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The map label for this gene is ldh

Identifier: 37522893

GI number: 37522893

Start: 3526660

End: 3527652

Strand: Reverse

Name: ldh

Synonym: gll3324

Alternate gene names: 37522893

Gene position: 3527652-3526660 (Counterclockwise)

Preceding gene: 37522894

Following gene: 37522892

Centisome position: 75.72

GC content: 63.34

Gene sequence:

>993_bases
ATGCAAGATCGACTGTTCGTCTCGATGGAGCACCCGCGTGCCCTTCCAGAAACGGATCTGATCAAAGGGGCGATCGTCGG
AGCCGGCGCAGTCGGCATGGCGATCGCCTATTCCATGCTCATCCAGAACACCTTCGACGAATTGGTGCTGGTCGATATCG
ACCGGCGCAAAGTCGAAGGGGAAGTGATGGACCTGGTCCACGGCATTCCCTTTGTCGAGCCGTCCGTGGTGCGCGCGGGC
ACCCTCGCCGATTGCCGGGGGGTGGATGTGGTGGTGATTACGGCGGGGGCCCGGCAGCGGGAGGGGGAGACCCGCCTGTC
GCTGGTGCAGCGCAACGTCGAAATTTTCCGCGGTCTGATTGGCGAGATCATGGAGCACTGCCCGAACGCCATTTTGCTGG
TGGTCAGCAACCCGGTGGACGTGATGACCTACGTGGCGATGAAACTGGCCGGATTGCCGCCCTCGCGGGTGATCGGTTCC
GGGACGGTGCTCGACACCGCCCGATTCCGCTATTTGCTCGCCGAACGGCTCAGAGTCGATCCGCGCAGTCTGCACGCCTA
CATCATCGGCGAGCACGGCGACAGCGAGGTGCCTGTCTGGAGCCGCGCCAACGTCGCCGGGGCTTTTTTGAGCGAGATCG
AGCCGGCGGTGGGCACCCCCGACGACCCGGCGAAGATGTTCGAAGTTTTTGAGCACGTCAAAAACGCCGCCTACGAAATC
ATCGAGCGCAAGGGGGCGACTTCCTGGGCGATTGGCCTCGCCACCACCCAGATCGTGCGCGCCATCACCCGCAACCAGAA
CCGGGTGCTGCCGGTGAGTGTCTTGATGAGCGGCCTGCACGGCATTGAGGAGGTGTGCCTGGCCTATCCGGCGGTGCTCA
ACCGCCAGGGGATCGACCGGCTGGTGAAATTTTCGCTCTCGCCGGGTGAGGAAGAGCAATTGCAGCGCTCGGCCCGGGTG
ATGCGCCAGACTCTCGACGGGATCCAGTTTTAA

Upstream 100 bases:

>100_bases
CTCCTGCCGGGTAAACGATCTGATCGTCGCGATGGCCCACAAAGAAAAACCCGCCGATTCCTAGAGGCAGGCGGCTCCAA
CCCCATCCCAAGGGATTTTT

Downstream 100 bases:

>100_bases
CCCTAATTTTCGAGGTAATGCGTTATGCAGCCTTTAGACCGTCGAACGAAAGTCGTCGCGACGATCGGTCCTGCGAGCAG
TTCGCCGGAAGTGCTTCGGC

Product: L-lactate dehydrogenase A chain

Products: NA

Alternate protein names: L-LDH

Number of amino acids: Translated: 330; Mature: 330

Protein sequence:

>330_residues
MQDRLFVSMEHPRALPETDLIKGAIVGAGAVGMAIAYSMLIQNTFDELVLVDIDRRKVEGEVMDLVHGIPFVEPSVVRAG
TLADCRGVDVVVITAGARQREGETRLSLVQRNVEIFRGLIGEIMEHCPNAILLVVSNPVDVMTYVAMKLAGLPPSRVIGS
GTVLDTARFRYLLAERLRVDPRSLHAYIIGEHGDSEVPVWSRANVAGAFLSEIEPAVGTPDDPAKMFEVFEHVKNAAYEI
IERKGATSWAIGLATTQIVRAITRNQNRVLPVSVLMSGLHGIEEVCLAYPAVLNRQGIDRLVKFSLSPGEEEQLQRSARV
MRQTLDGIQF

Sequences:

>Translated_330_residues
MQDRLFVSMEHPRALPETDLIKGAIVGAGAVGMAIAYSMLIQNTFDELVLVDIDRRKVEGEVMDLVHGIPFVEPSVVRAG
TLADCRGVDVVVITAGARQREGETRLSLVQRNVEIFRGLIGEIMEHCPNAILLVVSNPVDVMTYVAMKLAGLPPSRVIGS
GTVLDTARFRYLLAERLRVDPRSLHAYIIGEHGDSEVPVWSRANVAGAFLSEIEPAVGTPDDPAKMFEVFEHVKNAAYEI
IERKGATSWAIGLATTQIVRAITRNQNRVLPVSVLMSGLHGIEEVCLAYPAVLNRQGIDRLVKFSLSPGEEEQLQRSARV
MRQTLDGIQF
>Mature_330_residues
MQDRLFVSMEHPRALPETDLIKGAIVGAGAVGMAIAYSMLIQNTFDELVLVDIDRRKVEGEVMDLVHGIPFVEPSVVRAG
TLADCRGVDVVVITAGARQREGETRLSLVQRNVEIFRGLIGEIMEHCPNAILLVVSNPVDVMTYVAMKLAGLPPSRVIGS
GTVLDTARFRYLLAERLRVDPRSLHAYIIGEHGDSEVPVWSRANVAGAFLSEIEPAVGTPDDPAKMFEVFEHVKNAAYEI
IERKGATSWAIGLATTQIVRAITRNQNRVLPVSVLMSGLHGIEEVCLAYPAVLNRQGIDRLVKFSLSPGEEEQLQRSARV
MRQTLDGIQF

Specific function: Catalyzes The Reversible Oxidation Of Malate To Oxaloacetate. [C]

COG id: COG0039

COG function: function code C; Malate/lactate dehydrogenases

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the LDH/MDH superfamily. LDH family

Homologues:

Organism=Homo sapiens, GI5031857, Length=331, Percent_Identity=47.7341389728097, Blast_Score=306, Evalue=2e-83,
Organism=Homo sapiens, GI260099723, Length=331, Percent_Identity=47.7341389728097, Blast_Score=306, Evalue=2e-83,
Organism=Homo sapiens, GI15082234, Length=311, Percent_Identity=47.2668810289389, Blast_Score=305, Evalue=3e-83,
Organism=Homo sapiens, GI9257228, Length=318, Percent_Identity=49.3710691823899, Blast_Score=296, Evalue=1e-80,
Organism=Homo sapiens, GI4504973, Length=318, Percent_Identity=49.3710691823899, Blast_Score=296, Evalue=1e-80,
Organism=Homo sapiens, GI47059044, Length=304, Percent_Identity=48.0263157894737, Blast_Score=296, Evalue=2e-80,
Organism=Homo sapiens, GI221136809, Length=304, Percent_Identity=48.0263157894737, Blast_Score=296, Evalue=2e-80,
Organism=Homo sapiens, GI291575128, Length=302, Percent_Identity=47.682119205298, Blast_Score=291, Evalue=5e-79,
Organism=Homo sapiens, GI4557032, Length=302, Percent_Identity=47.682119205298, Blast_Score=291, Evalue=5e-79,
Organism=Homo sapiens, GI260099727, Length=234, Percent_Identity=48.7179487179487, Blast_Score=229, Evalue=4e-60,
Organism=Homo sapiens, GI260099725, Length=271, Percent_Identity=45.3874538745387, Blast_Score=228, Evalue=5e-60,
Organism=Homo sapiens, GI207028494, Length=216, Percent_Identity=48.1481481481481, Blast_Score=200, Evalue=1e-51,
Organism=Homo sapiens, GI103472011, Length=300, Percent_Identity=31.3333333333333, Blast_Score=143, Evalue=2e-34,
Organism=Homo sapiens, GI103472015, Length=181, Percent_Identity=34.2541436464088, Blast_Score=103, Evalue=2e-22,
Organism=Homo sapiens, GI21735621, Length=297, Percent_Identity=27.6094276094276, Blast_Score=82, Evalue=9e-16,
Organism=Escherichia coli, GI1789632, Length=311, Percent_Identity=27.6527331189711, Blast_Score=70, Evalue=3e-13,
Organism=Caenorhabditis elegans, GI17535107, Length=299, Percent_Identity=50.5016722408027, Blast_Score=294, Evalue=5e-80,
Organism=Saccharomyces cerevisiae, GI6322765, Length=300, Percent_Identity=26.3333333333333, Blast_Score=65, Evalue=1e-11,
Organism=Saccharomyces cerevisiae, GI6320125, Length=360, Percent_Identity=25.2777777777778, Blast_Score=65, Evalue=1e-11,
Organism=Drosophila melanogaster, GI17136226, Length=311, Percent_Identity=50.8038585209003, Blast_Score=318, Evalue=3e-87,
Organism=Drosophila melanogaster, GI45550422, Length=317, Percent_Identity=35.6466876971609, Blast_Score=213, Evalue=1e-55,
Organism=Drosophila melanogaster, GI24647881, Length=319, Percent_Identity=26.6457680250784, Blast_Score=77, Evalue=1e-14,
Organism=Drosophila melanogaster, GI24663599, Length=276, Percent_Identity=25.3623188405797, Blast_Score=70, Evalue=2e-12,

Paralogues:

None

Copy number: 2640 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 260 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 2380 Molecules/Cell In: Stationary-Phase, Rich-Media (Based on E. coli). 260 Molecules/Cell In: Stationary Phase

