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The map label for this gene is rmlA1 [C]

Identifier: 37522653

GI number: 37522653

Start: 3285259

End: 3286242

Strand: Reverse

Name: rmlA1 [C]

Synonym: gll3084

Alternate gene names: 37522653

Gene position: 3286242-3285259 (Counterclockwise)

Preceding gene: 37522654

Following gene: 37522652

Centisome position: 70.54

GC content: 60.57

Gene sequence:

>984_bases
ATGAAAGCCTTCGTGCTCGCCGCCGGCAAGGGCACCCGCCTGCGGCCCTTCACCGACGACATCCCCAAGCCGCTGGTGCC
GGTGCTCAACCGGCCCGTGATGGCCCGCGTGCTCGATCTGTGCCGCACCCACGGTTTTGATGAGGTCGTGGCCAACTTGC
ACTACAAAGGCGAGAAGATCAGCCGCCATTTCGAGGATGGTTCGCAGTACGGTGTGCGCCTGGATTATTCCTGGGAAAAA
GAGCTGATGGGCACGGCGGGCGGTGTGCGCCGTCAGGCAGAATTCTTGGGGGATGGTACTTTTCTGGTGATTTCCGGCGA
CGTGGTCACCGACTTGGACATCACCCGTCTGGTGCATTTTCACAAAGCCCATGGGGCTATTGCAACCATGGCGGTTAAGG
AAGTGGGCGATCCGAGCCGCTTCGGCATCGTCGTCACCGACGCAGCGGGTCAAATCCAGTCATTCCAAGAAAAGCCCGCC
GCTGGTACCGAGCGCTCCAATCTGGCCAATACGGGCATCTATGTCTTCGAACCGGAGGTCTTCGACTGGATTCCCGAGGG
GCAATTCTACGATTTTGGCAAAGATCTCTTCCCGGCCCTGGTCGAAAAGGGCGCACCGGTGTTTGCGATGGGCACAGGCG
ACTATTGGTCCGATGTCGGCACCCTGGGCCAGTACCTCTATACCCACTGGGATTTGCTCTGCCACCCGCACCTCAAGCAG
CGCATCGGCAAAGGCACCGTGATCGAGCCGGGGGCGATTCTCTCCAGCCATGCGCTGATTGGCGAGAATTGCCACATCGA
GCGCGGTGCGGTGGTGATGGGCTACAGCTGCATCGGCGACGGCTGCGTGGTGCGCTCGGGGGCGACGGTCTTCGACAGCA
TCGTCTGGGCGGCGGAGCAGATTTCGCTTACTGTGGCAGATGAACTGGTGCGCTCGATCTACGGAGATGATAAACAGGTG
GCACTGGGCGTACCGACGTTGTAG

Upstream 100 bases:

>100_bases
GTTCCCATAGGAACATGAACGGCATTAACGAAATGTATAAGGTCGAAATGCTGCATTATTCGCTGCACCTGTCAGCCAAC
CTTCGTGCGAGGAACCATCC

Downstream 100 bases:

>100_bases
ACAGGGCGTGAATCAGCGGGAGTTTCAAAAGCGGCTCAAAGCACTTTCAGACGCGCAGGAAGGGAAATTCGGTTATCCCT
TTGTGTCGTTGCGGGCAATC

Product: mannose-1-phosphate guanyltransferase

Products: NA

Alternate protein names: UDP-N-acetylglucosamine pyrophosphorylase; N-acetylglucosamine-1-phosphate uridyltransferase; Glucosamine-1-phosphate N-acetyltransferase [H]

Number of amino acids: Translated: 327; Mature: 327

Protein sequence:

>327_residues
MKAFVLAAGKGTRLRPFTDDIPKPLVPVLNRPVMARVLDLCRTHGFDEVVANLHYKGEKISRHFEDGSQYGVRLDYSWEK
ELMGTAGGVRRQAEFLGDGTFLVISGDVVTDLDITRLVHFHKAHGAIATMAVKEVGDPSRFGIVVTDAAGQIQSFQEKPA
AGTERSNLANTGIYVFEPEVFDWIPEGQFYDFGKDLFPALVEKGAPVFAMGTGDYWSDVGTLGQYLYTHWDLLCHPHLKQ
RIGKGTVIEPGAILSSHALIGENCHIERGAVVMGYSCIGDGCVVRSGATVFDSIVWAAEQISLTVADELVRSIYGDDKQV
ALGVPTL

