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The map label for this gene is atpA

Identifier: 37522474

GI number: 37522474

Start: 3101389

End: 3102930

Strand: Reverse

Name: atpA

Synonym: gvip398

Alternate gene names: 37522474

Gene position: 3102930-3101389 (Counterclockwise)

Preceding gene: 37522475

Following gene: 37522472

Centisome position: 66.6

GC content: 63.04

Gene sequence:

>1542_bases
ATGTTCACGATTCGCCCGGACGAAATCAGCTCCGTCATCCGCGATCAAATCCAGAAGTACAACACCGAACTGCAGGTGAC
CAACGTCGGCACGGTGCTGCAGGTCGGCGACGGCATCGCCCGCGTCTACGGTCTTGAAAAGTGCATGGCCTCCGAACTGC
TCGAATTCGAGGACGGCACGATCGGCATCGCCCTCAACCTCGAAGAGGACAACGTCGGCGCGGTGCTGATGGGCGCAGGC
CGCACGATCGAAGAAGGCTCCACCGTGCGCGCCACCGGCCGCATCGCTTCGATTCCGGTGGGACCGGCCTTCTTGGGCCG
GGTCGTCAATGCCCTGGCGATTCCCATCGACGGCAAGGGCGACATCGTCGGCAGCGAAACCCGCCTGCTCGAATCGCCCG
CCCCCGGCATCATCAAGCGCAAATCGGTCTACGAACCTTTGGCGACGGGCATCACCGCCATCGACGCCATGATCCCGATC
GGCCGCGGTCAGCGCGAGCTGATTATCGGCGACCGCCAGACCGGCAAGACGACGATCGCCATCGACACCATCCTCAACCA
GAAGGGTAAAGGCGTCGTTTGCGTCTACGTCGCCATTGGCCAGAAAGCTTCTACCGTGGCTCAGATCGTCGAGGTGCTGC
GCTCGCGCGGCGCCCTGGAATACACGATCATCGTCGCCGCCAATGCCAACGAGCCTGCCGCCCTGCAGTACCTGGCGCCT
TACACCGGTTGCACCCTGGGCGAGTACGTCATGTACAACGGCCTCACCCTGCCGGGCTCCGACAAAAAGATCAACGCCGC
CCTGCTGGTCTACGACGATCTCTCCAAGCAGGCGGTGGCCTACCGCCAGATGTCGCTGCTGTTGCGCCGTCCGCCGGGCC
GCGAAGCCTATCCGGGCGACGTGTTCTACTTGCACTCGCGCTTGCTTGAGCGCGCCGCCAAACTGAGCCCCGATCTGGGC
GAAGGTTCGCTCACCGCCCTGCCGATCATCGAGACCCAGGCGGGTGACGTCTCGGCCTACATCCCCACCAACGTCATCTC
GATCACCGACGGCCAGATCTTCCTCGATTCGGGCCTGTTCAACTCGGGACTGCGCCCTGCCATCGACGCGGGCATCTCGG
TCTCGCGGGTGGGCGGGGCCGCCCAGACCAAGGCGATGAAAAAAGTGGCCGGCAAACTGCGCCTCGATCTGGCCCAGTTC
AGCGAACTGGAGGCCTTTTCGCAGTTTGCCTCCGACCTCGATAAGGCCACCCAGGCCCAGCTCGCCCGCGGTCTGCGCCT
GCGCGAAATCCTCAAGCAGCCGCAGTACTCGCCCCTGTCGGTGGCCCAGCAGGTGGCGATCATCTATGCCGCCACCAACG
GCTACCTCGACGACATCGACGTCAAAGGCATCCAGCCCTTCAAGCAGCAGTTCCTCAACTATCTCGATTCCAGCGTGTCT
GAGTACGGCCAGGAAATCGAGACCACCAAAGCCCTCACCGACAAAGCGGTGGACCTGCTCAAAAAGGCGCTCAACGACTT
TAAGACGACCGTCAAGAAGTAG

Upstream 100 bases:

>100_bases
ATCATCAAGATTGGCGACGAAGTAATCGACGCCAGTCTGCGCGGCCAGCTGCGCAAGCTCACCTTGCAGCTCACGCTTTC
TTGAAAATCGAGAGGTAGCC

Downstream 100 bases:

>100_bases
GCGCAGATTTCGTTCAACCTCAAAGGGCGCGCAGCTGAAGCGCGCGCCTTTTTCTTTGGGACGATTGTGCGCATGAAGCA
GCAAAAGGTATGGTGACTAC

Product: F0F1 ATP synthase subunit alpha

Products: NA

Alternate protein names: ATP synthase F1 sector subunit alpha; F-ATPase subunit alpha

Number of amino acids: Translated: 513; Mature: 513

Protein sequence:

>513_residues
MFTIRPDEISSVIRDQIQKYNTELQVTNVGTVLQVGDGIARVYGLEKCMASELLEFEDGTIGIALNLEEDNVGAVLMGAG
RTIEEGSTVRATGRIASIPVGPAFLGRVVNALAIPIDGKGDIVGSETRLLESPAPGIIKRKSVYEPLATGITAIDAMIPI
GRGQRELIIGDRQTGKTTIAIDTILNQKGKGVVCVYVAIGQKASTVAQIVEVLRSRGALEYTIIVAANANEPAALQYLAP
YTGCTLGEYVMYNGLTLPGSDKKINAALLVYDDLSKQAVAYRQMSLLLRRPPGREAYPGDVFYLHSRLLERAAKLSPDLG
EGSLTALPIIETQAGDVSAYIPTNVISITDGQIFLDSGLFNSGLRPAIDAGISVSRVGGAAQTKAMKKVAGKLRLDLAQF
SELEAFSQFASDLDKATQAQLARGLRLREILKQPQYSPLSVAQQVAIIYAATNGYLDDIDVKGIQPFKQQFLNYLDSSVS
EYGQEIETTKALTDKAVDLLKKALNDFKTTVKK

Sequences:

>Translated_513_residues
MFTIRPDEISSVIRDQIQKYNTELQVTNVGTVLQVGDGIARVYGLEKCMASELLEFEDGTIGIALNLEEDNVGAVLMGAG
RTIEEGSTVRATGRIASIPVGPAFLGRVVNALAIPIDGKGDIVGSETRLLESPAPGIIKRKSVYEPLATGITAIDAMIPI
GRGQRELIIGDRQTGKTTIAIDTILNQKGKGVVCVYVAIGQKASTVAQIVEVLRSRGALEYTIIVAANANEPAALQYLAP
YTGCTLGEYVMYNGLTLPGSDKKINAALLVYDDLSKQAVAYRQMSLLLRRPPGREAYPGDVFYLHSRLLERAAKLSPDLG
EGSLTALPIIETQAGDVSAYIPTNVISITDGQIFLDSGLFNSGLRPAIDAGISVSRVGGAAQTKAMKKVAGKLRLDLAQF
SELEAFSQFASDLDKATQAQLARGLRLREILKQPQYSPLSVAQQVAIIYAATNGYLDDIDVKGIQPFKQQFLNYLDSSVS
EYGQEIETTKALTDKAVDLLKKALNDFKTTVKK
>Mature_513_residues
MFTIRPDEISSVIRDQIQKYNTELQVTNVGTVLQVGDGIARVYGLEKCMASELLEFEDGTIGIALNLEEDNVGAVLMGAG
RTIEEGSTVRATGRIASIPVGPAFLGRVVNALAIPIDGKGDIVGSETRLLESPAPGIIKRKSVYEPLATGITAIDAMIPI
GRGQRELIIGDRQTGKTTIAIDTILNQKGKGVVCVYVAIGQKASTVAQIVEVLRSRGALEYTIIVAANANEPAALQYLAP
YTGCTLGEYVMYNGLTLPGSDKKINAALLVYDDLSKQAVAYRQMSLLLRRPPGREAYPGDVFYLHSRLLERAAKLSPDLG
EGSLTALPIIETQAGDVSAYIPTNVISITDGQIFLDSGLFNSGLRPAIDAGISVSRVGGAAQTKAMKKVAGKLRLDLAQF
SELEAFSQFASDLDKATQAQLARGLRLREILKQPQYSPLSVAQQVAIIYAATNGYLDDIDVKGIQPFKQQFLNYLDSSVS
EYGQEIETTKALTDKAVDLLKKALNDFKTTVKK