Swissprot (AC and ID): LDH_GLOVI (Q7NG49)

Other databases:

- EMBL:   BA000045
- RefSeq:   NP_926270.1
- ProteinModelPortal:   Q7NG49
- SMR:   Q7NG49
- GeneID:   2601726
- GenomeReviews:   BA000045_GR
- KEGG:   gvi:gll3324
- NMPDR:   fig|251221.1.peg.3324
- HOGENOM:   HBG566126
- OMA:   MDLNHGV
- ProtClustDB:   CLSK923236
- BioCyc:   GVIO251221:GLL3324-MONOMER
- BRENDA:   1.1.1.27
- GO:   GO:0005737
- GO:   GO:0005488
- GO:   GO:0006096
- HAMAP:   MF_00488
- InterPro:   IPR001557
- InterPro:   IPR011304
- InterPro:   IPR018177
- InterPro:   IPR022383
- InterPro:   IPR001236
- InterPro:   IPR015955
- InterPro:   IPR016040
- Gene3D:   G3DSA:3.90.110.10
- Gene3D:   G3DSA:3.40.50.720
- PIRSF:   PIRSF000102
- PRINTS:   PR00086
- TIGRFAMs:   TIGR01771

Pfam domain/function: PF02866 Ldh_1_C; PF00056 Ldh_1_N; SSF56327 Lactate_DH/Glyco_hydro_4_C

EC number: =1.1.1.27

Molecular weight: Translated: 36216; Mature: 36216

Theoretical pI: Translated: 5.68; Mature: 5.68

Prosite motif: PS00064 L_LDH

Important sites: ACT_SITE 192-192 BINDING 98-98 BINDING 105-105 BINDING 137-137 BINDING 168-168 BINDING 247-247

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
3.3 %Met     (Translated Protein)
4.2 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
3.3 %Met     (Mature Protein)
4.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MQDRLFVSMEHPRALPETDLIKGAIVGAGAVGMAIAYSMLIQNTFDELVLVDIDRRKVEG
CCCCEEEEECCCCCCCCHHHHHHHHHCCHHHHHHHHHHHHHHHHHHCEEEEECCHHHHHH
EVMDLVHGIPFVEPSVVRAGTLADCRGVDVVVITAGARQREGETRLSLVQRNVEIFRGLI
HHHHHHHCCCCCCCCHHCCCCCCCCCCCCEEEEECCCCCCCCHHHHHHHHHHHHHHHHHH
GEIMEHCPNAILLVVSNPVDVMTYVAMKLAGLPPSRVIGSGTVLDTARFRYLLAERLRVD
HHHHHHCCCEEEEEECCCHHHHHHHHHHHCCCCHHHHCCCCCHHHHHHHHHHHHHHHCCC
PRSLHAYIIGEHGDSEVPVWSRANVAGAFLSEIEPAVGTPDDPAKMFEVFEHVKNAAYEI
HHHEEEEEEECCCCCCCCCCCCCCHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHH
IERKGATSWAIGLATTQIVRAITRNQNRVLPVSVLMSGLHGIEEVCLAYPAVLNRQGIDR
HHHCCCCHHHHHHHHHHHHHHHHCCCCCEEHHHHHHHHHHHHHHHHHHHHHHHCHHHHHH
LVKFSLSPGEEEQLQRSARVMRQTLDGIQF
HHHHCCCCCCHHHHHHHHHHHHHHHHCCCC
>Mature Secondary Structure
MQDRLFVSMEHPRALPETDLIKGAIVGAGAVGMAIAYSMLIQNTFDELVLVDIDRRKVEG
CCCCEEEEECCCCCCCCHHHHHHHHHCCHHHHHHHHHHHHHHHHHHCEEEEECCHHHHHH
EVMDLVHGIPFVEPSVVRAGTLADCRGVDVVVITAGARQREGETRLSLVQRNVEIFRGLI
HHHHHHHCCCCCCCCHHCCCCCCCCCCCCEEEEECCCCCCCCHHHHHHHHHHHHHHHHHH
GEIMEHCPNAILLVVSNPVDVMTYVAMKLAGLPPSRVIGSGTVLDTARFRYLLAERLRVD
HHHHHHCCCEEEEEECCCHHHHHHHHHHHCCCCHHHHCCCCCHHHHHHHHHHHHHHHCCC
PRSLHAYIIGEHGDSEVPVWSRANVAGAFLSEIEPAVGTPDDPAKMFEVFEHVKNAAYEI
HHHEEEEEEECCCCCCCCCCCCCCHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHH
IERKGATSWAIGLATTQIVRAITRNQNRVLPVSVLMSGLHGIEEVCLAYPAVLNRQGIDR
HHHCCCCHHHHHHHHHHHHHHHHCCCCCEEHHHHHHHHHHHHHHHHHHHHHHHCHHHHHH
LVKFSLSPGEEEQLQRSARVMRQTLDGIQF
HHHHCCCCCCHHHHHHHHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 14621292