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The map label for this gene is wzc [H]

Identifier: 37523285

GI number: 37523285

Start: 3926914

End: 3928965

Strand: Reverse

Name: wzc [H]

Synonym: gll3716

Alternate gene names: 37523285

Gene position: 3928965-3926914 (Counterclockwise)

Preceding gene: 37523286

Following gene: 37523284

Centisome position: 84.33

GC content: 65.45

Gene sequence:

>2052_bases
ATGCACGTAATTCAGGTTCTCAAGCGGCACTGGCGGCCGTTGCTGGTGCTCAATGGCCTGGTGCTGGCAGCCACGATCGG
GGTGGCCTGCTACTACCCGCGCACCTGGACGGCCACCACCCGGATCATCCTCCCCAGTACCAACAAAAATGCGGAAATCA
GCCTCGGGGCTTTGGGCGAAGTGCGCGAGACCGGCACGTCGTTTTCGAGTGAAGTGAACGCCCTCAAGGTGCAATCGGCA
ATTCTGACCAGCAGCGAGGTACTCTCCAAAGCCTGGCAGGCCGACCCGCAGCGCGAGAAATATCCGCAACTGGGTAGCTA
TGAGAAGTTGTTCAAGGCCGTTCCCCAAAGCCAGACGACGATCCTGGCGGTGGAAGCCAAAGGCAATGCGCCCGAGGTTG
CCGAGGCGCGGGCGGACCTGGTGGTACGCTCCTACGTGGCCCGGCTGGAGGAGTTGCGCAATGCCTACGCAGCTTCGCGC
GACACACTGTCGCAAAAAGAACTCGATCGCGCCCGCCGCGAACTGACCCGGGCGGAAGCTGCCCTGGCCCGCTTCAAGCG
TTCGACCGGACTGGTCAATACCGATCAGCAGACCGGCGGGTTGGTGGGGGTGATCAGTTCTCTGACCACCAGCCAAGCCC
AGGCCGTCGCCGAGGGCACCGCCGATAAAGCGCGCGCCCAGATGCTCACCGCCCGCCTGGGCATGGATGCCCCCCAGGCG
ATGCGCGCCCTGCGCCTGGGGGAGAGCAAAGAGTACCAGGCGATGCGCCTGAAACTCAGCTCCCTCGATACGGCCCTGGC
GGAGGCCAGGGGGCTCTACACCGAAAAACACGCCCGGGTGCAGTCGCTGCTGGTGCAGCGCGAGGAACTGCAACGCTCGC
TGCGCGAGCTGTTGGCGAAGGTTGTTCCGGCAAGCCGCACCGAGCGTGCCCTGGACGATTCGCTCGCCGGCGGCGGCAAC
CGCGACAGCCGCATCGACTTAATTTTGTCGCTGCTTGAAGCCGAGCGCGCCGCCGAGGCCCGCTCACGCCAGAGCGCCCA
GTTGGGCCGCACCATCGAGCAAGCCACCGAGCGGCTGAGCGCCATCTCGACCCGCCAGGCGACCTTGCTGGATCTGCAGC
GGCGCTACGAACTGGCGGAGGCGGCCTACAAAGCGATCGTCGCCCAGATGCAGCAGGCCCGCCTGAGCGCCTTCAACGCC
TTCCCGGATATCGAAGTGCTCGATAAAGCCTACTCCAACCCGAAAGAAGCCAACCCGAGGACGCTGCTTATCGCCCTGGG
CGGGCTGGTCGCCGCCGTCTTCGGCAGCCTGGGACTGATCTTGCGCAAAGAAGCGATCAATCCGCTCCTGGGCCCCAAGG
ACCTGCAAAGTGTCGAATTGCCGGTGCTCGCGCGCCTGCCCCGCACCAAGGGCTTGTTGCCGTCGGGCGATCCGCCCCGG
CTCGAATCGCGGCAGCTCGCCTCCACCGTCAGCCTGATGGATCTGCCCAACCGGCGGCTGATGATCACCAGTTCCACCGC
CGGGGAAGGCAAGACGACCCTCACCCTCGGGCTGGCCAACGCCCTGGCGGAAATGGGTTTTCGGGTGCTGCTCGTCGATG
CCGATTTTCGCCAGGCGAGCCTCAGCCGTCTGCTGGGCCATGGTCCCCAGGTGGAGGGAACCCAGGCGGAGCCCGTCTCG
GTCATTGCCGATCTCGATCTGGTACCGGCGCTCGCCATCGAGGACACCTCGACCGCCTTTTTCGTCCAGGGTGGTTTCGA
ACGTTACCTCGACGATGTGCAGACGGACGGCTACGACTACGTGCTGGTGGATAGCCCCCCCATCAGCCTGACCAGTGAGG
CGGCCTTGATGATCCCGGCGGTGCGCAACGTCTTGTTTGTCGTCCGCCCCGGGGTGAGCGGCCGCGACGCGGTGAGTGAG
AGCCTCGATCGCCTCGTCCGCCACAATGCTCGTCTGGTGGGGCTGGTGGTCAACGACGTGACGACCCGCCAGGAGGGCTA
CCGCTACAGTTACGGGCGCTATGGGCGGCAGAGCCTCGAGGTGGCCCCATGA

