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The map label for this gene is murB

Identifier: 37521886

GI number: 37521886

Start: 2482040

End: 2482933

Strand: Direct

Name: murB

Synonym: glr2317

Alternate gene names: 37521886

Gene position: 2482040-2482933 (Clockwise)

Preceding gene: 37521885

Following gene: 37521887

Centisome position: 53.27

GC content: 67.34

Gene sequence:

>894_bases
ATGAAAGATCAGCTGCAGCCGGGGGTCTCACTGGCGCTGCTCACCGCGTACCAGGTGGGCGGCCCGGCCGAGTGGTATCT
GCAGCCGACCAAAGCCGAGGTGCTCGACGAAGCCCTCGGTTGGGCACGCCGCTCCGAGTTGCCGGTCACGGTGATTGGGG
CGGGGACCAATTTGCTGATTAGTGACGTGGGCATCGGTGGATTGGTCGTCCACCTGCGCAGCTGGCGGGGTACCCAGATC
CTCGAAGAGGGGCTCATCGAAGTCAAAGCCGGCGAGTCGATCGCTGCTCTGGCCTTTCAGACGGCCCGCCGCGGCTGGGC
GGGGCTGGAGTGGGCGGTGGGGGTGCCCGGCAGCATCGGGGGGGCCGTGGTGATGAACGCCGGAGCCCACGGCGCCCAAT
TTTCCGACACCCTCGAAAGTGTCGAAGTGCTCACCGAGACCGGCGAGCGGCGGCGGGTGGCGGCGGGGGAACTCGGGCTT
ACCTATCGCTCGTCGCTATTGCAGCAGCGCGATTGGGTGGTGCTCAGCGCCCGGCTGCGGCTTGCTCCCGGCCACCAACC
GGCCCGCCTTATCGAGCACATCGACGAATTTAATACCTTTCGCCACCGCACCCAGCCCTCGGGCTTTCCCAACTGCGGCA
GCGTCTTTCGCAACCCCGGCGGCGAGAAAAAAGCCGGCTGGATGCTCGACCGCTCCGGGCTCAAGGGCCAGAGCGTCGGG
GCGGCCCAGGTGGCCGAGCAGCACGCCAACTTCATCCTCAACCGCGGCGGCGCCACTGCCCGCGACATCCTCACCCTGAT
GACCCGCATGCGCGACCGGGTCGTTGCGGACTGGGGCATTGCGCTCAAGCCGGAGGTGCGATTTTTGGGGCGTGGTTTGA
ACTGGGCGGGCTGA

Upstream 100 bases:

>100_bases
ATCTGCGCCCCGGGGATCTGGCGCTATTTTTGGGGGCGGGCAACCTCAACCGGATCATTCCCGAACTGTTGCAGCGGGCG
GAACCGCCGGCACTTGCCCT

Downstream 100 bases:

>100_bases
TTTCGAGCTAGCATCTAAGCGTGGCGTTGTCCCTGGCGTTGTACGCATTTGCATTTTTGGAACTGCCGCTGCCCATCTGC
CCGCCCATTGGCTGGCGCGG

Product: UDP-N-acetylenolpyruvylglucosamine reductase

Products: NA

Alternate protein names: UDP-N-acetylmuramate dehydrogenase

Number of amino acids: Translated: 297; Mature: 297

Protein sequence:

>297_residues
MKDQLQPGVSLALLTAYQVGGPAEWYLQPTKAEVLDEALGWARRSELPVTVIGAGTNLLISDVGIGGLVVHLRSWRGTQI
LEEGLIEVKAGESIAALAFQTARRGWAGLEWAVGVPGSIGGAVVMNAGAHGAQFSDTLESVEVLTETGERRRVAAGELGL
TYRSSLLQQRDWVVLSARLRLAPGHQPARLIEHIDEFNTFRHRTQPSGFPNCGSVFRNPGGEKKAGWMLDRSGLKGQSVG
AAQVAEQHANFILNRGGATARDILTLMTRMRDRVVADWGIALKPEVRFLGRGLNWAG

Sequences:

>Translated_297_residues
MKDQLQPGVSLALLTAYQVGGPAEWYLQPTKAEVLDEALGWARRSELPVTVIGAGTNLLISDVGIGGLVVHLRSWRGTQI
LEEGLIEVKAGESIAALAFQTARRGWAGLEWAVGVPGSIGGAVVMNAGAHGAQFSDTLESVEVLTETGERRRVAAGELGL
TYRSSLLQQRDWVVLSARLRLAPGHQPARLIEHIDEFNTFRHRTQPSGFPNCGSVFRNPGGEKKAGWMLDRSGLKGQSVG
AAQVAEQHANFILNRGGATARDILTLMTRMRDRVVADWGIALKPEVRFLGRGLNWAG
>Mature_297_residues
MKDQLQPGVSLALLTAYQVGGPAEWYLQPTKAEVLDEALGWARRSELPVTVIGAGTNLLISDVGIGGLVVHLRSWRGTQI
LEEGLIEVKAGESIAALAFQTARRGWAGLEWAVGVPGSIGGAVVMNAGAHGAQFSDTLESVEVLTETGERRRVAAGELGL
TYRSSLLQQRDWVVLSARLRLAPGHQPARLIEHIDEFNTFRHRTQPSGFPNCGSVFRNPGGEKKAGWMLDRSGLKGQSVG
AAQVAEQHANFILNRGGATARDILTLMTRMRDRVVADWGIALKPEVRFLGRGLNWAG

