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The map label for this gene is fbp

Identifier: 37522698

GI number: 37522698

Start: 3332240

End: 3333286

Strand: Direct

Name: fbp

Synonym: gvip434

Alternate gene names: 37522698

Gene position: 3332240-3333286 (Clockwise)

Preceding gene: 37522697

Following gene: 37522700

Centisome position: 71.52

GC content: 63.71

Gene sequence:

>1047_bases
ATGGACACCACGCCCCTCACCCCGCTCACCAAGGGCATCACCCTCTACCAGCACATCCTTTCCCAGCAGGCGCTCAATCC
CGACGCCACCGGCGAATTTAGCGGCCTGATGGTGCAGATCAGCCTGGCGGCCAAACTGATTTCGCGTCAGCTCGCCCAGG
CGGGCCTGGTCGAAAACGTGCTGGGCTTTACCGGCGAGACGAACGTCCAGGGCGAAGCGGTCCGTCACCTCGACCAGTAC
GCCAACGAGACGTTTATTCGCGTCTTCCAGAACACAAATCTGGTCTGCCTGCTGGTCTCCGAAGAACTCGAAGACCCCCT
GCCGCTCTCCAACCAGTGCCCGATCGGTTCCTACGCTCTGGTCATCGATCCGGTGGACGGCTCCAGCAACATCGATGTGA
ACGTCTCGGTGGCCTCGATTTTCTCGGTGCAGCGGCGCAACCCGCGCGCCACCGACGAGACAAGCAGCCTGCTGCAAAAA
GGCACCGGGCAGGTGGCGGCGGGCTACGTGCTCTACGGCCCCAACACGATGTTCGTCTACACCAGCAGCCAGGGGGTGCA
CGGTTTTACCCTCGACGCCGGTCTGGGGGAATTCGTCCTCTCCCACCCGAATATCCGCATCCCCGAGCGCGGCGATTACT
ACAGCATCAACGACGCCTACTCGGCCGAATGGCAGCCGGGCACGCGCGCCTTTATCGACTACCTCAAGCAGGCCAAAAGC
CGGGGCGAAAAAGCCTACTCCGCCCGCTACATCGGCTCGCTGGCCGCCGATGTGCACCGCACGCTGCTCACCGGGGGCAT
CTTTCTCTACCCGGGCACCGTCGCCAAGCCCAAGGGCAAGCTGCGGCTGCTCTACGAAGCCCAGCCCCTCGCGCTCATCG
CCGAGCAGGCGGGGGGCAAGGCGAGCACCGGCACCGAGCGTATCCTCGATATCGAGCCCAAGACACTCCACCAGCGGGTG
CCACTCGTCATCGGCAGTCCCTACGAAGTGGATCTGGCGGTGGCCTTCGCTCGGGGCGAAAAACAAACCGTGGTTGCCGG
TTCGTAA

Upstream 100 bases:

>100_bases
GGGCATGGGCATCGAGCGCATCGCCATGCTGCTGTACGACATCAACGACATTCGCCTGTTCTATACCAACGACCTGCGCT
TCTTGCGGCAGTTTTAACCG

Downstream 100 bases:

>100_bases
CCTCTACTCTGCAAAGATACTTCGCTCATACCAGTTCGTCCGGCAGCGCGTTCGGATCCAAACCCATCCGGCGCAGGCGC
TCCTCCAGAATGGCCGTGCG

Product: fructose-1,6-bisphosphatase

Products: NA

Alternate protein names: FBPase class 1; D-fructose-1,6-bisphosphate 1-phosphohydrolase class 1

Number of amino acids: Translated: 348; Mature: 348

Protein sequence:

>348_residues
MDTTPLTPLTKGITLYQHILSQQALNPDATGEFSGLMVQISLAAKLISRQLAQAGLVENVLGFTGETNVQGEAVRHLDQY
ANETFIRVFQNTNLVCLLVSEELEDPLPLSNQCPIGSYALVIDPVDGSSNIDVNVSVASIFSVQRRNPRATDETSSLLQK
GTGQVAAGYVLYGPNTMFVYTSSQGVHGFTLDAGLGEFVLSHPNIRIPERGDYYSINDAYSAEWQPGTRAFIDYLKQAKS
RGEKAYSARYIGSLAADVHRTLLTGGIFLYPGTVAKPKGKLRLLYEAQPLALIAEQAGGKASTGTERILDIEPKTLHQRV
PLVIGSPYEVDLAVAFARGEKQTVVAGS