Upstream 100 bases:

>100_bases
CCTTCCCAGAACACGATGGGCTTTTTGGACATGCTCAGCCCCCTGCTCAATCCTTTGGGATTCATGCTTCGCGCCTTTAT
CCGCTGACGGAGAAACAACC

Downstream 100 bases:

>100_bases
ACCAGGCCGTCTCCACCGCCATCCGCCGCCGGCCCTGGCAGGAGATCAAACTGCCGGGTCTGGGGATCAGCTGGTCGATG
CTCTCTGCCGCCGAGCGGCT

Product: hypothetical protein

Products: ADP; protein tyrosine phosphate [C]

Alternate protein names: NA

Number of amino acids: Translated: 683; Mature: 683

Protein sequence:

>683_residues
MHVIQVLKRHWRPLLVLNGLVLAATIGVACYYPRTWTATTRIILPSTNKNAEISLGALGEVRETGTSFSSEVNALKVQSA
ILTSSEVLSKAWQADPQREKYPQLGSYEKLFKAVPQSQTTILAVEAKGNAPEVAEARADLVVRSYVARLEELRNAYAASR
DTLSQKELDRARRELTRAEAALARFKRSTGLVNTDQQTGGLVGVISSLTTSQAQAVAEGTADKARAQMLTARLGMDAPQA
MRALRLGESKEYQAMRLKLSSLDTALAEARGLYTEKHARVQSLLVQREELQRSLRELLAKVVPASRTERALDDSLAGGGN
RDSRIDLILSLLEAERAAEARSRQSAQLGRTIEQATERLSAISTRQATLLDLQRRYELAEAAYKAIVAQMQQARLSAFNA
FPDIEVLDKAYSNPKEANPRTLLIALGGLVAAVFGSLGLILRKEAINPLLGPKDLQSVELPVLARLPRTKGLLPSGDPPR
LESRQLASTVSLMDLPNRRLMITSSTAGEGKTTLTLGLANALAEMGFRVLLVDADFRQASLSRLLGHGPQVEGTQAEPVS
VIADLDLVPALAIEDTSTAFFVQGGFERYLDDVQTDGYDYVLVDSPPISLTSEAALMIPAVRNVLFVVRPGVSGRDAVSE
SLDRLVRHNARLVGLVVNDVTTRQEGYRYSYGRYGRQSLEVAP

Sequences:

>Translated_683_residues
MHVIQVLKRHWRPLLVLNGLVLAATIGVACYYPRTWTATTRIILPSTNKNAEISLGALGEVRETGTSFSSEVNALKVQSA
ILTSSEVLSKAWQADPQREKYPQLGSYEKLFKAVPQSQTTILAVEAKGNAPEVAEARADLVVRSYVARLEELRNAYAASR
DTLSQKELDRARRELTRAEAALARFKRSTGLVNTDQQTGGLVGVISSLTTSQAQAVAEGTADKARAQMLTARLGMDAPQA
MRALRLGESKEYQAMRLKLSSLDTALAEARGLYTEKHARVQSLLVQREELQRSLRELLAKVVPASRTERALDDSLAGGGN
RDSRIDLILSLLEAERAAEARSRQSAQLGRTIEQATERLSAISTRQATLLDLQRRYELAEAAYKAIVAQMQQARLSAFNA
FPDIEVLDKAYSNPKEANPRTLLIALGGLVAAVFGSLGLILRKEAINPLLGPKDLQSVELPVLARLPRTKGLLPSGDPPR
LESRQLASTVSLMDLPNRRLMITSSTAGEGKTTLTLGLANALAEMGFRVLLVDADFRQASLSRLLGHGPQVEGTQAEPVS
VIADLDLVPALAIEDTSTAFFVQGGFERYLDDVQTDGYDYVLVDSPPISLTSEAALMIPAVRNVLFVVRPGVSGRDAVSE
SLDRLVRHNARLVGLVVNDVTTRQEGYRYSYGRYGRQSLEVAP
>Mature_683_residues
MHVIQVLKRHWRPLLVLNGLVLAATIGVACYYPRTWTATTRIILPSTNKNAEISLGALGEVRETGTSFSSEVNALKVQSA
ILTSSEVLSKAWQADPQREKYPQLGSYEKLFKAVPQSQTTILAVEAKGNAPEVAEARADLVVRSYVARLEELRNAYAASR
DTLSQKELDRARRELTRAEAALARFKRSTGLVNTDQQTGGLVGVISSLTTSQAQAVAEGTADKARAQMLTARLGMDAPQA
MRALRLGESKEYQAMRLKLSSLDTALAEARGLYTEKHARVQSLLVQREELQRSLRELLAKVVPASRTERALDDSLAGGGN
RDSRIDLILSLLEAERAAEARSRQSAQLGRTIEQATERLSAISTRQATLLDLQRRYELAEAAYKAIVAQMQQARLSAFNA
FPDIEVLDKAYSNPKEANPRTLLIALGGLVAAVFGSLGLILRKEAINPLLGPKDLQSVELPVLARLPRTKGLLPSGDPPR
LESRQLASTVSLMDLPNRRLMITSSTAGEGKTTLTLGLANALAEMGFRVLLVDADFRQASLSRLLGHGPQVEGTQAEPVS
VIADLDLVPALAIEDTSTAFFVQGGFERYLDDVQTDGYDYVLVDSPPISLTSEAALMIPAVRNVLFVVRPGVSGRDAVSE
SLDRLVRHNARLVGLVVNDVTTRQEGYRYSYGRYGRQSLEVAP

Specific function: Required for the extracellular polysaccharide colanic acid synthesis. The autophosphorylated form is inactive. Probably involved in the export of colanic acid from the cell to medium [H]

COG id: COG3206

COG function: function code M; Uncharacterized protein involved in exopolysaccharide biosynthesis

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the etk/wzc family [H]

Homologues:

Organism=Escherichia coli, GI87082032, Length=362, Percent_Identity=26.2430939226519, Blast_Score=102, Evalue=6e-23,
Organism=Escherichia coli, GI1787216, Length=372, Percent_Identity=25.2688172043011, Blast_Score=91, Evalue=2e-19,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002586
- InterPro:   IPR005702
- InterPro:   IPR003856 [H]

Pfam domain/function: PF01656 CbiA; PF02706 Wzz [H]

EC number: 2.7.1.112 [C]

