Click here to switch to the map view.

The map label for this gene is murC

Identifier: 37521885

GI number: 37521885

Start: 2480661

End: 2482043

Strand: Direct

Name: murC

Synonym: gvip316

Alternate gene names: 37521885

Gene position: 2480661-2482043 (Clockwise)

Preceding gene: 37521883

Following gene: 37521886

Centisome position: 53.24

GC content: 65.37

Gene sequence:

>1383_bases
GTGAATATGTCGCTGGACCCGCTGGTAACGGGTGAGGTTTCTCATTTTGTCGGTATCGGTGGCATCGGCATGTCCGGCCT
GGCTCTGGTATTGCGTTCGCAAGGAAAGCGCGTCAGCGGTTCGGATCTCAAGCCCAACCTGCAGACCCAGCGCCTGGAAG
CCTCGGGCATCTCGGTGTTCTACGGCCACCGCGCCGAAAATCTGCAGGGAGTGACGCGGCTGGTCTATTCGAGCGCCATC
CAACCCGACAACCCGGAACTGTTGGCGGCGCGCAGGGGAGGCGTCGCCGTCCGCCACCGCGCCCAGGTGCTCGCCCAACT
GGCGGAAGGCTACCGGATGATCGGCGTGTCGGGTACCCACGGCAAGACCACCACCAGCAGCTTGATCGCGGTGATGCTTT
ACCACTGCGGCTTGGACCCGACGGTGGTGGTGGGAGGCGAAGTGGACGAACTGGGTGGCAACGCCCGTTTGGGATCCGGC
CCGCACCTGGTGGCGGAGGTGGACGAATCGGATGGGTCGCTGGTGCTCTTTTCGCCGGAGGTGGCCGTGGTCACCAACAT
CGAGGGCGACCACCTCGACCATTACGCCAACCTCGAACAGATCGTCGAAGCTTTTCAGCAGTATGCCAATCAGGCGCGGG
TGGTCGTAGGCTGCCTCGACTGCCAGGCGGTGCGCGACCGGATGCCGTTGACTGTGAGCTACAGCCTGGATGGTCACCCG
CAGGCCGACTACACCGCCGACCGGGTGAGTTTCACCGCCCAGGGCACCACCGCCCGCGTCCTTGAGCGCGGCGAGGTATT
GGGAGAATTGAGCCTCAAATTGTTGGGCCGCCACAATCTGGCCAACGCCCTGGCGGCGGTGGCGGTGGGCCGCTATCTGG
GCCTCAGCTTCGAGCAGATTGCCGCCGGGCTGCGCGAATTTCGCGGTGCCCACCGCCGCTTTGAGCGGATCGGCGAGCGC
GACGACATTGTCTTCGTAGACGATTACGCCCACCATCCGAGCGAAGTGCGTGCCACCCTGGCCGCCGCCCGCCTGCAGGG
CCGCCGGGTGGTGGCGGTCTTTCAGCCCCACCGCTACAGCCGCTCGCAGCTGTTGCTCGACGAATTCGGTACGGCCTTCG
GCGATGCCGACGCGGTGGTGGTCACCGAGATTTATGCCGCCGGGGAGGCAAACACCCTCGGTGTGAGCGGCGAATTGGTG
GCCCGCAGGATTGCCGCTCACCACCCGGACGTGCACTTCGAGGCGACCAGCGACAGTCTCAAGCGCCACCTGGAGGCCCA
TCTGCGCCCCGGGGATCTGGCGCTATTTTTGGGGGCGGGCAACCTCAACCGGATCATTCCCGAACTGTTGCAGCGGGCGG
AACCGCCGGCACTTGCCCTATGA

Upstream 100 bases:

>100_bases
GAAAAAAACTTAATCCCCAGGGCTTGACATGGTAGATTATGGCCGTCATGATCTCGCGGGTCGTGATGTTTCTGTCTACA
ACAACCGGTGTGAAACAGGA

Downstream 100 bases:

>100_bases
AAGATCAGCTGCAGCCGGGGGTCTCACTGGCGCTGCTCACCGCGTACCAGGTGGGCGGCCCGGCCGAGTGGTATCTGCAG
CCGACCAAAGCCGAGGTGCT

Product: UDP-N-acetylmuramate--L-alanine ligase

Products: NA

Alternate protein names: UDP-N-acetylmuramoyl-L-alanine synthetase

Number of amino acids: Translated: 460; Mature: 460

Protein sequence:

