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The map label for this gene is ndhH

Identifier: 37521941

GI number: 37521941

Start: 2531908

End: 2533089

Strand: Direct

Name: ndhH

Synonym: gvip329

Alternate gene names: 37521941

Gene position: 2531908-2533089 (Clockwise)

Preceding gene: 37521940

Following gene: 37521944

Centisome position: 54.34

GC content: 61.51

Gene sequence:

>1182_bases
ATGTCGATGCTTGAGACCCGCGCGGAGCGCATGGTCATCAATCTCGGGCCGCACCACCCCTCGATGCACGGTGTGCTGCG
CCTGATTGTCACCCTTGACGGCGAGAATGTGGTCGATTGCGTGCCGGTGCTCGGCTATCTGCACCGCTCGATGGAGAAGA
TTGCCGAGAGCCGCACAATTATCCAGTACCTGCCCTACGTGACGCGCTGGGATTACCTGGCGACGATGTTCACCGAGGCG
ATCACCGTCAACGCGCCGGAGCAGTTGGCCGGGGTACAGGTACCGCGCCGGGCGCGGTACATCCGTGTGATCATGCTCGA
ACTGTCGCGGATTGCCAGCCATCTGTTGTGGCTCGGACCGTTTATGGCCGACATCGGCGCCACCTCGCCGTTTTTTTATA
TCTTCCGCGAGCGGGAGATGATCTACGACCTCTTTGAGGCGGCCACCGGCATGCGGATGATGCACAATTACTTTCGCGTC
GGCGGGGTGGCGGTGGACTTGCCCTACGGCTGGGTAGACAAGGCAAGAGACTTCTGCAATTACCTGCCGCCCAAAATCGA
CGAGTACGAACGGCTAATCACCAACAACCCGATCTTCCGAGGCCGCGTCGAAGGCCTCGGCTACATCGGCCGCGAGGATG
CGATCAACTGGGGGCTTTCCGGGCCGATGCTGCGCGCCTCGGGGGTCAACTGGGATCTGCGCAAGGTTGATCACTACGAA
ATTTACGACGAACTGGACTGGAATGTCGCCTGGGACACCGGCGGCGACACCCTGGCGCGCTACGTCGTGCGCATCCAGGA
AATGCGCGAATCGGTCAAAATGATTCGCCAGGCCCTCGATCAACTGCCCGGCGGCCCCTACGAGAATCTGGAGGCCCAGC
GGCTGTCCGGCGGCCCCAAGTCCGAATGGAATGGCTTCGACTACCAGTTCATCGGCAAGAAGTCCTCTCCGACTTTTAAG
ATGCCCAGGGGCGAGCACTACGTGCGCGTCGAAGCGCCCAAGGGCGAGCTGGGGGTGTATCTGATCGGCGACGACAGTAC
CTTCCCGTGGCGCTGGAAGATTCGGCCGCCCGGGTTTATCAACCTGGCGGTCCTGCCCAAGCTGGTGCAGGGGACGAAGC
TTGCCGACTTGATGGCGATTCTCGGGTCGGTGGACATCATCATGGGCGAGGTCGACCGCTAG

Upstream 100 bases:

>100_bases
GGCGATCGTGCACCAGCAGGCCAATGTGGGCGAGCAAAAAGTCGGCTGACCAACCGAGGCTATGCTTGAAGTAGAGCCCC
ACCCGTAAAGAGACATTGCC

Downstream 100 bases:

>100_bases
CGCCCCGGCTGTAACCAGTACAGGACGCTCGTGGCGGCGAAGATCGCCATCATCCCGATCGACAGGCCGTACCAGAACTG
CAAGGGCCGGTCCAGCAGCA

Product: NAD(P)H-quinone oxidoreductase subunit H

Products: NAD+; ubiquinol

Alternate protein names: NAD(P)H dehydrogenase subunit H 1; NADH-plastoquinone oxidoreductase subunit H 1; NDH-1 subunit H 1; NDH-H 1

Number of amino acids: Translated: 393; Mature: 392

Protein sequence:

>393_residues
MSMLETRAERMVINLGPHHPSMHGVLRLIVTLDGENVVDCVPVLGYLHRSMEKIAESRTIIQYLPYVTRWDYLATMFTEA
ITVNAPEQLAGVQVPRRARYIRVIMLELSRIASHLLWLGPFMADIGATSPFFYIFREREMIYDLFEAATGMRMMHNYFRV
GGVAVDLPYGWVDKARDFCNYLPPKIDEYERLITNNPIFRGRVEGLGYIGREDAINWGLSGPMLRASGVNWDLRKVDHYE
IYDELDWNVAWDTGGDTLARYVVRIQEMRESVKMIRQALDQLPGGPYENLEAQRLSGGPKSEWNGFDYQFIGKKSSPTFK
MPRGEHYVRVEAPKGELGVYLIGDDSTFPWRWKIRPPGFINLAVLPKLVQGTKLADLMAILGSVDIIMGEVDR

Sequences:

>Translated_393_residues
MSMLETRAERMVINLGPHHPSMHGVLRLIVTLDGENVVDCVPVLGYLHRSMEKIAESRTIIQYLPYVTRWDYLATMFTEA
ITVNAPEQLAGVQVPRRARYIRVIMLELSRIASHLLWLGPFMADIGATSPFFYIFREREMIYDLFEAATGMRMMHNYFRV
GGVAVDLPYGWVDKARDFCNYLPPKIDEYERLITNNPIFRGRVEGLGYIGREDAINWGLSGPMLRASGVNWDLRKVDHYE
IYDELDWNVAWDTGGDTLARYVVRIQEMRESVKMIRQALDQLPGGPYENLEAQRLSGGPKSEWNGFDYQFIGKKSSPTFK
MPRGEHYVRVEAPKGELGVYLIGDDSTFPWRWKIRPPGFINLAVLPKLVQGTKLADLMAILGSVDIIMGEVDR
>Mature_392_residues
SMLETRAERMVINLGPHHPSMHGVLRLIVTLDGENVVDCVPVLGYLHRSMEKIAESRTIIQYLPYVTRWDYLATMFTEAI
TVNAPEQLAGVQVPRRARYIRVIMLELSRIASHLLWLGPFMADIGATSPFFYIFREREMIYDLFEAATGMRMMHNYFRVG
GVAVDLPYGWVDKARDFCNYLPPKIDEYERLITNNPIFRGRVEGLGYIGREDAINWGLSGPMLRASGVNWDLRKVDHYEI
YDELDWNVAWDTGGDTLARYVVRIQEMRESVKMIRQALDQLPGGPYENLEAQRLSGGPKSEWNGFDYQFIGKKSSPTFKM
PRGEHYVRVEAPKGELGVYLIGDDSTFPWRWKIRPPGFINLAVLPKLVQGTKLADLMAILGSVDIIMGEVDR

Specific function: NDH-1 shuttles electrons from an unknown electron donor, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory and/or the photosynthetic chain. The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone

COG id: COG0649

COG function: function code C; NADH:ubiquinone oxidoreductase 49 kD subunit 7

Gene ontology:

Cell location: Cell inner membrane; Peripheral membrane protein; Cytoplasmic side

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the complex I 49 kDa subunit family

Homologues:

Organism=Homo sapiens, GI4758786, Length=391, Percent_Identity=41.1764705882353, Blast_Score=310, Evalue=1e-84,
Organism=Homo sapiens, GI260898743, Length=385, Percent_Identity=40.2597402597403, Blast_Score=297, Evalue=1e-80,
Organism=Escherichia coli, GI145693162, Length=389, Percent_Identity=39.3316195372751, Blast_Score=304, Evalue=7e-84,
Organism=Escherichia coli, GI1789076, Length=385, Percent_Identity=30.1298701298701, Blast_Score=150, Evalue=1e-37,
Organism=Escherichia coli, GI1788832, Length=393, Percent_Identity=28.2442748091603, Blast_Score=132, Evalue=4e-32,
Organism=Caenorhabditis elegans, GI17568379, Length=391, Percent_Identity=40.6649616368286, Blast_Score=325, Evalue=2e-89,
Organism=Caenorhabditis elegans, GI17555284, Length=392, Percent_Identity=40.3061224489796, Blast_Score=325, Evalue=3e-89,
Organism=Drosophila melanogaster, GI221459469, Length=388, Percent_Identity=43.298969072165, Blast_Score=332, Evalue=3e-91,
Organism=Drosophila melanogaster, GI24638644, Length=392, Percent_Identity=41.0714285714286, Blast_Score=328, Evalue=6e-90,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NDHH1_GLOVI (Q7NI12)

Other databases:

- EMBL:   BA000045
- RefSeq:   NP_925318.1
- HSSP:   Q56220
- ProteinModelPortal:   Q7NI12
- SMR:   Q7NI12
- GeneID:   2600773
- GenomeReviews:   BA000045_GR
- NMPDR:   fig|251221.1.peg.2372
- HOGENOM:   HBG459705
- ProtClustDB:   PRK07415
- BioCyc:   GVIO251221:GLR2372-MONOMER
- GO:   GO:0006810
- HAMAP:   MF_01358
- InterPro:   IPR001135
- InterPro:   IPR022885

Pfam domain/function: PF00346 Complex1_49kDa

EC number: 1.6.5.3

Molecular weight: Translated: 45017; Mature: 44885

Theoretical pI: Translated: 6.53; Mature: 6.53

Prosite motif: PS00535 COMPLEX1_49K

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
4.6 %Met     (Translated Protein)
5.1 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
4.3 %Met     (Mature Protein)
4.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSMLETRAERMVINLGPHHPSMHGVLRLIVTLDGENVVDCVPVLGYLHRSMEKIAESRTI
CCHHHHHHHEEEEEECCCCCHHHHHEEEEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHH
IQYLPYVTRWDYLATMFTEAITVNAPEQLAGVQVPRRARYIRVIMLELSRIASHLLWLGP
HHHCCHHHHHHHHHHHHHHHHCCCCHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHH
FMADIGATSPFFYIFREREMIYDLFEAATGMRMMHNYFRVGGVAVDLPYGWVDKARDFCN
HHHHHCCCCCEEEEEEHHHHHHHHHHHHHHHHHHHHHHHHCCEEEECCCCHHHHHHHHHH
YLPPKIDEYERLITNNPIFRGRVEGLGYIGREDAINWGLSGPMLRASGVNWDLRKVDHYE
CCCCCHHHHHHHHHCCCCEEEECCCCCCCCCCCCCCCCCCCCEEEECCCCCCHHCCCCEE
IYDELDWNVAWDTGGDTLARYVVRIQEMRESVKMIRQALDQLPGGPYENLEAQRLSGGPK
HHHCCCCEEEECCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHCCCCCC
SEWNGFDYQFIGKKSSPTFKMPRGEHYVRVEAPKGELGVYLIGDDSTFPWRWKIRPPGFI
CCCCCCCEEEECCCCCCCEECCCCCEEEEEECCCCCEEEEEEECCCCCCEEEEECCCCEE
NLAVLPKLVQGTKLADLMAILGSVDIIMGEVDR
EHHHHHHHHCCCHHHHHHHHHCCHHEEECCCCC
>Mature Secondary Structure 
SMLETRAERMVINLGPHHPSMHGVLRLIVTLDGENVVDCVPVLGYLHRSMEKIAESRTI
CHHHHHHHEEEEEECCCCCHHHHHEEEEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHH
IQYLPYVTRWDYLATMFTEAITVNAPEQLAGVQVPRRARYIRVIMLELSRIASHLLWLGP
HHHCCHHHHHHHHHHHHHHHHCCCCHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHH
FMADIGATSPFFYIFREREMIYDLFEAATGMRMMHNYFRVGGVAVDLPYGWVDKARDFCN
HHHHHCCCCCEEEEEEHHHHHHHHHHHHHHHHHHHHHHHHCCEEEECCCCHHHHHHHHHH
YLPPKIDEYERLITNNPIFRGRVEGLGYIGREDAINWGLSGPMLRASGVNWDLRKVDHYE
CCCCCHHHHHHHHHCCCCEEEECCCCCCCCCCCCCCCCCCCCEEEECCCCCCHHCCCCEE
IYDELDWNVAWDTGGDTLARYVVRIQEMRESVKMIRQALDQLPGGPYENLEAQRLSGGPK
HHHCCCCEEEECCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHCCCCCC
SEWNGFDYQFIGKKSSPTFKMPRGEHYVRVEAPKGELGVYLIGDDSTFPWRWKIRPPGFI
CCCCCCCEEEECCCCCCCEECCCCCEEEEEECCCCCEEEEEEECCCCCCEEEEECCCCEE
NLAVLPKLVQGTKLADLMAILGSVDIIMGEVDR
EHHHHHHHHCCCHHHHHHHHHCCHHEEECCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NADH; H+; ubiquinone

Specific reaction: NADH + H+ + ubiquinone = NAD+ + ubiquinol

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 14621292