Specific function: Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit

COG id: COG0056

COG function: function code C; F0F1-type ATP synthase, alpha subunit

Gene ontology:

Cell location: Cell inner membrane; Peripheral membrane protein

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ATPase alpha/beta chains family

Homologues:

Organism=Homo sapiens, GI50345984, Length=511, Percent_Identity=57.1428571428571, Blast_Score=569, Evalue=1e-162,
Organism=Homo sapiens, GI4757810, Length=511, Percent_Identity=57.1428571428571, Blast_Score=569, Evalue=1e-162,
Organism=Homo sapiens, GI19913428, Length=316, Percent_Identity=28.4810126582279, Blast_Score=100, Evalue=5e-21,
Organism=Homo sapiens, GI19913426, Length=317, Percent_Identity=29.0220820189274, Blast_Score=99, Evalue=1e-20,
Organism=Homo sapiens, GI32189394, Length=322, Percent_Identity=25.776397515528, Blast_Score=91, Evalue=2e-18,
Organism=Escherichia coli, GI1790172, Length=514, Percent_Identity=56.0311284046693, Blast_Score=566, Evalue=1e-162,
Organism=Escherichia coli, GI1788251, Length=338, Percent_Identity=28.1065088757396, Blast_Score=96, Evalue=6e-21,
Organism=Escherichia coli, GI1790170, Length=415, Percent_Identity=23.6144578313253, Blast_Score=90, Evalue=3e-19,
Organism=Caenorhabditis elegans, GI71988063, Length=513, Percent_Identity=56.7251461988304, Blast_Score=577, Evalue=1e-165,
Organism=Caenorhabditis elegans, GI71988080, Length=513, Percent_Identity=56.7251461988304, Blast_Score=575, Evalue=1e-164,
Organism=Caenorhabditis elegans, GI71988074, Length=513, Percent_Identity=53.411306042885, Blast_Score=529, Evalue=1e-150,
Organism=Caenorhabditis elegans, GI17510931, Length=388, Percent_Identity=27.5773195876289, Blast_Score=105, Evalue=6e-23,
Organism=Caenorhabditis elegans, GI17570191, Length=310, Percent_Identity=29.6774193548387, Blast_Score=99, Evalue=5e-21,
Organism=Caenorhabditis elegans, GI25144756, Length=322, Percent_Identity=25.4658385093168, Blast_Score=92, Evalue=1e-18,
Organism=Caenorhabditis elegans, GI71988068, Length=71, Percent_Identity=45.0704225352113, Blast_Score=70, Evalue=2e-12,
Organism=Caenorhabditis elegans, GI17565854, Length=267, Percent_Identity=28.4644194756554, Blast_Score=69, Evalue=6e-12,
Organism=Saccharomyces cerevisiae, GI6319370, Length=514, Percent_Identity=57.5875486381323, Blast_Score=579, Evalue=1e-166,
Organism=Saccharomyces cerevisiae, GI6319603, Length=353, Percent_Identity=29.4617563739377, Blast_Score=109, Evalue=1e-24,
Organism=Saccharomyces cerevisiae, GI6322581, Length=381, Percent_Identity=24.6719160104987, Blast_Score=96, Evalue=2e-20,
Organism=Drosophila melanogaster, GI24658560, Length=518, Percent_Identity=56.5637065637066, Blast_Score=567, Evalue=1e-162,
Organism=Drosophila melanogaster, GI281361666, Length=351, Percent_Identity=26.2108262108262, Blast_Score=105, Evalue=5e-23,
Organism=Drosophila melanogaster, GI24646341, Length=351, Percent_Identity=26.2108262108262, Blast_Score=105, Evalue=5e-23,
Organism=Drosophila melanogaster, GI17136796, Length=351, Percent_Identity=26.2108262108262, Blast_Score=105, Evalue=5e-23,
Organism=Drosophila melanogaster, GI24638766, Length=322, Percent_Identity=25.776397515528, Blast_Score=92, Evalue=9e-19,
Organism=Drosophila melanogaster, GI28574560, Length=421, Percent_Identity=24.9406175771971, Blast_Score=82, Evalue=1e-15,
Organism=Drosophila melanogaster, GI24583992, Length=268, Percent_Identity=27.9850746268657, Blast_Score=68, Evalue=1e-11,
Organism=Drosophila melanogaster, GI24583988, Length=265, Percent_Identity=27.9245283018868, Blast_Score=68, Evalue=2e-11,
Organism=Drosophila melanogaster, GI24583986, Length=265, Percent_Identity=27.9245283018868, Blast_Score=68, Evalue=2e-11,
Organism=Drosophila melanogaster, GI24583984, Length=265, Percent_Identity=27.9245283018868, Blast_Score=68, Evalue=2e-11,