Sequences:

>Translated_348_residues
MDTTPLTPLTKGITLYQHILSQQALNPDATGEFSGLMVQISLAAKLISRQLAQAGLVENVLGFTGETNVQGEAVRHLDQY
ANETFIRVFQNTNLVCLLVSEELEDPLPLSNQCPIGSYALVIDPVDGSSNIDVNVSVASIFSVQRRNPRATDETSSLLQK
GTGQVAAGYVLYGPNTMFVYTSSQGVHGFTLDAGLGEFVLSHPNIRIPERGDYYSINDAYSAEWQPGTRAFIDYLKQAKS
RGEKAYSARYIGSLAADVHRTLLTGGIFLYPGTVAKPKGKLRLLYEAQPLALIAEQAGGKASTGTERILDIEPKTLHQRV
PLVIGSPYEVDLAVAFARGEKQTVVAGS
>Mature_348_residues
MDTTPLTPLTKGITLYQHILSQQALNPDATGEFSGLMVQISLAAKLISRQLAQAGLVENVLGFTGETNVQGEAVRHLDQY
ANETFIRVFQNTNLVCLLVSEELEDPLPLSNQCPIGSYALVIDPVDGSSNIDVNVSVASIFSVQRRNPRATDETSSLLQK
GTGQVAAGYVLYGPNTMFVYTSSQGVHGFTLDAGLGEFVLSHPNIRIPERGDYYSINDAYSAEWQPGTRAFIDYLKQAKS
RGEKAYSARYIGSLAADVHRTLLTGGIFLYPGTVAKPKGKLRLLYEAQPLALIAEQAGGKASTGTERILDIEPKTLHQRV
PLVIGSPYEVDLAVAFARGEKQTVVAGS

Specific function: INVOLVED IN SEVERAL METABOLIC PATHWAYS. IN E.COLI AND YEAST IT IS NECESSARY FOR GROWTH ON SUBSTANCES SUCH AS GLYCEROL, SUCCINATE AND ACETATE. [C]

COG id: COG0158

COG function: function code G; Fructose-1,6-bisphosphatase

Gene ontology:

Cell location: Cytoplasm (Potential)

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the FBPase class 1 family

Homologues:

Organism=Homo sapiens, GI22907028, Length=329, Percent_Identity=41.6413373860182, Blast_Score=245, Evalue=3e-65,
Organism=Homo sapiens, GI189083692, Length=325, Percent_Identity=40, Blast_Score=237, Evalue=1e-62,
Organism=Homo sapiens, GI16579888, Length=325, Percent_Identity=40, Blast_Score=237, Evalue=1e-62,
Organism=Escherichia coli, GI1790679, Length=327, Percent_Identity=47.7064220183486, Blast_Score=295, Evalue=2e-81,
Organism=Caenorhabditis elegans, GI17508131, Length=329, Percent_Identity=45.5927051671732, Blast_Score=300, Evalue=6e-82,
Organism=Saccharomyces cerevisiae, GI6323409, Length=324, Percent_Identity=43.2098765432099, Blast_Score=260, Evalue=3e-70,
Organism=Drosophila melanogaster, GI45550998, Length=329, Percent_Identity=44.3768996960486, Blast_Score=268, Evalue=3e-72,
Organism=Drosophila melanogaster, GI19921562, Length=329, Percent_Identity=44.3768996960486, Blast_Score=268, Evalue=5e-72,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): F16PA_GLOVI (Q7NGN9)

Other databases:

- EMBL:   BA000045
- RefSeq:   NP_926075.1
- HSSP:   P46275
- ProteinModelPortal:   Q7NGN9
- SMR:   Q7NGN9
- GeneID:   2601530
- GenomeReviews:   BA000045_GR
- NMPDR:   fig|251221.1.peg.3129
- HOGENOM:   HBG731261
- OMA:   AMSISPE
- ProtClustDB:   PRK09293
- BioCyc:   GVIO251221:GLR3129-MONOMER
- GO:   GO:0005737
- HAMAP:   MF_01855
- InterPro:   IPR000146
- InterPro:   IPR020548
- PANTHER:   PTHR11556
- PRINTS:   PR00115

