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The map label for this gene is ggt [H]

Identifier: 37521928

GI number: 37521928

Start: 2519931

End: 2521460

Strand: Direct

Name: ggt [H]

Synonym: gvip325

Alternate gene names: 37521928

Gene position: 2519931-2521460 (Clockwise)

Preceding gene: 37521927

Following gene: 37521932

Centisome position: 54.09

GC content: 66.67

Gene sequence:

>1530_bases
TTGGGGACCAGGACGACGCTGAGCACGACCTGCGGAGTGATCGCCGCCGGACACGCCGAGACGGCGGCGGCCGGAGTCAA
AATTTTGCGCCTGGGCGGCAACGCCTTCGATGCGGCGGTGGCGGGAATGTTGGCGTCGTTTGTAGCCGAGGCGACGCTCA
CCTCCGCCGGGGGCAGCGGCTTCCTGCTGGCCCACACGGCCACCGGCGAGGACATTCTGTTTGATTTTTTCTCCCAGACG
CCTTTGCGCCGCCGGGCGGCCCGCGAGGTGAACTTCTATCCGGTCTCGGTCAATTTTGGCGACGCGGCGCAGGAATTTCA
CATCGGCCCGGGTTCGATGGCCGTCCCCGGCAACGTAGCGGGCCTGTTCCACGTCCACCGCCGCCTCGGCCGCTTGCCGA
TGGCGGTTGTCGCCGCCCCCGCCGTCGCCCTGGCCAAGAACGGCCTGCTGGTCAGCGATTTTCAGAGCTTTTGCCAGTCG
GTGCTGGAGCCGATTTTGCTGGCCACGCCTGAGGCACGACAAATTTTTGCCCCGGTGGGCCGCCTGCTCGCACCGGGGGA
GCGCCTGTCGATGCCCGAATTCGCCGACACCCTCGAATGGCTGGTGGCGGAAGGGCCGGCAGTGTTCTACGAGGGCGAAA
TCGCCCGGCGTCTGGTGGCCGACTCGGAGCGGTTGGGCGGCCACCTCACCGCCCGAGATCTGCGCGAATACCGGGTCATC
GAGCGGGTACCCCTGGGTTGCGGCTACCGGGGCTACCGGGTGCTCACCAACCCCGAACCGAGCGCCGGGGGCACCCTCAT
CGCCTTTGCGCTGCGGCTACTCGAACAGGCGGATTGCATCCGGCAGTCCTACGCCTCACCCGAGCACCTCGGCCTGCTTG
CAAATGTGATGCGTCTGACCGACGAGGCACGCCGCCACGACTTTGCCTCCGGCAGCGAAGCTCTTCTATCCGCTGGCACA
CTGGCGCGCTACGTCCGTCGCCTCACCAAGCCCTGGGGCAGCACCACCCACCTGAGCGTCCTGGACGAGGAGGGCAACGC
CGCGAGCGTCACTTCCACCAACGGCGAGGGTTCCGCCTACGTCATTCCCGGCACCGGCATCATGGTGAACAACATGCTGG
GCGAGGACGACCTGCACCCGGAGGGCTTCGAGAGTTGGGCCGAAAACCGCCGCATCGCCTCGATGATGGCGCCCTCGCTG
GTGCTCGAAGACGGGAGGCCCTGGGTGGTACTCGGTTCCGGTGGCTCCAAGCGCATCCGTACCGCGCTGTTGCAGGTGAT
TTCAAACCTGGTGGACTTTCAGATGCCCCTTTCGGAGGCCGTTGCAAGCCCCCGCCTACATTGGGAGAACCACGTTCTGC
ACCTGGAGCCGGGTCTGCTTGCCCCGACCCACAGCCTCCACGACGCGGTGATCCGCTGGCGCGAGCAAAACTTTTTTTTC
GGCGGCGTCCACGCCGTCGCCTGCGACGCGCTCGGAAACCTGACCGGCAGCGGCGACGGCAGGCGCAACGGTGCGGCGAG
GTTTAGTTAG

Upstream 100 bases:

>100_bases
CGACATGTCCAGAAAGTACAAAGAAACCTCCGAGGCGGGCCTTGCCCTCAGCAGTACCGAGTGCTGAAACGAAGCGTCCT
CTGCTATACTGCGCCCACGT

Downstream 100 bases:

>100_bases
GTGACAGGTTTCAGCATAAAAACAACGAGCCATCCCCTTCGCCGCAGTCGACACGCGTCGTGCAGGCCCTAGAAAAATAA
GCCCTTCCCACCCGCCAAGT

Product: gamma-glutamyltranspeptidase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 509; Mature: 508

Protein sequence:

>509_residues
MGTRTTLSTTCGVIAAGHAETAAAGVKILRLGGNAFDAAVAGMLASFVAEATLTSAGGSGFLLAHTATGEDILFDFFSQT
PLRRRAAREVNFYPVSVNFGDAAQEFHIGPGSMAVPGNVAGLFHVHRRLGRLPMAVVAAPAVALAKNGLLVSDFQSFCQS
VLEPILLATPEARQIFAPVGRLLAPGERLSMPEFADTLEWLVAEGPAVFYEGEIARRLVADSERLGGHLTARDLREYRVI
ERVPLGCGYRGYRVLTNPEPSAGGTLIAFALRLLEQADCIRQSYASPEHLGLLANVMRLTDEARRHDFASGSEALLSAGT
LARYVRRLTKPWGSTTHLSVLDEEGNAASVTSTNGEGSAYVIPGTGIMVNNMLGEDDLHPEGFESWAENRRIASMMAPSL
VLEDGRPWVVLGSGGSKRIRTALLQVISNLVDFQMPLSEAVASPRLHWENHVLHLEPGLLAPTHSLHDAVIRWREQNFFF
GGVHAVACDALGNLTGSGDGRRNGAARFS

Sequences:

>Translated_509_residues
MGTRTTLSTTCGVIAAGHAETAAAGVKILRLGGNAFDAAVAGMLASFVAEATLTSAGGSGFLLAHTATGEDILFDFFSQT
PLRRRAAREVNFYPVSVNFGDAAQEFHIGPGSMAVPGNVAGLFHVHRRLGRLPMAVVAAPAVALAKNGLLVSDFQSFCQS
VLEPILLATPEARQIFAPVGRLLAPGERLSMPEFADTLEWLVAEGPAVFYEGEIARRLVADSERLGGHLTARDLREYRVI
ERVPLGCGYRGYRVLTNPEPSAGGTLIAFALRLLEQADCIRQSYASPEHLGLLANVMRLTDEARRHDFASGSEALLSAGT
LARYVRRLTKPWGSTTHLSVLDEEGNAASVTSTNGEGSAYVIPGTGIMVNNMLGEDDLHPEGFESWAENRRIASMMAPSL
VLEDGRPWVVLGSGGSKRIRTALLQVISNLVDFQMPLSEAVASPRLHWENHVLHLEPGLLAPTHSLHDAVIRWREQNFFF
GGVHAVACDALGNLTGSGDGRRNGAARFS
>Mature_508_residues
GTRTTLSTTCGVIAAGHAETAAAGVKILRLGGNAFDAAVAGMLASFVAEATLTSAGGSGFLLAHTATGEDILFDFFSQTP
LRRRAAREVNFYPVSVNFGDAAQEFHIGPGSMAVPGNVAGLFHVHRRLGRLPMAVVAAPAVALAKNGLLVSDFQSFCQSV
LEPILLATPEARQIFAPVGRLLAPGERLSMPEFADTLEWLVAEGPAVFYEGEIARRLVADSERLGGHLTARDLREYRVIE
RVPLGCGYRGYRVLTNPEPSAGGTLIAFALRLLEQADCIRQSYASPEHLGLLANVMRLTDEARRHDFASGSEALLSAGTL
ARYVRRLTKPWGSTTHLSVLDEEGNAASVTSTNGEGSAYVIPGTGIMVNNMLGEDDLHPEGFESWAENRRIASMMAPSLV
LEDGRPWVVLGSGGSKRIRTALLQVISNLVDFQMPLSEAVASPRLHWENHVLHLEPGLLAPTHSLHDAVIRWREQNFFFG
GVHAVACDALGNLTGSGDGRRNGAARFS

Specific function: GGT PLAYS A KEY ROLE IN THE GAMMA-GLUTAMYL CYCLE, A PATHWAY FOR THE SYNTHESIS AND DEGRADATION OF GLUTATHIONE. [C]

COG id: COG0405

COG function: function code E; Gamma-glutamyltransferase

Gene ontology:

Cell location: Periplasmic Protein [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the gamma-glutamyltransferase family [H]

Homologues:

Organism=Homo sapiens, GI73915092, Length=484, Percent_Identity=29.7520661157025, Blast_Score=147, Evalue=3e-35,
Organism=Homo sapiens, GI73915090, Length=484, Percent_Identity=29.7520661157025, Blast_Score=147, Evalue=3e-35,
Organism=Homo sapiens, GI73915096, Length=484, Percent_Identity=29.7520661157025, Blast_Score=147, Evalue=3e-35,
Organism=Homo sapiens, GI73915094, Length=484, Percent_Identity=29.7520661157025, Blast_Score=147, Evalue=3e-35,
Organism=Homo sapiens, GI113429324, Length=482, Percent_Identity=29.045643153527, Blast_Score=134, Evalue=2e-31,
Organism=Homo sapiens, GI113429326, Length=486, Percent_Identity=29.0123456790123, Blast_Score=131, Evalue=2e-30,
Organism=Homo sapiens, GI153266885, Length=543, Percent_Identity=28.1767955801105, Blast_Score=130, Evalue=4e-30,
Organism=Homo sapiens, GI153266901, Length=544, Percent_Identity=28.125, Blast_Score=130, Evalue=4e-30,
Organism=Homo sapiens, GI153266907, Length=452, Percent_Identity=29.646017699115, Blast_Score=121, Evalue=1e-27,
Organism=Homo sapiens, GI109148539, Length=479, Percent_Identity=27.7661795407098, Blast_Score=100, Evalue=6e-21,
Organism=Escherichia coli, GI1789856, Length=535, Percent_Identity=29.9065420560748, Blast_Score=211, Evalue=6e-56,
Organism=Caenorhabditis elegans, GI212646519, Length=484, Percent_Identity=25.6198347107438, Blast_Score=111, Evalue=8e-25,
Organism=Caenorhabditis elegans, GI72000294, Length=484, Percent_Identity=25.6198347107438, Blast_Score=111, Evalue=9e-25,
Organism=Caenorhabditis elegans, GI17506189, Length=514, Percent_Identity=23.7354085603113, Blast_Score=81, Evalue=1e-15,
Organism=Saccharomyces cerevisiae, GI6323330, Length=476, Percent_Identity=23.5294117647059, Blast_Score=85, Evalue=4e-17,
Organism=Drosophila melanogaster, GI161077496, Length=519, Percent_Identity=25.626204238921, Blast_Score=119, Evalue=4e-27,
Organism=Drosophila melanogaster, GI45551474, Length=492, Percent_Identity=27.0325203252033, Blast_Score=116, Evalue=4e-26,
Organism=Drosophila melanogaster, GI161077880, Length=492, Percent_Identity=27.0325203252033, Blast_Score=116, Evalue=4e-26,
Organism=Drosophila melanogaster, GI24642670, Length=521, Percent_Identity=26.4875239923225, Blast_Score=116, Evalue=4e-26,
Organism=Drosophila melanogaster, GI24642666, Length=521, Percent_Identity=26.4875239923225, Blast_Score=116, Evalue=4e-26,
Organism=Drosophila melanogaster, GI161077878, Length=492, Percent_Identity=27.0325203252033, Blast_Score=116, Evalue=5e-26,
Organism=Drosophila melanogaster, GI18859893, Length=496, Percent_Identity=26.8145161290323, Blast_Score=115, Evalue=6e-26,
Organism=Drosophila melanogaster, GI18859741, Length=485, Percent_Identity=26.1855670103093, Blast_Score=97, Evalue=2e-20,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000101 [H]

Pfam domain/function: PF01019 G_glu_transpept [H]

EC number: =2.3.2.2 [H]

