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The map label for this gene is fus [C]

Identifier: 37522381

GI number: 37522381

Start: 2990743

End: 2992755

Strand: Direct

Name: fus [C]

Synonym: gvip388

Alternate gene names: 37522381

Gene position: 2990743-2992755 (Clockwise)

Preceding gene: 37522380

Following gene: 37522382

Centisome position: 64.19

GC content: 64.38

Gene sequence:

>2013_bases
ATGAATACCAGCACGAGCGCGCATTGGCGCAGTATTGCGATTGTAGGCCCCTACCAGAGCGGCAAATCGACGCTGTTAGA
AAGCCTGCTGTTCGTGACGGGAGCCATCTCCCGCAAGGGGACCGTTGAGGACGGCAACAGCGTCGCCGACGGTACCGCCG
AGGCGCGCGCCCGCCAGATGGGCGTTGAGGTCAACGCTGCCTTTGCCGAATACCAGGGGGTGCAGTTGAGCTTTTTGGAT
TGCCCGGGGTCGATCGAGTTTGCCCAGGAGACCTGGAATGCGCTGATCGGTGTGGACGCGGCGCTCGTCGTCTGCGAACC
GGAGGCGACCCGGGCCTTGATTGTGGCGCCGCTGCTCAAGTTTCTTGATGACTGGCAAATTCCCCATGTGCTCTTTATCA
ACAAGATGGACCGGGCCAGTACTCCCCTAAAAGAGGTCCTGGCTGCACTGCAGTCGATCTCAAGCCGTCCCCTCGCCCTG
CGCCAGTTCCCGATTGGCCAGGGCGATCGTTTAAGCGGGTTTATCGATTTGGTGAGCGAGCAGGCCTGGCAGTACCACCC
CGGCGGCCCGCCCGACCCGATTGCGCTACCGGAGATTTATCGCAGCGACGAGTTGGCGGCCCGGGCCGAACTGCTCGAAG
TGCTCGCCGAGTTCGACGATCACCTGCTCGAAGAACTGGTCGAAGAAATCGAGCCGCCCGAGGCGGAAATTCGCACCGAC
CTCAAGCGCGACCTCGAAGACGATCTGATCGTGCCGGTGTTCTGCGGGGTGGCGCTGCGCGATTTTGGAGTCAGGCCGCT
TCTGGCCGCGCTGCTTTCGGAGGTGCCGGAGGCGGCCTGTTCTGCTCGTCACCGGGGTATCGCCGCCGAAGGCCCGCCTG
TGGCCCAGGTGCTCAAGACTTTTTATTCGCCCCAGAGCGGCAAACTTTCGCTGGTGCGCATCTGGCGCGGGGTGTTGGCC
GACGGTGCCCAGATAAACGGTGCGCGCCTCGCCGGGTTGTATCGGCTGTGCGGCCAGCAGCAGACGGCCCTCGCGGCGGC
TGGACCCGGCGAGATTGTCGCCCTGGGTCGCCTCGAAGGGATCAAAACCGGCGACACCCTGGCACTCGGATCACAGGAAA
CTCCCCTGGCGAGCTGCGCGCCGCTCACCCCGGTTTTTGCCCTCGCCATCGCCCCCGAAAAGCGCGCCGACGAGGTCAAA
TTCAGCGCCGCCGTCGCCAAATTGCTCGAAGAAGATCCATCGCTCAGTTGGCAACAAAACAGCGGCACGCGCGAGGTGGT
TCTCTGGGGCCAGGGCGAAATTCACCTGCAGGTGGCCCTCGGCCGGTTGCGGCGCAAGTACAACCTGCCGATGCAGTCGC
ACCCGCCGCAGGTGCCCTACCGCGAGACCATCCGCCGCGCCTGGTCAAGCCACGGACGCTACAAGCATCAGACCGGCGGC
CACGGCCAGTTTGGCGATGTCTACCTCGACATTCGGCCTCTGGCGCGCGGTGAAGGGTTTCAATTTGCCGAGACGATTGT
GGGCGGTGTGGTGCCCCGGCAGTACGTTCCCGGCGTGGAGACGGGCGTGCGCGAAGCGCTGGAGCGCGGACCTTTGGGCT
ACCCGGTGGTGGACGTGGCGGTCACCCTCACCAACGGCTCCTACCACACCGTCGATAGTTCCGAGCAGGCGTTCAAGCAG
GCGGCCCGCATCGCGATGCACGAGGGCCTCGCCCGCTGCGAGCCGGTGCTGCTCGAACCGATTGTCGAACTTGACGTCTC
GGTGCCGGTGGAGTTTACCGCCCGCGCCCTGCGCCTGCTCAGCGGCAAACGCGGTCAGATCCTCCACTACCAGGGCGATG
GAGAGCGCCGCGAATGGGACTGCGTCAACGCCTTTTTGCCCCTCGCTCAGATGAACGAATTTGCTATCGAGTTGCGCTCG
CTGAGTCTTGGTGTCGGCTGTTTCGCCTGGCGGCCCGCCCACCTGCAGGAGGTGCCGGAAAAACTCGCCGAGCGTCTTCT
GGCACGCACTTGA

Upstream 100 bases:

>100_bases
TGCGAACTCCGTATACGATGTCGAGAATAGTTTTCAGACGCCAAATCCGCATTGCTGAGCCGGATTCCGTTTGAGTTTGC
CTATAAATTTGCGTGACGCC

Downstream 100 bases:

>100_bases
TCGGCACCGATGGAACCGGGAGCCCGGGCACTTCTTACTGCAGGCAGAGGGTGCCTCCTGCCCCCGACGATGACAATTGG
GCAGTTCAATGGCAAGTTTG

Product: elongation factor G

Products: GDP; phosphate

Alternate protein names: NA

Number of amino acids: Translated: 670; Mature: 670

Protein sequence:

>670_residues
MNTSTSAHWRSIAIVGPYQSGKSTLLESLLFVTGAISRKGTVEDGNSVADGTAEARARQMGVEVNAAFAEYQGVQLSFLD
CPGSIEFAQETWNALIGVDAALVVCEPEATRALIVAPLLKFLDDWQIPHVLFINKMDRASTPLKEVLAALQSISSRPLAL
RQFPIGQGDRLSGFIDLVSEQAWQYHPGGPPDPIALPEIYRSDELAARAELLEVLAEFDDHLLEELVEEIEPPEAEIRTD
LKRDLEDDLIVPVFCGVALRDFGVRPLLAALLSEVPEAACSARHRGIAAEGPPVAQVLKTFYSPQSGKLSLVRIWRGVLA
DGAQINGARLAGLYRLCGQQQTALAAAGPGEIVALGRLEGIKTGDTLALGSQETPLASCAPLTPVFALAIAPEKRADEVK
FSAAVAKLLEEDPSLSWQQNSGTREVVLWGQGEIHLQVALGRLRRKYNLPMQSHPPQVPYRETIRRAWSSHGRYKHQTGG
HGQFGDVYLDIRPLARGEGFQFAETIVGGVVPRQYVPGVETGVREALERGPLGYPVVDVAVTLTNGSYHTVDSSEQAFKQ
AARIAMHEGLARCEPVLLEPIVELDVSVPVEFTARALRLLSGKRGQILHYQGDGERREWDCVNAFLPLAQMNEFAIELRS
LSLGVGCFAWRPAHLQEVPEKLAERLLART

Sequences:

>Translated_670_residues
MNTSTSAHWRSIAIVGPYQSGKSTLLESLLFVTGAISRKGTVEDGNSVADGTAEARARQMGVEVNAAFAEYQGVQLSFLD
CPGSIEFAQETWNALIGVDAALVVCEPEATRALIVAPLLKFLDDWQIPHVLFINKMDRASTPLKEVLAALQSISSRPLAL
RQFPIGQGDRLSGFIDLVSEQAWQYHPGGPPDPIALPEIYRSDELAARAELLEVLAEFDDHLLEELVEEIEPPEAEIRTD
LKRDLEDDLIVPVFCGVALRDFGVRPLLAALLSEVPEAACSARHRGIAAEGPPVAQVLKTFYSPQSGKLSLVRIWRGVLA
DGAQINGARLAGLYRLCGQQQTALAAAGPGEIVALGRLEGIKTGDTLALGSQETPLASCAPLTPVFALAIAPEKRADEVK
FSAAVAKLLEEDPSLSWQQNSGTREVVLWGQGEIHLQVALGRLRRKYNLPMQSHPPQVPYRETIRRAWSSHGRYKHQTGG
HGQFGDVYLDIRPLARGEGFQFAETIVGGVVPRQYVPGVETGVREALERGPLGYPVVDVAVTLTNGSYHTVDSSEQAFKQ
AARIAMHEGLARCEPVLLEPIVELDVSVPVEFTARALRLLSGKRGQILHYQGDGERREWDCVNAFLPLAQMNEFAIELRS
LSLGVGCFAWRPAHLQEVPEKLAERLLART
>Mature_670_residues
MNTSTSAHWRSIAIVGPYQSGKSTLLESLLFVTGAISRKGTVEDGNSVADGTAEARARQMGVEVNAAFAEYQGVQLSFLD
CPGSIEFAQETWNALIGVDAALVVCEPEATRALIVAPLLKFLDDWQIPHVLFINKMDRASTPLKEVLAALQSISSRPLAL
RQFPIGQGDRLSGFIDLVSEQAWQYHPGGPPDPIALPEIYRSDELAARAELLEVLAEFDDHLLEELVEEIEPPEAEIRTD
LKRDLEDDLIVPVFCGVALRDFGVRPLLAALLSEVPEAACSARHRGIAAEGPPVAQVLKTFYSPQSGKLSLVRIWRGVLA
DGAQINGARLAGLYRLCGQQQTALAAAGPGEIVALGRLEGIKTGDTLALGSQETPLASCAPLTPVFALAIAPEKRADEVK
FSAAVAKLLEEDPSLSWQQNSGTREVVLWGQGEIHLQVALGRLRRKYNLPMQSHPPQVPYRETIRRAWSSHGRYKHQTGG
HGQFGDVYLDIRPLARGEGFQFAETIVGGVVPRQYVPGVETGVREALERGPLGYPVVDVAVTLTNGSYHTVDSSEQAFKQ
AARIAMHEGLARCEPVLLEPIVELDVSVPVEFTARALRLLSGKRGQILHYQGDGERREWDCVNAFLPLAQMNEFAIELRS
LSLGVGCFAWRPAHLQEVPEKLAERLLART

Specific function: This Protein Promotes The GTP-Dependent Translocation Of The Nascent Protein Chain From The A-Site To The P-Site Of The Ribosome. [C]

COG id: COG0480

COG function: function code J; Translation elongation factors (GTPases)

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the GTP-binding elongation factor family. EF-G/EF-2 subfamily [H]

Homologues:

Organism=Homo sapiens, GI18390331, Length=681, Percent_Identity=28.3406754772394, Blast_Score=261, Evalue=2e-69,
Organism=Homo sapiens, GI19923640, Length=714, Percent_Identity=26.0504201680672, Blast_Score=210, Evalue=4e-54,
Organism=Homo sapiens, GI25306287, Length=708, Percent_Identity=24.7175141242938, Blast_Score=180, Evalue=4e-45,
Organism=Homo sapiens, GI25306283, Length=382, Percent_Identity=26.1780104712042, Blast_Score=114, Evalue=2e-25,
Organism=Escherichia coli, GI1789738, Length=713, Percent_Identity=29.45301542777, Blast_Score=321, Evalue=1e-88,
Organism=Escherichia coli, GI1790835, Length=464, Percent_Identity=23.0603448275862, Blast_Score=84, Evalue=3e-17,
Organism=Caenorhabditis elegans, GI17533571, Length=677, Percent_Identity=27.6218611521418, Blast_Score=258, Evalue=6e-69,
Organism=Caenorhabditis elegans, GI17556745, Length=708, Percent_Identity=22.5988700564972, Blast_Score=138, Evalue=1e-32,
Organism=Saccharomyces cerevisiae, GI6323098, Length=677, Percent_Identity=29.8375184638109, Blast_Score=275, Evalue=2e-74,
Organism=Saccharomyces cerevisiae, GI6322359, Length=786, Percent_Identity=23.027989821883, Blast_Score=163, Evalue=9e-41,
Organism=Drosophila melanogaster, GI24582462, Length=673, Percent_Identity=31.2035661218425, Blast_Score=282, Evalue=6e-76,
Organism=Drosophila melanogaster, GI221458488, Length=722, Percent_Identity=26.1772853185596, Blast_Score=189, Evalue=6e-48,

Paralogues:

None

Copy number: 1080 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 2520 Molecules/Cell In: Growth-Phase, Minimal-Media (Based on E. coli). 20 Molecules/Cell In: Stationary Phase, Rich Media (Based on E. coli). 7984 Molecules/Cell In: Growth Phase, Gl

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR009022
- InterPro:   IPR000795
- InterPro:   IPR020568
- InterPro:   IPR014721
- InterPro:   IPR005225
- InterPro:   IPR000640
- InterPro:   IPR005517
- InterPro:   IPR004161
- InterPro:   IPR009000 [H]

Pfam domain/function: PF00679 EFG_C; PF03764 EFG_IV; PF00009 GTP_EFTU; PF03144 GTP_EFTU_D2 [H]

EC number: 3.6.5.3

Molecular weight: Translated: 73037; Mature: 73037

Theoretical pI: Translated: 5.11; Mature: 5.11

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
0.9 %Met     (Translated Protein)
2.2 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
0.9 %Met     (Mature Protein)
2.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNTSTSAHWRSIAIVGPYQSGKSTLLESLLFVTGAISRKGTVEDGNSVADGTAEARARQM
CCCCCCCCEEEEEEECCCCCCHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCHHHHHHHHH
GVEVNAAFAEYQGVQLSFLDCPGSIEFAQETWNALIGVDAALVVCEPEATRALIVAPLLK
CCEEEEHHHHCCCCEEEEECCCCCCHHHHHHHHHHHCCCEEEEEECCCHHHHHHHHHHHH
FLDDWQIPHVLFINKMDRASTPLKEVLAALQSISSRPLALRQFPIGQGDRLSGFIDLVSE
HHHCCCCCEEEEEECCCCCCCCHHHHHHHHHHHCCCCEEEEECCCCCCCCHHHHHHHHHH
QAWQYHPGGPPDPIALPEIYRSDELAARAELLEVLAEFDDHLLEELVEEIEPPEAEIRTD
HCCCCCCCCCCCCCCCHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHH
LKRDLEDDLIVPVFCGVALRDFGVRPLLAALLSEVPEAACSARHRGIAAEGPPVAQVLKT
HHHCHHCCCCHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHH
FYSPQSGKLSLVRIWRGVLADGAQINGARLAGLYRLCGQQQTALAAAGPGEIVALGRLEG
HHCCCCCCCHHHHHHHHHHCCCCCCCCHHHHHHHHHHCCCHHEEEECCCCCEEEEECCCC
IKTGDTLALGSQETPLASCAPLTPVFALAIAPEKRADEVKFSAAVAKLLEEDPSLSWQQN
CCCCCEEEECCCCCCCCCCCCCCHHHHEEECCCCHHHHHHHHHHHHHHHHCCCCCCEECC
SGTREVVLWGQGEIHLQVALGRLRRKYNLPMQSHPPQVPYRETIRRAWSSHGRYKHQTGG
CCCEEEEEECCCCEEEHHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHCCCEECCCCC
HGQFGDVYLDIRPLARGEGFQFAETIVGGVVPRQYVPGVETGVREALERGPLGYPVVDVA
CCCCCEEEEEEEECCCCCCCHHHHHHHHCCCCHHHCCCHHHHHHHHHHHCCCCCCEEEEE
VTLTNGSYHTVDSSEQAFKQAARIAMHEGLARCEPVLLEPIVELDVSVPVEFTARALRLL
EEEECCCEEECCCHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHCCCCCCHHHHHHHHHHH
SGKRGQILHYQGDGERREWDCVNAFLPLAQMNEFAIELRSLSLGVGCFAWRPAHLQEVPE
CCCCCCEEEECCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHCCCCHHHHHHHH
KLAERLLART
HHHHHHHCCC
>Mature Secondary Structure
MNTSTSAHWRSIAIVGPYQSGKSTLLESLLFVTGAISRKGTVEDGNSVADGTAEARARQM
CCCCCCCCEEEEEEECCCCCCHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCHHHHHHHHH
GVEVNAAFAEYQGVQLSFLDCPGSIEFAQETWNALIGVDAALVVCEPEATRALIVAPLLK
CCEEEEHHHHCCCCEEEEECCCCCCHHHHHHHHHHHCCCEEEEEECCCHHHHHHHHHHHH
FLDDWQIPHVLFINKMDRASTPLKEVLAALQSISSRPLALRQFPIGQGDRLSGFIDLVSE
HHHCCCCCEEEEEECCCCCCCCHHHHHHHHHHHCCCCEEEEECCCCCCCCHHHHHHHHHH
QAWQYHPGGPPDPIALPEIYRSDELAARAELLEVLAEFDDHLLEELVEEIEPPEAEIRTD
HCCCCCCCCCCCCCCCHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHH
LKRDLEDDLIVPVFCGVALRDFGVRPLLAALLSEVPEAACSARHRGIAAEGPPVAQVLKT
HHHCHHCCCCHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHH
FYSPQSGKLSLVRIWRGVLADGAQINGARLAGLYRLCGQQQTALAAAGPGEIVALGRLEG
HHCCCCCCCHHHHHHHHHHCCCCCCCCHHHHHHHHHHCCCHHEEEECCCCCEEEEECCCC
IKTGDTLALGSQETPLASCAPLTPVFALAIAPEKRADEVKFSAAVAKLLEEDPSLSWQQN
CCCCCEEEECCCCCCCCCCCCCCHHHHEEECCCCHHHHHHHHHHHHHHHHCCCCCCEECC
SGTREVVLWGQGEIHLQVALGRLRRKYNLPMQSHPPQVPYRETIRRAWSSHGRYKHQTGG
CCCEEEEEECCCCEEEHHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHCCCEECCCCC
HGQFGDVYLDIRPLARGEGFQFAETIVGGVVPRQYVPGVETGVREALERGPLGYPVVDVA
CCCCCEEEEEEEECCCCCCCHHHHHHHHCCCCHHHCCCHHHHHHHHHHHCCCCCCEEEEE
VTLTNGSYHTVDSSEQAFKQAARIAMHEGLARCEPVLLEPIVELDVSVPVEFTARALRLL
EEEECCCEEECCCHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHCCCCCCHHHHHHHHHHH
SGKRGQILHYQGDGERREWDCVNAFLPLAQMNEFAIELRSLSLGVGCFAWRPAHLQEVPE
CCCCCCEEEECCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHCCCCHHHHHHHH
KLAERLLART
HHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: GTP; H2O

Specific reaction: GTP + H2O = GDP + phosphate

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8590279; 8905231 [H]