Click here to switch to the map view.

The map label for this gene is hemN [C]

Identifier: 37522654

GI number: 37522654

Start: 3286370

End: 3287596

Strand: Reverse

Name: hemN [C]

Synonym: gvip426

Alternate gene names: 37522654

Gene position: 3287596-3286370 (Counterclockwise)

Preceding gene: 37522657

Following gene: 37522653

Centisome position: 70.56

GC content: 62.43

Gene sequence:

>1227_bases
ATGGAACGACAGGACGAGGCGAACACACAGATTATAGCCTCTACCGTCCCGCATCCTCCCTGTGCAACACTTCCTCAAAC
TTGCCCAGGGCGCTTCGGTGAACTGCCCACCGCCGCCTACCTGCACATTCCGTTTTGTCGCACGCGCTGCCGCTACTGCG
ACTTTGCCGTCACCGTCGGCACCGAAGGGCTGATCGAAAAGTACGTGCGCTTTTTGCTCGCGGAGATCGCCTTGACCCCG
AGCGGGGGCCAGGGATTGGACACGGTCTACTTCGGAGGCGGCACGCCGTCGCTGTTGTCGGTCGAACAACTCGGCCGCGT
TCTGGCGGCTCTGCGGGAGCACTTCGGCGGTTTTGCCCCCGATGCCGAAATTTCGCTGGAGGCCAACCCCGGCACTTTTG
ATTGCAAGAAACTCACCGGTTACCGCTCGCTGGGGGTCAACCGCCTGAGCGTCGGCGTCCAGGCCTTTCAGTCCCACCTA
CTGGCCCTTTGCGGCCGTTCCCACGGACTTGAGGAGGTCTACTCCTCCGTGGCTACGGTGCGGGCGGCAGGTTTCGAGAA
TTTCAACCTCGACCTCATCTTCGGTCTGCCCCACCAGAGCCTTGCCGATTGGGAGTTTTCGCTCTCTGAAGTTTTGCGGC
TGGAGCCTACCCATCTATCGCTCTACGACCTGATTCTCGAAGAAGAGACCCCTTTTGGCCGGGAGTTCCTGGGGGGTCAG
GCGCCCCTGCCGGGTGACGACGACACCGTGGCGATGTACCTGCGCGCCTGCGAGCGGTTGCAGGGGCAGGGCTACCGGCA
GTATGAGATTGCCAATTTTGCCCGGCCCGGTTTTCGCTGCCGCCACAACCGGGTTTACTGGGACAACCGGCCCTACTACG
GAATCGGCAACGGTGCGACCGGTTATGTCCGGGGGGCGCGCGTCGAGAGACCGCGCCGATTGCACGATTATTTTGCCTGG
GTCGAGGGGGGCGAGTTTCCGGCGGGTGCACCGGTCATGCCCGAAGAAGAGTTAGCCGATACGCTGCTGTTGGGCCTGCG
GCTGCTCGAAGGGGTGGAAGTGAATGCGCTGGTGCAGCGCTTCGGCCACCTTGCAGTCACGCACCAGCTCGAGGCGTTGC
AAAGCGCCCTGGAGCGGGGACTGTTGATACTATACGACGGCCGCTTGCGGCTGAGCGTCCCGGAGGGACTGCTGCTGTCC
AACGAAGTCTTCACGCTTTTGGTGTAG

Upstream 100 bases:

>100_bases
AAGGCAGAAAAGCGATGCTGTTAAAGCCGATTCCTGCCCCTGCTAGGATGAAAAGGCAAACGATGGCGACATCTAACATC
CGGAACAATTCCGCTCGCGA

Downstream 100 bases:

>100_bases
GACAGAAGGTAACTGAGCCTTTACGATGTTCCCATAGGAACATGAACGGCATTAACGAAATGTATAAGGTCGAAATGCTG
CATTATTCGCTGCACCTGTC

Product: coproporphyrinogen III oxidase

Products: Protoporphyrinogen IX; CO2; H2O

Alternate protein names: NA

Number of amino acids: Translated: 408; Mature: 408

Protein sequence:

>408_residues
MERQDEANTQIIASTVPHPPCATLPQTCPGRFGELPTAAYLHIPFCRTRCRYCDFAVTVGTEGLIEKYVRFLLAEIALTP
SGGQGLDTVYFGGGTPSLLSVEQLGRVLAALREHFGGFAPDAEISLEANPGTFDCKKLTGYRSLGVNRLSVGVQAFQSHL
LALCGRSHGLEEVYSSVATVRAAGFENFNLDLIFGLPHQSLADWEFSLSEVLRLEPTHLSLYDLILEEETPFGREFLGGQ
APLPGDDDTVAMYLRACERLQGQGYRQYEIANFARPGFRCRHNRVYWDNRPYYGIGNGATGYVRGARVERPRRLHDYFAW
VEGGEFPAGAPVMPEEELADTLLLGLRLLEGVEVNALVQRFGHLAVTHQLEALQSALERGLLILYDGRLRLSVPEGLLLS
NEVFTLLV

Sequences:

>Translated_408_residues
MERQDEANTQIIASTVPHPPCATLPQTCPGRFGELPTAAYLHIPFCRTRCRYCDFAVTVGTEGLIEKYVRFLLAEIALTP
SGGQGLDTVYFGGGTPSLLSVEQLGRVLAALREHFGGFAPDAEISLEANPGTFDCKKLTGYRSLGVNRLSVGVQAFQSHL
LALCGRSHGLEEVYSSVATVRAAGFENFNLDLIFGLPHQSLADWEFSLSEVLRLEPTHLSLYDLILEEETPFGREFLGGQ
APLPGDDDTVAMYLRACERLQGQGYRQYEIANFARPGFRCRHNRVYWDNRPYYGIGNGATGYVRGARVERPRRLHDYFAW
VEGGEFPAGAPVMPEEELADTLLLGLRLLEGVEVNALVQRFGHLAVTHQLEALQSALERGLLILYDGRLRLSVPEGLLLS
NEVFTLLV
>Mature_408_residues
MERQDEANTQIIASTVPHPPCATLPQTCPGRFGELPTAAYLHIPFCRTRCRYCDFAVTVGTEGLIEKYVRFLLAEIALTP
SGGQGLDTVYFGGGTPSLLSVEQLGRVLAALREHFGGFAPDAEISLEANPGTFDCKKLTGYRSLGVNRLSVGVQAFQSHL
LALCGRSHGLEEVYSSVATVRAAGFENFNLDLIFGLPHQSLADWEFSLSEVLRLEPTHLSLYDLILEEETPFGREFLGGQ
APLPGDDDTVAMYLRACERLQGQGYRQYEIANFARPGFRCRHNRVYWDNRPYYGIGNGATGYVRGARVERPRRLHDYFAW
VEGGEFPAGAPVMPEEELADTLLLGLRLLEGVEVNALVQRFGHLAVTHQLEALQSALERGLLILYDGRLRLSVPEGLLLS
NEVFTLLV

Specific function: Unknown

COG id: COG0635

COG function: function code H; Coproporphyrinogen III oxidase and related Fe-S oxidoreductases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the anaerobic coproporphyrinogen-III oxidase family [H]

Homologues:

Organism=Homo sapiens, GI8922911, Length=285, Percent_Identity=35.4385964912281, Blast_Score=160, Evalue=3e-39,
Organism=Escherichia coli, GI1789325, Length=272, Percent_Identity=39.7058823529412, Blast_Score=190, Evalue=1e-49,
Organism=Escherichia coli, GI87082341, Length=250, Percent_Identity=32, Blast_Score=129, Evalue=4e-31,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006638
- InterPro:   IPR004559
- InterPro:   IPR010723
- InterPro:   IPR007197 [H]

Pfam domain/function: PF06969 HemN_C; PF04055 Radical_SAM [H]

EC number: 1.3.3.3

Molecular weight: Translated: 45120; Mature: 45120

Theoretical pI: Translated: 5.17; Mature: 5.17

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.2 %Cys     (Translated Protein)
0.7 %Met     (Translated Protein)
2.9 %Cys+Met (Translated Protein)
2.2 %Cys     (Mature Protein)
0.7 %Met     (Mature Protein)
2.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MERQDEANTQIIASTVPHPPCATLPQTCPGRFGELPTAAYLHIPFCRTRCRYCDFAVTVG
CCCCCCCCCEEEEECCCCCCCCCCCCCCCCCCCCCCCEEEEECHHHHHHHHHCCEEEEEC
TEGLIEKYVRFLLAEIALTPSGGQGLDTVYFGGGTPSLLSVEQLGRVLAALREHFGGFAP
CHHHHHHHHHHHHHHHHCCCCCCCCCCEEEECCCCCCHHHHHHHHHHHHHHHHHHCCCCC
DAEISLEANPGTFDCKKLTGYRSLGVNRLSVGVQAFQSHLLALCGRSHGLEEVYSSVATV
CCEEEEECCCCCCCHHHHCCHHHCCCHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHH
RAAGFENFNLDLIFGLPHQSLADWEFSLSEVLRLEPTHLSLYDLILEEETPFGREFLGGQ
HHCCCCCCCEEEEECCCCCCHHCCHHHHHHHHHCCCCHHHHHHHHHCCCCCCCHHHCCCC
APLPGDDDTVAMYLRACERLQGQGYRQYEIANFARPGFRCRHNRVYWDNRPYYGIGNGAT
CCCCCCCHHHHHHHHHHHHHHCCCCCEEEHHHHCCCCCEEECCEEEECCCCEEECCCCCC
GYVRGARVERPRRLHDYFAWVEGGEFPAGAPVMPEEELADTLLLGLRLLEGVEVNALVQR
CCEECCCCCCCHHHHHHHHHCCCCCCCCCCCCCCHHHHHHHHHHHHHHHCCCCHHHHHHH
FGHLAVTHQLEALQSALERGLLILYDGRLRLSVPEGLLLSNEVFTLLV
HHHHHHHHHHHHHHHHHHCCEEEEECCEEEEECCCCEEECCCEEEEEC
>Mature Secondary Structure
MERQDEANTQIIASTVPHPPCATLPQTCPGRFGELPTAAYLHIPFCRTRCRYCDFAVTVG
CCCCCCCCCEEEEECCCCCCCCCCCCCCCCCCCCCCCEEEEECHHHHHHHHHCCEEEEEC
TEGLIEKYVRFLLAEIALTPSGGQGLDTVYFGGGTPSLLSVEQLGRVLAALREHFGGFAP
CHHHHHHHHHHHHHHHHCCCCCCCCCCEEEECCCCCCHHHHHHHHHHHHHHHHHHCCCCC
DAEISLEANPGTFDCKKLTGYRSLGVNRLSVGVQAFQSHLLALCGRSHGLEEVYSSVATV
CCEEEEECCCCCCCHHHHCCHHHCCCHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHH
RAAGFENFNLDLIFGLPHQSLADWEFSLSEVLRLEPTHLSLYDLILEEETPFGREFLGGQ
HHCCCCCCCEEEEECCCCCCHHCCHHHHHHHHHCCCCHHHHHHHHHCCCCCCCHHHCCCC
APLPGDDDTVAMYLRACERLQGQGYRQYEIANFARPGFRCRHNRVYWDNRPYYGIGNGAT
CCCCCCCHHHHHHHHHHHHHHCCCCCEEEHHHHCCCCCEEECCEEEECCCCEEECCCCCC
GYVRGARVERPRRLHDYFAWVEGGEFPAGAPVMPEEELADTLLLGLRLLEGVEVNALVQR
CCEECCCCCCCHHHHHHHHHCCCCCCCCCCCCCCHHHHHHHHHHHHHHHCCCCHHHHHHH
FGHLAVTHQLEALQSALERGLLILYDGRLRLSVPEGLLLSNEVFTLLV
HHHHHHHHHHHHHHHHHHCCEEEEECCEEEEECCCCEEECCCEEEEEC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: Coproporphyrinogen III; O2; H+

Specific reaction: coproporphyrinogen-III + O2 + 2 H+ = protoporphyrinogen-IX + 2 CO2 + 2 H2O

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8905231 [H]