Molecular weight: Translated: 54481; Mature: 54349

Theoretical pI: Translated: 6.51; Mature: 6.51

Prosite motif: PS00443 GATASE_TYPE_II

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
2.2 %Met     (Translated Protein)
3.1 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
2.0 %Met     (Mature Protein)
3.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MGTRTTLSTTCGVIAAGHAETAAAGVKILRLGGNAFDAAVAGMLASFVAEATLTSAGGSG
CCCCCCHHHHCCEEECCCCHHHHHCEEEEEECCCHHHHHHHHHHHHHHHHHHHHCCCCCC
FLLAHTATGEDILFDFFSQTPLRRRAAREVNFYPVSVNFGDAAQEFHIGPGSMAVPGNVA
EEEEEECCCHHHHHHHHHCCHHHHHHHCCCCEEEEEEECCCCCHHEECCCCCEECCCCHH
GLFHVHRRLGRLPMAVVAAPAVALAKNGLLVSDFQSFCQSVLEPILLATPEARQIFAPVG
HHHHHHHHHCCCCHHHHHHHHHHHHCCCEEHHHHHHHHHHHHHHHHCCCCCHHHHHHHHH
RLLAPGERLSMPEFADTLEWLVAEGPAVFYEGEIARRLVADSERLGGHLTARDLREYRVI
HHHCCCCCCCCCHHHHHHHHHHHCCCEEEECHHHHHHHHHCHHHHCCCCCHHHHHHHHHH
ERVPLGCGYRGYRVLTNPEPSAGGTLIAFALRLLEQADCIRQSYASPEHLGLLANVMRLT
HHCCCCCCCCCCEEECCCCCCCCCHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHH
DEARRHDFASGSEALLSAGTLARYVRRLTKPWGSTTHLSVLDEEGNAASVTSTNGEGSAY
HHHHHCCCCCCHHHHHHHHHHHHHHHHHHCCCCCCEEEEEEECCCCEEEEEECCCCCCEE
VIPGTGIMVNNMLGEDDLHPEGFESWAENRRIASMMAPSLVLEDGRPWVVLGSGGSKRIR
EECCCCEEEECCCCCCCCCCCHHHHHHHCCHHHHHHCCHHEEECCCCEEEECCCCCHHHH
TALLQVISNLVDFQMPLSEAVASPRLHWENHVLHLEPGLLAPTHSLHDAVIRWREQNFFF
HHHHHHHHHHHHHCCCHHHHHCCCCCCCCCCEEEECCCCCCCCHHHHHHHHHHHHCCEEE
GGVHAVACDALGNLTGSGDGRRNGAARFS
CCHHHHHHHHHHCCCCCCCCCCCCCCCCC
>Mature Secondary Structure 
GTRTTLSTTCGVIAAGHAETAAAGVKILRLGGNAFDAAVAGMLASFVAEATLTSAGGSG
CCCCCHHHHCCEEECCCCHHHHHCEEEEEECCCHHHHHHHHHHHHHHHHHHHHCCCCCC
FLLAHTATGEDILFDFFSQTPLRRRAAREVNFYPVSVNFGDAAQEFHIGPGSMAVPGNVA
EEEEEECCCHHHHHHHHHCCHHHHHHHCCCCEEEEEEECCCCCHHEECCCCCEECCCCHH
GLFHVHRRLGRLPMAVVAAPAVALAKNGLLVSDFQSFCQSVLEPILLATPEARQIFAPVG
HHHHHHHHHCCCCHHHHHHHHHHHHCCCEEHHHHHHHHHHHHHHHHCCCCCHHHHHHHHH
RLLAPGERLSMPEFADTLEWLVAEGPAVFYEGEIARRLVADSERLGGHLTARDLREYRVI
HHHCCCCCCCCCHHHHHHHHHHHCCCEEEECHHHHHHHHHCHHHHCCCCCHHHHHHHHHH
ERVPLGCGYRGYRVLTNPEPSAGGTLIAFALRLLEQADCIRQSYASPEHLGLLANVMRLT
HHCCCCCCCCCCEEECCCCCCCCCHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHH
DEARRHDFASGSEALLSAGTLARYVRRLTKPWGSTTHLSVLDEEGNAASVTSTNGEGSAY
HHHHHCCCCCCHHHHHHHHHHHHHHHHHHCCCCCCEEEEEEECCCCEEEEEECCCCCCEE
VIPGTGIMVNNMLGEDDLHPEGFESWAENRRIASMMAPSLVLEDGRPWVVLGSGGSKRIR
EECCCCEEEECCCCCCCCCCCHHHHHHHCCHHHHHHCCHHEEECCCCEEEECCCCCHHHH
TALLQVISNLVDFQMPLSEAVASPRLHWENHVLHLEPGLLAPTHSLHDAVIRWREQNFFF
HHHHHHHHHHHHHCCCHHHHHCCCCCCCCCCEEEECCCCCCCCHHHHHHHHHHHHCCEEE
GGVHAVACDALGNLTGSGDGRRNGAARFS
CCHHHHHHHHHHCCCCCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8905231 [H]