Pfam domain/function: PF00316 FBPase

EC number: =3.1.3.11

Molecular weight: Translated: 37591; Mature: 37591

Theoretical pI: Translated: 5.66; Mature: 5.66

Prosite motif: PS00124 FBPASE

Important sites: BINDING 217-217 BINDING 250-250 BINDING 280-280

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
0.9 %Met     (Translated Protein)
1.4 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
0.9 %Met     (Mature Protein)
1.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MDTTPLTPLTKGITLYQHILSQQALNPDATGEFSGLMVQISLAAKLISRQLAQAGLVENV
CCCCCCCHHHHHHHHHHHHHHHHCCCCCCCCCCCCEEEEHHHHHHHHHHHHHHHHHHHHH
LGFTGETNVQGEAVRHLDQYANETFIRVFQNTNLVCLLVSEELEDPLPLSNQCPIGSYAL
HCCCCCCCCCHHHHHHHHHHHCCEEEEEECCCCEEEEEEECCCCCCCCCCCCCCCCCEEE
VIDPVDGSSNIDVNVSVASIFSVQRRNPRATDETSSLLQKGTGQVAAGYVLYGPNTMFVY
EEEECCCCCCEEEEEEHHHHHHHHCCCCCCCCHHHHHHHCCCCCEEEEEEEECCCEEEEE
TSSQGVHGFTLDAGLGEFVLSHPNIRIPERGDYYSINDAYSAEWQPGTRAFIDYLKQAKS
ECCCCCCEEEECCCCHHHHHCCCCEECCCCCCEEECCCCCCCCCCCCHHHHHHHHHHHHH
RGEKAYSARYIGSLAADVHRTLLTGGIFLYPGTVAKPKGKLRLLYEAQPLALIAEQAGGK
CCCHHHHHHHHHHHHHHHHHHHHHCCEEEECCCCCCCCCCEEEEEECCCCEEEEHHCCCC
ASTGTERILDIEPKTLHQRVPLVIGSPYEVDLAVAFARGEKQTVVAGS
CCCCCCEEEECCCHHHHCCCCEEECCCCEEEEEEEEECCCCCEEEECC
>Mature Secondary Structure
MDTTPLTPLTKGITLYQHILSQQALNPDATGEFSGLMVQISLAAKLISRQLAQAGLVENV
CCCCCCCHHHHHHHHHHHHHHHHCCCCCCCCCCCCEEEEHHHHHHHHHHHHHHHHHHHHH
LGFTGETNVQGEAVRHLDQYANETFIRVFQNTNLVCLLVSEELEDPLPLSNQCPIGSYAL
HCCCCCCCCCHHHHHHHHHHHCCEEEEEECCCCEEEEEEECCCCCCCCCCCCCCCCCEEE
VIDPVDGSSNIDVNVSVASIFSVQRRNPRATDETSSLLQKGTGQVAAGYVLYGPNTMFVY
EEEECCCCCCEEEEEEHHHHHHHHCCCCCCCCHHHHHHHCCCCCEEEEEEEECCCEEEEE
TSSQGVHGFTLDAGLGEFVLSHPNIRIPERGDYYSINDAYSAEWQPGTRAFIDYLKQAKS
ECCCCCCEEEECCCCHHHHHCCCCEECCCCCCEEECCCCCCCCCCCCHHHHHHHHHHHHH
RGEKAYSARYIGSLAADVHRTLLTGGIFLYPGTVAKPKGKLRLLYEAQPLALIAEQAGGK
CCCHHHHHHHHHHHHHHHHHHHHHCCEEEECCCCCCCCCCEEEEEECCCCEEEEHHCCCC
ASTGTERILDIEPKTLHQRVPLVIGSPYEVDLAVAFARGEKQTVVAGS
CCCCCCEEEECCCHHHHCCCCEEECCCCEEEEEEEEECCCCCEEEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 14621292