Sequences:

>Translated_327_residues
MKAFVLAAGKGTRLRPFTDDIPKPLVPVLNRPVMARVLDLCRTHGFDEVVANLHYKGEKISRHFEDGSQYGVRLDYSWEK
ELMGTAGGVRRQAEFLGDGTFLVISGDVVTDLDITRLVHFHKAHGAIATMAVKEVGDPSRFGIVVTDAAGQIQSFQEKPA
AGTERSNLANTGIYVFEPEVFDWIPEGQFYDFGKDLFPALVEKGAPVFAMGTGDYWSDVGTLGQYLYTHWDLLCHPHLKQ
RIGKGTVIEPGAILSSHALIGENCHIERGAVVMGYSCIGDGCVVRSGATVFDSIVWAAEQISLTVADELVRSIYGDDKQV
ALGVPTL
>Mature_327_residues
MKAFVLAAGKGTRLRPFTDDIPKPLVPVLNRPVMARVLDLCRTHGFDEVVANLHYKGEKISRHFEDGSQYGVRLDYSWEK
ELMGTAGGVRRQAEFLGDGTFLVISGDVVTDLDITRLVHFHKAHGAIATMAVKEVGDPSRFGIVVTDAAGQIQSFQEKPA
AGTERSNLANTGIYVFEPEVFDWIPEGQFYDFGKDLFPALVEKGAPVFAMGTGDYWSDVGTLGQYLYTHWDLLCHPHLKQ
RIGKGTVIEPGAILSSHALIGENCHIERGAVVMGYSCIGDGCVVRSGATVFDSIVWAAEQISLTVADELVRSIYGDDKQV
ALGVPTL

Specific function: Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetyl-glucosamine (UDP- GlcNAc). Responsible for the acetylation of GlcN-1-P to GlcNAc-1- P, and for the uridyl transfer from UTP to GlcNAc-1-P, to produce UDP-GlcN

COG id: COG1208

COG function: function code MJ; Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis/translation initiation factor 2B, gamma/epsilon subunits (eIF-2Bgamma/eIF-2Bepsilon)

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: In the C-terminal section; belongs to the transferase hexapeptide repeat family [H]

Homologues:

Organism=Homo sapiens, GI11761621, Length=299, Percent_Identity=31.1036789297659, Blast_Score=147, Evalue=2e-35,
Organism=Homo sapiens, GI11761619, Length=299, Percent_Identity=31.1036789297659, Blast_Score=147, Evalue=2e-35,
Organism=Homo sapiens, GI31881779, Length=350, Percent_Identity=25.1428571428571, Blast_Score=86, Evalue=4e-17,
Organism=Homo sapiens, GI45447090, Length=350, Percent_Identity=25.1428571428571, Blast_Score=86, Evalue=4e-17,
Organism=Escherichia coli, GI1788351, Length=227, Percent_Identity=29.5154185022026, Blast_Score=84, Evalue=2e-17,
Organism=Escherichia coli, GI1790224, Length=229, Percent_Identity=28.82096069869, Blast_Score=80, Evalue=2e-16,
Organism=Escherichia coli, GI1789837, Length=274, Percent_Identity=28.1021897810219, Blast_Score=79, Evalue=3e-16,
Organism=Caenorhabditis elegans, GI133931050, Length=306, Percent_Identity=31.6993464052288, Blast_Score=153, Evalue=9e-38,
Organism=Caenorhabditis elegans, GI17509979, Length=322, Percent_Identity=28.8819875776398, Blast_Score=91, Evalue=1e-18,
Organism=Caenorhabditis elegans, GI17509981, Length=312, Percent_Identity=27.8846153846154, Blast_Score=84, Evalue=7e-17,
Organism=Saccharomyces cerevisiae, GI6320148, Length=320, Percent_Identity=30.9375, Blast_Score=139, Evalue=6e-34,
Organism=Drosophila melanogaster, GI21355443, Length=299, Percent_Identity=31.438127090301, Blast_Score=149, Evalue=2e-36,
Organism=Drosophila melanogaster, GI24644084, Length=299, Percent_Identity=31.438127090301, Blast_Score=149, Evalue=2e-36,
Organism=Drosophila melanogaster, GI24653912, Length=352, Percent_Identity=25.2840909090909, Blast_Score=87, Evalue=2e-17,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005835
- InterPro:   IPR011004 [H]

Pfam domain/function: PF00483 NTP_transferase [H]

EC number: =2.7.7.23; =2.3.1.157 [H]

Molecular weight: Translated: 35686; Mature: 35686

Theoretical pI: Translated: 5.55; Mature: 5.55

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.5 %Cys     (Translated Protein)
1.8 %Met     (Translated Protein)
3.4 %Cys+Met (Translated Protein)
1.5 %Cys     (Mature Protein)
1.8 %Met     (Mature Protein)
3.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKAFVLAAGKGTRLRPFTDDIPKPLVPVLNRPVMARVLDLCRTHGFDEVVANLHYKGEKI
CCEEEEECCCCCCCCCCCCCCCCCHHHHHCCHHHHHHHHHHHHCCHHHHHHHHCCCCHHH
SRHFEDGSQYGVRLDYSWEKELMGTAGGVRRQAEFLGDGTFLVISGDVVTDLDITRLVHF
HHHHCCCCCCCEEEECCHHHHHHCCCCCHHHHHHHHCCCEEEEEECCEEECHHHHHHHHH
HKAHGAIATMAVKEVGDPSRFGIVVTDAAGQIQSFQEKPAAGTERSNLANTGIYVFEPEV
HHHCCHHHHHHHHHCCCCCCEEEEEECCCHHHHHHHHCCCCCCCCCCCCCCCEEEECCHH
FDWIPEGQFYDFGKDLFPALVEKGAPVFAMGTGDYWSDVGTLGQYLYTHWDLLCHPHLKQ
HHCCCCCCCCCCCHHHHHHHHHCCCCEEEEECCHHHHHHHHHHHHHHHHHHHHCCHHHHH
RIGKGTVIEPGAILSSHALIGENCHIERGAVVMGYSCIGDGCVVRSGATVFDSIVWAAEQ
HCCCCCEECCCCHHHCCCEECCCCEEECCCEEEEEEECCCCEEEECCCHHHHHHHHHHHH
ISLTVADELVRSIYGDDKQVALGVPTL
HHHHHHHHHHHHHHCCCCEEEECCCCC
>Mature Secondary Structure
MKAFVLAAGKGTRLRPFTDDIPKPLVPVLNRPVMARVLDLCRTHGFDEVVANLHYKGEKI
CCEEEEECCCCCCCCCCCCCCCCCHHHHHCCHHHHHHHHHHHHCCHHHHHHHHCCCCHHH
SRHFEDGSQYGVRLDYSWEKELMGTAGGVRRQAEFLGDGTFLVISGDVVTDLDITRLVHF
HHHHCCCCCCCEEEECCHHHHHHCCCCCHHHHHHHHCCCEEEEEECCEEECHHHHHHHHH
HKAHGAIATMAVKEVGDPSRFGIVVTDAAGQIQSFQEKPAAGTERSNLANTGIYVFEPEV
HHHCCHHHHHHHHHCCCCCCEEEEEECCCHHHHHHHHCCCCCCCCCCCCCCCEEEECCHH
FDWIPEGQFYDFGKDLFPALVEKGAPVFAMGTGDYWSDVGTLGQYLYTHWDLLCHPHLKQ
HHCCCCCCCCCCCHHHHHHHHHCCCCEEEEECCHHHHHHHHHHHHHHHHHHHHCCHHHHH
RIGKGTVIEPGAILSSHALIGENCHIERGAVVMGYSCIGDGCVVRSGATVFDSIVWAAEQ
HCCCCCEECCCCHHHCCCEECCCCEEECCCEEEEEEECCCCEEEECCCHHHHHHHHHHHH
ISLTVADELVRSIYGDDKQVALGVPTL
HHHHHHHHHHHHHHCCCCEEEECCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA