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The map label for this gene is folK [H]

Identifier: 37522216

GI number: 37522216

Start: 2802275

End: 2803345

Strand: Direct

Name: folK [H]

Synonym: glr2647

Alternate gene names: 37522216

Gene position: 2802275-2803345 (Clockwise)

Preceding gene: 37522213

Following gene: 37522217

Centisome position: 60.15

GC content: 68.16

Gene sequence:

>1071_bases
ATGCAGCTCGCTGCTTCAGCGGTGCTGAAGAAAGATTCTCTCGAAATATATCCTGGTGGAAAAGAGAGGGCAACAGCCAT
GGCCAGAGCAGCGATCGCGCTGGGCGCCAATCTCGGGGAGCGCCTGGAGACGCTTACCCGGGCGGTGCGCTCGCTGCACC
GTCCTGGGGACGGTCTGGCGGTGACGGCAATTTCCAGCTGGTACGAGACAGAACCGGTCGGTCCGGTGCAACCGCTTTAT
ATCAACGGCTGCCTAACCCTCCAGACCGAGCTGGCCCCGGTGAGCCTGTTGGGCGAGTTGCAGCAGCGCGAGGCGGCGGC
CGGGCGGACGCGCGAGGTGCACTGGGGGGCACGCACGCTAGATCTCGATTTGCTGTGGTACGACGACTGGGTGCAGGCGG
ATACCGTCCTGACGCTGCCCCATCCGCGCCTGGAGGAGCGCCCCTTCGTGCTGGTGCCGCTGGCCCAGATCGCTCCCGAC
TGGCGCCATCCGCTCACGGACAAGCGCGTCGCCGATCTGGGCGCCGAGGTTTCGGCGCGGGGCGTCGAGCGCGTCGTGGA
ACGGGCCGTGGTGGCCACTGCCCTCGGCCCGGTGGATCTCAGACCCCTTGCCCCGGCGGATCACCCGCCGCTCAGGGATC
TGGCGGTGCGCTGCTGGTGGGCGACCTACCGGGGCCTGCTCGAAGAGGAATATATCGAATCGTTCGTGGGCCACACCTAC
AGCCTCGAAGCGATTGGCCGGGCTGCCGCCCGCCCGGACGGCCATTTTTGGGTGGCGGAGGCGCCGGGGGGCGCCCTGGT
GGGTTTTACCCAGGTGCTGGCGGTCGGGCGGGTCGCGCATCTGGTCCGCCTCTACGTGGCTCCCGAGGTGCAGGCCCTAG
GTATCGGTTCCGCCCTGTGGCGCCTGGTCCACAGCAAGCTCGCCGCAATCGGGGTGGGGGTGTGCACCCTGACGGTGCTT
GCCACCAACGTCGGCGCCGTCCGCTTCTACGAGCGCCAAGGTTTTGAGCGCACCGGCAGCACCCCCGGCAACCGCTTCGA
GTACCGCATCCGGATCGGGGGCGATGGCTGA

Upstream 100 bases:

>100_bases
CGAGGGAGCCGGCCCAGCGCGGCGAAGTCGGCAAGGGCAACAGGTGAACGACCCCGATGATCGGTTTGGCCGTCAAAAAG
AGATCTACCAAAAGTGACAC

Downstream 100 bases:

>100_bases
ATCGGCTCTCACTCCCCTGCGACTGGCCCAACTGCGCCGTTTTGCCGCCCGCTTCGCACTCAGTGAACCGGAAGCCCTCA
GTTGGGAGTTGTTGCACCGG

Product: 2-amino-4-hydroxy-6- hydroxymethyldihydropteridine pyrophosphokinase

Products: NA

Alternate protein names: 6-hydroxymethyl-7,8-dihydropterin pyrophosphokinase; PPPK; 7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase; HPPK [H]

Number of amino acids: Translated: 356; Mature: 356

Protein sequence:

>356_residues
MQLAASAVLKKDSLEIYPGGKERATAMARAAIALGANLGERLETLTRAVRSLHRPGDGLAVTAISSWYETEPVGPVQPLY
INGCLTLQTELAPVSLLGELQQREAAAGRTREVHWGARTLDLDLLWYDDWVQADTVLTLPHPRLEERPFVLVPLAQIAPD
WRHPLTDKRVADLGAEVSARGVERVVERAVVATALGPVDLRPLAPADHPPLRDLAVRCWWATYRGLLEEEYIESFVGHTY
SLEAIGRAAARPDGHFWVAEAPGGALVGFTQVLAVGRVAHLVRLYVAPEVQALGIGSALWRLVHSKLAAIGVGVCTLTVL
ATNVGAVRFYERQGFERTGSTPGNRFEYRIRIGGDG

Sequences:

>Translated_356_residues
MQLAASAVLKKDSLEIYPGGKERATAMARAAIALGANLGERLETLTRAVRSLHRPGDGLAVTAISSWYETEPVGPVQPLY
INGCLTLQTELAPVSLLGELQQREAAAGRTREVHWGARTLDLDLLWYDDWVQADTVLTLPHPRLEERPFVLVPLAQIAPD
WRHPLTDKRVADLGAEVSARGVERVVERAVVATALGPVDLRPLAPADHPPLRDLAVRCWWATYRGLLEEEYIESFVGHTY
SLEAIGRAAARPDGHFWVAEAPGGALVGFTQVLAVGRVAHLVRLYVAPEVQALGIGSALWRLVHSKLAAIGVGVCTLTVL
ATNVGAVRFYERQGFERTGSTPGNRFEYRIRIGGDG
>Mature_356_residues
MQLAASAVLKKDSLEIYPGGKERATAMARAAIALGANLGERLETLTRAVRSLHRPGDGLAVTAISSWYETEPVGPVQPLY
INGCLTLQTELAPVSLLGELQQREAAAGRTREVHWGARTLDLDLLWYDDWVQADTVLTLPHPRLEERPFVLVPLAQIAPD
WRHPLTDKRVADLGAEVSARGVERVVERAVVATALGPVDLRPLAPADHPPLRDLAVRCWWATYRGLLEEEYIESFVGHTY
SLEAIGRAAARPDGHFWVAEAPGGALVGFTQVLAVGRVAHLVRLYVAPEVQALGIGSALWRLVHSKLAAIGVGVCTLTVL
ATNVGAVRFYERQGFERTGSTPGNRFEYRIRIGGDG

Specific function: Dihydrofolate biosynthesis; first step. [C]

COG id: COG0801

COG function: function code H; 7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the HPPK family [H]

Homologues:

Organism=Escherichia coli, GI1786335, Length=140, Percent_Identity=40.7142857142857, Blast_Score=94, Evalue=2e-20,
Organism=Saccharomyces cerevisiae, GI6324073, Length=152, Percent_Identity=34.2105263157895, Blast_Score=86, Evalue=7e-18,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000550 [H]

Pfam domain/function: PF01288 HPPK [H]

EC number: =2.7.6.3 [H]

Molecular weight: Translated: 38731; Mature: 38731

Theoretical pI: Translated: 6.80; Mature: 6.80

Prosite motif: PS00794 HPPK

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
0.6 %Met     (Translated Protein)
1.4 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
0.6 %Met     (Mature Protein)
1.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MQLAASAVLKKDSLEIYPGGKERATAMARAAIALGANLGERLETLTRAVRSLHRPGDGLA
CCCHHHHHHCCCCEEECCCCHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHCCCCCCEE
VTAISSWYETEPVGPVQPLYINGCLTLQTELAPVSLLGELQQREAAAGRTREVHWGARTL
EEEEHHHHCCCCCCCCCCEEECCEEEEEECCCHHHHHHHHHHHHHHCCCCEEEECCCEEE
DLDLLWYDDWVQADTVLTLPHPRLEERPFVLVPLAQIAPDWRHPLTDKRVADLGAEVSAR
EEEEEEECCCCCCCEEEECCCCCCCCCCEEEEEHHHHCCCCCCCCCCHHHHHCCCHHHHH
GVERVVERAVVATALGPVDLRPLAPADHPPLRDLAVRCWWATYRGLLEEEYIESFVGHTY
HHHHHHHHHHHHHHCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCE
SLEAIGRAAARPDGHFWVAEAPGGALVGFTQVLAVGRVAHLVRLYVAPEVQALGIGSALW
EHHHHHHHHCCCCCCEEEEECCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCEECCHHHHH
RLVHSKLAAIGVGVCTLTVLATNVGAVRFYERQGFERTGSTPGNRFEYRIRIGGDG
HHHHHHHHHHHHHHHHHHHHHHCCCCEEEHHHCCCCCCCCCCCCEEEEEEEECCCC
>Mature Secondary Structure
MQLAASAVLKKDSLEIYPGGKERATAMARAAIALGANLGERLETLTRAVRSLHRPGDGLA
CCCHHHHHHCCCCEEECCCCHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHCCCCCCEE
VTAISSWYETEPVGPVQPLYINGCLTLQTELAPVSLLGELQQREAAAGRTREVHWGARTL
EEEEHHHHCCCCCCCCCCEEECCEEEEEECCCHHHHHHHHHHHHHHCCCCEEEECCCEEE
DLDLLWYDDWVQADTVLTLPHPRLEERPFVLVPLAQIAPDWRHPLTDKRVADLGAEVSAR
EEEEEEECCCCCCCEEEECCCCCCCCCCEEEEEHHHHCCCCCCCCCCHHHHHCCCHHHHH
GVERVVERAVVATALGPVDLRPLAPADHPPLRDLAVRCWWATYRGLLEEEYIESFVGHTY
HHHHHHHHHHHHHHCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCE
SLEAIGRAAARPDGHFWVAEAPGGALVGFTQVLAVGRVAHLVRLYVAPEVQALGIGSALW
EHHHHHHHHCCCCCCEEEEECCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCEECCHHHHH
RLVHSKLAAIGVGVCTLTVLATNVGAVRFYERQGFERTGSTPGNRFEYRIRIGGDG
HHHHHHHHHHHHHHHHHHHHHHCCCCEEEHHHCCCCCCCCCCCCEEEEEEEECCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8905231 [H]