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The map label for this gene is rnc [H]

Identifier: 37522217

GI number: 37522217

Start: 2803338

End: 2804066

Strand: Direct

Name: rnc [H]

Synonym: gvip371

Alternate gene names: 37522217

Gene position: 2803338-2804066 (Clockwise)

Preceding gene: 37522216

Following gene: 37522218

Centisome position: 60.17

GC content: 67.08

Gene sequence:

>729_bases
ATGGCTGAATCGGCTCTCACTCCCCTGCGACTGGCCCAACTGCGCCGTTTTGCCGCCCGCTTCGCACTCAGTGAACCGGA
AGCCCTCAGTTGGGAGTTGTTGCACCGGGCGCTCATCCACCCGAGCTGGTCCGCCCAGGAAGGCGGCGAGGACAACGACC
GGCTCGAATTTTTGGGCGATGAAATCCTGCGGCTGCTGGCGGCGGAATTTTTGTACCGGGCCGACCCGGAACTGACGGTG
GGCGAGATGACCGCCGTGCGCTCGGTGCTGGTGAGCGATGTGGCCCTGGCCGAGCTGGCGGAAGGTTACGACCTGGGGGA
ATTTCTGGTGGTGGGCCGCTCCGCGAGCGGTGACGAGCGCGGTCGGATCACACGACTGGCGGACGGATTCGAGGCGGTGA
TCGGGGCGCTGTATCTGAGCACCGGCGATTTGGGCCTGATTCGCCCGTGGCTTTTGCCCCATCTGGCACACCTTGCCGAA
TCGGTGATGGCCGACCCGACCCGCGGCAACCACAAATCGGCGCTGCAGGAGCTGACCCAGAAGCTCGCCGCCGGCGAGTT
GCCCGAGTACCGACTGGTGGATCCGGGGCCGCCCTTTCGCTATGAAGTCTGGGCGTTGGGCCGCCTGTGGGGTAGCGGCG
AAGGGCCGTCCAAAAAGCTCGCCCAGCAGCGGGCCGCCCGGGGCGCCTACGCGGCCCTGCGCTCGGCCTTCGATACGGCG
CTGCAGTAG

Upstream 100 bases:

>100_bases
ACCAACGTCGGCGCCGTCCGCTTCTACGAGCGCCAAGGTTTTGAGCGCACCGGCAGCACCCCCGGCAACCGCTTCGAGTA
CCGCATCCGGATCGGGGGCG

Downstream 100 bases:

>100_bases
GATAGGGACAACTTTGCCGCCGGTCTATGCTCGCCTTTGAGATCCTGCAGAGCTTTGTCAACTTCCTGGGTTTCCTGTTA
TTGATCCTCGTGCAGGGGAT

Product: ribonuclease III

Products: NA

Alternate protein names: Ribonuclease III 2; RNase III 2 [H]

Number of amino acids: Translated: 242; Mature: 241

Protein sequence:

>242_residues
MAESALTPLRLAQLRRFAARFALSEPEALSWELLHRALIHPSWSAQEGGEDNDRLEFLGDEILRLLAAEFLYRADPELTV
GEMTAVRSVLVSDVALAELAEGYDLGEFLVVGRSASGDERGRITRLADGFEAVIGALYLSTGDLGLIRPWLLPHLAHLAE
SVMADPTRGNHKSALQELTQKLAAGELPEYRLVDPGPPFRYEVWALGRLWGSGEGPSKKLAQQRAARGAYAALRSAFDTA
LQ

Sequences:

>Translated_242_residues
MAESALTPLRLAQLRRFAARFALSEPEALSWELLHRALIHPSWSAQEGGEDNDRLEFLGDEILRLLAAEFLYRADPELTV
GEMTAVRSVLVSDVALAELAEGYDLGEFLVVGRSASGDERGRITRLADGFEAVIGALYLSTGDLGLIRPWLLPHLAHLAE
SVMADPTRGNHKSALQELTQKLAAGELPEYRLVDPGPPFRYEVWALGRLWGSGEGPSKKLAQQRAARGAYAALRSAFDTA
LQ
>Mature_241_residues
AESALTPLRLAQLRRFAARFALSEPEALSWELLHRALIHPSWSAQEGGEDNDRLEFLGDEILRLLAAEFLYRADPELTVG
EMTAVRSVLVSDVALAELAEGYDLGEFLVVGRSASGDERGRITRLADGFEAVIGALYLSTGDLGLIRPWLLPHLAHLAES
VMADPTRGNHKSALQELTQKLAAGELPEYRLVDPGPPFRYEVWALGRLWGSGEGPSKKLAQQRAARGAYAALRSAFDTAL
Q

Specific function: Digests double-stranded RNA. Involved in the processing of ribosomal RNA precursors and of some mRNAs [H]

COG id: COG0571

COG function: function code K; dsRNA-specific ribonuclease

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 RNase III domain [H]

Homologues:

Organism=Homo sapiens, GI155030236, Length=188, Percent_Identity=30.3191489361702, Blast_Score=65, Evalue=4e-11,
Organism=Homo sapiens, GI155030234, Length=188, Percent_Identity=30.3191489361702, Blast_Score=65, Evalue=4e-11,
Organism=Escherichia coli, GI1788920, Length=151, Percent_Identity=37.0860927152318, Blast_Score=72, Evalue=2e-14,
Organism=Caenorhabditis elegans, GI193202651, Length=197, Percent_Identity=30.9644670050761, Blast_Score=71, Evalue=5e-13,
Organism=Caenorhabditis elegans, GI17506883, Length=197, Percent_Identity=30.9644670050761, Blast_Score=71, Evalue=5e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001159
- InterPro:   IPR014720
- InterPro:   IPR000999
- InterPro:   IPR011907 [H]

Pfam domain/function: PF00035 dsrm; PF00636 Ribonuclease_3 [H]

EC number: =3.1.26.3 [H]

Molecular weight: Translated: 26473; Mature: 26342

Theoretical pI: Translated: 4.90; Mature: 4.90

Prosite motif: PS50137 DS_RBD ; PS50142 RNASE_3_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
1.2 %Met     (Translated Protein)
1.2 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
0.8 %Met     (Mature Protein)
0.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAESALTPLRLAQLRRFAARFALSEPEALSWELLHRALIHPSWSAQEGGEDNDRLEFLGD
CCCCCCCHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHCCCCCCCCCCCCCHHHHHHHH
EILRLLAAEFLYRADPELTVGEMTAVRSVLVSDVALAELAEGYDLGEFLVVGRSASGDER
HHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCHHEEECCCCCCCCC
GRITRLADGFEAVIGALYLSTGDLGLIRPWLLPHLAHLAESVMADPTRGNHKSALQELTQ
CCHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHH
KLAAGELPEYRLVDPGPPFRYEVWALGRLWGSGEGPSKKLAQQRAARGAYAALRSAFDTA
HHHHCCCCCCEECCCCCCCCCHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHH
LQ
CC
>Mature Secondary Structure 
AESALTPLRLAQLRRFAARFALSEPEALSWELLHRALIHPSWSAQEGGEDNDRLEFLGD
CCCCCCHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHCCCCCCCCCCCCCHHHHHHHH
EILRLLAAEFLYRADPELTVGEMTAVRSVLVSDVALAELAEGYDLGEFLVVGRSASGDER
HHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCHHEEECCCCCCCCC
GRITRLADGFEAVIGALYLSTGDLGLIRPWLLPHLAHLAESVMADPTRGNHKSALQELTQ
CCHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHH
KLAAGELPEYRLVDPGPPFRYEVWALGRLWGSGEGPSKKLAQQRAARGAYAALRSAFDTA
HHHHCCCCCCEECCCCCCCCCHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHH
LQ
CC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8590279; 8905231 [H]