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The map label for this gene is apt

Identifier: 37522316

GI number: 37522316

Start: 2918275

End: 2918790

Strand: Direct

Name: apt

Synonym: glr2747

Alternate gene names: 37522316

Gene position: 2918275-2918790 (Clockwise)

Preceding gene: 37522315

Following gene: 37522317

Centisome position: 62.64

GC content: 60.27

Gene sequence:

>516_bases
ATGGACCTCAAAGACTACATCCGCACCGTCCCCGATTTTCCCGAACCCGGCATTCTCTTTCGCGACATCACCACGCTGCT
GCACGAACCCAAGGCCCTGCGCTACACCATCGACAGTCTGGCGGAACAGACTGGCTCCCTCGGTGCCGATTATGTCGTGG
GCATCGAATCGCGGGGGTTCATGTTCGGTACGCCTCTGGCGATCAAACTGGACTGCGGCTTCGTGCCGGTGCGCAAACCC
GGCAAGTTGCCGGCGGCAGTATTTAAAGAGGAATACACCCTCGAATACGGCAAGAACGCCCTCGAAATCCACCAGGACGC
CTTTGCGGCCCCCAGCCGCGTGCTGGTGGTCGACGATTTGCTGGCCACCGGCGGGACCGCCGTCGCCGCCGCCCAACTGG
TCGAGCGGGCCGGGGGTACAGTTGTGGGATTCGGATTTATCATAGAGCTAACCTTTCTCAATGGGCGCGCGAAACTGCCG
GAGGGTCCTTCGGCAGTTGCTTTGGTCTCTTATTAA

Upstream 100 bases:

>100_bases
TCGCAAGCCGAGGGCGGATCCATCGGATAACCGACGGCCCTCTGCGAAGGCCATAGGTGTCGCAGATGCTACCATTGGCC
ACAACCGAGGCGTGTTCACC

Downstream 100 bases:

>100_bases
TGTGAGAAAAGGGGTGGTGGGCGGTATGCATCTGGTCTCAGCCGAGTTCGAAACGCTCCAGCTTCCTGACTGGCTCAAAG
ATTGCCTGGATCATCCGCAC

Product: adenine phosphoribosyltransferase

Products: NA

Alternate protein names: APRT

Number of amino acids: Translated: 171; Mature: 171

Protein sequence:

>171_residues
MDLKDYIRTVPDFPEPGILFRDITTLLHEPKALRYTIDSLAEQTGSLGADYVVGIESRGFMFGTPLAIKLDCGFVPVRKP
GKLPAAVFKEEYTLEYGKNALEIHQDAFAAPSRVLVVDDLLATGGTAVAAAQLVERAGGTVVGFGFIIELTFLNGRAKLP
EGPSAVALVSY

Sequences:

>Translated_171_residues
MDLKDYIRTVPDFPEPGILFRDITTLLHEPKALRYTIDSLAEQTGSLGADYVVGIESRGFMFGTPLAIKLDCGFVPVRKP
GKLPAAVFKEEYTLEYGKNALEIHQDAFAAPSRVLVVDDLLATGGTAVAAAQLVERAGGTVVGFGFIIELTFLNGRAKLP
EGPSAVALVSY
>Mature_171_residues
MDLKDYIRTVPDFPEPGILFRDITTLLHEPKALRYTIDSLAEQTGSLGADYVVGIESRGFMFGTPLAIKLDCGFVPVRKP
GKLPAAVFKEEYTLEYGKNALEIHQDAFAAPSRVLVVDDLLATGGTAVAAAQLVERAGGTVVGFGFIIELTFLNGRAKLP
EGPSAVALVSY

Specific function: Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis

COG id: COG0503

COG function: function code F; Adenine/guanine phosphoribosyltransferases and related PRPP-binding proteins

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the purine/pyrimidine phosphoribosyltransferase family

Homologues:

Organism=Homo sapiens, GI4502171, Length=164, Percent_Identity=46.3414634146341, Blast_Score=137, Evalue=3e-33,
Organism=Homo sapiens, GI71773201, Length=125, Percent_Identity=48, Blast_Score=115, Evalue=2e-26,
Organism=Escherichia coli, GI1786675, Length=170, Percent_Identity=51.7647058823529, Blast_Score=168, Evalue=2e-43,
Organism=Caenorhabditis elegans, GI17509087, Length=171, Percent_Identity=44.4444444444444, Blast_Score=130, Evalue=4e-31,
Organism=Saccharomyces cerevisiae, GI6323619, Length=162, Percent_Identity=45.679012345679, Blast_Score=129, Evalue=3e-31,
Organism=Saccharomyces cerevisiae, GI6320649, Length=162, Percent_Identity=35.8024691358025, Blast_Score=89, Evalue=4e-19,
Organism=Drosophila melanogaster, GI17136334, Length=164, Percent_Identity=43.2926829268293, Blast_Score=126, Evalue=9e-30,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): APT_GLOVI (Q7NGZ0)

Other databases:

- EMBL:   BA000045
- RefSeq:   NP_925693.1
- ProteinModelPortal:   Q7NGZ0
- SMR:   Q7NGZ0
- GeneID:   2601148
- GenomeReviews:   BA000045_GR
- KEGG:   gvi:glr2747
- NMPDR:   fig|251221.1.peg.2747
- HOGENOM:   HBG703830
- OMA:   GILFYDI
- ProtClustDB:   PRK02304
- BioCyc:   GVIO251221:GLR2747-MONOMER
- BRENDA:   2.4.2.7
- GO:   GO:0005737
- HAMAP:   MF_00004
- InterPro:   IPR005764
- InterPro:   IPR000836
- TIGRFAMs:   TIGR01090

Pfam domain/function: PF00156 Pribosyltran

EC number: =2.4.2.7

Molecular weight: Translated: 18359; Mature: 18359

Theoretical pI: Translated: 4.79; Mature: 4.79

Prosite motif: PS00103 PUR_PYR_PR_TRANSFER

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
1.2 %Met     (Translated Protein)
1.8 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
1.2 %Met     (Mature Protein)
1.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MDLKDYIRTVPDFPEPGILFRDITTLLHEPKALRYTIDSLAEQTGSLGADYVVGIESRGF
CCHHHHHHHCCCCCCCCHHHHHHHHHHCCCHHHHHHHHHHHHHHCCCCCCEEEEECCCCE
MFGTPLAIKLDCGFVPVRKPGKLPAAVFKEEYTLEYGKNALEIHQDAFAAPSRVLVVDDL
EEECCEEEEEECCEEECCCCCCCCHHHHHHHHHHHHCCCHHHHHHHHHCCCCEEEEEEHH
LATGGTAVAAAQLVERAGGTVVGFGFIIELTFLNGRAKLPEGPSAVALVSY
HHCCCHHHHHHHHHHHCCCCEEEEEEEEEEEEECCCCCCCCCCCEEEEEEC
>Mature Secondary Structure
MDLKDYIRTVPDFPEPGILFRDITTLLHEPKALRYTIDSLAEQTGSLGADYVVGIESRGF
CCHHHHHHHCCCCCCCCHHHHHHHHHHCCCHHHHHHHHHHHHHHCCCCCCEEEEECCCCE
MFGTPLAIKLDCGFVPVRKPGKLPAAVFKEEYTLEYGKNALEIHQDAFAAPSRVLVVDDL
EEECCEEEEEECCEEECCCCCCCCHHHHHHHHHHHHCCCHHHHHHHHHCCCCEEEEEEHH
LATGGTAVAAAQLVERAGGTVVGFGFIIELTFLNGRAKLPEGPSAVALVSY
HHCCCHHHHHHHHHHHCCCCEEEEEEEEEEEEECCCCCCCCCCCEEEEEEC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 14621292