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The map label for this gene is yycF [H]

Identifier: 37522238

GI number: 37522238

Start: 2831236

End: 2831973

Strand: Direct

Name: yycF [H]

Synonym: glr2669

Alternate gene names: 37522238

Gene position: 2831236-2831973 (Clockwise)

Preceding gene: 37522237

Following gene: 37522242

Centisome position: 60.77

GC content: 63.28

Gene sequence:

>738_bases
GTGGTGGGCAACTTGGACAACCGCAAAGAAAAGATTCTTGTTGTCGACGACGAGGCCAGCATCCGCCGCATCCTGGAGAC
CCGTCTGTCGATGATTGGCTACGACGTGGTCACGGCTGCCGACGGTGAAGAGGCGCTCGAAGTCTTCAGCCGCGAGCACC
CGGACCTGGTCGTGCTCGATGTGATGATGCCGAAGCTGGACGGCTACGGCGTCTGCCAGGAACTGCGCAAGGACTCCGAC
GTCCCGATTATCATGCTGACCGCCCTGGGCGACGTGGCCGACCGGATCACGGGTCTGGAGCTGGGAGCGGACGACTACGT
CGTCAAGCCCTTCTCGCCTAAGGAACTGGAGGCGCGCATCCGCTCGGTCCTGCGCCGGGCCGACCGCGACACCGCGAGCG
GCATCCCGAGTTCGGGCGTCATTCACGTGGGCGATCTCAAGATCGACACCAACAAGCGCCAGGTCTACAAGCGCGGCGAG
CGCATTCGCCTGACCGGCATGGAATTTTCGCTGTTGGAGCTGGTGGTCAGCCGCTCCGGCGAGCCCTTTTCGCGCTCGGA
GATCCTTCAAGAAGTTTGGGGCTACACGCCCGAGCGCCACGTAGACACCCGCGTGGTCGATGTGCACATCTCGCGACTGC
GCTCCAAGCTCGAGGACGACCCGTCCAACCCGGAACTGATCCTCACTGCCCGCGGCACCGGCTATCTGTTCCAGCGCATC
ACCGAACCCAAAGAATAG

Upstream 100 bases:

>100_bases
TCCCGGCTTTCTTGAGAAAGTGTTAAAAGAAACAAAAGTTGAACATGGAGTTTACAACAATCTGATAGACTAAACAAAAG
TCATCAAAAGTTATTAATGG

Downstream 100 bases:

>100_bases
CGCCATTGCTCAGTTGCCGGGCGAACCCGGCAACTGTCACTTCTGCAACGAATTAGTCATTACAGATTTCTAGATTTCGC
GCCACACTCTGCACAGCGGC

Product: two-component response regulator

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 245; Mature: 245

Protein sequence:

>245_residues
MVGNLDNRKEKILVVDDEASIRRILETRLSMIGYDVVTAADGEEALEVFSREHPDLVVLDVMMPKLDGYGVCQELRKDSD
VPIIMLTALGDVADRITGLELGADDYVVKPFSPKELEARIRSVLRRADRDTASGIPSSGVIHVGDLKIDTNKRQVYKRGE
RIRLTGMEFSLLELVVSRSGEPFSRSEILQEVWGYTPERHVDTRVVDVHISRLRSKLEDDPSNPELILTARGTGYLFQRI
TEPKE

Sequences:

>Translated_245_residues
MVGNLDNRKEKILVVDDEASIRRILETRLSMIGYDVVTAADGEEALEVFSREHPDLVVLDVMMPKLDGYGVCQELRKDSD
VPIIMLTALGDVADRITGLELGADDYVVKPFSPKELEARIRSVLRRADRDTASGIPSSGVIHVGDLKIDTNKRQVYKRGE
RIRLTGMEFSLLELVVSRSGEPFSRSEILQEVWGYTPERHVDTRVVDVHISRLRSKLEDDPSNPELILTARGTGYLFQRI
TEPKE
>Mature_245_residues
MVGNLDNRKEKILVVDDEASIRRILETRLSMIGYDVVTAADGEEALEVFSREHPDLVVLDVMMPKLDGYGVCQELRKDSD
VPIIMLTALGDVADRITGLELGADDYVVKPFSPKELEARIRSVLRRADRDTASGIPSSGVIHVGDLKIDTNKRQVYKRGE
RIRLTGMEFSLLELVVSRSGEPFSRSEILQEVWGYTPERHVDTRVVDVHISRLRSKLEDDPSNPELILTARGTGYLFQRI
TEPKE

Specific function: Member of the two-component regulatory system YycG/YycF involved in the regulation of the ftsAZ operon, the yocH, ykvT, cwlO, lytE, ydjM, yjeA, yoeB genes and the tagAB and tagDEF operons. Probably phosphorylates YycF. Binds to the ftsAZ P1 promoter seque

COG id: COG0745

COG function: function code TK; Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain

Gene ontology:

Cell location: Cytoplasmic [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 response regulatory domain [H]

Homologues:

Organism=Escherichia coli, GI1789809, Length=230, Percent_Identity=43.9130434782609, Blast_Score=179, Evalue=2e-46,
Organism=Escherichia coli, GI1786784, Length=229, Percent_Identity=38.8646288209607, Blast_Score=156, Evalue=2e-39,
Organism=Escherichia coli, GI1786599, Length=230, Percent_Identity=40, Blast_Score=155, Evalue=3e-39,
Organism=Escherichia coli, GI87082012, Length=227, Percent_Identity=38.7665198237885, Blast_Score=147, Evalue=4e-37,
Organism=Escherichia coli, GI1788394, Length=236, Percent_Identity=36.0169491525424, Blast_Score=146, Evalue=1e-36,
Organism=Escherichia coli, GI2367329, Length=234, Percent_Identity=41.4529914529915, Blast_Score=144, Evalue=4e-36,
Organism=Escherichia coli, GI1786911, Length=227, Percent_Identity=35.2422907488987, Blast_Score=144, Evalue=5e-36,
Organism=Escherichia coli, GI1790863, Length=235, Percent_Identity=34.468085106383, Blast_Score=131, Evalue=4e-32,
Organism=Escherichia coli, GI1790860, Length=233, Percent_Identity=36.0515021459227, Blast_Score=130, Evalue=6e-32,
Organism=Escherichia coli, GI1790552, Length=231, Percent_Identity=35.4978354978355, Blast_Score=122, Evalue=2e-29,
Organism=Escherichia coli, GI1787375, Length=230, Percent_Identity=32.6086956521739, Blast_Score=119, Evalue=2e-28,
Organism=Escherichia coli, GI1789402, Length=226, Percent_Identity=34.9557522123894, Blast_Score=119, Evalue=2e-28,
Organism=Escherichia coli, GI145693140, Length=232, Percent_Identity=35.7758620689655, Blast_Score=117, Evalue=8e-28,
Organism=Escherichia coli, GI1787229, Length=229, Percent_Identity=33.6244541484716, Blast_Score=115, Evalue=2e-27,
Organism=Escherichia coli, GI1788550, Length=116, Percent_Identity=37.9310344827586, Blast_Score=96, Evalue=3e-21,
Organism=Escherichia coli, GI145693157, Length=108, Percent_Identity=40.7407407407407, Blast_Score=76, Evalue=2e-15,
Organism=Escherichia coli, GI1787487, Length=102, Percent_Identity=35.2941176470588, Blast_Score=75, Evalue=4e-15,
Organism=Escherichia coli, GI1790299, Length=101, Percent_Identity=34.6534653465347, Blast_Score=74, Evalue=9e-15,
Organism=Escherichia coli, GI1790437, Length=114, Percent_Identity=35.9649122807018, Blast_Score=72, Evalue=3e-14,
Organism=Escherichia coli, GI1788191, Length=126, Percent_Identity=32.5396825396825, Blast_Score=70, Evalue=9e-14,
Organism=Escherichia coli, GI1788713, Length=105, Percent_Identity=39.0476190476191, Blast_Score=69, Evalue=3e-13,
Organism=Escherichia coli, GI1788905, Length=107, Percent_Identity=35.5140186915888, Blast_Score=65, Evalue=4e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011006
- InterPro:   IPR001867
- InterPro:   IPR001789
- InterPro:   IPR011991 [H]

Pfam domain/function: PF00072 Response_reg; PF00486 Trans_reg_C [H]

EC number: NA

Molecular weight: Translated: 27603; Mature: 27603

Theoretical pI: Translated: 4.90; Mature: 4.90

Prosite motif: PS50110 RESPONSE_REGULATORY

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
2.4 %Met     (Translated Protein)
2.9 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
2.4 %Met     (Mature Protein)
2.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MVGNLDNRKEKILVVDDEASIRRILETRLSMIGYDVVTAADGEEALEVFSREHPDLVVLD
CCCCCCCCCCEEEEECCHHHHHHHHHHHHHHHHHHEEEECCCHHHHHHHHCCCCCEEEEE
VMMPKLDGYGVCQELRKDSDVPIIMLTALGDVADRITGLELGADDYVVKPFSPKELEARI
EHHCCCCCCHHHHHHHCCCCCCEEEEEHHHHHHHHHHCCEECCCCEEECCCCHHHHHHHH
RSVLRRADRDTASGIPSSGVIHVGDLKIDTNKRQVYKRGERIRLTGMEFSLLELVVSRSG
HHHHHHHCCCHHCCCCCCCEEEEECEEEECCHHHHHHCCCEEEEECCHHHHHHHHHHCCC
EPFSRSEILQEVWGYTPERHVDTRVVDVHISRLRSKLEDDPSNPELILTARGTGYLFQRI
CCCCHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHCCCCCCCCEEEEECCCHHHHHHH
TEPKE
CCCCC
>Mature Secondary Structure
MVGNLDNRKEKILVVDDEASIRRILETRLSMIGYDVVTAADGEEALEVFSREHPDLVVLD
CCCCCCCCCCEEEEECCHHHHHHHHHHHHHHHHHHEEEECCCHHHHHHHHCCCCCEEEEE
VMMPKLDGYGVCQELRKDSDVPIIMLTALGDVADRITGLELGADDYVVKPFSPKELEARI
EHHCCCCCCHHHHHHHCCCCCCEEEEEHHHHHHHHHHCCEECCCCEEECCCCHHHHHHHH
RSVLRRADRDTASGIPSSGVIHVGDLKIDTNKRQVYKRGERIRLTGMEFSLLELVVSRSG
HHHHHHHCCCHHCCCCCCCEEEEECEEEECCHHHHHHCCCEEEEECCHHHHHHHHHHCCC
EPFSRSEILQEVWGYTPERHVDTRVVDVHISRLRSKLEDDPSNPELILTARGTGYLFQRI
CCCCHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHCCCCCCCCEEEEECCCHHHHHHH
TEPKE
CCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 7584024; 9384377; 9829949; 10878122 [H]