Click here to switch to the map view.

The map label for this gene is pdhA [H]

Identifier: 37522413

GI number: 37522413

Start: 3031051

End: 3032046

Strand: Direct

Name: pdhA [H]

Synonym: glr2844

Alternate gene names: 37522413

Gene position: 3031051-3032046 (Clockwise)

Preceding gene: 37522412

Following gene: 37522414

Centisome position: 65.06

GC content: 61.35

Gene sequence:

>996_bases
ATGAACACCGTTGCTCAAGTCCTTCGTCCGGCCGTCGAGCGCTCTGAGGCGTTGGCTCTCTACCGCGATATGGTCCTCGG
GCGGACGTTCGAAGACACCTGCGCCCAGATGTACTACCGCGGCAAGTTGTTCGGTTTCGTCCATCTCTACAACGGCCAGG
AAGCCGTCTCCACCGGAATCATCAAAGCTTTGCGCCCCGATGATTACGTAACTAGCACCTACCGCGATCACGTCCATGCC
CTCTCGAAGGGCGTTTCGGCGCGCTCGGTGATGGCGGAGCTGTTCGGCAAGGCCACCGGTTGCTCCAAGGGCCGCGGCGG
CTCGATGCACCTCTTTTCGGCGGAGCACAACTTTCTCGGCGGGTTTGCATTTATCGGCGAGGGCATTCCGATTGCCTGCG
GGGCGGCCTTCACCGCGAAGTACCAGGGGACTGACCGGGTGAGCGCCTCTTTTTTCGGCGACGGCACTACCAACAACGGC
CAGTTCTTCGAGTGCCTGAACATGGCGGCTTTGTGGAAGTTACCGATTCTCTTCGTGGTCGAAAATAACCTCTGGTCGAT
CGGCATGTATCACCCTCGCGCCTCCTCGGTCGTCGAAATCTACAAAAAAGCGGACGCCTTCGGCATACCCGGGGTGCGCG
TGGATGGGATGGATGTGCTCGCCGTGCGCGCAGTGGCCAAAGAGGCGGTCGAGCGCGCCCGCACAGGCGGCGGCCCGACT
TTAATCGAATGCACGACCTACCGCTTCCGGGGCCATTCGCTGGCGGACCCGGACGAGTTGCGCGATCCGGCCGAAAAAGC
ACACTGGCGCAAACAAGATCCCCTGCCGCGCCTGAGAGTCTGGCTTGAAGAGCAGGGTCTGGCGAGCGTGGAGGATCTGA
AGCGGATCGAGCAGGAAGTGCGCGCCGAGGTTGACGATGCGGTGCAATTTGCGGAGGACTCCCCCGAGCCGCCCCTCGAC
GAACTCTATCGTTTCCAGTTTGCCGAAGACGATTGA

Upstream 100 bases:

>100_bases
TTGCTCTGGCAGGGAGATTTGCCCATCGTGCTGTGGAAAATCGGTCTGATTGACCTTGCCACGCTTGCCAGTCTCATCGA
CCTTTAGCCCCGGTTATTTT

Downstream 100 bases:

>100_bases
TCCACTGCCTAGCGAGCACGAGCCTTGCCTCGATGTCAGGAGTTTGAGCACGATGTTGCGGACCGTTTTGTTGAGCAAAA
TTCACCGCGCTACCGTCACC

Product: pyruvate dehydrogenase E1 alpha-subunit

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 331; Mature: 331

Protein sequence:

>331_residues
MNTVAQVLRPAVERSEALALYRDMVLGRTFEDTCAQMYYRGKLFGFVHLYNGQEAVSTGIIKALRPDDYVTSTYRDHVHA
LSKGVSARSVMAELFGKATGCSKGRGGSMHLFSAEHNFLGGFAFIGEGIPIACGAAFTAKYQGTDRVSASFFGDGTTNNG
QFFECLNMAALWKLPILFVVENNLWSIGMYHPRASSVVEIYKKADAFGIPGVRVDGMDVLAVRAVAKEAVERARTGGGPT
LIECTTYRFRGHSLADPDELRDPAEKAHWRKQDPLPRLRVWLEEQGLASVEDLKRIEQEVRAEVDDAVQFAEDSPEPPLD
ELYRFQFAEDD

Sequences:

>Translated_331_residues
MNTVAQVLRPAVERSEALALYRDMVLGRTFEDTCAQMYYRGKLFGFVHLYNGQEAVSTGIIKALRPDDYVTSTYRDHVHA
LSKGVSARSVMAELFGKATGCSKGRGGSMHLFSAEHNFLGGFAFIGEGIPIACGAAFTAKYQGTDRVSASFFGDGTTNNG
QFFECLNMAALWKLPILFVVENNLWSIGMYHPRASSVVEIYKKADAFGIPGVRVDGMDVLAVRAVAKEAVERARTGGGPT
LIECTTYRFRGHSLADPDELRDPAEKAHWRKQDPLPRLRVWLEEQGLASVEDLKRIEQEVRAEVDDAVQFAEDSPEPPLD
ELYRFQFAEDD
>Mature_331_residues
MNTVAQVLRPAVERSEALALYRDMVLGRTFEDTCAQMYYRGKLFGFVHLYNGQEAVSTGIIKALRPDDYVTSTYRDHVHA
LSKGVSARSVMAELFGKATGCSKGRGGSMHLFSAEHNFLGGFAFIGEGIPIACGAAFTAKYQGTDRVSASFFGDGTTNNG
QFFECLNMAALWKLPILFVVENNLWSIGMYHPRASSVVEIYKKADAFGIPGVRVDGMDVLAVRAVAKEAVERARTGGGPT
LIECTTYRFRGHSLADPDELRDPAEKAHWRKQDPLPRLRVWLEEQGLASVEDLKRIEQEVRAEVDDAVQFAEDSPEPPLD
ELYRFQFAEDD

Specific function: The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2). It contains multiple copies of three enzymatic components:pyruvate dehydrogenase (E1), dihydrolipoamide acetyltransferase (E2) and lipoamide dehydroge

COG id: COG1071

COG function: function code C; Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, alpha subunit

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: NA

Homologues:

Organism=Homo sapiens, GI4885543, Length=321, Percent_Identity=43.3021806853583, Blast_Score=271, Evalue=9e-73,
Organism=Homo sapiens, GI4505685, Length=321, Percent_Identity=42.9906542056075, Blast_Score=249, Evalue=2e-66,
Organism=Homo sapiens, GI291084742, Length=321, Percent_Identity=42.9906542056075, Blast_Score=249, Evalue=2e-66,
Organism=Homo sapiens, GI291084744, Length=328, Percent_Identity=42.0731707317073, Blast_Score=242, Evalue=3e-64,
Organism=Homo sapiens, GI291084757, Length=321, Percent_Identity=39.2523364485981, Blast_Score=204, Evalue=7e-53,
Organism=Homo sapiens, GI11386135, Length=329, Percent_Identity=30.6990881458967, Blast_Score=132, Evalue=4e-31,
Organism=Homo sapiens, GI258645172, Length=334, Percent_Identity=30.5389221556886, Blast_Score=132, Evalue=6e-31,
Organism=Caenorhabditis elegans, GI32564172, Length=314, Percent_Identity=40.4458598726115, Blast_Score=236, Evalue=2e-62,
Organism=Caenorhabditis elegans, GI17536047, Length=314, Percent_Identity=40.4458598726115, Blast_Score=235, Evalue=2e-62,
Organism=Caenorhabditis elegans, GI86563357, Length=302, Percent_Identity=30.1324503311258, Blast_Score=127, Evalue=1e-29,
Organism=Caenorhabditis elegans, GI86563355, Length=302, Percent_Identity=30.1324503311258, Blast_Score=127, Evalue=1e-29,
Organism=Saccharomyces cerevisiae, GI6321026, Length=308, Percent_Identity=38.6363636363636, Blast_Score=233, Evalue=2e-62,
Organism=Drosophila melanogaster, GI24639748, Length=321, Percent_Identity=40.809968847352, Blast_Score=234, Evalue=7e-62,
Organism=Drosophila melanogaster, GI24639744, Length=327, Percent_Identity=38.8379204892966, Blast_Score=232, Evalue=3e-61,
Organism=Drosophila melanogaster, GI28571106, Length=327, Percent_Identity=38.8379204892966, Blast_Score=232, Evalue=3e-61,
Organism=Drosophila melanogaster, GI24639740, Length=327, Percent_Identity=38.2262996941896, Blast_Score=232, Evalue=3e-61,
Organism=Drosophila melanogaster, GI24639746, Length=305, Percent_Identity=38.6885245901639, Blast_Score=226, Evalue=2e-59,
Organism=Drosophila melanogaster, GI21355903, Length=324, Percent_Identity=24.6913580246914, Blast_Score=98, Evalue=6e-21,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001017
- InterPro:   IPR017597 [H]

Pfam domain/function: PF00676 E1_dh [H]

EC number: =1.2.4.1 [H]

Molecular weight: Translated: 36718; Mature: 36718

Theoretical pI: Translated: 5.45; Mature: 5.45

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.5 %Cys     (Translated Protein)
2.4 %Met     (Translated Protein)
3.9 %Cys+Met (Translated Protein)
1.5 %Cys     (Mature Protein)
2.4 %Met     (Mature Protein)
3.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNTVAQVLRPAVERSEALALYRDMVLGRTFEDTCAQMYYRGKLFGFVHLYNGQEAVSTGI
CCHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHCCEEEEEEEECCHHHHHHHH
IKALRPDDYVTSTYRDHVHALSKGVSARSVMAELFGKATGCSKGRGGSMHLFSAEHNFLG
HHHCCCCCHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHCCCCCCCCCCEEEEECCCCCCC
GFAFIGEGIPIACGAAFTAKYQGTDRVSASFFGDGTTNNGQFFECLNMAALWKLPILFVV
HHHHHCCCCCEEECCEEEEEECCCCCCEEEEECCCCCCCCHHHHHHHHHHHHHCCEEEEE
ENNLWSIGMYHPRASSVVEIYKKADAFGIPGVRVDGMDVLAVRAVAKEAVERARTGGGPT
ECCEEEEEECCCCHHHHHHHHHHHCCCCCCCEEECCHHHHHHHHHHHHHHHHHHCCCCCE
LIECTTYRFRGHSLADPDELRDPAEKAHWRKQDPLPRLRVWLEEQGLASVEDLKRIEQEV
EEEEEEEEECCCCCCCHHHHCCHHHHHCCCCCCCCHHHHHHHHHCCCCCHHHHHHHHHHH
RAEVDDAVQFAEDSPEPPLDELYRFQFAEDD
HHHHHHHHHHHCCCCCCCHHHHHHHHCCCCC
>Mature Secondary Structure
MNTVAQVLRPAVERSEALALYRDMVLGRTFEDTCAQMYYRGKLFGFVHLYNGQEAVSTGI
CCHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHCCEEEEEEEECCHHHHHHHH
IKALRPDDYVTSTYRDHVHALSKGVSARSVMAELFGKATGCSKGRGGSMHLFSAEHNFLG
HHHCCCCCHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHCCCCCCCCCCEEEEECCCCCCC
GFAFIGEGIPIACGAAFTAKYQGTDRVSASFFGDGTTNNGQFFECLNMAALWKLPILFVV
HHHHHCCCCCEEECCEEEEEECCCCCCEEEEECCCCCCCCHHHHHHHHHHHHHCCEEEEE
ENNLWSIGMYHPRASSVVEIYKKADAFGIPGVRVDGMDVLAVRAVAKEAVERARTGGGPT
ECCEEEEEECCCCHHHHHHHHHHHCCCCCCCEEECCHHHHHHHHHHHHHHHHHHCCCCCE
LIECTTYRFRGHSLADPDELRDPAEKAHWRKQDPLPRLRVWLEEQGLASVEDLKRIEQEV
EEEEEEEEECCCCCCCHHHHCCHHHHHCCCCCCCCHHHHHHHHHCCCCCHHHHHHHHHHH
RAEVDDAVQFAEDSPEPPLDELYRFQFAEDD
HHHHHHHHHHHCCCCCCCHHHHHHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA