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The map label for this gene is sdaB [H]

Identifier: 37521927

GI number: 37521927

Start: 2518527

End: 2519897

Strand: Direct

Name: sdaB [H]

Synonym: glr2358

Alternate gene names: 37521927

Gene position: 2518527-2519897 (Clockwise)

Preceding gene: 37521924

Following gene: 37521928

Centisome position: 54.06

GC content: 61.2

Gene sequence:

>1371_bases
ATGGGTGCAATCACCACTTCGATTTTCGAGCTGTTCAAAGTCGGTCCGGGGCCTTCGAGTTCCCACACGATCGGGCCGAT
GAAGGCGGCTTTCGATTTTTTGATTCGCATCAACGCCCTGGACGACACTCAGGTGCTCGCGGCTTCGGCGGTCGAAGCGT
TTTTATTCGGCTCTCTCAGTGCCACCGGCAAAGGCCACGGTACCGACCGGGCGGTGATTGCGGGGCTGTTGGGCTGGACA
CCCGAGGGGTGCGATCCGGTTGCTTTTTCAGCCCTGCTCAGTGACGACAATGAACACTACTTTGTCGCTATCCATGATCG
CCGCATCCCGATAAGTGCCGCCAATATTCACTTTGTCAAAGGCCAGCAGGACTTTCCCTTCAGCAACACGATGATTCTGC
GGCTGATGGGCGATGATTCAGTACTTTTCGAGCAAGAATATTACTCGATAGGCGGTGGTTTCATCCAGCGCAAGGGCGAA
GATGCGCAGGCCGGCCCCCCTGTCGAGCCGCCCTACGGCTATGGAACGATGAAGGAACTCAAAGCGCAGATGACCACCCA
CAGCCTGGGGCTCGACGAAGTGATCCTGGCCAACGAGATGGTGATCACTGGCCAGGGCCGCAAGCAGATTTATCGGCGCA
TCGACGATATTTTCGACTTTATGCACCGGGCGGTGCGCCGGGGCCTCAAAAGCGAAGGCATCCTGCCCGGCACCATCCGG
TTGGAGCGCAAGGCCCCCGGCCTCCACCGCACCGCCCGCGCCCTGCGGGGCAACCCGGATAGCTTTCTGGTCTTTCTCAA
CGCCTACAGTCTGGCGGCTTCCGAAGAAAACGCCGCCGGCCGCATCGTGGTCACCGCCCCCACCTCGGGCGCTTCGGGGG
TGATTCCCGGTGTCAGTTATCTACTCAAGAAGCACTACCGCTACGACAAGCAGAAGCTGCGCTCGGGCCTGCTTGCCGCC
GCCGCCGTCGGATTTCTGGTCAAGCACAACGCCAGCATCTCGGGGGCGGAGATGGGCTGCATGGGGGAAGTGGGCACCGC
CGCGGCGATGGGGGCGGCGATGCTCGCCCACTGCGCCGGCCACCCGATCGAAGTGGTGGAGGCCGCCGCTGAGATTGCCA
TCGAGCACCACCTGGGCATGACCTGCGATCCGATCGGCGGCTACGTGCAGATTCCCTGCATCGAGCGCAACGCCATGGGA
GCGGTCAAGGCCTACAACGCCTATTTGCTCGCCTCGGCGGGAAGCTCCAGCAAGCAAAAAATTTCCCTGGACAATGTCAT
CCGGGTGATGCGCGCCACCGGCCTCGACATGTCCAGAAAGTACAAAGAAACCTCCGAGGCGGGCCTTGCCCTCAGCAGTA
CCGAGTGCTGA

Upstream 100 bases:

>100_bases
TGACAACCGCGGGGGACGGCCCGGCCGTGGCCGATAATTGAACCAGGGGCGCGCCGCAGCGAGGGGGCGCTTGGTCGGTA
AGTCGTTCGAGAGCCTGGGC

Downstream 100 bases:

>100_bases
AACGAAGCGTCCTCTGCTATACTGCGCCCACGTTTGGGGACCAGGACGACGCTGAGCACGACCTGCGGAGTGATCGCCGC
CGGACACGCCGAGACGGCGG

Product: L-serine dehydratase

Products: NA

Alternate protein names: SDH 2; L-serine deaminase 2; L-SD2 [H]

Number of amino acids: Translated: 456; Mature: 455

Protein sequence:

>456_residues
MGAITTSIFELFKVGPGPSSSHTIGPMKAAFDFLIRINALDDTQVLAASAVEAFLFGSLSATGKGHGTDRAVIAGLLGWT
PEGCDPVAFSALLSDDNEHYFVAIHDRRIPISAANIHFVKGQQDFPFSNTMILRLMGDDSVLFEQEYYSIGGGFIQRKGE
DAQAGPPVEPPYGYGTMKELKAQMTTHSLGLDEVILANEMVITGQGRKQIYRRIDDIFDFMHRAVRRGLKSEGILPGTIR
LERKAPGLHRTARALRGNPDSFLVFLNAYSLAASEENAAGRIVVTAPTSGASGVIPGVSYLLKKHYRYDKQKLRSGLLAA
AAVGFLVKHNASISGAEMGCMGEVGTAAAMGAAMLAHCAGHPIEVVEAAAEIAIEHHLGMTCDPIGGYVQIPCIERNAMG
AVKAYNAYLLASAGSSSKQKISLDNVIRVMRATGLDMSRKYKETSEAGLALSSTEC

Sequences:

>Translated_456_residues
MGAITTSIFELFKVGPGPSSSHTIGPMKAAFDFLIRINALDDTQVLAASAVEAFLFGSLSATGKGHGTDRAVIAGLLGWT
PEGCDPVAFSALLSDDNEHYFVAIHDRRIPISAANIHFVKGQQDFPFSNTMILRLMGDDSVLFEQEYYSIGGGFIQRKGE
DAQAGPPVEPPYGYGTMKELKAQMTTHSLGLDEVILANEMVITGQGRKQIYRRIDDIFDFMHRAVRRGLKSEGILPGTIR
LERKAPGLHRTARALRGNPDSFLVFLNAYSLAASEENAAGRIVVTAPTSGASGVIPGVSYLLKKHYRYDKQKLRSGLLAA
AAVGFLVKHNASISGAEMGCMGEVGTAAAMGAAMLAHCAGHPIEVVEAAAEIAIEHHLGMTCDPIGGYVQIPCIERNAMG
AVKAYNAYLLASAGSSSKQKISLDNVIRVMRATGLDMSRKYKETSEAGLALSSTEC
>Mature_455_residues
GAITTSIFELFKVGPGPSSSHTIGPMKAAFDFLIRINALDDTQVLAASAVEAFLFGSLSATGKGHGTDRAVIAGLLGWTP
EGCDPVAFSALLSDDNEHYFVAIHDRRIPISAANIHFVKGQQDFPFSNTMILRLMGDDSVLFEQEYYSIGGGFIQRKGED
AQAGPPVEPPYGYGTMKELKAQMTTHSLGLDEVILANEMVITGQGRKQIYRRIDDIFDFMHRAVRRGLKSEGILPGTIRL
ERKAPGLHRTARALRGNPDSFLVFLNAYSLAASEENAAGRIVVTAPTSGASGVIPGVSYLLKKHYRYDKQKLRSGLLAAA
AVGFLVKHNASISGAEMGCMGEVGTAAAMGAAMLAHCAGHPIEVVEAAAEIAIEHHLGMTCDPIGGYVQIPCIERNAMGA
VKAYNAYLLASAGSSSKQKISLDNVIRVMRATGLDMSRKYKETSEAGLALSSTEC

Specific function: Deaminates also threonine, particularly when it is present in high concentration [H]

COG id: COG1760

COG function: function code E; L-serine deaminase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the iron-sulfur dependent L-serine dehydratase family [H]

Homologues:

Organism=Escherichia coli, GI1789161, Length=463, Percent_Identity=41.2526997840173, Blast_Score=320, Evalue=1e-88,
Organism=Escherichia coli, GI1788116, Length=459, Percent_Identity=40.7407407407407, Blast_Score=295, Evalue=5e-81,
Organism=Escherichia coli, GI48994925, Length=468, Percent_Identity=40.8119658119658, Blast_Score=292, Evalue=3e-80,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004644
- InterPro:   IPR005130
- InterPro:   IPR005131 [H]

Pfam domain/function: PF03313 SDH_alpha; PF03315 SDH_beta [H]

EC number: =4.3.1.17 [H]

Molecular weight: Translated: 48713; Mature: 48582

Theoretical pI: Translated: 7.20; Mature: 7.20

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
3.5 %Met     (Translated Protein)
4.8 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
3.3 %Met     (Mature Protein)
4.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MGAITTSIFELFKVGPGPSSSHTIGPMKAAFDFLIRINALDDTQVLAASAVEAFLFGSLS
CCCHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHEEEECCCCHHHHHHHHHHHHHHCCCC
ATGKGHGTDRAVIAGLLGWTPEGCDPVAFSALLSDDNEHYFVAIHDRRIPISAANIHFVK
CCCCCCCCCHHHHHHHHCCCCCCCCHHHHHHHHCCCCCEEEEEEECCCCCEEECCEEEEE
GQQDFPFSNTMILRLMGDDSVLFEQEYYSIGGGFIQRKGEDAQAGPPVEPPYGYGTMKEL
CCCCCCCCCEEEEEEECCCCEEEEHHHHHCCCCCEEECCCCCCCCCCCCCCCCCCHHHHH
KAQMTTHSLGLDEVILANEMVITGQGRKQIYRRIDDIFDFMHRAVRRGLKSEGILPGTIR
HHHHHHHHCCCCCEEEECCEEEECCCHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCEEE
LERKAPGLHRTARALRGNPDSFLVFLNAYSLAASEENAAGRIVVTAPTSGASGVIPGVSY
EECCCCCHHHHHHHHCCCCCEEEEEEEEHHHCCCCCCCCCEEEEECCCCCCCCCHHHHHH
LLKKHYRYDKQKLRSGLLAAAAVGFLVKHNASISGAEMGCMGEVGTAAAMGAAMLAHCAG
HHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHCC
HPIEVVEAAAEIAIEHHLGMTCDPIGGYVQIPCIERNAMGAVKAYNAYLLASAGSSSKQK
CHHHHHHHHHHHHHHHHCCCEECCCCCEEEEEEECCCCCCHHHHCCEEEEEECCCCCCCE
ISLDNVIRVMRATGLDMSRKYKETSEAGLALSSTEC
ECHHHHHHHHHHCCCCHHHHHHHHHHCCEEECCCCC
>Mature Secondary Structure 
GAITTSIFELFKVGPGPSSSHTIGPMKAAFDFLIRINALDDTQVLAASAVEAFLFGSLS
CCHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHEEEECCCCHHHHHHHHHHHHHHCCCC
ATGKGHGTDRAVIAGLLGWTPEGCDPVAFSALLSDDNEHYFVAIHDRRIPISAANIHFVK
CCCCCCCCCHHHHHHHHCCCCCCCCHHHHHHHHCCCCCEEEEEEECCCCCEEECCEEEEE
GQQDFPFSNTMILRLMGDDSVLFEQEYYSIGGGFIQRKGEDAQAGPPVEPPYGYGTMKEL
CCCCCCCCCEEEEEEECCCCEEEEHHHHHCCCCCEEECCCCCCCCCCCCCCCCCCHHHHH
KAQMTTHSLGLDEVILANEMVITGQGRKQIYRRIDDIFDFMHRAVRRGLKSEGILPGTIR
HHHHHHHHCCCCCEEEECCEEEECCCHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCEEE
LERKAPGLHRTARALRGNPDSFLVFLNAYSLAASEENAAGRIVVTAPTSGASGVIPGVSY
EECCCCCHHHHHHHHCCCCCEEEEEEEEHHHCCCCCCCCCEEEEECCCCCCCCCHHHHHH
LLKKHYRYDKQKLRSGLLAAAAVGFLVKHNASISGAEMGCMGEVGTAAAMGAAMLAHCAG
HHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHCC
HPIEVVEAAAEIAIEHHLGMTCDPIGGYVQIPCIERNAMGAVKAYNAYLLASAGSSSKQK
CHHHHHHHHHHHHHHHHCCCEECCCCCEEEEEEECCCCCCHHHHCCEEEEEECCCCCCCE
ISLDNVIRVMRATGLDMSRKYKETSEAGLALSSTEC
ECHHHHHHHHHHCCCCHHHHHHHHHHCCEEECCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8385012; 9278503 [H]