Specific function: Cell wall formation

COG id: COG0812

COG function: function code M; UDP-N-acetylmuramate dehydrogenase

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 FAD-binding PCMH-type domain

Homologues:

Organism=Escherichia coli, GI1790407, Length=291, Percent_Identity=28.5223367697594, Blast_Score=98, Evalue=8e-22,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): MURB_GLOVI (Q7NI66)

Other databases:

- EMBL:   BA000045
- RefSeq:   NP_925263.1
- ProteinModelPortal:   Q7NI66
- SMR:   Q7NI66
- GeneID:   2600719
- GenomeReviews:   BA000045_GR
- KEGG:   gvi:glr2317
- NMPDR:   fig|251221.1.peg.2317
- HOGENOM:   HBG686573
- OMA:   LESSKIP
- BioCyc:   GVIO251221:GLR2317-MONOMER
- BRENDA:   1.1.1.158
- GO:   GO:0005737
- HAMAP:   MF_00037
- InterPro:   IPR016169
- InterPro:   IPR016166
- InterPro:   IPR016167
- InterPro:   IPR003170
- InterPro:   IPR011601
- InterPro:   IPR006094
- Gene3D:   G3DSA:3.30.465.10
- Gene3D:   G3DSA:3.30.43.10
- Gene3D:   G3DSA:3.90.78.10
- PANTHER:   PTHR21071
- TIGRFAMs:   TIGR00179

Pfam domain/function: PF01565 FAD_binding_4; PF02873 MurB_C; SSF56176 FAD-binding_2; SSF56194 MurB_C

EC number: =1.1.1.158

Molecular weight: Translated: 32045; Mature: 32045

Theoretical pI: Translated: 9.60; Mature: 9.60

Prosite motif: PS51387 FAD_PCMH

Important sites: ACT_SITE 163-163 ACT_SITE 214-214 ACT_SITE 285-285

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
1.7 %Met     (Translated Protein)
2.0 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
1.7 %Met     (Mature Protein)
2.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKDQLQPGVSLALLTAYQVGGPAEWYLQPTKAEVLDEALGWARRSELPVTVIGAGTNLLI
CCCCCCCCCCEEEHHHHHCCCCHHEEECCHHHHHHHHHHHHHHHCCCCEEEEECCCEEEE
SDVGIGGLVVHLRSWRGTQILEEGLIEVKAGESIAALAFQTARRGWAGLEWAVGVPGSIG
ECCCCCEEEEEECCCCCHHHHHHCCEEEECCCHHHHHHHHHHHCCCCCCEEECCCCCCCC
GAVVMNAGAHGAQFSDTLESVEVLTETGERRRVAAGELGLTYRSSLLQQRDWVVLSARLR
CEEEEECCCCCCHHHHHHHHHHHHHHCCCCCEEHHCCCCHHHHHHHHHHCCEEEEEEEEE
LAPGHQPARLIEHIDEFNTFRHRTQPSGFPNCGSVFRNPGGEKKAGWMLDRSGLKGQSVG
ECCCCCHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHCCCCCCCCCCEEEECCCCCCCCCC
AAQVAEQHANFILNRGGATARDILTLMTRMRDRVVADWGIALKPEVRFLGRGLNWAG
HHHHHHHHHHHEEECCCCHHHHHHHHHHHHHHHHHHCCCCEECCCHHHHCCCCCCCC
>Mature Secondary Structure
MKDQLQPGVSLALLTAYQVGGPAEWYLQPTKAEVLDEALGWARRSELPVTVIGAGTNLLI
CCCCCCCCCCEEEHHHHHCCCCHHEEECCHHHHHHHHHHHHHHHCCCCEEEEECCCEEEE
SDVGIGGLVVHLRSWRGTQILEEGLIEVKAGESIAALAFQTARRGWAGLEWAVGVPGSIG
ECCCCCEEEEEECCCCCHHHHHHCCEEEECCCHHHHHHHHHHHCCCCCCEEECCCCCCCC
GAVVMNAGAHGAQFSDTLESVEVLTETGERRRVAAGELGLTYRSSLLQQRDWVVLSARLR
CEEEEECCCCCCHHHHHHHHHHHHHHCCCCCEEHHCCCCHHHHHHHHHHCCEEEEEEEEE
LAPGHQPARLIEHIDEFNTFRHRTQPSGFPNCGSVFRNPGGEKKAGWMLDRSGLKGQSVG
ECCCCCHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHCCCCCCCCCCEEEECCCCCCCCCC
AAQVAEQHANFILNRGGATARDILTLMTRMRDRVVADWGIALKPEVRFLGRGLNWAG
HHHHHHHHHHHEEECCCCHHHHHHHHHHHHHHHHHHCCCCEECCCHHHHCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 14621292