLQEIGR
CCEECCCCCCCCHHCCCCCCCCCCHHHHHHHHHEEECCCCCCCCCCCHHHHHHHHHHHCC
VPLLGRDEEVELAQQVQKLMKLTALKESLQTSLGSEYSDEQWAEAAKVGLFELKRQVLAG
CCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHC
SRAKKKMIEANLRLVVSVAKKYQNRGLELLDLVQEGTLGLERAVEKFDPTKGYRFSTYAY
CHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHCCHHHHHHHHHCCCCCCCEEHHHHH
WWIRQGITRAIATQSRTIRLPVHITEKLNRIKKTQRKLSQNLGRTPTISEIAEELEMEPA
HHHHHHHHHHHHCCCCEEEECHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHCCCHH
HVRELMSRVPRSVSLETRVGKDKDTELGELLEAEEVSPEESAVQESLRRDVKELLDDLTL
HHHHHHHHCCCCEEHHHHCCCCCCCHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHH
RERDVITMRYGLLDGRTYSLSEIGRALDLSRERVRQIESKALQKLRQPRRRAKVRDYLEL
CCCCHHHHHHHHCCCCEECHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
ME
HC
>Mature Secondary Structure
MHIVDIDRMATPDELEGGPDPVLDPQTLEAFVQVDITDERPARPGSSTDLVRVYLQEIGR
CCEECCCCCCCCHHCCCCCCCCCCHHHHHHHHHEEECCCCCCCCCCCHHHHHHHHHHHCC
VPLLGRDEEVELAQQVQKLMKLTALKESLQTSLGSEYSDEQWAEAAKVGLFELKRQVLAG
CCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHC
SRAKKKMIEANLRLVVSVAKKYQNRGLELLDLVQEGTLGLERAVEKFDPTKGYRFSTYAY
CHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHCCHHHHHHHHHCCCCCCCEEHHHHH
WWIRQGITRAIATQSRTIRLPVHITEKLNRIKKTQRKLSQNLGRTPTISEIAEELEMEPA
HHHHHHHHHHHHCCCCEEEECHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHCCCHH
HVRELMSRVPRSVSLETRVGKDKDTELGELLEAEEVSPEESAVQESLRRDVKELLDDLTL
HHHHHHHHCCCCEEHHHHCCCCCCCHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHH
RERDVITMRYGLLDGRTYSLSEIGRALDLSRERVRQIESKALQKLRQPRRRAKVRDYLEL
CCCCHHHHHHHHCCCCEECHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
ME
HC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: DNA [C]

Specific reaction: Protein + DNA = Protein-DNA [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 1385387; 11759840 [H]