>460_residues
MNMSLDPLVTGEVSHFVGIGGIGMSGLALVLRSQGKRVSGSDLKPNLQTQRLEASGISVFYGHRAENLQGVTRLVYSSAI
QPDNPELLAARRGGVAVRHRAQVLAQLAEGYRMIGVSGTHGKTTTSSLIAVMLYHCGLDPTVVVGGEVDELGGNARLGSG
PHLVAEVDESDGSLVLFSPEVAVVTNIEGDHLDHYANLEQIVEAFQQYANQARVVVGCLDCQAVRDRMPLTVSYSLDGHP
QADYTADRVSFTAQGTTARVLERGEVLGELSLKLLGRHNLANALAAVAVGRYLGLSFEQIAAGLREFRGAHRRFERIGER
DDIVFVDDYAHHPSEVRATLAAARLQGRRVVAVFQPHRYSRSQLLLDEFGTAFGDADAVVVTEIYAAGEANTLGVSGELV
ARRIAAHHPDVHFEATSDSLKRHLEAHLRPGDLALFLGAGNLNRIIPELLQRAEPPALAL

Sequences:

>Translated_460_residues
MNMSLDPLVTGEVSHFVGIGGIGMSGLALVLRSQGKRVSGSDLKPNLQTQRLEASGISVFYGHRAENLQGVTRLVYSSAI
QPDNPELLAARRGGVAVRHRAQVLAQLAEGYRMIGVSGTHGKTTTSSLIAVMLYHCGLDPTVVVGGEVDELGGNARLGSG
PHLVAEVDESDGSLVLFSPEVAVVTNIEGDHLDHYANLEQIVEAFQQYANQARVVVGCLDCQAVRDRMPLTVSYSLDGHP
QADYTADRVSFTAQGTTARVLERGEVLGELSLKLLGRHNLANALAAVAVGRYLGLSFEQIAAGLREFRGAHRRFERIGER
DDIVFVDDYAHHPSEVRATLAAARLQGRRVVAVFQPHRYSRSQLLLDEFGTAFGDADAVVVTEIYAAGEANTLGVSGELV
ARRIAAHHPDVHFEATSDSLKRHLEAHLRPGDLALFLGAGNLNRIIPELLQRAEPPALAL
>Mature_460_residues
MNMSLDPLVTGEVSHFVGIGGIGMSGLALVLRSQGKRVSGSDLKPNLQTQRLEASGISVFYGHRAENLQGVTRLVYSSAI
QPDNPELLAARRGGVAVRHRAQVLAQLAEGYRMIGVSGTHGKTTTSSLIAVMLYHCGLDPTVVVGGEVDELGGNARLGSG
PHLVAEVDESDGSLVLFSPEVAVVTNIEGDHLDHYANLEQIVEAFQQYANQARVVVGCLDCQAVRDRMPLTVSYSLDGHP
QADYTADRVSFTAQGTTARVLERGEVLGELSLKLLGRHNLANALAAVAVGRYLGLSFEQIAAGLREFRGAHRRFERIGER
DDIVFVDDYAHHPSEVRATLAAARLQGRRVVAVFQPHRYSRSQLLLDEFGTAFGDADAVVVTEIYAAGEANTLGVSGELV
ARRIAAHHPDVHFEATSDSLKRHLEAHLRPGDLALFLGAGNLNRIIPELLQRAEPPALAL

Specific function: Cell wall formation

COG id: COG0773

COG function: function code M; UDP-N-acetylmuramate-alanine ligase

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the MurCDEF family

Homologues:

Organism=Escherichia coli, GI1786279, Length=453, Percent_Identity=37.9690949227373, Blast_Score=228, Evalue=8e-61,
Organism=Escherichia coli, GI1790680, Length=462, Percent_Identity=29.6536796536797, Blast_Score=160, Evalue=1e-40,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): MURC_GLOVI (Q7NI67)

Other databases:

- EMBL:   BA000045
- RefSeq:   NP_925262.1
- ProteinModelPortal:   Q7NI67
- SMR:   Q7NI67
- GeneID:   2600718
- GenomeReviews:   BA000045_GR
- NMPDR:   fig|251221.1.peg.2316
- HOGENOM:   HBG476594
- OMA:   YQPHRYS
- ProtClustDB:   PRK00421
- BioCyc:   GVIO251221:GLR2316-MONOMER
- BRENDA:   6.3.2.8
- GO:   GO:0005737
- HAMAP:   MF_00046
- InterPro:   IPR004101
- InterPro:   IPR013221
- InterPro:   IPR000713
- InterPro:   IPR016040
- InterPro:   IPR005758
- Gene3D:   G3DSA:3.90.190.20
- Gene3D:   G3DSA:3.40.1190.10
- Gene3D:   G3DSA:3.40.50.720
- TIGRFAMs:   TIGR01082

Pfam domain/function: PF01225 Mur_ligase; PF02875 Mur_ligase_C; PF08245 Mur_ligase_M; SSF53244 Mur_ligase_C; SSF53623 Mur_ligase_cen

EC number: =6.3.2.8

Molecular weight: Translated: 49483; Mature: 49483

Theoretical pI: Translated: 6.38; Mature: 6.38

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
1.3 %Met     (Translated Protein)
2.0 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
1.3 %Met     (Mature Protein)
2.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNMSLDPLVTGEVSHFVGIGGIGMSGLALVLRSQGKRVSGSDLKPNLQTQRLEASGISVF
CCCCCCCCCCCCHHHHHEECCCCHHHHHHHHHHCCCCCCCCCCCCCCHHHEECCCCEEEE
YGHRAENLQGVTRLVYSSAIQPDNPELLAARRGGVAVRHRAQVLAQLAEGYRMIGVSGTH
ECCCCHHHHHHHHHHHHHCCCCCCCCEEEECCCCCHHHHHHHHHHHHHCCCEEEEECCCC
GKTTTSSLIAVMLYHCGLDPTVVVGGEVDELGGNARLGSGPHLVAEVDESDGSLVLFSPE
CCCHHHHHHHHHHHHCCCCCEEEECCCHHHCCCCCCCCCCCEEEEEEECCCCCEEEECCC
VAVVTNIEGDHLDHYANLEQIVEAFQQYANQARVVVGCLDCQAVRDRMPLTVSYSLDGHP
EEEEECCCCCCHHHHCCHHHHHHHHHHHHCCCEEEEEEECHHHHHCCCCEEEEEECCCCC
QADYTADRVSFTAQGTTARVLERGEVLGELSLKLLGRHNLANALAAVAVGRYLGLSFEQI
CCCCCCCCEEEEECCCHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHCCCHHHH
AAGLREFRGAHRRFERIGERDDIVFVDDYAHHPSEVRATLAAARLQGRRVVAVFQPHRYS
HHHHHHHHHHHHHHHHCCCCCCEEEEECCCCCHHHHHHHHHHHHHCCCEEEEEECCCCCC
RSQLLLDEFGTAFGDADAVVVTEIYAAGEANTLGVSGELVARRIAAHHPDVHFEATSDSL
HHHHHHHHHCCCCCCCCEEEEEEEECCCCCCEECCCHHHHHHHHHHCCCCCEEECCHHHH
KRHLEAHLRPGDLALFLGAGNLNRIIPELLQRAEPPALAL
HHHHHHHCCCCCEEEEEECCCHHHHHHHHHHHCCCCCCCC
>Mature Secondary Structure
MNMSLDPLVTGEVSHFVGIGGIGMSGLALVLRSQGKRVSGSDLKPNLQTQRLEASGISVF
CCCCCCCCCCCCHHHHHEECCCCHHHHHHHHHHCCCCCCCCCCCCCCHHHEECCCCEEEE
YGHRAENLQGVTRLVYSSAIQPDNPELLAARRGGVAVRHRAQVLAQLAEGYRMIGVSGTH
ECCCCHHHHHHHHHHHHHCCCCCCCCEEEECCCCCHHHHHHHHHHHHHCCCEEEEECCCC
GKTTTSSLIAVMLYHCGLDPTVVVGGEVDELGGNARLGSGPHLVAEVDESDGSLVLFSPE
CCCHHHHHHHHHHHHCCCCCEEEECCCHHHCCCCCCCCCCCEEEEEEECCCCCEEEECCC
VAVVTNIEGDHLDHYANLEQIVEAFQQYANQARVVVGCLDCQAVRDRMPLTVSYSLDGHP
EEEEECCCCCCHHHHCCHHHHHHHHHHHHCCCEEEEEEECHHHHHCCCCEEEEEECCCCC
QADYTADRVSFTAQGTTARVLERGEVLGELSLKLLGRHNLANALAAVAVGRYLGLSFEQI
CCCCCCCCEEEEECCCHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHCCCHHHH
AAGLREFRGAHRRFERIGERDDIVFVDDYAHHPSEVRATLAAARLQGRRVVAVFQPHRYS
HHHHHHHHHHHHHHHHCCCCCCEEEEECCCCCHHHHHHHHHHHHHCCCEEEEEECCCCCC
RSQLLLDEFGTAFGDADAVVVTEIYAAGEANTLGVSGELVARRIAAHHPDVHFEATSDSL
HHHHHHHHHCCCCCCCCEEEEEEEECCCCCCEECCCHHHHHHHHHHCCCCCEEECCHHHH
KRHLEAHLRPGDLALFLGAGNLNRIIPELLQRAEPPALAL
HHHHHHHCCCCCEEEEEECCCHHHHHHHHHHHCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 14621292