Molecular weight: Translated: 74414; Mature: 74414

Theoretical pI: Translated: 9.55; Mature: 9.55

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.1 %Cys     (Translated Protein)
1.5 %Met     (Translated Protein)
1.6 %Cys+Met (Translated Protein)
0.1 %Cys     (Mature Protein)
1.5 %Met     (Mature Protein)
1.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MHVIQVLKRHWRPLLVLNGLVLAATIGVACYYPRTWTATTRIILPSTNKNAEISLGALGE
CHHHHHHHHCCCHHHHHHHHHHHHHHHHHEECCCCCCCEEEEEEECCCCCCEEEECCCHH
VRETGTSFSSEVNALKVQSAILTSSEVLSKAWQADPQREKYPQLGSYEKLFKAVPQSQTT
HHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHCCCCCCCHHHHHHHCCCCCEE
ILAVEAKGNAPEVAEARADLVVRSYVARLEELRNAYAASRDTLSQKELDRARRELTRAEA
EEEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
ALARFKRSTGLVNTDQQTGGLVGVISSLTTSQAQAVAEGTADKARAQMLTARLGMDAPQA
HHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHCCCCHHH
MRALRLGESKEYQAMRLKLSSLDTALAEARGLYTEKHARVQSLLVQREELQRSLRELLAK
HHHHHCCCCCCHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHH
VVPASRTERALDDSLAGGGNRDSRIDLILSLLEAERAAEARSRQSAQLGRTIEQATERLS
HCCCCHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
AISTRQATLLDLQRRYELAEAAYKAIVAQMQQARLSAFNAFPDIEVLDKAYSNPKEANPR
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHCCCCCCCCC
TLLIALGGLVAAVFGSLGLILRKEAINPLLGPKDLQSVELPVLARLPRTKGLLPSGDPPR
EEEHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCHHHHHCCCCCCCCCCCCCCC
LESRQLASTVSLMDLPNRRLMITSSTAGEGKTTLTLGLANALAEMGFRVLLVDADFRQAS
CCHHHHHHHHHHHCCCCCEEEEEECCCCCCCEEEEHHHHHHHHHCCCEEEEEECCHHHHH
LSRLLGHGPQVEGTQAEPVSVIADLDLVPALAIEDTSTAFFVQGGFERYLDDVQTDGYDY
HHHHHCCCCCCCCCCCCCHHHEECCCHHCCEEECCCCCEEEEECCHHHHHHHHCCCCCCE
VLVDSPPISLTSEAALMIPAVRNVLFVVRPGVSGRDAVSESLDRLVRHNARLVGLVVNDV
EEECCCCCCCCCCHHHHHHHHHCEEEEECCCCCCHHHHHHHHHHHHHCCCEEEEEEECCH
TTRQEGYRYSYGRYGRQSLEVAP
HHHCCCCCCCCCCCCCCCCCCCC
>Mature Secondary Structure
MHVIQVLKRHWRPLLVLNGLVLAATIGVACYYPRTWTATTRIILPSTNKNAEISLGALGE
CHHHHHHHHCCCHHHHHHHHHHHHHHHHHEECCCCCCCEEEEEEECCCCCCEEEECCCHH
VRETGTSFSSEVNALKVQSAILTSSEVLSKAWQADPQREKYPQLGSYEKLFKAVPQSQTT
HHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHCCCCCCCHHHHHHHCCCCCEE
ILAVEAKGNAPEVAEARADLVVRSYVARLEELRNAYAASRDTLSQKELDRARRELTRAEA
EEEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
ALARFKRSTGLVNTDQQTGGLVGVISSLTTSQAQAVAEGTADKARAQMLTARLGMDAPQA
HHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHCCCCHHH
MRALRLGESKEYQAMRLKLSSLDTALAEARGLYTEKHARVQSLLVQREELQRSLRELLAK
HHHHHCCCCCCHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHH
VVPASRTERALDDSLAGGGNRDSRIDLILSLLEAERAAEARSRQSAQLGRTIEQATERLS
HCCCCHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
AISTRQATLLDLQRRYELAEAAYKAIVAQMQQARLSAFNAFPDIEVLDKAYSNPKEANPR
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHCCCCCCCCC
TLLIALGGLVAAVFGSLGLILRKEAINPLLGPKDLQSVELPVLARLPRTKGLLPSGDPPR
EEEHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCHHHHHCCCCCCCCCCCCCCC
LESRQLASTVSLMDLPNRRLMITSSTAGEGKTTLTLGLANALAEMGFRVLLVDADFRQAS
CCHHHHHHHHHHHCCCCCEEEEEECCCCCCCEEEEHHHHHHHHHCCCEEEEEECCHHHHH
LSRLLGHGPQVEGTQAEPVSVIADLDLVPALAIEDTSTAFFVQGGFERYLDDVQTDGYDY
HHHHHCCCCCCCCCCCCCHHHEECCCHHCCEEECCCCCEEEEECCHHHHHHHHCCCCCCE
VLVDSPPISLTSEAALMIPAVRNVLFVVRPGVSGRDAVSESLDRLVRHNARLVGLVVNDV
EEECCCCCCCCCCHHHHHHHHHCEEEEECCCCCCHHHHHHHHHHHHHCCCEEEEEEECCH
TTRQEGYRYSYGRYGRQSLEVAP
HHHCCCCCCCCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: ATP; a protein tyrosine [C]

Specific reaction: ATP + a protein tyrosine = ADP + protein tyrosine phosphate [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 11677608; 12644504 [H]