Paralogues:

None

Copy number: 9,000 Molecules/Cell In: Glucose minimal media [C]

Swissprot (AC and ID): ATPA_GLOVI (Q7NCS3)

Other databases:

- EMBL:   BA000045
- RefSeq:   NP_925851.1
- ProteinModelPortal:   Q7NCS3
- SMR:   Q7NCS3
- GeneID:   2601306
- GenomeReviews:   BA000045_GR
- NMPDR:   fig|251221.1.peg.2905
- HOGENOM:   HBG565875
- OMA:   EMALTLW
- ProtClustDB:   PRK09281
- BioCyc:   GVIO251221:GLL2905-MONOMER
- BRENDA:   3.6.3.14
- HAMAP:   MF_01346
- InterPro:   IPR020003
- InterPro:   IPR000194
- InterPro:   IPR005294
- InterPro:   IPR017458
- InterPro:   IPR018118
- InterPro:   IPR000793
- InterPro:   IPR004100
- PANTHER:   PTHR15184:SF3
- TIGRFAMs:   TIGR00962

Pfam domain/function: PF00006 ATP-synt_ab; PF00306 ATP-synt_ab_C; PF02874 ATP-synt_ab_N; SSF47917 ATPase_a/b_C; SSF50615 ATPase_a/b_N

EC number: =3.6.3.14

Molecular weight: Translated: 55131; Mature: 55131

Theoretical pI: Translated: 5.43; Mature: 5.43

Prosite motif: PS00152 ATPASE_ALPHA_BETA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
1.4 %Met     (Translated Protein)
1.9 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
1.4 %Met     (Mature Protein)
1.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MFTIRPDEISSVIRDQIQKYNTELQVTNVGTVLQVGDGIARVYGLEKCMASELLEFEDGT
CCCCCHHHHHHHHHHHHHHHCCEEEEECCCEEEECCCHHHHHHHHHHHHHHHHHHCCCCE
IGIALNLEEDNVGAVLMGAGRTIEEGSTVRATGRIASIPVGPAFLGRVVNALAIPIDGKG
EEEEEEECCCCCCEEEEECCCEECCCCEEEECCCEEECCCCHHHHHHHHHHHEECCCCCC
DIVGSETRLLESPAPGIIKRKSVYEPLATGITAIDAMIPIGRGQRELIIGDRQTGKTTIA
CCCCCCHHHHCCCCCCCEEHHHHHHHHHHHHHHHHHHCCCCCCCEEEEEECCCCCCEEEE
IDTILNQKGKGVVCVYVAIGQKASTVAQIVEVLRSRGALEYTIIVAANANEPAALQYLAP
EEHHHCCCCCCEEEEEEEECCCHHHHHHHHHHHHHCCCEEEEEEEEECCCCCCEEEEECC
YTGCTLGEYVMYNGLTLPGSDKKINAALLVYDDLSKQAVAYRQMSLLLRRPPGREAYPGD
CCCCCHHHHHHHCCEECCCCCCCEEEEEEEEECCCHHHHHHHHHHHHHCCCCCCCCCCCH
VFYLHSRLLERAAKLSPDLGEGSLTALPIIETQAGDVSAYIPTNVISITDGQIFLDSGLF
HHHHHHHHHHHHHHCCCCCCCCCEEEEEEEECCCCCEEEECCCCEEEEECCEEEEECCCC
NSGLRPAIDAGISVSRVGGAAQTKAMKKVAGKLRLDLAQFSELEAFSQFASDLDKATQAQ
CCCCCHHHHCCCCHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
LARGLRLREILKQPQYSPLSVAQQVAIIYAATNGYLDDIDVKGIQPFKQQFLNYLDSSVS
HHHCHHHHHHHCCCCCCHHHHHHEEEEEEEECCCCCCCCCCCCCCHHHHHHHHHHHHHHH
EYGQEIETTKALTDKAVDLLKKALNDFKTTVKK
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCC
>Mature Secondary Structure
MFTIRPDEISSVIRDQIQKYNTELQVTNVGTVLQVGDGIARVYGLEKCMASELLEFEDGT
CCCCCHHHHHHHHHHHHHHHCCEEEEECCCEEEECCCHHHHHHHHHHHHHHHHHHCCCCE
IGIALNLEEDNVGAVLMGAGRTIEEGSTVRATGRIASIPVGPAFLGRVVNALAIPIDGKG
EEEEEEECCCCCCEEEEECCCEECCCCEEEECCCEEECCCCHHHHHHHHHHHEECCCCCC
DIVGSETRLLESPAPGIIKRKSVYEPLATGITAIDAMIPIGRGQRELIIGDRQTGKTTIA
CCCCCCHHHHCCCCCCCEEHHHHHHHHHHHHHHHHHHCCCCCCCEEEEEECCCCCCEEEE
IDTILNQKGKGVVCVYVAIGQKASTVAQIVEVLRSRGALEYTIIVAANANEPAALQYLAP
EEHHHCCCCCCEEEEEEEECCCHHHHHHHHHHHHHCCCEEEEEEEEECCCCCCEEEEECC
YTGCTLGEYVMYNGLTLPGSDKKINAALLVYDDLSKQAVAYRQMSLLLRRPPGREAYPGD
CCCCCHHHHHHHCCEECCCCCCCEEEEEEEEECCCHHHHHHHHHHHHHCCCCCCCCCCCH
VFYLHSRLLERAAKLSPDLGEGSLTALPIIETQAGDVSAYIPTNVISITDGQIFLDSGLF
HHHHHHHHHHHHHHCCCCCCCCCEEEEEEEECCCCCEEEECCCCEEEEECCEEEEECCCC
NSGLRPAIDAGISVSRVGGAAQTKAMKKVAGKLRLDLAQFSELEAFSQFASDLDKATQAQ
CCCCCHHHHCCCCHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
LARGLRLREILKQPQYSPLSVAQQVAIIYAATNGYLDDIDVKGIQPFKQQFLNYLDSSVS
HHHCHHHHHHHCCCCCCHHHHHHEEEEEEEECCCCCCCCCCCCCCHHHHHHHHHHHHHHH
EYGQEIETTKALTDKAVDLLKKALNDFKTTVKK
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 14621292