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The map label for this gene is pyrH

Identifier: 37521909

GI number: 37521909

Start: 2500995

End: 2501702

Strand: Reverse

Name: pyrH

Synonym: gvip321

Alternate gene names: 37521909

Gene position: 2501702-2500995 (Counterclockwise)

Preceding gene: 37521910

Following gene: 37521908

Centisome position: 53.7

GC content: 61.44

Gene sequence:

>708_bases
ATGAAGTATCGCCGCGTCCTTTTGAAGCTGAGCGGGGAAGCCCTGATGGGCGACCGCGAATTCGGGATCGACCCGGAGGT
AGTCAAGTCGCTTGCCGGTGAGATCGCCCGGGTGGTGGAAGCGGGTACCGAACTGGCGGTGGTGGTGGGCGGCGGCAATA
TCTTCCGCGGCGTCAAGGCGAGCTCCTCGGGAATGGACCGGGCGACGGCCGACTACGTCGGGATGCTCGCCACGGTGATG
AACGCCCTGACGCTGCAGGATGCCCTCGAACAGCAGTTCCAGGTCCAGACGCGGTTACTCTCGGCCATCGAGATGAAGGA
GGTGGCCGAGCCGTTTATCCGCCGCCGGGCGATGCGCCACCTCGAAAAAGGACGGGTGGTCATCTTCGGGGCCGGTTCGG
GCAATCCATTTTTTACCACCGACACCACCGCCGCCCTGCGCGCCGCCGAAATCGACGCTCAGGTAATCTTTAAAGCGACC
CGCGTCGACGGCATCTACGACAGCGATCCGAAGTTCAACCCCCAGGCGGTGCGCTTCGAGAAAATTACCTTCCACGAAGT
GCTGGTCCAAAATCTGCGGGTGATGGACTCGACCGCCATCGCCCTGTGCCGCGAAAACAACATCCCGATCCTGGTTTTCA
ATGTCTTCGAAAAAAACAGCATCTACCGGGCGGTGCAGGGCGAGGCGGTGGGCACTTACGTCTGTTAA

Upstream 100 bases:

>100_bases
ATAGCGGTCTTTATTTCACCCACCGGCCTGCGGGCCGGTTTTTTGATCGAGGGTGTTATTCTTTGACAGGACAATCCTCT
CTAGCCAGCGCCAAATCGCC

Downstream 100 bases:

>100_bases
ATCCCGTCTGACGGCCGGTGCAGGCGGGCCTTGCCGAAATCTATGCGCAACGGACCGAATGATGCACAATGGGGTGGGAT
CACGCCTGTCAGGGAAGTGC

Product: uridylate kinase

Products: NA

Alternate protein names: UK; Uridine monophosphate kinase; UMP kinase; UMPK

Number of amino acids: Translated: 235; Mature: 235

Protein sequence:

>235_residues
MKYRRVLLKLSGEALMGDREFGIDPEVVKSLAGEIARVVEAGTELAVVVGGGNIFRGVKASSSGMDRATADYVGMLATVM
NALTLQDALEQQFQVQTRLLSAIEMKEVAEPFIRRRAMRHLEKGRVVIFGAGSGNPFFTTDTTAALRAAEIDAQVIFKAT
RVDGIYDSDPKFNPQAVRFEKITFHEVLVQNLRVMDSTAIALCRENNIPILVFNVFEKNSIYRAVQGEAVGTYVC

Sequences:

>Translated_235_residues
MKYRRVLLKLSGEALMGDREFGIDPEVVKSLAGEIARVVEAGTELAVVVGGGNIFRGVKASSSGMDRATADYVGMLATVM
NALTLQDALEQQFQVQTRLLSAIEMKEVAEPFIRRRAMRHLEKGRVVIFGAGSGNPFFTTDTTAALRAAEIDAQVIFKAT
RVDGIYDSDPKFNPQAVRFEKITFHEVLVQNLRVMDSTAIALCRENNIPILVFNVFEKNSIYRAVQGEAVGTYVC
>Mature_235_residues
MKYRRVLLKLSGEALMGDREFGIDPEVVKSLAGEIARVVEAGTELAVVVGGGNIFRGVKASSSGMDRATADYVGMLATVM
NALTLQDALEQQFQVQTRLLSAIEMKEVAEPFIRRRAMRHLEKGRVVIFGAGSGNPFFTTDTTAALRAAEIDAQVIFKAT
RVDGIYDSDPKFNPQAVRFEKITFHEVLVQNLRVMDSTAIALCRENNIPILVFNVFEKNSIYRAVQGEAVGTYVC

Specific function: Catalyzes the reversible phosphorylation of UMP to UDP

COG id: COG0528

COG function: function code F; Uridylate kinase

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the UMP kinase family

Homologues:

Organism=Escherichia coli, GI1786367, Length=232, Percent_Identity=47.4137931034483, Blast_Score=228, Evalue=3e-61,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): PYRH_GLOVI (Q7NI44)

Other databases:

- EMBL:   BA000045
- RefSeq:   NP_925286.1
- HSSP:   P0A7E9
- ProteinModelPortal:   Q7NI44
- SMR:   Q7NI44
- GeneID:   2600741
- GenomeReviews:   BA000045_GR
- NMPDR:   fig|251221.1.peg.2340
- HOGENOM:   HBG497552
- OMA:   RHMEKGR
- ProtClustDB:   PRK00358
- BioCyc:   GVIO251221:GLL2340-MONOMER
- BRENDA:   2.7.4.22
- GO:   GO:0005737
- HAMAP:   MF_01220_B
- InterPro:   IPR001048
- InterPro:   IPR011817
- InterPro:   IPR015963
- Gene3D:   G3DSA:3.40.1160.10
- PIRSF:   PIRSF005650
- TIGRFAMs:   TIGR02075

Pfam domain/function: PF00696 AA_kinase; SSF53633 Aa_kinase

EC number: =2.7.4.22

Molecular weight: Translated: 25853; Mature: 25853

Theoretical pI: Translated: 7.41; Mature: 7.41

Prosite motif: NA

Important sites: BINDING 51-51 BINDING 52-52 BINDING 56-56 BINDING 71-71 BINDING 160-160 BINDING 166-166 BINDING 169-169

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
3.4 %Met     (Translated Protein)
4.3 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
3.4 %Met     (Mature Protein)
4.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKYRRVLLKLSGEALMGDREFGIDPEVVKSLAGEIARVVEAGTELAVVVGGGNIFRGVKA
CCHHHEEEEECCCCEECCCCCCCCHHHHHHHHHHHHHHHHCCCCEEEEEECCCEECCCCC
SSSGMDRATADYVGMLATVMNALTLQDALEQQFQVQTRLLSAIEMKEVAEPFIRRRAMRH
CCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
LEKGRVVIFGAGSGNPFFTTDTTAALRAAEIDAQVIFKATRVDGIYDSDPKFNPQAVRFE
HHCCCEEEEECCCCCCEEECCHHHHHHHHHCCHHHEEEEHHCCCCCCCCCCCCCCEEEEE
KITFHEVLVQNLRVMDSTAIALCRENNIPILVFNVFEKNSIYRAVQGEAVGTYVC
HHHHHHHHHHHHHHHHHHHEEEEECCCCCEEEEEECCCCCCHHHHCCCCCEECCC
>Mature Secondary Structure
MKYRRVLLKLSGEALMGDREFGIDPEVVKSLAGEIARVVEAGTELAVVVGGGNIFRGVKA
CCHHHEEEEECCCCEECCCCCCCCHHHHHHHHHHHHHHHHCCCCEEEEEECCCEECCCCC
SSSGMDRATADYVGMLATVMNALTLQDALEQQFQVQTRLLSAIEMKEVAEPFIRRRAMRH
CCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
LEKGRVVIFGAGSGNPFFTTDTTAALRAAEIDAQVIFKATRVDGIYDSDPKFNPQAVRFE
HHCCCEEEEECCCCCCEEECCHHHHHHHHHCCHHHEEEEHHCCCCCCCCCCCCCCEEEEE
KITFHEVLVQNLRVMDSTAIALCRENNIPILVFNVFEKNSIYRAVQGEAVGTYVC
HHHHHHHHHHHHHHHHHHHEEEEECCCCCEEEEEECCCCCCHHHHCCCCCEECCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 14621292